Reviewed, UniProtKB/Swiss-Prot Q3IFT7 (ASTD1_PSEHT)

Names and origin

Protein names

Recommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase 1
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase 1
      Short name=SGSD 1

Gene names

Name:	astD1
Ordered Locus Names:	PSHAa0196

Organism

Pseudoalteromonas haloplanktis (strain TAC 125) [Complete proteome] [HAMAP]

Taxonomic identifier

326442 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Pseudoalteromonadaceae › Pseudoalteromonas

Protein attributes

Sequence length	489 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 489	489	N-succinylglutamate 5-semialdehyde dehydrogenase 1 HAMAP MF_01174		PRO_0000262412
Regions
	Nucleotide binding	223 – 228	6	NAD By similarity
Sites
	Active site	246	1	By similarity
	Active site	280	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3IFT7-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: CA361C82827678A9	FASTA	489	52,132
	10 20 30 40 50 60 MTHPAQFING QWSQGQGTEF SSVNPANNNV IFQANSATAE QVDAAVSAAR EAFYAWADKT 70 80 90 100 110 120 FAERLEIVKA FAAQLKENSE ELAITIAQET GKPLWETRTE AGAMVGKIAI SEKAFLERTG 130 140 150 160 170 180 DVENAMPLGR AMIRHKPHGV VAVFGPYNFP GHLPNGHIVP ALLAGNTVIF KPSELTPKVA 190 200 210 220 230 240 ELTLKLWEKA GLPAGVINLV QGEVATGKAL AAHKGIDGLF FTGSSRTGHI LHEQFAGQPG 250 260 270 280 290 300 KILALEMGGN NPLIITDVED TKAVVHDIIQ SAFISSGQRC TCARKLFLPT GSKGDVILER 310 320 330 340 350 360 LITATKAIKV GNYDDADQPF MGSMISSAAA AGMVKAQNEL VELGAQVLVE LEHTVNTGFV 370 380 390 400 410 420 TPGIIECTNI SDFPDEEHFG PLLKVFRFDD FDQAIDKAND TSFGLSAGLL SDSAADYEHF 430 440 450 460 470 480 LRRIRAGIVN WNRPITGASS AAPFGGIGAS GNHRASAYYA ADYCAYPVAS VELEKVAMPA TLSPGLKID

References

[1]

"Coping with cold: the genome of the versatile marine Antarctica bacterium Pseudoalteromonas haloplanktis TAC125." Medigue C., Krin E., Pascal G., Barbe V., Bernsel A., Bertin P.N., Cheung F., Cruveiller S., D'Amico S., Duilio A., Fang G., Feller G., Ho C., Mangenot S., Marino G., Nilsson J., Parrilli E., Rocha E.P.C. , Rouy Z., Sekowska A., Tutino M.L., Vallenet D., von Heijne G., Danchin A. Genome Res. 15:1325-1335(2005) [PubMed: 16169927] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR954246 Genomic DNA. Translation: CAI85299.1.
RefSeq	YP_338742.1.
3D structure databases
SMR	Q3IFT7. Positions 1-464.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3IFT7.
Genome annotation databases
GeneID	3708763.
GenomeReviews	Gene locus PSHAa0196 in contig CR954246_GR.
KEGG	pha:PSHAa0196.
NMPDR	fig|326442.4.peg.280.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1012.
HOGENOM	HBG752218.
OMA	EELAITI.
PhylomeDB	Q3IFT7.
Enzyme and pathway databases
BioCyc	PHAL326442:PSHAA0196-MONOMER.
Family and domain databases
HAMAP	MF_01174. Aldedh_AstD. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03240. arg_catab_astD. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD1_PSEHT

Accession

Primary (citable) accession number: Q3IFT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	November 8, 2005
Last modified:	February 9, 2010
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)