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Q3IFD2

- PDXA_PSEHT

UniProt

Q3IFD2 - PDXA_PSEHT

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Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene
pdxA, PSHAa2634
Organism
Pseudoalteromonas haloplanktis (strain TAC 125)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity.UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.UniRule annotation

Cofactori

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei134 – 1341Substrate By similarity
Binding sitei135 – 1351Substrate By similarity
Metal bindingi164 – 1641Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi209 – 2091Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi264 – 2641Divalent metal cation; shared with dimeric partner By similarity
Binding sitei272 – 2721Substrate By similarity
Binding sitei281 – 2811Substrate By similarity
Binding sitei290 – 2901Substrate By similarity

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. cobalt ion binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. NAD binding Source: InterPro
  5. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

BioCyciPHAL326442:GJIU-2689-MONOMER.
UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenase (EC:1.1.1.262)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene namesi
Name:pdxA
Ordered Locus Names:PSHAa2634
OrganismiPseudoalteromonas haloplanktis (strain TAC 125)
Taxonomic identifieri326442 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
ProteomesiUP000006843: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3303304-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotationPRO_1000128258Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi326442.PSHAa2634.

Structurei

3D structure databases

ProteinModelPortaliQ3IFD2.
SMRiQ3IFD2. Positions 2-322.

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.

Phylogenomic databases

eggNOGiCOG1995.
HOGENOMiHOG000221592.
KOiK00097.
OMAiDTLFQDK.
OrthoDBiEOG6GN6ZC.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3IFD2-1 [UniParc]FASTAAdd to Basket

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MTLRIAITPG EPAGIGPDLL LKLAQQTWDA QLVAIADANM LKQRAKHLGL    50
SIKLIEFDQH AAATPAPAGS LYLHQVDVAE PVELGVLNDA NGQYVLDTLR 100
IASEKNMDGT FAAVVTGPVH KGIINKAGIS FSGHTEYFAQ QSNTADVVMM 150
LATQGLRVAL VTTHIPLAYV SRAITEDRLI KVASILNHDL QTKFGIEKPR 200
ILVCGLNPHA GEDGHLGREE IDTIIPTLEI LNNQGMNLIG PLPADTLFQD 250
KYLNEADAVL AMYHDQGLPV LKYKGFGNSV NITLGLPFIR TSVDHGTALD 300
LAGKGTADVG SFELAIREAI KLAQEKAQNQ 330
Length:330
Mass (Da):35,458
Last modified:November 8, 2005 - v1
Checksum:iFF12BF416F5F8AFF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR954246 Genomic DNA. Translation: CAI87682.1.
RefSeqiWP_011329282.1. NC_007481.1.
YP_341124.1. NC_007481.1.

Genome annotation databases

EnsemblBacteriaiCAI87682; CAI87682; PSHAa2634.
GeneIDi3709962.
KEGGipha:PSHAa2634.
PATRICi32298853. VBIPseHal105694_2544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR954246 Genomic DNA. Translation: CAI87682.1 .
RefSeqi WP_011329282.1. NC_007481.1.
YP_341124.1. NC_007481.1.

3D structure databases

ProteinModelPortali Q3IFD2.
SMRi Q3IFD2. Positions 2-322.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326442.PSHAa2634.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI87682 ; CAI87682 ; PSHAa2634 .
GeneIDi 3709962.
KEGGi pha:PSHAa2634.
PATRICi 32298853. VBIPseHal105694_2544.

Phylogenomic databases

eggNOGi COG1995.
HOGENOMi HOG000221592.
KOi K00097.
OMAi DTLFQDK.
OrthoDBi EOG6GN6ZC.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .
BioCyci PHAL326442:GJIU-2689-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00557. pdxA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TAC 125.

Entry informationi

Entry nameiPDXA_PSEHT
AccessioniPrimary (citable) accession number: Q3IFD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 8, 2005
Last modified: September 3, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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