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Q3IEN6

- ACDH_PSEHT

UniProt

Q3IEN6 - ACDH_PSEHT

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Protein
Acetaldehyde dehydrogenase
Gene
mhpF, PSHAa2142
Organism
Pseudoalteromonas haloplanktis (strain TAC 125)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291Acyl-thioester intermediate By similarity
Binding sitei271 – 2711NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 144NAD By similarity
Nucleotide bindingi160 – 1689NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: UniProtKB-HAMAP
  2. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciPHAL326442:GJIU-2199-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene namesi
Name:mhpF
Ordered Locus Names:PSHAa2142
OrganismiPseudoalteromonas haloplanktis (strain TAC 125)
Taxonomic identifieri326442 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
ProteomesiUP000006843: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300Acetaldehyde dehydrogenaseUniRule annotation
PRO_0000387705Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326442.PSHAa2142.

Structurei

3D structure databases

ProteinModelPortaliQ3IEN6.
SMRiQ3IEN6. Positions 2-292.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiREVQKYV.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3IEN6-1 [UniParc]FASTAAdd to Basket

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MKKIKCALIG SGNIGTDLLY KLKRSEILEP VWMVGIDPDS EGLARARELG    50
IKTTADGIDG LIPHIEADEI KIAFDATSAY VHGENSAKVN AKGVLMIDLT 100
PAAIGPFCVP PVNLNQLNAD IKNVNMVTCG GQATIPMVAA VSRVQPVEYG 150
EIVATVSSKS VGPGTRQNID EFTRTTSGAV EQIGGAKKGK AIIIINPAEP 200
PLLMRDTIHC LTETEPDQAA ITASVHEMIA EVQKYVPGYK LKNGPVFDGR 250
KVSIFLEVEG LGDYLPKYAG NLDIMTASAA RTAEMFALQM LGQSPSDSQS 300
Length:300
Mass (Da):31,906
Last modified:November 8, 2005 - v1
Checksum:i58C82B9BB5E4DAF3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR954246 Genomic DNA. Translation: CAI87198.1.
RefSeqiYP_340640.1. NC_007481.1.

Genome annotation databases

EnsemblBacteriaiCAI87198; CAI87198; PSHAa2142.
GeneIDi3710160.
KEGGipha:PSHAa2142.
PATRICi32297871. VBIPseHal105694_2059.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR954246 Genomic DNA. Translation: CAI87198.1 .
RefSeqi YP_340640.1. NC_007481.1.

3D structure databases

ProteinModelPortali Q3IEN6.
SMRi Q3IEN6. Positions 2-292.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326442.PSHAa2142.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI87198 ; CAI87198 ; PSHAa2142 .
GeneIDi 3710160.
KEGGi pha:PSHAa2142.
PATRICi 32297871. VBIPseHal105694_2059.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi REVQKYV.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci PHAL326442:GJIU-2199-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TAC 125.

Entry informationi

Entry nameiACDH_PSEHT
AccessioniPrimary (citable) accession number: Q3IEN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 8, 2005
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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