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Q3IEN6

- ACDH_PSEHT

UniProt

Q3IEN6 - ACDH_PSEHT

Protein

Acetaldehyde dehydrogenase

Gene

mhpF

Organism
Pseudoalteromonas haloplanktis (strain TAC 125)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei129 – 1291Acyl-thioester intermediateUniRule annotation
    Binding sitei271 – 2711NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 144NADUniRule annotation
    Nucleotide bindingi160 – 1689NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciPHAL326442:GJIU-2199-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating]UniRule annotation
    Gene namesi
    Name:mhpFUniRule annotation
    Ordered Locus Names:PSHAa2142
    OrganismiPseudoalteromonas haloplanktis (strain TAC 125)
    Taxonomic identifieri326442 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
    ProteomesiUP000006843: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 300300Acetaldehyde dehydrogenasePRO_0000387705Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi326442.PSHAa2142.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3IEN6.
    SMRiQ3IEN6. Positions 2-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiREVQKYV.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3IEN6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKIKCALIG SGNIGTDLLY KLKRSEILEP VWMVGIDPDS EGLARARELG    50
    IKTTADGIDG LIPHIEADEI KIAFDATSAY VHGENSAKVN AKGVLMIDLT 100
    PAAIGPFCVP PVNLNQLNAD IKNVNMVTCG GQATIPMVAA VSRVQPVEYG 150
    EIVATVSSKS VGPGTRQNID EFTRTTSGAV EQIGGAKKGK AIIIINPAEP 200
    PLLMRDTIHC LTETEPDQAA ITASVHEMIA EVQKYVPGYK LKNGPVFDGR 250
    KVSIFLEVEG LGDYLPKYAG NLDIMTASAA RTAEMFALQM LGQSPSDSQS 300
    Length:300
    Mass (Da):31,906
    Last modified:November 8, 2005 - v1
    Checksum:i58C82B9BB5E4DAF3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR954246 Genomic DNA. Translation: CAI87198.1.
    RefSeqiYP_340640.1. NC_007481.1.

    Genome annotation databases

    EnsemblBacteriaiCAI87198; CAI87198; PSHAa2142.
    GeneIDi3710160.
    KEGGipha:PSHAa2142.
    PATRICi32297871. VBIPseHal105694_2059.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR954246 Genomic DNA. Translation: CAI87198.1 .
    RefSeqi YP_340640.1. NC_007481.1.

    3D structure databases

    ProteinModelPortali Q3IEN6.
    SMRi Q3IEN6. Positions 2-292.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 326442.PSHAa2142.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI87198 ; CAI87198 ; PSHAa2142 .
    GeneIDi 3710160.
    KEGGi pha:PSHAa2142.
    PATRICi 32297871. VBIPseHal105694_2059.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi REVQKYV.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci PHAL326442:GJIU-2199-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TAC 125.

    Entry informationi

    Entry nameiACDH_PSEHT
    AccessioniPrimary (citable) accession number: Q3IEN6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3