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Q3IE45 (ILVC_PSEHT) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase
EC=1.1.1.86
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase
Gene names
Name:ilvC
Ordered Locus Names:PSHAa0849
OrganismPseudoalteromonas haloplanktis (strain TAC 125) [Complete proteome] [HAMAP]
Taxonomic identifier326442 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Pseudoalteromonadaceae › Pseudoalteromonas

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Ketol-acid reductoisomerase HAMAP MF_00435
PRO_1000124324

Sites

Active site1321 Potential

Sequences

Sequence LengthMass (Da)Tools
Q3IE45 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 8781BDB464DB679A

FASTA49054,050
        10         20         30         40         50         60 
MANYFNTLPL REQLAQLAQC EFMNADEFTD GVDALKGKKL VIVGCGAQGL NQGLNLRDSG 

        70         80         90        100        110        120 
LDVSYTLRDS AISERRQSFL NASENGFTVG TYQELIPTAD VVLNLTPDKQ HTSVVNAIMP 

       130        140        150        160        170        180 
LMKQGSTLAY SHGFNIVEEG MQVRDDITVI MVAPKCPGSE VREEYKRGFG VPTLIAVHPE 

       190        200        210        220        230        240 
NDPQGHGLAQ AKAYAAGTGG HRAGVLKSSF IAEVKSDLMG EQTILCGMLQ TGSILCFDKM 

       250        260        270        280        290        300 
IEKGIDAGYA SKLIQYGWEV ITEALKYGGV TNMLDRLSNP AKVKAFELSE ELKQIMRPLY 

       310        320        330        340        350        360 
NKHQDDIIDG TFSRTMMEDW NNDDANLLKW RAETAETHFE KTPAGNVEIA EQEFFDNGIL 

       370        380        390        400        410        420 
MVAMVKAGVE LAFETMTAAG IIAESAYYES LHETPLIANT IARKKLFEMN RTISDTAEYG 

       430        440        450        460        470        480 
CYLYNHACLP LLQDFMQKID TDVIGKGLGE HSNQVDNQTL IQINTALREH PVEKVGATLR 

       490 
GYMSAMKKIV

« Hide

References

[1]"Coping with cold: the genome of the versatile marine Antarctica bacterium Pseudoalteromonas haloplanktis TAC125."
Medigue C., Krin E., Pascal G., Barbe V., Bernsel A., Bertin P.N., Cheung F., Cruveiller S., D'Amico S., Duilio A., Fang G., Feller G., Ho C., Mangenot S., Marino G., Nilsson J., Parrilli E., Rocha E.P.C. expand/collapse author list , Rouy Z., Sekowska A., Tutino M.L., Vallenet D., von Heijne G., Danchin A.
Genome Res. 15:1325-1335(2005) [PubMed: 16169927] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TAC 125.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR954246 Genomic DNA. Translation: CAI85930.1.
RefSeqYP_339373.1. NC_007481.1.

3D structure databases

HSSPHSSP built from PDB template 1YRL based on UniProtKB P05793.
ProteinModelPortalQ3IE45.
SMRQ3IE45. Positions 3-489.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3IE45.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3710092.
GenomeReviewsGene locus PSHAa0849 in contig CR954246_GR.
KEGGpha:PSHAa0849.
NMPDRfig|326442.4.peg.2077.
PATRIC32295227. VBIPseHal105694_0812.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0059.
HOGENOMHBG297205.
OMAEKHMDDI.
PhylomeDBQ3IE45.
ProtClustDBPRK05225.

Enzyme and pathway databases

BioCycPHAL326442:PSHAA0849-MONOMER.

Family and domain databases

HAMAPMF_00435. IlvC.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
IPR014359. KetolA_reductoisomerase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00053.
PANTHERPTHR21371. AcH_isomrdctse. 1 hit.
PTHR21371:SF2. PTHR21371:SF2. 1 hit.
PfamPF01450. IlvC. 2 hits.
PF07991. IlvN. 1 hit.
[Graphical view]
PIRSFPIRSF000116. IlvC_gammaproteo. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 2 hits.
TIGRFAMsTIGR00465. IlvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameILVC_PSEHT
AccessionPrimary (citable) accession number: Q3IE45
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 8, 2005
Last modified: January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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