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Q3IDD5 (GPPA_PSEHT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

EC=3.6.1.40
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene names
Name:gppA
Ordered Locus Names:PSHAa0115
OrganismPseudoalteromonas haloplanktis (strain TAC 125) [Complete proteome] [HAMAP]
Taxonomic identifier326442 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity. HAMAP-Rule MF_01550

Catalytic activity

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate. HAMAP-Rule MF_01550

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. HAMAP-Rule MF_01550

Sequence similarities

Belongs to the GppA/Ppx family. GppA subfamily.

Sequence caution

The sequence CAI85224.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase HAMAP-Rule MF_01550
PRO_0000194285

Sequences

Sequence LengthMass (Da)Tools
Q3IDD5 [UniParc].

Last modified December 20, 2005. Version 2.
Checksum: C7E1CC2B2FEB8A26

FASTA49754,968
        10         20         30         40         50         60 
MGQLKPQKNV YAVIDLGSNS FHMLIAKSIA GGLQTIGRVK RKVRLAAGLD IDNVLSSEAM 

        70         80         90        100        110        120 
HRGWECLALF AERLQDIPKQ NITIVATATL RLASNADVFK AQAEKILGHK VNVISGELEA 

       130        140        150        160        170        180 
RTIYKGVAHT SSCTGSQLVI DIGGASTEVI IGKNFDALLY KSLNIGCVTY LERYFKDCKL 

       190        200        210        220        230        240 
SNANFNTAIK AARTVIDEIA SEYKVKGWQI ASGASGTVQA IQEIMIAQNL DELLTLEKLY 

       250        260        270        280        290        300 
TIKKQSIAYK TIAALDLPGL SEDRRLVFVS GLAILIALFE SLEIEKMGLA GGALREGVLY 

       310        320        330        340        350        360 
SMLPELHNSD IRKRTIDGFI DRYHVDQKQA SRVASLVLNL ASEVNESWPI KALNGLPLLT 

       370        380        390        400        410        420 
AVAQLHEIGL LIEYKQYHKH SAYILKNTEM PGFSQSEHKV IVAVAKGHRS DLQKGYFDSL 

       430        440        450        460        470        480 
GANSVLAQYL VRLIRIAVIL CMRRQDDVLP EFAITVKDDV LNLQFENDWL KNHPLMASEL 

       490 
QQESKQQAKL GWKLIVN 

« Hide

References

[1]"Coping with cold: the genome of the versatile marine Antarctica bacterium Pseudoalteromonas haloplanktis TAC125."
Medigue C., Krin E., Pascal G., Barbe V., Bernsel A., Bertin P.N., Cheung F., Cruveiller S., D'Amico S., Duilio A., Fang G., Feller G., Ho C., Mangenot S., Marino G., Nilsson J., Parrilli E., Rocha E.P.C. expand/collapse author list , Rouy Z., Sekowska A., Tutino M.L., Vallenet D., von Heijne G., Danchin A.
Genome Res. 15:1325-1335(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TAC 125.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR954246 Genomic DNA. Translation: CAI85224.1. Different initiation.
RefSeqYP_338667.2. NC_007481.1.

3D structure databases

ProteinModelPortalQ3IDD5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING326442.PSHAa0115.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI85224; CAI85224; PSHAa0115.
GeneID3707992.
KEGGpha:PSHAa0115.
PATRIC32293765. VBIPseHal105694_0114.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0248.
HOGENOMHOG000258672.
KOK01524.
OrthoDBEOG6M6JN6.

Enzyme and pathway databases

BioCycPHAL326442:GJIU-117-MONOMER.
UniPathwayUPA00908; UER00884.

Family and domain databases

HAMAPMF_01550. GppA.
InterProIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamPF02541. Ppx-GppA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPPA_PSEHT
AccessionPrimary (citable) accession number: Q3IDD5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: May 14, 2014
This is version 51 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways