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Q3IDD5

- GPPA_PSEHT

UniProt

Q3IDD5 - GPPA_PSEHT

Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Pseudoalteromonas haloplanktis (strain TAC 125)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 2 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

    Catalytic activityi

    Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. guanosine pentaphosphate catabolic process Source: InterPro
    2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciPHAL326442:GJIU-117-MONOMER.
    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
    Alternative name(s):
    Guanosine pentaphosphate phosphohydrolaseUniRule annotation
    pppGpp-5'-phosphohydrolaseUniRule annotation
    Gene namesi
    Name:gppAUniRule annotation
    Ordered Locus Names:PSHAa0115
    OrganismiPseudoalteromonas haloplanktis (strain TAC 125)
    Taxonomic identifieri326442 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
    ProteomesiUP000006843: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000194285Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi326442.PSHAa0115.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3IDD5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0248.
    HOGENOMiHOG000258672.
    KOiK01524.
    OrthoDBiEOG6M6JN6.

    Family and domain databases

    HAMAPiMF_01550. GppA.
    InterProiIPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3IDD5-1 [UniParc]FASTAAdd to Basket

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    MGQLKPQKNV YAVIDLGSNS FHMLIAKSIA GGLQTIGRVK RKVRLAAGLD    50
    IDNVLSSEAM HRGWECLALF AERLQDIPKQ NITIVATATL RLASNADVFK 100
    AQAEKILGHK VNVISGELEA RTIYKGVAHT SSCTGSQLVI DIGGASTEVI 150
    IGKNFDALLY KSLNIGCVTY LERYFKDCKL SNANFNTAIK AARTVIDEIA 200
    SEYKVKGWQI ASGASGTVQA IQEIMIAQNL DELLTLEKLY TIKKQSIAYK 250
    TIAALDLPGL SEDRRLVFVS GLAILIALFE SLEIEKMGLA GGALREGVLY 300
    SMLPELHNSD IRKRTIDGFI DRYHVDQKQA SRVASLVLNL ASEVNESWPI 350
    KALNGLPLLT AVAQLHEIGL LIEYKQYHKH SAYILKNTEM PGFSQSEHKV 400
    IVAVAKGHRS DLQKGYFDSL GANSVLAQYL VRLIRIAVIL CMRRQDDVLP 450
    EFAITVKDDV LNLQFENDWL KNHPLMASEL QQESKQQAKL GWKLIVN 497
    Length:497
    Mass (Da):54,968
    Last modified:December 20, 2005 - v2
    Checksum:iC7E1CC2B2FEB8A26
    GO

    Sequence cautioni

    The sequence CAI85224.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR954246 Genomic DNA. Translation: CAI85224.1. Different initiation.
    RefSeqiYP_338667.2. NC_007481.1.

    Genome annotation databases

    EnsemblBacteriaiCAI85224; CAI85224; PSHAa0115.
    GeneIDi3707992.
    KEGGipha:PSHAa0115.
    PATRICi32293765. VBIPseHal105694_0114.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR954246 Genomic DNA. Translation: CAI85224.1 . Different initiation.
    RefSeqi YP_338667.2. NC_007481.1.

    3D structure databases

    ProteinModelPortali Q3IDD5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 326442.PSHAa0115.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI85224 ; CAI85224 ; PSHAa0115 .
    GeneIDi 3707992.
    KEGGi pha:PSHAa0115.
    PATRICi 32293765. VBIPseHal105694_0114.

    Phylogenomic databases

    eggNOGi COG0248.
    HOGENOMi HOG000258672.
    KOi K01524.
    OrthoDBi EOG6M6JN6.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .
    BioCyci PHAL326442:GJIU-117-MONOMER.

    Family and domain databases

    HAMAPi MF_01550. GppA.
    InterProi IPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TAC 125.

    Entry informationi

    Entry nameiGPPA_PSEHT
    AccessioniPrimary (citable) accession number: Q3IDD5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 52 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3