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Q3IDA4

- UPPP2_PSEHT

UniProt

Q3IDA4 - UPPP2_PSEHT

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Protein

Undecaprenyl-diphosphatase 2

Gene

uppP2

Organism
Pseudoalteromonas haloplanktis (strain TAC 125)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciPHAL326442:GJIU-3334-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 2UniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance protein 2UniRule annotation
Undecaprenyl pyrophosphate phosphatase 2UniRule annotation
Gene namesi
Name:uppP2UniRule annotation
Ordered Locus Names:PSHAb0269
OrganismiPseudoalteromonas haloplanktis (strain TAC 125)
Taxonomic identifieri326442 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
ProteomesiUP000006843: Chromosome II

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256Undecaprenyl-diphosphatase 2PRO_0000227628Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326442.PSHAb0269.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalUniRule annotationAdd
BLAST
Transmembranei38 – 5821HelicalUniRule annotationAdd
BLAST
Transmembranei70 – 9021HelicalUniRule annotationAdd
BLAST
Transmembranei97 – 11721HelicalUniRule annotationAdd
BLAST
Transmembranei134 – 15421HelicalUniRule annotationAdd
BLAST
Transmembranei175 – 19521HelicalUniRule annotationAdd
BLAST
Transmembranei208 – 22821HelicalUniRule annotationAdd
BLAST
Transmembranei236 – 25621HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiWRKISSS.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3IDA4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDIFNAIILG IIEGITEFLP ISSTGHIIVA AQWLGIEATA TNQAFGVIIQ
60 70 80 90 100
LAAILAVLAN YKDKFTPKHL NLWIKVAIAF IPLGIIAFIF SDVIKALFNV
110 120 130 140 150
PVVGVMFIVG GVIFLLLERN YKEQNCTTTD VTQVTYKQAI WIGIAQVFAL
160 170 180 190 200
IPGTSRAGSS IVGAMLCGLN RKASAEFSFL LGLPVLAAAS GYDLLKHYDL
210 220 230 240 250
FTFDDLTALA VGFVTSFIVA YFTIKLFIRF LENFTFVSFG IYRIVFGVIL

LTIAYV
Length:256
Mass (Da):27,979
Last modified:November 8, 2005 - v1
Checksum:iCC732AC0024ECA59
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR954247 Genomic DNA. Translation: CAI89310.1.
RefSeqiYP_341756.1. NC_007482.1.

Genome annotation databases

EnsemblBacteriaiCAI89310; CAI89310; PSHAb0269.
GeneIDi3711227.
KEGGipha:PSHAb0269.
PATRICi32300150. VBIPseHal105694_3179.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR954247 Genomic DNA. Translation: CAI89310.1 .
RefSeqi YP_341756.1. NC_007482.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326442.PSHAb0269.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI89310 ; CAI89310 ; PSHAb0269 .
GeneIDi 3711227.
KEGGi pha:PSHAb0269.
PATRICi 32300150. VBIPseHal105694_3179.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi WRKISSS.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci PHAL326442:GJIU-3334-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TAC 125.

Entry informationi

Entry nameiUPPP2_PSEHT
AccessioniPrimary (citable) accession number: Q3IDA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 8, 2005
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3