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Q3ICF4

- HIS4_PSEHT

UniProt

Q3ICF4 - HIS4_PSEHT

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Protein

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Gene
hisA, PSHAb0489
Organism
Pseudoalteromonas haloplanktis (strain TAC 125)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei7 – 71Proton acceptor By similarity
Active sitei129 – 1291Proton donor By similarity

GO - Molecular functioni

  1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

BioCyciPHAL326442:GJIU-3550-MONOMER.
UniPathwayiUPA00031; UER00009.

Names & Taxonomyi

Protein namesi
Recommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC:5.3.1.16)
Alternative name(s):
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Gene namesi
Name:hisA
Ordered Locus Names:PSHAb0489
OrganismiPseudoalteromonas haloplanktis (strain TAC 125)
Taxonomic identifieri326442 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
ProteomesiUP000006843: Chromosome II

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2422421-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseUniRule annotationPRO_0000229071Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326442.PSHAb0489.

Structurei

3D structure databases

ProteinModelPortaliQ3ICF4.

Family & Domainsi

Sequence similaritiesi

Belongs to the HisA/HisF family.

Phylogenomic databases

eggNOGiCOG0106.
HOGENOMiHOG000224614.
KOiK01814.
OMAiINGWEED.
OrthoDBiEOG6H1Q3W.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01014. HisA.
InterProiIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3ICF4-1 [UniParc]FASTAAdd to Basket

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MIIPALDVLQ NQIVRLYQGK YETVQFYPFE LGARLKEYAD SGAGKLHLVD    50
LEGARDPSKK QWQHIQAATK ALNVPYQVGG GIRCEQDVSD WLKAGANQVV 100
IGSMAVEKRE QVKAWIEQFG AEHFVIALDV NKTATGWAPA THGWLTESEF 150
GLLELVDFYA NLGVIDFLCT DISKDGTMTG PSFALYEDLI KHNSTIKVQA 200
SGGVSSLDDI KKLKELGIGG IILGKSLLDG AFSVEEALAV TR 242
Length:242
Mass (Da):26,427
Last modified:November 8, 2005 - v1
Checksum:i23260B335AFAF38A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR954247 Genomic DNA. Translation: CAI89526.1.
RefSeqiYP_341972.1. NC_007482.1.

Genome annotation databases

EnsemblBacteriaiCAI89526; CAI89526; PSHAb0489.
GeneIDi3711503.
KEGGipha:PSHAb0489.
PATRICi32300586. VBIPseHal105694_3397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR954247 Genomic DNA. Translation: CAI89526.1 .
RefSeqi YP_341972.1. NC_007482.1.

3D structure databases

ProteinModelPortali Q3ICF4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326442.PSHAb0489.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI89526 ; CAI89526 ; PSHAb0489 .
GeneIDi 3711503.
KEGGi pha:PSHAb0489.
PATRICi 32300586. VBIPseHal105694_3397.

Phylogenomic databases

eggNOGi COG0106.
HOGENOMi HOG000224614.
KOi K01814.
OMAi INGWEED.
OrthoDBi EOG6H1Q3W.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00009 .
BioCyci PHAL326442:GJIU-3550-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01014. HisA.
InterProi IPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00977. His_biosynth. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TAC 125.

Entry informationi

Entry nameiHIS4_PSEHT
AccessioniPrimary (citable) accession number: Q3ICF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 8, 2005
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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