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Q3ICF0

- HISX_PSEHT

UniProt

Q3ICF0 - HISX_PSEHT

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Protein

Histidinol dehydrogenase

Gene
hisD, PSHAb0493
Organism
Pseudoalteromonas haloplanktis (strain TAC 125)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei236 – 2361Substrate By similarity
Metal bindingi258 – 2581Zinc By similarity
Binding sitei258 – 2581Substrate By similarity
Metal bindingi261 – 2611Zinc By similarity
Binding sitei261 – 2611Substrate By similarity
Active sitei325 – 3251Proton acceptor By similarity
Active sitei326 – 3261Proton acceptor By similarity
Binding sitei326 – 3261Substrate By similarity
Metal bindingi359 – 3591Zinc By similarity
Binding sitei359 – 3591Substrate By similarity
Binding sitei413 – 4131Substrate By similarity
Metal bindingi418 – 4181Zinc By similarity
Binding sitei418 – 4181Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciPHAL326442:GJIU-3554-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:PSHAb0493
OrganismiPseudoalteromonas haloplanktis (strain TAC 125)
Taxonomic identifieri326442 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
ProteomesiUP000006843: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Histidinol dehydrogenaseUniRule annotationPRO_0000135818Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326442.PSHAb0493.

Structurei

3D structure databases

ProteinModelPortaliQ3ICF0.
SMRiQ3ICF0. Positions 1-432.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3ICF0-1 [UniParc]FASTAAdd to Basket

« Hide

MLRWNEESSQ AQAAALTRPA VSASAKVEAI CKTILAKVKE QGDDALLDMA    50
KEFDNRANPR LRVPLDEINA SEQALSAELK YAIDTAYANV KCFHEAQLPK 100
DIKLSTQPGV VCELKYQAIE AVGIYVPGGS APLPSSVIMQ GVLAQLSGAK 150
TVVLATPVQG DKAINPAILY AAKLCGITTL IESGGAGAIA AMAYGTESVP 200
KVNKIFGPGN SFVTMAKQLV AQTVPGMAID MPAGPSEVLV IADERANPEF 250
IAADLLSQAE HGADSQVILL CNSESIIEQT QQALTRQLAK LSRKETAEQA 300
LANSSLILVD SIAQAFDVSA QYGPEHLILQ LADSTPYLDK VKNAGSVFVG 350
DYTPESAGDY ASGTNHVLPT YGYSASYSSL NLLDFFRTYT VQTITKSGLT 400
QLSKAILPLA NAEGLDAHAN AVSIRLEAIK NEQ 433
Length:433
Mass (Da):45,811
Last modified:November 8, 2005 - v1
Checksum:iC517A5BA9A324F16
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR954247 Genomic DNA. Translation: CAI89530.1.
RefSeqiWP_011330117.1. NC_007482.1.
YP_341976.1. NC_007482.1.

Genome annotation databases

EnsemblBacteriaiCAI89530; CAI89530; PSHAb0493.
GeneIDi3711506.
KEGGipha:PSHAb0493.
PATRICi32300594. VBIPseHal105694_3401.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR954247 Genomic DNA. Translation: CAI89530.1 .
RefSeqi WP_011330117.1. NC_007482.1.
YP_341976.1. NC_007482.1.

3D structure databases

ProteinModelPortali Q3ICF0.
SMRi Q3ICF0. Positions 1-432.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326442.PSHAb0493.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI89530 ; CAI89530 ; PSHAb0493 .
GeneIDi 3711506.
KEGGi pha:PSHAb0493.
PATRICi 32300594. VBIPseHal105694_3401.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci PHAL326442:GJIU-3554-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TAC 125.

Entry informationi

Entry nameiHISX_PSEHT
AccessioniPrimary (citable) accession number: Q3ICF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 8, 2005
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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