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Q3ICF0

- HISX_PSEHT

UniProt

Q3ICF0 - HISX_PSEHT

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Pseudoalteromonas haloplanktis (strain TAC 125)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei236 – 2361SubstrateUniRule annotation
    Metal bindingi258 – 2581ZincUniRule annotation
    Binding sitei258 – 2581SubstrateUniRule annotation
    Metal bindingi261 – 2611ZincUniRule annotation
    Binding sitei261 – 2611SubstrateUniRule annotation
    Active sitei325 – 3251Proton acceptorUniRule annotation
    Active sitei326 – 3261Proton acceptorUniRule annotation
    Binding sitei326 – 3261SubstrateUniRule annotation
    Metal bindingi359 – 3591ZincUniRule annotation
    Binding sitei359 – 3591SubstrateUniRule annotation
    Binding sitei413 – 4131SubstrateUniRule annotation
    Metal bindingi418 – 4181ZincUniRule annotation
    Binding sitei418 – 4181SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciPHAL326442:GJIU-3554-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:PSHAb0493
    OrganismiPseudoalteromonas haloplanktis (strain TAC 125)
    Taxonomic identifieri326442 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
    ProteomesiUP000006843: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 433433Histidinol dehydrogenasePRO_0000135818Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi326442.PSHAb0493.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3ICF0.
    SMRiQ3ICF0. Positions 1-432.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3ICF0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRWNEESSQ AQAAALTRPA VSASAKVEAI CKTILAKVKE QGDDALLDMA    50
    KEFDNRANPR LRVPLDEINA SEQALSAELK YAIDTAYANV KCFHEAQLPK 100
    DIKLSTQPGV VCELKYQAIE AVGIYVPGGS APLPSSVIMQ GVLAQLSGAK 150
    TVVLATPVQG DKAINPAILY AAKLCGITTL IESGGAGAIA AMAYGTESVP 200
    KVNKIFGPGN SFVTMAKQLV AQTVPGMAID MPAGPSEVLV IADERANPEF 250
    IAADLLSQAE HGADSQVILL CNSESIIEQT QQALTRQLAK LSRKETAEQA 300
    LANSSLILVD SIAQAFDVSA QYGPEHLILQ LADSTPYLDK VKNAGSVFVG 350
    DYTPESAGDY ASGTNHVLPT YGYSASYSSL NLLDFFRTYT VQTITKSGLT 400
    QLSKAILPLA NAEGLDAHAN AVSIRLEAIK NEQ 433
    Length:433
    Mass (Da):45,811
    Last modified:November 8, 2005 - v1
    Checksum:iC517A5BA9A324F16
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR954247 Genomic DNA. Translation: CAI89530.1.
    RefSeqiWP_011330117.1. NC_007482.1.
    YP_341976.1. NC_007482.1.

    Genome annotation databases

    EnsemblBacteriaiCAI89530; CAI89530; PSHAb0493.
    GeneIDi3711506.
    KEGGipha:PSHAb0493.
    PATRICi32300594. VBIPseHal105694_3401.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR954247 Genomic DNA. Translation: CAI89530.1 .
    RefSeqi WP_011330117.1. NC_007482.1.
    YP_341976.1. NC_007482.1.

    3D structure databases

    ProteinModelPortali Q3ICF0.
    SMRi Q3ICF0. Positions 1-432.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 326442.PSHAb0493.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI89530 ; CAI89530 ; PSHAb0493 .
    GeneIDi 3711506.
    KEGGi pha:PSHAb0493.
    PATRICi 32300594. VBIPseHal105694_3401.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci PHAL326442:GJIU-3554-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TAC 125.

    Entry informationi

    Entry nameiHISX_PSEHT
    AccessioniPrimary (citable) accession number: Q3ICF0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3