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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Pseudoalteromonas haloplanktis (strain TAC 125)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit hisH (IGP synthase glutamine amidotransferase subunit) (IGP synthase subunit hisH) (ImGP synthase subunit hisH) (IGPS subunit hisH) (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Histidine biosynthesis bifunctional protein HisB (hisB)
  7. Histidinol phosphate aminotransferase (hisC)
  8. Histidine biosynthesis bifunctional protein HisB (hisB)
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei236SubstrateUniRule annotation1
Metal bindingi258ZincUniRule annotation1
Binding sitei258SubstrateUniRule annotation1
Metal bindingi261ZincUniRule annotation1
Binding sitei261SubstrateUniRule annotation1
Active sitei325Proton acceptorUniRule annotation1
Active sitei326Proton acceptorUniRule annotation1
Binding sitei326SubstrateUniRule annotation1
Metal bindingi359ZincUniRule annotation1
Binding sitei359SubstrateUniRule annotation1
Binding sitei413SubstrateUniRule annotation1
Metal bindingi418ZincUniRule annotation1
Binding sitei418SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciPHAL326442:G1GI4-3454-MONOMER
UniPathwayiUPA00031; UER00014

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:PSHAb0493
OrganismiPseudoalteromonas haloplanktis (strain TAC 125)
Taxonomic identifieri326442 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
Proteomesi
  • UP000006843 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001358181 – 433Histidinol dehydrogenaseAdd BLAST433

Proteomic databases

PRIDEiQ3ICF0

Interactioni

Protein-protein interaction databases

STRINGi326442.PSHAb0493

Structurei

3D structure databases

ProteinModelPortaliQ3ICF0
SMRiQ3ICF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEK Bacteria
COG0141 LUCA
HOGENOMiHOG000243914
KOiK00013
OMAiQAEHDPM
OrthoDBiPOG091H03YX

Family and domain databases

CDDicd06572 Histidinol_dh, 1 hit
HAMAPiMF_01024 HisD, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR001692 Histidinol_DH_CS
IPR022695 Histidinol_DH_monofunct
IPR012131 Hstdl_DH
PANTHERiPTHR21256 PTHR21256, 1 hit
PfamiView protein in Pfam
PF00815 Histidinol_dh, 1 hit
PIRSFiPIRSF000099 Histidinol_dh, 1 hit
PRINTSiPR00083 HOLDHDRGNASE
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00069 hisD, 1 hit
PROSITEiView protein in PROSITE
PS00611 HISOL_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q3ICF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRWNEESSQ AQAAALTRPA VSASAKVEAI CKTILAKVKE QGDDALLDMA
60 70 80 90 100
KEFDNRANPR LRVPLDEINA SEQALSAELK YAIDTAYANV KCFHEAQLPK
110 120 130 140 150
DIKLSTQPGV VCELKYQAIE AVGIYVPGGS APLPSSVIMQ GVLAQLSGAK
160 170 180 190 200
TVVLATPVQG DKAINPAILY AAKLCGITTL IESGGAGAIA AMAYGTESVP
210 220 230 240 250
KVNKIFGPGN SFVTMAKQLV AQTVPGMAID MPAGPSEVLV IADERANPEF
260 270 280 290 300
IAADLLSQAE HGADSQVILL CNSESIIEQT QQALTRQLAK LSRKETAEQA
310 320 330 340 350
LANSSLILVD SIAQAFDVSA QYGPEHLILQ LADSTPYLDK VKNAGSVFVG
360 370 380 390 400
DYTPESAGDY ASGTNHVLPT YGYSASYSSL NLLDFFRTYT VQTITKSGLT
410 420 430
QLSKAILPLA NAEGLDAHAN AVSIRLEAIK NEQ
Length:433
Mass (Da):45,811
Last modified:November 8, 2005 - v1
Checksum:iC517A5BA9A324F16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR954247 Genomic DNA Translation: CAI89530.1
RefSeqiWP_011330117.1, NC_007482.1

Genome annotation databases

EnsemblBacteriaiCAI89530; CAI89530; PSHAb0493
KEGGipha:PSHAb0493
PATRICifig|326442.8.peg.3401

Similar proteinsi

Entry informationi

Entry nameiHISX_PSEHT
AccessioniPrimary (citable) accession number: Q3ICF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 8, 2005
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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