Reviewed, UniProtKB/Swiss-Prot Q3IC91 (ASTD2_PSEHT)

Names and origin

Protein names

Recommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase 2
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase 2
      Short name=SGSD 2

Gene names

Name:	astD2
Ordered Locus Names:	PSHAb0426

Organism

Pseudoalteromonas haloplanktis (strain TAC 125) [Complete proteome] [HAMAP]

Taxonomic identifier

326442 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Pseudoalteromonadaceae › Pseudoalteromonas

Protein attributes

Sequence length	488 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 488	488	N-succinylglutamate 5-semialdehyde dehydrogenase 2 HAMAP MF_01174		PRO_0000262413
Regions
	Nucleotide binding	221 – 226	6	NAD By similarity
Sites
	Active site	244	1	By similarity
	Active site	278	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3IC91-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 9A089958B43646BD	FASTA	488	51,971
	10 20 30 40 50 60 MNTQLINNQW QAGQGPAFAS INPSNGETIW QGNGASAEQV NSAIKAARAA QLQWADTPLE 70 80 90 100 110 120 QRITILENFA AQLKEHSEEF AVIIAQETGK PLWETRTEVG AMTGKVAISV KAYNERTGTT 130 140 150 160 170 180 ENPMPGAKAF IRHKPHGVVA IFGPYNFPGH LPNGHIVPAI LAGNTVVFKP SELTPHVAQF 190 200 210 220 230 240 TLSLWLKAGL PAGVINLVQG EIETGKALAA HQDIDGLFFT GSSNTGHLLH KQFAGHPGKI 250 260 270 280 290 300 LALEMGGNNP LIIKDVNDVS AAVHDIIQSG FITSGQRCTC ARRVFIENSS NGDAILAKLI 310 320 330 340 350 360 SATKNIVVDD SFATEQPFMG AMISEKAALG MVAAQNELVA KGAEVLVELK QLKPGTGFVS 370 380 390 400 410 420 PGIIDVTNVN DMPDEEHFGP LIKIYRYSDF DSAINEANNT SFGLSAGLLA DSENDYNHFL 430 440 450 460 470 480 KRIRAGIVNW NRPITGASSA APFGGIGASG NHRASAYYAA DYCAYPVASV ESDKVTLPQT LAPGLIIE

References

[1]

"Coping with cold: the genome of the versatile marine Antarctica bacterium Pseudoalteromonas haloplanktis TAC125." Medigue C., Krin E., Pascal G., Barbe V., Bernsel A., Bertin P.N., Cheung F., Cruveiller S., D'Amico S., Duilio A., Fang G., Feller G., Ho C., Mangenot S., Marino G., Nilsson J., Parrilli E., Rocha E.P.C. , Rouy Z., Sekowska A., Tutino M.L., Vallenet D., von Heijne G., Danchin A. Genome Res. 15:1325-1335(2005) [PubMed: 16169927] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR954247 Genomic DNA. Translation: CAI89463.1.
RefSeq	YP_341909.1.
3D structure databases
SMR	Q3IC91. Positions 4-460.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3IC91.
Genome annotation databases
GeneID	3711347.
GenomeReviews	Gene locus PSHAb0426 in contig CR954247_GR.
KEGG	pha:PSHAb0426.
NMPDR	fig|326442.4.peg.3352.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1012.
HOGENOM	HBG752218.
OMA	GHLLHKQ.
PhylomeDB	Q3IC91.
Enzyme and pathway databases
BioCyc	PHAL326442:PSHAB0426-MONOMER.
Family and domain databases
HAMAP	MF_01174. Aldedh_AstD. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03240. arg_catab_astD. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD2_PSEHT

Accession

Primary (citable) accession number: Q3IC91

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	November 8, 2005
Last modified:	February 9, 2010
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)