Q3IBX5 (CDD_PSEHT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidine deaminase
EC=3.5.4.5

Alternative name(s):
Cytidine aminohydrolase
Short name=CDA

Gene names

Name:	cdd
Ordered Locus Names:	PSHAb0315

Organism

Pseudoalteromonas haloplanktis (strain TAC 125) [Complete proteome] [HAMAP]

Taxonomic identifier

326442 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Pseudoalteromonadaceae › Pseudoalteromonas

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity. HAMAP MF_01558
Catalytic activity	Cytidine + H2O = uridine + NH3. HAMAP MF_01558
Cofactor	Binds 1 zinc ion By similarity. HAMAP MF_01558
Subunit structure	Homodimer By similarity. HAMAP MF_01558
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cytidine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	cytidine deaminase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Cytidine deaminase HAMAP MF_01558		PRO_0000171659
Regions
	Region	100 – 102	3	Substrate binding By similarity
Sites
	Active site	115	1	Proton donor By similarity
	Metal binding	113	1	Zinc; catalytic By similarity
	Metal binding	140	1	Zinc; catalytic By similarity
	Metal binding	143	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3IBX5-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 5B3D57E86EF87DC8	FASTA	309	33,242
	10 20 30 40 50 60 MASATFLVQA NTALSNTHIS LSVAQTQALR SQLKTQRGIL NANNINQLCA QLNVTNDALL 70 80 90 100 110 120 QGLVPLASEF AVAPVSNFHV GAIVKALDES GEVNFYFGAN AEFNRQALSL VVHAEQSAIN 130 140 150 160 170 180 NAWLNGAKKI LKIAISDAPC GYCRQFMNEL ADAREFDILL PEQQFKLADL LPHSFGPTDL 190 200 210 220 230 240 GNQYSLFNPA PQARSFNNTE VEQQLAAYAL AAYVPYSQNY SAVKITTFNN GDFYGSYAEN 250 260 270 280 290 300 AAYSPSLSPL QSALSQLFLA GLSFDQHTVK GITLLETAGH ENQAGVAQAV LASFVNLPPL ELISAPLSE

References

[1]

"Coping with cold: the genome of the versatile marine Antarctica bacterium Pseudoalteromonas haloplanktis TAC125." Medigue C., Krin E., Pascal G., Barbe V., Bernsel A., Bertin P.N., Cheung F., Cruveiller S., D'Amico S., Duilio A., Fang G., Feller G., Ho C., Mangenot S., Marino G., Nilsson J., Parrilli E., Rocha E.P.C. , Rouy Z., Sekowska A., Tutino M.L., Vallenet D., von Heijne G., Danchin A. Genome Res. 15:1325-1335(2005) [PubMed: 16169927] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR954247 Genomic DNA. Translation: CAI89355.1.
RefSeq	YP_341801.1.
3D structure databases
ProteinModelPortal	Q3IBX5.
SMR	Q3IBX5. Positions 25-303.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3IBX5.
Genome annotation databases
GeneID	3711463.
GenomeReviews	Gene locus PSHAb0315 in contig CR954247_GR.
KEGG	pha:PSHAb0315.
NMPDR	fig|326442.4.peg.3244.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0295.
OMA	NRSHAPY.
PhylomeDB	Q3IBX5.
ProtClustDB	PRK09027.
Enzyme and pathway databases
BioCyc	PHAL326442:PSHAB0315-MONOMER.
Family and domain databases
HAMAP	MF_01558. Cyt_deam. [Tree]
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn-bd. IPR013171. Cyd/dCyd_deaminase_Zn-bd. IPR006263. Cyt_deam_dimer. IPR016193. Cytidine_deaminase-like. IPR020797. Cytidine_deaminase_bacteria. [Graphical view]
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. PF08211. dCMP_cyt_deam_2. 1 hit. [Graphical view]
PIRSF	PIRSF006334. Cdd_plus_pseudo. 1 hit.
SUPFAM	SSF53927. Cytidine_deaminase-like. 2 hits.
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDD_PSEHT

Accession

Primary (citable) accession number: Q3IBX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	November 8, 2005
Last modified:	August 10, 2010
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)