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Q3IBX5 (CDD_PSEHT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytidine deaminase

EC=3.5.4.5
Alternative name(s):
Cytidine aminohydrolase
Short name=CDA
Gene names
Name:cdd
Ordered Locus Names:PSHAb0315
OrganismPseudoalteromonas haloplanktis (strain TAC 125) [Complete proteome] [HAMAP]
Taxonomic identifier326442 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity. HAMAP-Rule MF_01558

Catalytic activity

Cytidine + H2O = uridine + NH3. HAMAP-Rule MF_01558

2'deoxycytidine + H2O = 2'-deoxyuridine + NH3. HAMAP-Rule MF_01558

Cofactor

Binds 1 zinc ion By similarity. HAMAP-Rule MF_01558

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01558

Sequence similarities

Belongs to the cytidine and deoxycytidylate deaminase family.

Contains 1 CMP/dCMP deaminase zinc-binding domain.

Ontologies

Keywords
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functioncytidine deaminase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Cytidine deaminase HAMAP-Rule MF_01558
PRO_0000171659

Regions

Domain64 – 15188CMP/dCMP deaminase zinc-binding
Region100 – 1023Substrate binding By similarity

Sites

Active site1151Proton donor By similarity
Metal binding1131Zinc; catalytic By similarity
Metal binding1401Zinc; catalytic By similarity
Metal binding1431Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3IBX5 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 5B3D57E86EF87DC8

FASTA30933,242
        10         20         30         40         50         60 
MASATFLVQA NTALSNTHIS LSVAQTQALR SQLKTQRGIL NANNINQLCA QLNVTNDALL 

        70         80         90        100        110        120 
QGLVPLASEF AVAPVSNFHV GAIVKALDES GEVNFYFGAN AEFNRQALSL VVHAEQSAIN 

       130        140        150        160        170        180 
NAWLNGAKKI LKIAISDAPC GYCRQFMNEL ADAREFDILL PEQQFKLADL LPHSFGPTDL 

       190        200        210        220        230        240 
GNQYSLFNPA PQARSFNNTE VEQQLAAYAL AAYVPYSQNY SAVKITTFNN GDFYGSYAEN 

       250        260        270        280        290        300 
AAYSPSLSPL QSALSQLFLA GLSFDQHTVK GITLLETAGH ENQAGVAQAV LASFVNLPPL 


ELISAPLSE 

« Hide

References

[1]"Coping with cold: the genome of the versatile marine Antarctica bacterium Pseudoalteromonas haloplanktis TAC125."
Medigue C., Krin E., Pascal G., Barbe V., Bernsel A., Bertin P.N., Cheung F., Cruveiller S., D'Amico S., Duilio A., Fang G., Feller G., Ho C., Mangenot S., Marino G., Nilsson J., Parrilli E., Rocha E.P.C. expand/collapse author list , Rouy Z., Sekowska A., Tutino M.L., Vallenet D., von Heijne G., Danchin A.
Genome Res. 15:1325-1335(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TAC 125.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR954247 Genomic DNA. Translation: CAI89355.1.
RefSeqYP_341801.1. NC_007482.1.

3D structure databases

ProteinModelPortalQ3IBX5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING326442.PSHAb0315.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI89355; CAI89355; PSHAb0315.
GeneID3711463.
KEGGpha:PSHAb0315.
PATRIC32300238. VBIPseHal105694_3223.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0295.
HOGENOMHOG000218617.
KOK01489.
OMANRSHAPY.
OrthoDBEOG6XDH25.

Enzyme and pathway databases

BioCycPHAL326442:GJIU-3379-MONOMER.

Family and domain databases

HAMAPMF_01558. Cyt_deam.
InterProIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR013171. Cyd/dCyd_deaminase_Zn-bd.
IPR006263. Cyt_deam_dimer.
IPR016193. Cytidine_deaminase-like.
IPR020797. Cytidine_deaminase_bacteria.
[Graphical view]
PfamPF00383. dCMP_cyt_deam_1. 1 hit.
PF08211. dCMP_cyt_deam_2. 1 hit.
[Graphical view]
PIRSFPIRSF006334. Cdd_plus_pseudo. 1 hit.
SUPFAMSSF53927. SSF53927. 2 hits.
PROSITEPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDD_PSEHT
AccessionPrimary (citable) accession number: Q3IBX5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 8, 2005
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families