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Protein

Putative acyl-coenzyme A thioesterase 6

Gene

ACOT6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei18 – 181Charge relay systemSequence Analysis
Active sitei112 – 1121Charge relay systemSequence Analysis
Active sitei146 – 1461Charge relay systemSequence Analysis

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Enzyme and pathway databases

BRENDAi3.1.2.20. 2681.

Protein family/group databases

ESTHERihuman-ACOT6. Acyl-CoA_Thioesterase.
MEROPSiS09.030.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative acyl-coenzyme A thioesterase 6 (EC:3.1.2.-)
Short name:
Putative acyl-CoA thioesterase 6
Gene namesi
Name:ACOT6
Synonyms:C14orf42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:33159. ACOT6.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cytosol Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162375329.

Polymorphism and mutation databases

BioMutaiACOT6.
DMDMi121942509.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Putative acyl-coenzyme A thioesterase 6PRO_0000305098Add
BLAST

Proteomic databases

PaxDbiQ3I5F7.
PRIDEiQ3I5F7.

PTM databases

PhosphoSiteiQ3I5F7.

Expressioni

Gene expression databases

BgeeiQ3I5F7.
CleanExiHS_ACOT6.
ExpressionAtlasiQ3I5F7. baseline and differential.
GenevisibleiQ3I5F7. HS.

Organism-specific databases

HPAiHPA058258.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000370531.

Structurei

3D structure databases

ProteinModelPortaliQ3I5F7.
SMRiQ3I5F7. Positions 1-196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the C/M/P thioester hydrolase family.Curated

Phylogenomic databases

eggNOGieuNOG20562.
GeneTreeiENSGT00390000001046.
HOGENOMiHOG000033784.
HOVERGENiHBG000331.
InParanoidiQ3I5F7.
KOiK11993.
OMAiNPLEEPY.
PhylomeDBiQ3I5F7.
TreeFamiTF314911.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR014940. BAAT_C.
[Graphical view]
PfamiPF08840. BAAT_C. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 2 hits.

Sequencei

Sequence statusi: Complete.

Q3I5F7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQHPKVKGP SIALLGFSKG GDLCLSMASF LKGITATVLI NACVANTVAP
60 70 80 90 100
LHYKDMIIPK LVDDLGKVKI TKSGFLTFMD TWSNPLEEHN HQSLVPLEKA
110 120 130 140 150
QVPFLFIVGM DDQSWKSEFY AQIASERLQA HGKERPQIIC YPETGHCIDP
160 170 180 190 200
PYFPPSRASV HAVLGEAIFY GGEPKAHSKA QVDAWQQIQT FFHKHLNGKK

SVKHSKI
Length:207
Mass (Da):22,991
Last modified:November 8, 2005 - v1
Checksum:iB77AB1DC5760D306
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti166 – 1661E → K.
Corresponds to variant rs17782052 [ dbSNP | Ensembl ].
VAR_052302

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ082756 mRNA. Translation: AAZ31238.1.
BC126378 mRNA. Translation: AAI26379.1.
BC126380 mRNA. Translation: AAI26381.1.
CCDSiCCDS32118.1.
RefSeqiNP_001032239.1. NM_001037162.1.
UniGeneiHs.122038.

Genome annotation databases

EnsembliENST00000381139; ENSP00000370531; ENSG00000205669.
GeneIDi641372.
KEGGihsa:641372.
UCSCiuc001xop.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ082756 mRNA. Translation: AAZ31238.1.
BC126378 mRNA. Translation: AAI26379.1.
BC126380 mRNA. Translation: AAI26381.1.
CCDSiCCDS32118.1.
RefSeqiNP_001032239.1. NM_001037162.1.
UniGeneiHs.122038.

3D structure databases

ProteinModelPortaliQ3I5F7.
SMRiQ3I5F7. Positions 1-196.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000370531.

Protein family/group databases

ESTHERihuman-ACOT6. Acyl-CoA_Thioesterase.
MEROPSiS09.030.

PTM databases

PhosphoSiteiQ3I5F7.

Polymorphism and mutation databases

BioMutaiACOT6.
DMDMi121942509.

Proteomic databases

PaxDbiQ3I5F7.
PRIDEiQ3I5F7.

Protocols and materials databases

DNASUi641372.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381139; ENSP00000370531; ENSG00000205669.
GeneIDi641372.
KEGGihsa:641372.
UCSCiuc001xop.3. human.

Organism-specific databases

CTDi641372.
GeneCardsiGC14P074083.
HGNCiHGNC:33159. ACOT6.
HPAiHPA058258.
MIMi614267. gene.
neXtProtiNX_Q3I5F7.
PharmGKBiPA162375329.
GenAtlasiSearch...

Phylogenomic databases

eggNOGieuNOG20562.
GeneTreeiENSGT00390000001046.
HOGENOMiHOG000033784.
HOVERGENiHBG000331.
InParanoidiQ3I5F7.
KOiK11993.
OMAiNPLEEPY.
PhylomeDBiQ3I5F7.
TreeFamiTF314911.

Enzyme and pathway databases

BRENDAi3.1.2.20. 2681.

Miscellaneous databases

GenomeRNAii641372.
NextBioi113129.
PROiQ3I5F7.
SOURCEiSearch...

Gene expression databases

BgeeiQ3I5F7.
CleanExiHS_ACOT6.
ExpressionAtlasiQ3I5F7. baseline and differential.
GenevisibleiQ3I5F7. HS.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR014940. BAAT_C.
[Graphical view]
PfamiPF08840. BAAT_C. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs."
    Hunt M.C., Rautanen A., Westin M.A.K., Svensson L.T., Alexson S.E.H.
    FASEB J. 20:1855-1864(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PROBABLE ABSENCE OF CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiACOT6_HUMAN
AccessioniPrimary (citable) accession number: Q3I5F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: November 8, 2005
Last modified: June 24, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

May lack catalytic activity, even though the active site residues are conserved.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.