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Q3I5F7 (ACOT6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative acyl-coenzyme A thioesterase 6

Short name=Putative acyl-CoA thioesterase 6
EC=3.1.2.-
Gene names
Name:ACOT6
Synonyms:C14orf42
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length207 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cytoplasm Ref.1.

Sequence similarities

Belongs to the C/M/P thioester hydrolase family.

Caution

May lack catalytic activity, even though the active site residues are conserved.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityPolymorphism
   Molecular functionHydrolase
Serine esterase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytosol

Inferred from direct assay Ref.1. Source: HGNC

   Molecular_functionhydrolase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 207207Putative acyl-coenzyme A thioesterase 6
PRO_0000305098

Sites

Active site181Charge relay system Potential
Active site1121Charge relay system Potential
Active site1461Charge relay system Potential

Natural variations

Natural variant1661E → K.
Corresponds to variant rs17782052 [ dbSNP | Ensembl ].
VAR_052302

Sequences

Sequence LengthMass (Da)Tools
Q3I5F7 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: B77AB1DC5760D306

FASTA20722,991
        10         20         30         40         50         60 
MLQHPKVKGP SIALLGFSKG GDLCLSMASF LKGITATVLI NACVANTVAP LHYKDMIIPK 

        70         80         90        100        110        120 
LVDDLGKVKI TKSGFLTFMD TWSNPLEEHN HQSLVPLEKA QVPFLFIVGM DDQSWKSEFY 

       130        140        150        160        170        180 
AQIASERLQA HGKERPQIIC YPETGHCIDP PYFPPSRASV HAVLGEAIFY GGEPKAHSKA 

       190        200 
QVDAWQQIQT FFHKHLNGKK SVKHSKI 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs."
Hunt M.C., Rautanen A., Westin M.A.K., Svensson L.T., Alexson S.E.H.
FASEB J. 20:1855-1864(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PROBABLE ABSENCE OF CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ082756 mRNA. Translation: AAZ31238.1.
BC126378 mRNA. Translation: AAI26379.1.
BC126380 mRNA. Translation: AAI26381.1.
RefSeqNP_001032239.1. NM_001037162.1.
UniGeneHs.122038.

3D structure databases

ProteinModelPortalQ3I5F7.
SMRQ3I5F7. Positions 1-196.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ3I5F7.

Polymorphism databases

DMDM121942509.

Proteomic databases

PaxDbQ3I5F7.
PRIDEQ3I5F7.

Protocols and materials databases

DNASU641372.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000381139; ENSP00000370531; ENSG00000205669.
GeneID641372.
KEGGhsa:641372.
UCSCuc001xop.3. human.

Organism-specific databases

CTD641372.
GeneCardsGC14P074083.
HGNCHGNC:33159. ACOT6.
HPAHPA058258.
MIM614267. gene.
neXtProtNX_Q3I5F7.
PharmGKBPA162375329.
GenAtlasSearch...

Phylogenomic databases

eggNOGeuNOG20562.
HOGENOMHOG000033784.
HOVERGENHBG000331.
InParanoidQ3I5F7.
KOK11993.
OMANPLEEPY.
PhylomeDBQ3I5F7.
TreeFamTF314911.

Gene expression databases

ArrayExpressQ3I5F7.
BgeeQ3I5F7.
CleanExHS_ACOT6.
GenevestigatorQ3I5F7.

Family and domain databases

InterProIPR014940. BAAT_C.
[Graphical view]
PfamPF08840. BAAT_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi641372.
NextBio113129.
PROQ3I5F7.
SOURCESearch...

Entry information

Entry nameACOT6_HUMAN
AccessionPrimary (citable) accession number: Q3I5F7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: November 8, 2005
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM