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Q3I5F7

- ACOT6_HUMAN

UniProt

Q3I5F7 - ACOT6_HUMAN

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Protein

Putative acyl-coenzyme A thioesterase 6

Gene

ACOT6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei18 – 181Charge relay systemSequence Analysis
Active sitei112 – 1121Charge relay systemSequence Analysis
Active sitei146 – 1461Charge relay systemSequence Analysis

GO - Molecular functioni

  1. carboxylic ester hydrolase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Protein family/group databases

MEROPSiS09.030.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative acyl-coenzyme A thioesterase 6 (EC:3.1.2.-)
Short name:
Putative acyl-CoA thioesterase 6
Gene namesi
Name:ACOT6
Synonyms:C14orf42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:33159. ACOT6.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytosol Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162375329.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Putative acyl-coenzyme A thioesterase 6PRO_0000305098Add
BLAST

Proteomic databases

PaxDbiQ3I5F7.
PRIDEiQ3I5F7.

PTM databases

PhosphoSiteiQ3I5F7.

Expressioni

Gene expression databases

BgeeiQ3I5F7.
CleanExiHS_ACOT6.
ExpressionAtlasiQ3I5F7. baseline and differential.
GenevestigatoriQ3I5F7.

Organism-specific databases

HPAiHPA058258.

Structurei

3D structure databases

ProteinModelPortaliQ3I5F7.
SMRiQ3I5F7. Positions 1-196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the C/M/P thioester hydrolase family.Curated

Phylogenomic databases

eggNOGieuNOG20562.
GeneTreeiENSGT00390000001046.
HOGENOMiHOG000033784.
HOVERGENiHBG000331.
InParanoidiQ3I5F7.
KOiK11993.
OMAiNPLEEPY.
PhylomeDBiQ3I5F7.
TreeFamiTF314911.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR014940. BAAT_C.
[Graphical view]
PfamiPF08840. BAAT_C. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 2 hits.

Sequencei

Sequence statusi: Complete.

Q3I5F7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLQHPKVKGP SIALLGFSKG GDLCLSMASF LKGITATVLI NACVANTVAP
60 70 80 90 100
LHYKDMIIPK LVDDLGKVKI TKSGFLTFMD TWSNPLEEHN HQSLVPLEKA
110 120 130 140 150
QVPFLFIVGM DDQSWKSEFY AQIASERLQA HGKERPQIIC YPETGHCIDP
160 170 180 190 200
PYFPPSRASV HAVLGEAIFY GGEPKAHSKA QVDAWQQIQT FFHKHLNGKK

SVKHSKI
Length:207
Mass (Da):22,991
Last modified:November 8, 2005 - v1
Checksum:iB77AB1DC5760D306
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti166 – 1661E → K.
Corresponds to variant rs17782052 [ dbSNP | Ensembl ].
VAR_052302

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ082756 mRNA. Translation: AAZ31238.1.
BC126378 mRNA. Translation: AAI26379.1.
BC126380 mRNA. Translation: AAI26381.1.
CCDSiCCDS32118.1.
RefSeqiNP_001032239.1. NM_001037162.1.
UniGeneiHs.122038.

Genome annotation databases

EnsembliENST00000381139; ENSP00000370531; ENSG00000205669.
GeneIDi641372.
KEGGihsa:641372.
UCSCiuc001xop.3. human.

Polymorphism databases

DMDMi121942509.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ082756 mRNA. Translation: AAZ31238.1 .
BC126378 mRNA. Translation: AAI26379.1 .
BC126380 mRNA. Translation: AAI26381.1 .
CCDSi CCDS32118.1.
RefSeqi NP_001032239.1. NM_001037162.1.
UniGenei Hs.122038.

3D structure databases

ProteinModelPortali Q3I5F7.
SMRi Q3I5F7. Positions 1-196.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S09.030.

PTM databases

PhosphoSitei Q3I5F7.

Polymorphism databases

DMDMi 121942509.

Proteomic databases

PaxDbi Q3I5F7.
PRIDEi Q3I5F7.

Protocols and materials databases

DNASUi 641372.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381139 ; ENSP00000370531 ; ENSG00000205669 .
GeneIDi 641372.
KEGGi hsa:641372.
UCSCi uc001xop.3. human.

Organism-specific databases

CTDi 641372.
GeneCardsi GC14P074083.
HGNCi HGNC:33159. ACOT6.
HPAi HPA058258.
MIMi 614267. gene.
neXtProti NX_Q3I5F7.
PharmGKBi PA162375329.
GenAtlasi Search...

Phylogenomic databases

eggNOGi euNOG20562.
GeneTreei ENSGT00390000001046.
HOGENOMi HOG000033784.
HOVERGENi HBG000331.
InParanoidi Q3I5F7.
KOi K11993.
OMAi NPLEEPY.
PhylomeDBi Q3I5F7.
TreeFami TF314911.

Miscellaneous databases

GenomeRNAii 641372.
NextBioi 113129.
PROi Q3I5F7.
SOURCEi Search...

Gene expression databases

Bgeei Q3I5F7.
CleanExi HS_ACOT6.
ExpressionAtlasi Q3I5F7. baseline and differential.
Genevestigatori Q3I5F7.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR014940. BAAT_C.
[Graphical view ]
Pfami PF08840. BAAT_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs."
    Hunt M.C., Rautanen A., Westin M.A.K., Svensson L.T., Alexson S.E.H.
    FASEB J. 20:1855-1864(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PROBABLE ABSENCE OF CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiACOT6_HUMAN
AccessioniPrimary (citable) accession number: Q3I5F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: November 8, 2005
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

May lack catalytic activity, even though the active site residues are conserved.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3