Reviewed, UniProtKB/Swiss-Prot Q3I5F7 (ACOT6_HUMAN)

Names and origin

Protein names

Recommended name:
    Putative acyl-coenzyme A thioesterase 6
      Short name=Acyl-CoA thioesterase 6
    EC=3.1.2.-

Gene names

Name:

ACOT6

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Cytoplasm Ref.1.
Sequence similarities	Belongs to the C/M/P thioester hydrolase family.
Caution	May lack catalytic activity, even though the active site residues are conserved.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Molecular function	Hydrolase Serine esterase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytosol Ref.1 Inferred from direct assay. Source: HGNC
Molecular function	carboxylesterase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	Putative acyl-coenzyme A thioesterase 6		PRO_0000305098
Sites
	Active site	18	1	Charge relay system Potential
	Active site	112	1	Charge relay system Potential
	Active site	146	1	Charge relay system Potential
Natural variations
	Natural variant	166	1	E → K: dbSNP rs17782052.		VAR_052302

Sequences

	Sequence		Length	Mass (Da)
	Q3I5F7-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: B77AB1DC5760D306	FASTA	207	22,991
	10 20 30 40 50 60 MLQHPKVKGP SIALLGFSKG GDLCLSMASF LKGITATVLI NACVANTVAP LHYKDMIIPK 70 80 90 100 110 120 LVDDLGKVKI TKSGFLTFMD TWSNPLEEHN HQSLVPLEKA QVPFLFIVGM DDQSWKSEFY 130 140 150 160 170 180 AQIASERLQA HGKERPQIIC YPETGHCIDP PYFPPSRASV HAVLGEAIFY GGEPKAHSKA 190 200 QVDAWQQIQT FFHKHLNGKK SVKHSKI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs." Hunt M.C., Rautanen A., Westin M.A.K., Svensson L.T., Alexson S.E.H. FASEB J. 20:1855-1864(2006) [PubMed: 16940157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PROBABLE ABSENCE OF CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ082756 mRNA. Translation: AAZ31238.1. BC126378 mRNA. Translation: AAI26379.1. BC126380 mRNA. Translation: AAI26381.1.
IPI	IPI00655830.
RefSeq	NP_001032239.1.
UniGene	Hs.122038
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q3I5F7.
Genome annotation databases
Ensembl	ENST00000381139; ENSP00000370531; ENSG00000205669; Homo sapiens. [Genome view]
GeneID	641372.
KEGG	hsa:641372.
UCSC	uc001xop.1. human.
Organism-specific databases
CTD	641372.
GeneCards	GC14P073153.
HGNC	HGNC:33159. ACOT6.
GenAtlas	Search...
Phylogenomic databases
InParanoid	Q3I5F7.
OMA	ETGHCID.
OrthoDB	EOG9F4VX5.
Gene expression databases
ArrayExpress	Q3I5F7.
Bgee	Q3I5F7.
CleanEx	HS_ACOT6.
Genevestigator	Q3I5F7.
Family and domain databases
InterPro	IPR014940. BAAT_C. [Graphical view]
Pfam	PF08840. BAAT_C. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	113129.

Entry information

Entry name

ACOT6_HUMAN

Accession

Primary (citable) accession number: Q3I5F7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	November 8, 2005
Last modified:	December 15, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.