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Q3I5F7

- ACOT6_HUMAN

UniProt

Q3I5F7 - ACOT6_HUMAN

Protein

Putative acyl-coenzyme A thioesterase 6

Gene

ACOT6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei18 – 181Charge relay systemSequence Analysis
    Active sitei112 – 1121Charge relay systemSequence Analysis
    Active sitei146 – 1461Charge relay systemSequence Analysis

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Serine esterase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative acyl-coenzyme A thioesterase 6 (EC:3.1.2.-)
    Short name:
    Putative acyl-CoA thioesterase 6
    Gene namesi
    Name:ACOT6
    Synonyms:C14orf42
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:33159. ACOT6.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosol Source: HGNC

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162375329.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 207207Putative acyl-coenzyme A thioesterase 6PRO_0000305098Add
    BLAST

    Proteomic databases

    PaxDbiQ3I5F7.
    PRIDEiQ3I5F7.

    PTM databases

    PhosphoSiteiQ3I5F7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ3I5F7.
    BgeeiQ3I5F7.
    CleanExiHS_ACOT6.
    GenevestigatoriQ3I5F7.

    Organism-specific databases

    HPAiHPA058258.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3I5F7.
    SMRiQ3I5F7. Positions 1-196.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the C/M/P thioester hydrolase family.Curated

    Phylogenomic databases

    eggNOGieuNOG20562.
    HOGENOMiHOG000033784.
    HOVERGENiHBG000331.
    InParanoidiQ3I5F7.
    KOiK11993.
    OMAiNPLEEPY.
    PhylomeDBiQ3I5F7.
    TreeFamiTF314911.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR014940. BAAT_C.
    [Graphical view]
    PfamiPF08840. BAAT_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q3I5F7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLQHPKVKGP SIALLGFSKG GDLCLSMASF LKGITATVLI NACVANTVAP    50
    LHYKDMIIPK LVDDLGKVKI TKSGFLTFMD TWSNPLEEHN HQSLVPLEKA 100
    QVPFLFIVGM DDQSWKSEFY AQIASERLQA HGKERPQIIC YPETGHCIDP 150
    PYFPPSRASV HAVLGEAIFY GGEPKAHSKA QVDAWQQIQT FFHKHLNGKK 200
    SVKHSKI 207
    Length:207
    Mass (Da):22,991
    Last modified:November 8, 2005 - v1
    Checksum:iB77AB1DC5760D306
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti166 – 1661E → K.
    Corresponds to variant rs17782052 [ dbSNP | Ensembl ].
    VAR_052302

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ082756 mRNA. Translation: AAZ31238.1.
    BC126378 mRNA. Translation: AAI26379.1.
    BC126380 mRNA. Translation: AAI26381.1.
    CCDSiCCDS32118.1.
    RefSeqiNP_001032239.1. NM_001037162.1.
    UniGeneiHs.122038.

    Genome annotation databases

    EnsembliENST00000381139; ENSP00000370531; ENSG00000205669.
    GeneIDi641372.
    KEGGihsa:641372.
    UCSCiuc001xop.3. human.

    Polymorphism databases

    DMDMi121942509.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ082756 mRNA. Translation: AAZ31238.1 .
    BC126378 mRNA. Translation: AAI26379.1 .
    BC126380 mRNA. Translation: AAI26381.1 .
    CCDSi CCDS32118.1.
    RefSeqi NP_001032239.1. NM_001037162.1.
    UniGenei Hs.122038.

    3D structure databases

    ProteinModelPortali Q3I5F7.
    SMRi Q3I5F7. Positions 1-196.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q3I5F7.

    Polymorphism databases

    DMDMi 121942509.

    Proteomic databases

    PaxDbi Q3I5F7.
    PRIDEi Q3I5F7.

    Protocols and materials databases

    DNASUi 641372.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381139 ; ENSP00000370531 ; ENSG00000205669 .
    GeneIDi 641372.
    KEGGi hsa:641372.
    UCSCi uc001xop.3. human.

    Organism-specific databases

    CTDi 641372.
    GeneCardsi GC14P074083.
    HGNCi HGNC:33159. ACOT6.
    HPAi HPA058258.
    MIMi 614267. gene.
    neXtProti NX_Q3I5F7.
    PharmGKBi PA162375329.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi euNOG20562.
    HOGENOMi HOG000033784.
    HOVERGENi HBG000331.
    InParanoidi Q3I5F7.
    KOi K11993.
    OMAi NPLEEPY.
    PhylomeDBi Q3I5F7.
    TreeFami TF314911.

    Miscellaneous databases

    GenomeRNAii 641372.
    NextBioi 113129.
    PROi Q3I5F7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3I5F7.
    Bgeei Q3I5F7.
    CleanExi HS_ACOT6.
    Genevestigatori Q3I5F7.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR014940. BAAT_C.
    [Graphical view ]
    Pfami PF08840. BAAT_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs."
      Hunt M.C., Rautanen A., Westin M.A.K., Svensson L.T., Alexson S.E.H.
      FASEB J. 20:1855-1864(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PROBABLE ABSENCE OF CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiACOT6_HUMAN
    AccessioniPrimary (citable) accession number: Q3I5F7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    May lack catalytic activity, even though the active site residues are conserved.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3