Q3I5F7 (ACOT6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative acyl-coenzyme A thioesterase 6
Short name=Putative acyl-CoA thioesterase 6
EC=3.1.2.-

Gene names

Name:	ACOT6
Synonyms:	C14orf42

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cytoplasm Ref.1.
Sequence similarities	Belongs to the C/M/P thioester hydrolase family.
Caution	May lack catalytic activity, even though the active site residues are conserved.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Molecular function	Hydrolase Serine esterase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytosol Inferred from direct assay Ref.1. Source: HGNC
Molecular_function	carboxylesterase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	Putative acyl-coenzyme A thioesterase 6		PRO_0000305098
Sites
	Active site	18	1	Charge relay system Potential
	Active site	112	1	Charge relay system Potential
	Active site	146	1	Charge relay system Potential
Natural variations
	Natural variant	166	1	E → K. Corresponds to variant rs17782052 [ dbSNP | Ensembl ].		VAR_052302

Sequences

	Sequence		Length	Mass (Da)
	Q3I5F7 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: B77AB1DC5760D306	FASTA	207	22,991
	10 20 30 40 50 60 MLQHPKVKGP SIALLGFSKG GDLCLSMASF LKGITATVLI NACVANTVAP LHYKDMIIPK 70 80 90 100 110 120 LVDDLGKVKI TKSGFLTFMD TWSNPLEEHN HQSLVPLEKA QVPFLFIVGM DDQSWKSEFY 130 140 150 160 170 180 AQIASERLQA HGKERPQIIC YPETGHCIDP PYFPPSRASV HAVLGEAIFY GGEPKAHSKA 190 200 QVDAWQQIQT FFHKHLNGKK SVKHSKI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs." Hunt M.C., Rautanen A., Westin M.A.K., Svensson L.T., Alexson S.E.H. FASEB J. 20:1855-1864(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PROBABLE ABSENCE OF CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ082756 mRNA. Translation: AAZ31238.1. BC126378 mRNA. Translation: AAI26379.1. BC126380 mRNA. Translation: AAI26381.1.
IPI	IPI00655830.
RefSeq	NP_001032239.1. NM_001037162.1.
UniGene	Hs.122038.
3D structure databases
ProteinModelPortal	Q3I5F7.
ModBase	Search...
PTM databases
PhosphoSite	Q3I5F7.
Polymorphism databases
DMDM	121942509.
Proteomic databases
PaxDb	Q3I5F7.
PRIDE	Q3I5F7.
Protocols and materials databases
DNASU	641372.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000381139; ENSP00000370531; ENSG00000205669.
GeneID	641372.
KEGG	hsa:641372.
UCSC	uc001xop.3. human.
Organism-specific databases
CTD	641372.
GeneCards	GC14P074083.
HGNC	HGNC:33159. ACOT6.
MIM	614267. gene.
neXtProt	NX_Q3I5F7.
PharmGKB	PA162375329.
GenAtlas	Search...
Phylogenomic databases
eggNOG	euNOG20562.
HOGENOM	HOG000033784.
HOVERGEN	HBG000331.
InParanoid	Q3I5F7.
KO	K11993.
OMA	KDMIIPK.
OrthoDB	EOG4KKZ42.
Gene expression databases
ArrayExpress	Q3I5F7.
Bgee	Q3I5F7.
CleanEx	HS_ACOT6.
Genevestigator	Q3I5F7.
Family and domain databases
InterPro	IPR014940. BAAT_C. [Graphical view]
Pfam	PF08840. BAAT_C. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	641372.
NextBio	113129.
SOURCE	Search...

Entry information

Entry name

ACOT6_HUMAN

Accession

Primary (citable) accession number: Q3I5F7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	November 8, 2005
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.