Carbonic anhydrase 2 - Cryptococcus neoformans var. grubii

Preferred order of sections

Names and origin

Protein names

Submitted name:
Carbonic anhydrase 2 EMBL AAZ30051.1

Gene names

Name:

CAN2 EMBL AAZ30051.1

Organism

Cryptococcus neoformans var. grubii (Filobasidiella neoformans var. grubii) EMBL AAZ30051.1

Taxonomic identifier

178876 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Tremellomycetes › Tremellales › Tremellaceae › Filobasidiella › Filobasidiella/Cryptococcus neoformans species complex ›

Protein attributes

Sequence length	239 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Metal-binding PDB 2W3N PDB 2W3Q Zinc PDB 2W3N PDB 2W3Q
Technical term	3D-structure PDB 2W3N PDB 2W3Q
Gene Ontology (GO)
Molecular_function	carbonate dehydratase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Sites

Metal binding

68

1

Zinc PDB 2W3N PDB 2W3Q

Metal binding

124

1

Zinc; via tele nitrogen PDB 2W3N PDB 2W3Q

Metal binding

127

1

Zinc PDB 2W3N PDB 2W3Q

Sequences

Sequence

Length

Mass (Da)

Tools

Q3I4V7 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: CAA169E1F89BDF01
Show »

FASTA

239

26,600

        10         20         30         40         50         60 
MPFHAEPLKP SDEIDMDLGH SVAAQKFKEI REVLEGNRYW ARKVTSEEPE FMAEQVKGQA 

        70         80         90        100        110        120 
PNFLWIGCAD SRVPEVTIMA RKPGDVFVQR NVANQFKPED DSSQALLNYA IMNVGVTHVM 

       130        140        150        160        170        180 
VVGHTGCGGC IAAFDQPLPT EENPGGTPLV RYLEPIIRLK HSLPEGSDVN DLIKENVKMA 

       190        200        210        220        230 
VKNVVNSPTI QGAWEQARKG EFREVFVHGW LYDLSTGNIV DLNVTQGPHP FVDDRVPRA

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References

[1]	"Carbonic anhydrase and CO2 sensing during Cryptococcus neoformans growth, differentiation, and virulence." Bahn Y.-S., Cox G.M., Perfect J.R., Heitman J. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: H99 EMBL AAZ30051.1.
[2]	"Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans." Schlicker C., Hall R.A., Vullo D., Middelhaufe S., Gertz M., Supuran C.T., Muhlschlegel F.A., Steegborn C. J. Mol. Biol. 385:1207-1220(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.34 ANGSTROMS) IN COMPLEX WITH ZINC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

DQ115790 mRNA. Translation: AAZ30051.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2W3N	X-ray	2.05	A/B/C	1-239	[»]
2W3Q	X-ray	1.34	A	1-239	[»]

ProteinModelPortal

Q3I4V7.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

3.40.1050.10. 1 hit.

InterPro

IPR001765. Carbonic_anhydrase.
[Graphical view]

PANTHER

PTHR11002. PTHR11002. 1 hit.

Pfam

PF00484. Pro_CA. 1 hit.
[Graphical view]

SMART

SM00947. Pro_CA. 1 hit.
[Graphical view]

SUPFAM

SSF53056. Prok_plnt_COanhd. 1 hit.

ProtoNet

Search...

Other

BindingDB

Q3I4V7.

ChEMBL

CHEMBL1697676.

EvolutionaryTrace

Q3I4V7.

Entry information

Entry name

Q3I4V7_CRYNV

Accession

Primary (citable) accession number: Q3I4V7

Entry history

Integrated into UniProtKB/TrEMBL:	November 8, 2005
Last sequence update:	November 8, 2005
Last modified:	April 3, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)