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Protein
Submitted name:

Alpha-1-antitrypsin NULL(BRESCIA) variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. endopeptidase inhibitor activity Source: Ensembl

GO - Biological processi

  1. inflammatory response Source: Ensembl
  2. negative regulation of serine-type endopeptidase activity Source: Ensembl
  3. response to chromate Source: Ensembl
  4. response to cytokine Source: Ensembl
  5. response to estradiol Source: Ensembl
  6. response to hypoxia Source: Ensembl
  7. response to lead ion Source: Ensembl
  8. response to lipopolysaccharide Source: Ensembl
  9. response to methanol Source: Ensembl
  10. response to triglyceride Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-1-antitrypsin NULL(BRESCIA) variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ3I0J7.

Expressioni

Gene expression databases

BgeeiQ3I0J7.
ExpressionAtlasiQ3I0J7. baseline and differential.

Family & Domainsi

Family and domain databases

InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q3I0J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KWERPFEVKD TEEEDFHVDQ VTTVKVPMMK RLGMFNIQHC KKLSSWVLLM
60
KYLGNATAIF FLPD
Length:64
Mass (Da):7,618
Last modified:November 8, 2005 - v1
Checksum:iE6255C708F319E4F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ174461 Genomic DNA. Translation: ABA41642.1.
UniGeneiHs.525557.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ174461 Genomic DNA. Translation: ABA41642.1.
UniGeneiHs.525557.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ3I0J7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Gene expression databases

BgeeiQ3I0J7.
ExpressionAtlasiQ3I0J7. baseline and differential.

Family and domain databases

InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "PI NULL(BRESCIA): A Novel Variant of Alpha-1 Antitrypsin Gene With Stop-Codon in Position 257."
    Medicina D.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ3I0J7_HUMAN
AccessioniPrimary (citable) accession number: Q3I0J7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 8, 2005
Last sequence update: November 8, 2005
Last modified: March 4, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.