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Protein

DNA topoisomerase 4 subunit B

Gene

parE

Organism
Streptococcus pneumoniae
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation, Ca2+UniRule annotationNote: Binds two Mg2+ per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn2+ or Ca2+.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei11ATPUniRule annotation1
Binding sitei51ATPUniRule annotation1
Binding sitei78ATPUniRule annotation1
Binding sitei344ATPUniRule annotation1
Metal bindingi433Magnesium 1; catalyticUniRule annotation1
Metal bindingi506Magnesium 1; catalyticUniRule annotation1
Metal bindingi506Magnesium 2UniRule annotation1
Metal bindingi508Magnesium 2UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi118 – 124ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, TopoisomeraseUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, DNA-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomerase 4 subunit BUniRule annotation (EC:5.99.1.3UniRule annotation)
Alternative name(s):
Topoisomerase IV subunit BUniRule annotation
Gene namesi
Name:parEUniRule annotationImported
Synonyms:gyrBImported, parE_2Imported
ORF Names:AWW74_02480Imported, ERS003549_00143Imported, ERS013931_01942Imported, ERS020135_01913Imported, ERS020141_01769Imported, ERS020145_01936Imported, ERS020146_02047Imported, ERS020148_02032Imported, ERS020155_02101Imported, ERS020491_01644Imported, ERS020520_01939Imported, ERS020539_02044Imported, ERS020692_01365Imported, ERS020822_04226Imported, ERS021300_01930Imported, ERS021354_07390Imported, ERS021449_01450Imported, ERS021634_06660Imported, ERS022045_05659Imported, ERS043879_00489Imported, ERS077235_02181Imported, ERS232471_01998Imported, ERS232499_02043Imported, ERS367337_00603Imported, ERS409165_01556Imported, ERS409444_00259Imported, ERS455085_02076Imported
OrganismiStreptococcus pneumoniaeImported
Taxonomic identifieri1313 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000046356 Componenti: Unassembled WGS sequence
  • UP000074827 Componenti: Unassembled WGS sequence
  • UP000071227 Componenti: Unassembled WGS sequence
  • UP000070671 Componenti: Unassembled WGS sequence
  • UP000039303 Componenti: Unassembled WGS sequence
  • UP000073722 Componenti: Unassembled WGS sequence
  • UP000071406 Componenti: Unassembled WGS sequence
  • UP000045409 Componenti: Unassembled WGS sequence
  • UP000047188 Componenti: Unassembled WGS sequence
  • UP000072289 Componenti: Unassembled WGS sequence
  • UP000044228 Componenti: Unassembled WGS sequence
  • UP000040775 Componenti: Unassembled WGS sequence
  • UP000043880 Componenti: Unassembled WGS sequence
  • UP000039362 Componenti: Unassembled WGS sequence
  • UP000040760 Componenti: Unassembled WGS sequence
  • UP000043492 Componenti: Unassembled WGS sequence
  • UP000047832 Componenti: Unassembled WGS sequence
  • UP000042702 Componenti: Unassembled WGS sequence
  • UP000042569 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Subunit structurei

Heterotetramer composed of ParC and ParE.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei458Interaction with DNAUniRule annotation1
Sitei461Interaction with DNAUniRule annotation1
Sitei513Interaction with DNAUniRule annotation1
Sitei629Interaction with DNAUniRule annotation1

Protein-protein interaction databases

STRINGi171101.spr0756.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I3HX-ray3.70A/B1-647[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini427 – 541ToprimInterPro annotationAdd BLAST115

Sequence similaritiesi

Belongs to the type II topoisomerase family. ParE type 2 subfamily.UniRule annotation
Contains 1 Toprim domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C7D. Bacteria.
COG0187. LUCA.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
3.40.50.670. 1 hit.
HAMAPiMF_00939. ParE_type2. 1 hit.
InterProiIPR002288. DNA_gyrase_B_C.
IPR003594. HATPase_C.
IPR005740. ParE_type2.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR001241. Topo_IIA.
IPR013760. Topo_IIA-like_dom.
IPR013506. Topo_IIA_bsu_dom2.
IPR013759. Topo_IIA_cen_dom.
IPR018522. TopoIIA_CS.
IPR006171. Toprim_domain.
[Graphical view]
PfamiPF00204. DNA_gyraseB. 1 hit.
PF00986. DNA_gyraseB_C. 1 hit.
PF02518. HATPase_c. 1 hit.
PF01751. Toprim. 1 hit.
[Graphical view]
PRINTSiPR00418. TPI2FAMILY.
SMARTiSM00387. HATPase_c. 1 hit.
SM00433. TOP2c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
SSF56719. SSF56719. 1 hit.
TIGRFAMsiTIGR01058. parE_Gpos. 1 hit.
PROSITEiPS00177. TOPOISOMERASE_II. 1 hit.
PS50880. TOPRIM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3HZ71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKEININN YNDDAIQVLE GLDAVRKRPG MYIGSTDGAG LHHLVWEIVD
60 70 80 90 100
NAVDEALSGF GDRIDVTINK DGSLTVQDHG RGMPTGMHAM GIPTVEVIFT
110 120 130 140 150
ILHAGGKFGQ GGYKTSGGLH GVGSSVVNAL SSWLEVEITR DGAVYKQRFE
160 170 180 190 200
NGGKPVTTLK KIGTAPKSKT GTKVTFMPDA TIFSTTDFKY NTISERLNES
210 220 230 240 250
AFLLKNVTLS LTDKRTDEAI EFHYENGVQD FVSYLNEDKE ILTPVLYFEG
260 270 280 290 300
EDNGFQVEVA LQYNDGFSDN ILSFVNNVRT KDGGTHETGL KSAITKVMND
310 320 330 340 350
YARKTGLLKE KDKNLEGSDY REGLAAVLSI LVPEEHLQFE GQTKDKLGSP
360 370 380 390 400
LARPVVDGIV ADKLTFFLME NGELASNLIR KAIKARDARE AARKARDESR
410 420 430 440 450
NGKKNKKDKG LLSGKLTPAQ SKNPAKNELY LVEGDSAGGS AKQGRDRKFQ
460 470 480 490 500
AILPLRGKVI NTAKAKMADI LKNEEINTMI YTIGAGVGAD FSIEDANYDK
510 520 530 540 550
IIIMTDADTD GAHIQTLLLT FFYRYMRPLV EAGHVYIALP PLYKMSKGKG
560 570 580 590 600
KKEEVAYAWT DGELEELRKQ FGKGATLQRY KGLGEMNADQ LWETTMNPET
610 620 630 640
RTLIRVTIED LARAERRVNV LMGDKVEPRR KWIEDNVKFT LEEATVF
Length:647
Mass (Da):71,649
Last modified:November 8, 2005 - v1
Checksum:iDB5CF701D5F80AB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ175245 Genomic DNA. Translation: AAZ93046.1.
DQ175255 Genomic DNA. Translation: AAZ93056.1.
DQ175258 Genomic DNA. Translation: AAZ93059.1.
DQ175263 Genomic DNA. Translation: AAZ93064.1.
DQ175273 Genomic DNA. Translation: AAZ93074.1.
DQ175279 Genomic DNA. Translation: AAZ93080.1.
DQ175285 Genomic DNA. Translation: AAZ93086.1.
DQ175288 Genomic DNA. Translation: AAZ93089.1.
CFBS01000042 Genomic DNA. Translation: CEV85061.1.
CGAR01000058 Genomic DNA. Translation: CFP94753.1.
CHOW01000021 Genomic DNA. Translation: CGF82212.1.
CKVP01000017 Genomic DNA. Translation: CJC19113.1.
CLBL01000031 Genomic DNA. Translation: CJF70972.1.
CLCG01000071 Genomic DNA. Translation: CJH87374.1.
CLFU01000110 Genomic DNA. Translation: CJK05363.1.
CLJU01000097 Genomic DNA. Translation: CJM27994.1.
CMOR01000044 Genomic DNA. Translation: CKE43604.1.
CMQD01000054 Genomic DNA. Translation: CKF19613.1.
CPUD01000041 Genomic DNA. Translation: CNB04816.1.
CQYJ01000040 Genomic DNA. Translation: COC14526.1.
CQYM01000029 Genomic DNA. Translation: COC19313.1.
CQYS01000048 Genomic DNA. Translation: COC33248.1.
CQYV01000028 Genomic DNA. Translation: COC43564.1.
CQZB01000046 Genomic DNA. Translation: COC44067.1.
CRHY01000066 Genomic DNA. Translation: COJ67808.1.
CRPE01000013 Genomic DNA. Translation: CON34525.1.
CHUI01000033 Genomic DNA. Translation: COO54451.1.
CRRM01000024 Genomic DNA. Translation: COP37457.1.
CNOG02000106 Genomic DNA. Translation: CTO24870.1.
FDIR01000018 Genomic DNA. Translation: CVV02122.1.
FEBA01000004 Genomic DNA. Translation: CWE44943.1.
FEIL01000001 Genomic DNA. Translation: CWI36264.1.
FHPX01000036 Genomic DNA. Translation: CYM07797.1.
FIYJ01000001 Genomic DNA. Translation: CZD58490.1.
LRSN01000172 Genomic DNA. Translation: KWX82366.1.
RefSeqiWP_000037275.1. NZ_MCJA01000013.1.

Genome annotation databases

EnsemblBacteriaiCEW14521; CEW14521; ERS022179_02017.
CEZ65328; CEZ65328; ERS068727_02048.
CFE13986; CFE13986; ERS069276_02058.
CFP94753; CFP94753; ERS013931_01942.
CGF82212; CGF82212; ERS020491_01644.
CGG23173; CGG23173; ERS020121_01920.
CGG88538; CGG88538; ERS020808_01002.
CIO24650; CIO24650; ERS019163_01202.
CIQ06059; CIQ06059; ERS019291_00674.
CIZ98874; CIZ98874; ERS021374_02134.
CJC19113; CJC19113; ERS021449_01450.
CJF70972; CJF70972; ERS021300_01930.
CJG54184; CJG54184; ERS021536_02104.
CJG77180; CJG77180; ERS021551_02044.
CJH43255; CJH43255; ERS021560_02480.
CJH87374; CJH87374; ERS021354_07390.
CJK05363; CJK05363; ERS021634_06660.
CJK66556; CJK66556; ERS022016_02053.
CJK75796; CJK75796; ERS022051_00573.
CJL98969; CJL98969; ERS022165_02021.
CJM27994; CJM27994; ERS022045_05659.
CJN42093; CJN42093; ERS022246_02176.
CJO11161; CJO11161; ERS021948_02079.
CJQ09721; CJQ09721; ERS022077_02120.
CJR58101; CJR58101; ERS021718_02180.
CJU19380; CJU19380; ERS021862_02106.
CJV33881; CJV33881; ERS022356_00661.
CJV56312; CJV56312; ERS022373_02093.
CJX87145; CJX87145; ERS022282_02163.
CJY67535; CJY67535; ERS022329_02027.
CKD02960; CKD02960; ERS022641_02107.
CKD44552; CKD44552; ERS022629_02079.
CKE43604; CKE43604; ERS232471_01998.
CKE44695; CKE44695; ERS232474_02100.
CKF05268; CKF05268; ERS232512_01799.
CKF19613; CKF19613; ERS232499_02043.
CKF62060; CKF62060; ERS232514_02009.
CMV68322; CMV68322; ERS077274_02209.
CMW76663; CMW76663; ERS077257_02175.
CMX34649; CMX34649; ERS077238_02195.
CMX97947; CMX97947; ERS036307_02129.
CMY06700; CMY06700; ERS069380_00646.
CMY11941; CMY11941; ERS077296_02129.
CNA76848; CNA76848; ERS077210_02210.
CNB04816; CNB04816; ERS077235_02181.
CNB26455; CNB26455; ERS077244_02138.
CNZ87836; CNZ87836; ERS020901_02122.
COE58655; COE58655; ERS020500_02044.
COH00858; COH00858; ERS020728_02106.
COH22112; COH22112; ERS020747_02075.
COH53733; COH53733; ERS020755_02106.
COH98572; COH98572; ERS020762_02053.
COJ67808; COJ67808; ERS020822_04226.
COK44271; COK44271; ERS021056_02016.
COM60194; COM60194; ERS020644_02038.
CON34525; CON34525; ERS020692_01365.
CON63611; CON63611; ERS020337_02089.
COQ15296; COQ15296; ERS020969_02060.
COU09946; COU09946; ERS077289_02164.
CTC87544; CTC87544; ERS070055_00784.
CTD85576; CTD85576; ERS043989_00886.
CTJ94489; CTJ94489; ERS069939_00794.
CTO24870; CTO24870; ERS043879_00489.
CTP18142; CTP18142; ERS043844_01009.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ175245 Genomic DNA. Translation: AAZ93046.1.
DQ175255 Genomic DNA. Translation: AAZ93056.1.
DQ175258 Genomic DNA. Translation: AAZ93059.1.
DQ175263 Genomic DNA. Translation: AAZ93064.1.
DQ175273 Genomic DNA. Translation: AAZ93074.1.
DQ175279 Genomic DNA. Translation: AAZ93080.1.
DQ175285 Genomic DNA. Translation: AAZ93086.1.
DQ175288 Genomic DNA. Translation: AAZ93089.1.
CFBS01000042 Genomic DNA. Translation: CEV85061.1.
CGAR01000058 Genomic DNA. Translation: CFP94753.1.
CHOW01000021 Genomic DNA. Translation: CGF82212.1.
CKVP01000017 Genomic DNA. Translation: CJC19113.1.
CLBL01000031 Genomic DNA. Translation: CJF70972.1.
CLCG01000071 Genomic DNA. Translation: CJH87374.1.
CLFU01000110 Genomic DNA. Translation: CJK05363.1.
CLJU01000097 Genomic DNA. Translation: CJM27994.1.
CMOR01000044 Genomic DNA. Translation: CKE43604.1.
CMQD01000054 Genomic DNA. Translation: CKF19613.1.
CPUD01000041 Genomic DNA. Translation: CNB04816.1.
CQYJ01000040 Genomic DNA. Translation: COC14526.1.
CQYM01000029 Genomic DNA. Translation: COC19313.1.
CQYS01000048 Genomic DNA. Translation: COC33248.1.
CQYV01000028 Genomic DNA. Translation: COC43564.1.
CQZB01000046 Genomic DNA. Translation: COC44067.1.
CRHY01000066 Genomic DNA. Translation: COJ67808.1.
CRPE01000013 Genomic DNA. Translation: CON34525.1.
CHUI01000033 Genomic DNA. Translation: COO54451.1.
CRRM01000024 Genomic DNA. Translation: COP37457.1.
CNOG02000106 Genomic DNA. Translation: CTO24870.1.
FDIR01000018 Genomic DNA. Translation: CVV02122.1.
FEBA01000004 Genomic DNA. Translation: CWE44943.1.
FEIL01000001 Genomic DNA. Translation: CWI36264.1.
FHPX01000036 Genomic DNA. Translation: CYM07797.1.
FIYJ01000001 Genomic DNA. Translation: CZD58490.1.
LRSN01000172 Genomic DNA. Translation: KWX82366.1.
RefSeqiWP_000037275.1. NZ_MCJA01000013.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I3HX-ray3.70A/B1-647[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi171101.spr0756.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCEW14521; CEW14521; ERS022179_02017.
CEZ65328; CEZ65328; ERS068727_02048.
CFE13986; CFE13986; ERS069276_02058.
CFP94753; CFP94753; ERS013931_01942.
CGF82212; CGF82212; ERS020491_01644.
CGG23173; CGG23173; ERS020121_01920.
CGG88538; CGG88538; ERS020808_01002.
CIO24650; CIO24650; ERS019163_01202.
CIQ06059; CIQ06059; ERS019291_00674.
CIZ98874; CIZ98874; ERS021374_02134.
CJC19113; CJC19113; ERS021449_01450.
CJF70972; CJF70972; ERS021300_01930.
CJG54184; CJG54184; ERS021536_02104.
CJG77180; CJG77180; ERS021551_02044.
CJH43255; CJH43255; ERS021560_02480.
CJH87374; CJH87374; ERS021354_07390.
CJK05363; CJK05363; ERS021634_06660.
CJK66556; CJK66556; ERS022016_02053.
CJK75796; CJK75796; ERS022051_00573.
CJL98969; CJL98969; ERS022165_02021.
CJM27994; CJM27994; ERS022045_05659.
CJN42093; CJN42093; ERS022246_02176.
CJO11161; CJO11161; ERS021948_02079.
CJQ09721; CJQ09721; ERS022077_02120.
CJR58101; CJR58101; ERS021718_02180.
CJU19380; CJU19380; ERS021862_02106.
CJV33881; CJV33881; ERS022356_00661.
CJV56312; CJV56312; ERS022373_02093.
CJX87145; CJX87145; ERS022282_02163.
CJY67535; CJY67535; ERS022329_02027.
CKD02960; CKD02960; ERS022641_02107.
CKD44552; CKD44552; ERS022629_02079.
CKE43604; CKE43604; ERS232471_01998.
CKE44695; CKE44695; ERS232474_02100.
CKF05268; CKF05268; ERS232512_01799.
CKF19613; CKF19613; ERS232499_02043.
CKF62060; CKF62060; ERS232514_02009.
CMV68322; CMV68322; ERS077274_02209.
CMW76663; CMW76663; ERS077257_02175.
CMX34649; CMX34649; ERS077238_02195.
CMX97947; CMX97947; ERS036307_02129.
CMY06700; CMY06700; ERS069380_00646.
CMY11941; CMY11941; ERS077296_02129.
CNA76848; CNA76848; ERS077210_02210.
CNB04816; CNB04816; ERS077235_02181.
CNB26455; CNB26455; ERS077244_02138.
CNZ87836; CNZ87836; ERS020901_02122.
COE58655; COE58655; ERS020500_02044.
COH00858; COH00858; ERS020728_02106.
COH22112; COH22112; ERS020747_02075.
COH53733; COH53733; ERS020755_02106.
COH98572; COH98572; ERS020762_02053.
COJ67808; COJ67808; ERS020822_04226.
COK44271; COK44271; ERS021056_02016.
COM60194; COM60194; ERS020644_02038.
CON34525; CON34525; ERS020692_01365.
CON63611; CON63611; ERS020337_02089.
COQ15296; COQ15296; ERS020969_02060.
COU09946; COU09946; ERS077289_02164.
CTC87544; CTC87544; ERS070055_00784.
CTD85576; CTD85576; ERS043989_00886.
CTJ94489; CTJ94489; ERS069939_00794.
CTO24870; CTO24870; ERS043879_00489.
CTP18142; CTP18142; ERS043844_01009.

Phylogenomic databases

eggNOGiENOG4105C7D. Bacteria.
COG0187. LUCA.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
3.40.50.670. 1 hit.
HAMAPiMF_00939. ParE_type2. 1 hit.
InterProiIPR002288. DNA_gyrase_B_C.
IPR003594. HATPase_C.
IPR005740. ParE_type2.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR001241. Topo_IIA.
IPR013760. Topo_IIA-like_dom.
IPR013506. Topo_IIA_bsu_dom2.
IPR013759. Topo_IIA_cen_dom.
IPR018522. TopoIIA_CS.
IPR006171. Toprim_domain.
[Graphical view]
PfamiPF00204. DNA_gyraseB. 1 hit.
PF00986. DNA_gyraseB_C. 1 hit.
PF02518. HATPase_c. 1 hit.
PF01751. Toprim. 1 hit.
[Graphical view]
PRINTSiPR00418. TPI2FAMILY.
SMARTiSM00387. HATPase_c. 1 hit.
SM00433. TOP2c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
SSF56719. SSF56719. 1 hit.
TIGRFAMsiTIGR01058. parE_Gpos. 1 hit.
PROSITEiPS00177. TOPOISOMERASE_II. 1 hit.
PS50880. TOPRIM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ3HZ71_STREE
AccessioniPrimary (citable) accession number: Q3HZ71
Entry historyi
Integrated into UniProtKB/TrEMBL: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 30, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.