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Protein

DNA topoisomerase (ATP-hydrolyzing)

Gene

parC

Organism
Streptococcus pneumoniae
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. DNA binding Source: UniProtKB-KW
  3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA topological change Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, TopoisomeraseSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomerase (ATP-hydrolyzing)SAAS annotation (EC:5.99.1.3SAAS annotation)
Gene namesi
Name:parCImported
OrganismiStreptococcus pneumoniaeImported
Taxonomic identifieri1313 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: InterPro
Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2NOVX-ray2.67A/B/C/D1-493[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPiMF_00937. ParC_type2.
InterProiIPR024946. Arg_repress_C-like.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
IPR005741. TopoIV_A_Gpos.
[Graphical view]
PfamiPF03989. DNA_gyraseA_C. 5 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.
TIGRFAMsiTIGR01061. parC_Gpos. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q3HYJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
IQNMSLEDIM GERFGRYSKY IIQDRALPDI RDGLKPVQRR ILYSMNKDSN
60 70 80 90 100
TFDKSYRKSA KSVGNIMGNF HPHGDSSIYD AMVRMSQNWK NREILVEMHG
110 120 130 140 150
NNGSMDGDPP AAMRYTEARL SEIAGYLLQD IEKKTVPFAW NFDDTEKEPT
160 170 180 190 200
VLPAAFPNLL VNGSTGISAG YATDIPPHNL AEVIDAAVYM IDHPTAKIDK
210 220 230 240 250
LMEFLPGPDF PTGAIIQGRD EIKKAYETGK GRVVVRSKTE IEKLKGGKEQ
260 270 280 290 300
IVITEIPYEI NKANLVKKID DVRVNNKVAG IAEVRDESDR DGLRIAIELK
310 320 330 340 350
KDANTELVLN YLFKYTDLQI NYNFNMVAID NFTPRQVGIV PILSSYIAHR
360 370 380 390 400
REVILARSRF DKEKAEKRLH IVEGLIRVIS ILDEVIALIR ASENKADAKE
410 420 430 440 450
NLKVSYDFTE EQAEAIVTLQ LYRLTNTDVV VLQEEEAELR EKIAMLAAII
460 470 480 490 500
GDERTMYNLM KKELREVKKK FATPRLSSLE DTAKAIEIDT ASLIAEEDTY
510 520 530 540 550
VSVTKAGYIK RTSPRSFAAS TLEEIGKRDD DRLIFVQSAK TTQHLLMFTS
560 570 580 590 600
LGNVIYRPIH ELADIRWKDI GEHLSQTITN FETNEEILYV EVLDQFDDAT
610 620 630 640 650
TYFAVTRLGQ IKRVERKEFT PWRTYRSKSV KYAKLKDDTD QIVAVAPIKL
660 670 680 690 700
DDVVLVSQNG YALRFNIEEV PVVGAKAAGV KAMNLKEDDV LQSGFICNTS
710 720 730 740 750
SFYLLTQRGS LKRVSIEEIL ATSRAKRGLQ VLRELKNKPH RVFLAGAVAE
760 770 780 790 800
QGFVGDFFST EVDVNDQTLL VQSNKGTIYE SRLQDLNLSE RTSNGSFISD
810 820
TISDEEVFDA YLQEVVTEDK
Length:820
Mass (Da):92,789
Last modified:November 8, 2005 - v1
Checksum:i18D452B5041F82FD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ176455 Genomic DNA. Translation: AAZ93278.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ176455 Genomic DNA. Translation: AAZ93278.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2NOVX-ray2.67A/B/C/D1-493[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPiMF_00937. ParC_type2.
InterProiIPR024946. Arg_repress_C-like.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
IPR005741. TopoIV_A_Gpos.
[Graphical view]
PfamiPF03989. DNA_gyraseA_C. 5 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.
TIGRFAMsiTIGR01061. parC_Gpos. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular evolution perspectives on intraspecific lateral DNA transfer of topoisomerase and gyrase loci in Streptococcus pneumoniae, with implications for fluoroquinolone resistance development and spread."
    Stanhope M.J., Walsh S.L., Becker J.A., Italia M.J., Ingraham K.A., Gwynn M.N., Mathie T., Poupard J.A., Miller L.A., Brown J.R., Amrine-Madsen H.
    Antimicrob. Agents Chemother. 49:4315-4326(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 0.15GR00SImported.
  2. "Breakage-reunion domain of Streptococcus pneumoniae topoisomerase IV: crystal structure of a gram-positive quinolone target."
    Laponogov I., Veselkov D.A., Sohi M.K., Pan X.S., Achari A., Yang C., Ferrara J.D., Fisher L.M., Sanderson M.R.
    PLoS ONE 2:E301-E301(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.67 ANGSTROMS) OF 1-493.

Entry informationi

Entry nameiQ3HYJ3_STREE
AccessioniPrimary (citable) accession number: Q3HYJ3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 8, 2005
Last sequence update: November 8, 2005
Last modified: March 4, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.