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Q3HYJ3

- Q3HYJ3_STREE

UniProt

Q3HYJ3 - Q3HYJ3_STREE

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Protein
Submitted name:

Topoisomerase IV subunit A

Gene
parC
Organism
Streptococcus pneumoniae
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.SAAS annotations

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. DNA binding Source: UniProtKB-KW
  3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: InterPro

GO - Biological processi

  1. DNA topological change Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, TopoisomeraseSAAS annotations

Keywords - Ligandi

DNA-bindingSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Topoisomerase IV subunit AImported
Gene namesi
Name:parCImported
OrganismiStreptococcus pneumoniaeImported
Taxonomic identifieri1313 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: InterPro
Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2NOVX-ray2.67A/B/C/D1-493[»]

Family & Domainsi

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPiMF_00937. ParC_type2.
InterProiIPR024946. Arg_repress_C-like.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
IPR005741. TopoIV_A_Gpos.
[Graphical view]
PfamiPF03989. DNA_gyraseA_C. 5 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.
TIGRFAMsiTIGR01061. parC_Gpos. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q3HYJ3-1 [UniParc]FASTAAdd to Basket

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IQNMSLEDIM GERFGRYSKY IIQDRALPDI RDGLKPVQRR ILYSMNKDSN    50
TFDKSYRKSA KSVGNIMGNF HPHGDSSIYD AMVRMSQNWK NREILVEMHG 100
NNGSMDGDPP AAMRYTEARL SEIAGYLLQD IEKKTVPFAW NFDDTEKEPT 150
VLPAAFPNLL VNGSTGISAG YATDIPPHNL AEVIDAAVYM IDHPTAKIDK 200
LMEFLPGPDF PTGAIIQGRD EIKKAYETGK GRVVVRSKTE IEKLKGGKEQ 250
IVITEIPYEI NKANLVKKID DVRVNNKVAG IAEVRDESDR DGLRIAIELK 300
KDANTELVLN YLFKYTDLQI NYNFNMVAID NFTPRQVGIV PILSSYIAHR 350
REVILARSRF DKEKAEKRLH IVEGLIRVIS ILDEVIALIR ASENKADAKE 400
NLKVSYDFTE EQAEAIVTLQ LYRLTNTDVV VLQEEEAELR EKIAMLAAII 450
GDERTMYNLM KKELREVKKK FATPRLSSLE DTAKAIEIDT ASLIAEEDTY 500
VSVTKAGYIK RTSPRSFAAS TLEEIGKRDD DRLIFVQSAK TTQHLLMFTS 550
LGNVIYRPIH ELADIRWKDI GEHLSQTITN FETNEEILYV EVLDQFDDAT 600
TYFAVTRLGQ IKRVERKEFT PWRTYRSKSV KYAKLKDDTD QIVAVAPIKL 650
DDVVLVSQNG YALRFNIEEV PVVGAKAAGV KAMNLKEDDV LQSGFICNTS 700
SFYLLTQRGS LKRVSIEEIL ATSRAKRGLQ VLRELKNKPH RVFLAGAVAE 750
QGFVGDFFST EVDVNDQTLL VQSNKGTIYE SRLQDLNLSE RTSNGSFISD 800
TISDEEVFDA YLQEVVTEDK 820
Length:820
Mass (Da):92,789
Last modified:November 8, 2005 - v1
Checksum:i18D452B5041F82FD
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ176455 Genomic DNA. Translation: AAZ93278.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ176455 Genomic DNA. Translation: AAZ93278.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2NOV X-ray 2.67 A/B/C/D 1-493 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPi MF_00937. ParC_type2.
InterProi IPR024946. Arg_repress_C-like.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
IPR005741. TopoIV_A_Gpos.
[Graphical view ]
Pfami PF03989. DNA_gyraseA_C. 5 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view ]
SMARTi SM00434. TOP4c. 1 hit.
[Graphical view ]
SUPFAMi SSF56719. SSF56719. 1 hit.
TIGRFAMsi TIGR01061. parC_Gpos. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular evolution perspectives on intraspecific lateral DNA transfer of topoisomerase and gyrase loci in Streptococcus pneumoniae, with implications for fluoroquinolone resistance development and spread."
    Stanhope M.J., Walsh S.L., Becker J.A., Italia M.J., Ingraham K.A., Gwynn M.N., Mathie T., Poupard J.A., Miller L.A., Brown J.R., Amrine-Madsen H.
    Antimicrob. Agents Chemother. 49:4315-4326(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 0.15GR00SImported.
  2. "Breakage-reunion domain of Streptococcus pneumoniae topoisomerase IV: crystal structure of a gram-positive quinolone target."
    Laponogov I., Veselkov D.A., Sohi M.K., Pan X.S., Achari A., Yang C., Ferrara J.D., Fisher L.M., Sanderson M.R.
    PLoS ONE 2:E301-E301(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.67 ANGSTROMS) OF 1-493.

Entry informationi

Entry nameiQ3HYJ3_STREE
AccessioniPrimary (citable) accession number: Q3HYJ3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 8, 2005
Last sequence update: November 8, 2005
Last modified: September 3, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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