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Q3HYJ3

- Q3HYJ3_STREE

UniProt

Q3HYJ3 - Q3HYJ3_STREE

Protein
Submitted name:

Topoisomerase IV subunit A

Gene

parC

Organism
Streptococcus pneumoniae
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP-dependent breakage, passage and rejoining of double-stranded DNA.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. DNA binding Source: UniProtKB-KW
    3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: InterPro

    GO - Biological processi

    1. DNA topological change Source: InterPro

    Keywords - Molecular functioni

    Isomerase, TopoisomeraseSAAS annotation

    Keywords - Ligandi

    DNA-bindingSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Topoisomerase IV subunit AImported
    Gene namesi
    Name:parCImported
    OrganismiStreptococcus pneumoniaeImported
    Taxonomic identifieri1313 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

    Subcellular locationi

    GO - Cellular componenti

    1. chromosome Source: InterPro

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2NOVX-ray2.67A/B/C/D1-493[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    Gene3Di3.30.1360.40. 1 hit.
    3.90.199.10. 2 hits.
    HAMAPiMF_00937. ParC_type2.
    InterProiIPR024946. Arg_repress_C-like.
    IPR006691. GyrA/parC_pinwhl.
    IPR002205. Topo_IIA_A/C.
    IPR013758. Topo_IIA_A/C_ab.
    IPR013760. Topo_IIA_like_dom.
    IPR005741. TopoIV_A_Gpos.
    [Graphical view]
    PfamiPF03989. DNA_gyraseA_C. 5 hits.
    PF00521. DNA_topoisoIV. 1 hit.
    [Graphical view]
    SMARTiSM00434. TOP4c. 1 hit.
    [Graphical view]
    SUPFAMiSSF56719. SSF56719. 1 hit.
    TIGRFAMsiTIGR01061. parC_Gpos. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q3HYJ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    IQNMSLEDIM GERFGRYSKY IIQDRALPDI RDGLKPVQRR ILYSMNKDSN    50
    TFDKSYRKSA KSVGNIMGNF HPHGDSSIYD AMVRMSQNWK NREILVEMHG 100
    NNGSMDGDPP AAMRYTEARL SEIAGYLLQD IEKKTVPFAW NFDDTEKEPT 150
    VLPAAFPNLL VNGSTGISAG YATDIPPHNL AEVIDAAVYM IDHPTAKIDK 200
    LMEFLPGPDF PTGAIIQGRD EIKKAYETGK GRVVVRSKTE IEKLKGGKEQ 250
    IVITEIPYEI NKANLVKKID DVRVNNKVAG IAEVRDESDR DGLRIAIELK 300
    KDANTELVLN YLFKYTDLQI NYNFNMVAID NFTPRQVGIV PILSSYIAHR 350
    REVILARSRF DKEKAEKRLH IVEGLIRVIS ILDEVIALIR ASENKADAKE 400
    NLKVSYDFTE EQAEAIVTLQ LYRLTNTDVV VLQEEEAELR EKIAMLAAII 450
    GDERTMYNLM KKELREVKKK FATPRLSSLE DTAKAIEIDT ASLIAEEDTY 500
    VSVTKAGYIK RTSPRSFAAS TLEEIGKRDD DRLIFVQSAK TTQHLLMFTS 550
    LGNVIYRPIH ELADIRWKDI GEHLSQTITN FETNEEILYV EVLDQFDDAT 600
    TYFAVTRLGQ IKRVERKEFT PWRTYRSKSV KYAKLKDDTD QIVAVAPIKL 650
    DDVVLVSQNG YALRFNIEEV PVVGAKAAGV KAMNLKEDDV LQSGFICNTS 700
    SFYLLTQRGS LKRVSIEEIL ATSRAKRGLQ VLRELKNKPH RVFLAGAVAE 750
    QGFVGDFFST EVDVNDQTLL VQSNKGTIYE SRLQDLNLSE RTSNGSFISD 800
    TISDEEVFDA YLQEVVTEDK 820
    Length:820
    Mass (Da):92,789
    Last modified:November 8, 2005 - v1
    Checksum:i18D452B5041F82FD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ176455 Genomic DNA. Translation: AAZ93278.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ176455 Genomic DNA. Translation: AAZ93278.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2NOV X-ray 2.67 A/B/C/D 1-493 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.30.1360.40. 1 hit.
    3.90.199.10. 2 hits.
    HAMAPi MF_00937. ParC_type2.
    InterProi IPR024946. Arg_repress_C-like.
    IPR006691. GyrA/parC_pinwhl.
    IPR002205. Topo_IIA_A/C.
    IPR013758. Topo_IIA_A/C_ab.
    IPR013760. Topo_IIA_like_dom.
    IPR005741. TopoIV_A_Gpos.
    [Graphical view ]
    Pfami PF03989. DNA_gyraseA_C. 5 hits.
    PF00521. DNA_topoisoIV. 1 hit.
    [Graphical view ]
    SMARTi SM00434. TOP4c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56719. SSF56719. 1 hit.
    TIGRFAMsi TIGR01061. parC_Gpos. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular evolution perspectives on intraspecific lateral DNA transfer of topoisomerase and gyrase loci in Streptococcus pneumoniae, with implications for fluoroquinolone resistance development and spread."
      Stanhope M.J., Walsh S.L., Becker J.A., Italia M.J., Ingraham K.A., Gwynn M.N., Mathie T., Poupard J.A., Miller L.A., Brown J.R., Amrine-Madsen H.
      Antimicrob. Agents Chemother. 49:4315-4326(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 0.15GR00SImported.
    2. "Breakage-reunion domain of Streptococcus pneumoniae topoisomerase IV: crystal structure of a gram-positive quinolone target."
      Laponogov I., Veselkov D.A., Sohi M.K., Pan X.S., Achari A., Yang C., Ferrara J.D., Fisher L.M., Sanderson M.R.
      PLoS ONE 2:E301-E301(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.67 ANGSTROMS) OF 1-493.

    Entry informationi

    Entry nameiQ3HYJ3_STREE
    AccessioniPrimary (citable) accession number: Q3HYJ3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 8, 2005
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3