Unreviewed, UniProtKB/TrEMBL Q3HSE5 (Q3HSE5_RAT)

Names and origin

Protein names	Submitted name:     Protein kinase B beta EMBL ABA42095.1
Organism	Rattus norvegicus (Rat) EMBL ABA42095.1
Taxonomic identifier	10116 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	481 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein. Spearmint SPM017892
Sequence similarities	Belongs to the protein kinase superfamily. RuleBase RU000305V3 Contains 1 AGC-kinase C-terminal domain. Spearmint SPM017892 Contains 1 PH domain. RuleBase RU003350V0

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304V2 Spearmint SPM017892 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase RuleBase RU000305V3 Spearmint SPM017892 Transferase
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from direct assay. Source: RGD regulation of JNK cascade Inferred from electronic annotation. Source: Compara
Cellular component	cytosol Inferred from direct assay. Source: RGD insulin-responsive compartment Inferred from direct assay. Source: RGD lamellipodium Inferred from electronic annotation. Source: Compara microsome Inferred from direct assay. Source: RGD plasma membrane Inferred from direct assay. Source: RGD soluble fraction Inferred from direct assay. Source: RGD
Molecular function	ATP binding Inferred from direct assay. Source: RGD protein binding Inferred from electronic annotation. Source: Compara protein serine/threonine kinase activity Inferred from direct assay. Source: RGD
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q3HSE5-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 4738A48046FE8714	FASTA	481	55,629
	10 20 30 40 50 60 MNEVSVIKEG WLHKRGEYIK TWRPRYFLLK SDGSFIGYKE RPEAPDQTLP PLNNFSVAEC 70 80 90 100 110 120 QLMKTERPRP NTFVIRCLQW TTVIERTFHV DSPDEREEWI RAIQMVANSL KQRGPGEDAM 130 140 150 160 170 180 DYKCGSPSDS STSEMMEVAV SKARAKVTMN DFDYLKLLGK GTFGKVILVR EKATGRYYAM 190 200 210 220 230 240 KILRKEVIIA KDEVAHTVTE SRVLQNTRHP FLTALKYAFQ THDRLCFVME YANGGELFFH 250 260 270 280 290 300 LSRERVFTED RARFYGAEIV SALEYLHSRD VVYRDIKLEN LMLDKDGHIK ITDFGLCKEG 310 320 330 340 350 360 ISDGATMKTF CGTPEYLAPE VLEDNDYGRA VDWWGLGVVM YEMMCGRLPF YNQDHERLFE 370 380 390 400 410 420 LILMEEIRFP RTLGPEAKSL LAGLLKKDPK QRLGGGPSDA KEVMEHRFFL SINWQDVVQK 430 440 450 460 470 480 KLLPPFKPQV TSEVDTRYFD DEFTAQSITI TPPDRYDSLG SLELDQRTHF PQFSYSASIR E

References

[1]

"Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane." He L., Simmen F.A., Mehendale H.M., Ronis M.J., Badger T.M. J. Biol. Chem. 281:11126-11134(2006) [PubMed: 16452480] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Sprague-Dawley EMBL ABA42095.1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ198085 mRNA. Translation: ABA42095.1.
IPI	IPI00212846.
UniGene	Rn.87066
3D structure databases
SMR	Q3HSE5. Positions 1-111.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3HSE5.
Genome annotation databases
Ensembl	ENSRNOT00000025303; ENSRNOP00000025303; ENSRNOG00000018677; Rattus norvegicus. [Genome view]
NMPDR	fig|10116.3.peg.1369.
Phylogenomic databases
HOVERGEN	Q3HSE5.
OMA	XALKYAF.
Gene expression databases
ArrayExpress	Q3HSE5.
Genevestigator	Q3HSE5.
Family and domain databases
InterPro	IPR000961. AGC-kinase_C. IPR011009. Kinase-like_dom. IPR011993. PH_type. IPR017892. Pkinase_C. IPR001849. Pleckstrin_homology. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR002290. Ser/Thr_prot_kinase_dom. IPR015744. Serine/threonine_Kinase_Rac. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 1 hit.
PANTHER	PTHR22985:SF69. Akt. 1 hit.
Pfam	PF00169. PH. 1 hit. PF00069. Pkinase. 1 hit. PF00433. Pkinase_C. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00233. PH. 1 hit. SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS51285. AGC_KINASE_CTER. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q3HSE5_RAT

Accession

Primary (citable) accession number: Q3HSE5

Entry history

Integrated into UniProtKB/TrEMBL:	November 8, 2005
Last sequence update:	November 8, 2005
Last modified:	November 3, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)