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Q3HNQ2

- Q3HNQ2_RHDV

UniProt

Q3HNQ2 - Q3HNQ2_RHDV

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Protein
Submitted name:

Polyprotein

Gene
RHDV
Organism
Rabbit hemorrhagic disease virus (RHDV)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

NTP + H2O = NDP + phosphate.SAAS annotations
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotations

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cysteine-type endopeptidase activity Source: InterPro
  3. RNA binding Source: InterPro
  4. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  5. RNA helicase activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
  2. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseSAAS annotations, Thiol proteaseSAAS annotations, Transferase

Keywords - Biological processi

Viral RNA replicationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
PolyproteinImported
Gene namesi
Name:RHDVImported
OrganismiRabbit hemorrhagic disease virus (RHDV)Imported
Taxonomic identifieri11976 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeLagovirus
Virus hostiOryctolagus cuniculus (Rabbit) [TaxID: 9986]

Subcellular locationi

GO - Cellular componenti

  1. viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinSAAS annotations, Virion

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotations

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4EGTX-ray2.00A/B1993-2344[»]
4EJRX-ray2.00A/B1766-1995[»]
ProteinModelPortaliQ3HNQ2.

Family & Domainsi

Sequence similaritiesi

Contains RdRp catalytic domain.SAAS annotations
Contains SF3 helicase domain.SAAS annotations
Contains SFhelicase domain.SAAS annotations

Family and domain databases

Gene3Di2.60.120.20. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR004005. Calicivirus_coat.
IPR004004. Helic/Pol/Pept_Calicivir-typ.
IPR000605. Helicase_SF3_ssDNA/RNA_vir.
IPR014759. Helicase_SF3_ssRNA_vir.
IPR027417. P-loop_NTPase.
IPR000317. Peptidase_C24.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
IPR009003. Trypsin-like_Pept_dom.
IPR029053. Viral_coat.
[Graphical view]
PfamiPF00915. Calici_coat. 1 hit.
PF03510. Peptidase_C24. 1 hit.
PF00680. RdRP_1. 1 hit.
PF00910. RNA_helicase. 1 hit.
[Graphical view]
PRINTSiPR00916. 2CENDOPTASE.
PR00918. CALICVIRUSNS.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
PS51218. SF3_HELICASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3HNQ2-1 [UniParc]FASTAAdd to Basket

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MPPMSRLIGM TTAILPEKKP LSFFLDLRDK TPPCCIRATG ELAWPVFLGQ     50
NENEGLLETC DKCGKWLNGF GNFGLEDLGN VCLCSIAQQK HKFGPVCLCN 100
RAYIHDCGRW RRRSRFLKHY KALNKVIPCA YQFDEGSSPS VFEGEVDDLF 150
VELGAPTSMG FMDKKLLKKG KKLMDKFVDV DEPCLTSRDA GLLDSIASDN 200
TIRAKLEEEY GIEMVQAARD RKDFMKNLRL ALDNRPANPV TWYTKLGNIT 250
DKGKQWAKKV VYGACKATEP LKTLASILLV GLHNVIAVDT TVMLSTFKPV 300
NLLAILMDWT NDLTGFVTTL VRLLELYGVV QVTVNLIIEG VKSFWDKVIC 350
ATDRCFDLLK RLFDTFEDSV PTGPTAGCLI FMAFVFSTVV GYLPNNNVIT 400
TFMKGAGKLT TFAGVIGAIR TLWITINQHM VAKDLTSIQQ KVMTVVKMAN 450
EAATLDQLEI VSCLCSDLEN TLTNRCTLPS YNQHLGILNA SQKVVSDLHT 500
MVLGKINMTK QRPQPVAVIF KGAPGIGKTH LVHRIARDLG CQHPSTINFG 550
LDHFDSYTGE EVAIADEFNT CGDGESWVEL FIQMVNTNPC PLNCDKVENK 600
NKVFNSKYLL CTTNSNTILN ATHPRAGAFY RRVLIVEARN KAVESWQATR 650
HGSRPGKSCY SKDMSHLTFQ VYPHNMPAPG FVFVGDKLVR SQVAPREYKY 700
SELLDLIKSE HPDVASFEGA NKFNFIYPDA QYEQALLMWK QYFVMYGCVA 750
RLAKNFVDDI PYNQVHISKA SDPKIDGCVE YQCKFQHLWR MVPQFVLGCV 800
NMTNQLGTPL TQQQLDRITN GVEGVTVTTV NNILPFHSQT TLINPSFIKL 850
IWAVRKHLKG LSGVTKVAQF IWRVMTNPVD AYGSLVRTLT GAATFSDNPV 900
STTIICSNCT IQIHSCGGLL VRYSRDPVPV ASDNADRGDQ GVDVFTDPNL 950
ISGFSWRRIA HLFVEVISHL CANHLVNLAT MAALGAVATK AFQGVKGKTK 1000
RGRGARVNLG NDEYDEWQAA RREFVNAHDM TAEEYLAMKN KAAMGSDDQD 1050
SVMFRSWWTR RQLRPDEDQV TIVGRGGVRN EVIRTRARQA PKGPKTLDDG 1100
GFYDNDYEGL PGFMRHNGSG WMIHIGNGLY ISNTHTARSS CSEIVTCSPT 1150
TDLCLVKGEI IRSVAQIAEG TPVCDWKKSP ISTYGIKKTL SDSTKIDVLA 1200
YDGCTQTTHG DCGLPLYDSS GKIVAIHTGK LLGFSKMCTL VDLTITKGVY 1250
ETSNFFCGEP IDYRGITAHR LVGAEPRPPV SGTRYARVPG VPDEYRTGYR 1300
PANLGRGDPD SDKSLMNIAV KSLQVYQQEP KLDKVDEFIE RAAADVLGYL 1350
RFLTKGERQV NLNFKAAFNT LDLSTSCGPF VPGKKIDHIK DGVMDQVLAK 1400
HLYKCWSVAN SGKALHHIYA CGLKDELRPL DKVKEGKKRL LWGCDVGVAV 1450
CAAAVFHNIC YKLKMVARFG PIAVGVDMTS RDFDVIINNL TVKASDFLCL 1500
DYSKWDSTMS PCVVRLAIDI LADCCEQTEL TKSVVLTLKS HPMTILDAMI 1550
VQTKRGLPSG MPFTSVINSI CHWLLWSAAV YKSCAEIGLH CSNLYEDAPF 1600
YTYGDDGVYA MTPMMVSLLP AIIENLRDYG LSPTAADKTE FIDVCPLNKI 1650
SFLKRTFELT DIGWVSKLDK SSILRQLEWS KTTSRHMVIE ETYDLAKEER 1700
GVQLEELQVA AAAHGQEFFN FVRKELERQQ AYTQFSVYSY DAARKVLADR 1750
KRVVSVVPDD EFVNVMEGKT RTAPQGEAAG TATTASVPGT TTDGMDPGVV 1800
AATSVVTAEN SSASVATAGI GGPPQQVDQQ ETWRTNFYYN DVFTWSVADA 1850
PGSILYTVQH SPQNNPFTAV LSQMYAGWAG GMQFRFIVAG SGVFGGRLVA 1900
AVIPPGIEIG PGLEVRQFPH VVIDARSLEP VTITMPDLRP NMYHPTGDPG 1950
LVPTLVLSVY NNLINPFGGS TNAIQVTVET RPSDDFEFVM IRAPSSKTVD 2000
SISPAGLLTT PVLTGVGNDN RWNGQIVGLQ PVPGGFSTCN RHWNLNGSTY 2050
GWSSPRFADI DHRRGSASYS GNSSTNVLQF WYANAGSAID NPISQVAPDG 2100
FPDMSFVPFN SPNIPTAGWV GFGGIWNSNN GAPAATTVQA YELGFATGAP 2150
NNLQPTTNTS GAQTVAKSIY AVVTGTNQNP TGLFVMASGV ISTPNASAVT 2200
YTPQPDRIVT TPGTPAAAPV GKNTPIMFAS VVRRTGDVNA AAGSTNGTQY 2250
GTGSQPLPVT IGLSLNNYSS ALMPGQFFVW QLTFASGFME IGLSVDGYFY 2300
AGTGASTTLI DLTELIDVRP VGPRPSKSTL VFNLGGTTNG FSYV 2344
Length:2,344
Mass (Da):257,035
Last modified:November 8, 2005 - v1
Checksum:iB5E2D9F0570D50EE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ205345 mRNA. Translation: ABA46865.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ205345 mRNA. Translation: ABA46865.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4EGT X-ray 2.00 A/B 1993-2344 [» ]
4EJR X-ray 2.00 A/B 1766-1995 [» ]
ProteinModelPortali Q3HNQ2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.120.20. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR004005. Calicivirus_coat.
IPR004004. Helic/Pol/Pept_Calicivir-typ.
IPR000605. Helicase_SF3_ssDNA/RNA_vir.
IPR014759. Helicase_SF3_ssRNA_vir.
IPR027417. P-loop_NTPase.
IPR000317. Peptidase_C24.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
IPR009003. Trypsin-like_Pept_dom.
IPR029053. Viral_coat.
[Graphical view ]
Pfami PF00915. Calici_coat. 1 hit.
PF03510. Peptidase_C24. 1 hit.
PF00680. RdRP_1. 1 hit.
PF00910. RNA_helicase. 1 hit.
[Graphical view ]
PRINTSi PR00916. 2CENDOPTASE.
PR00918. CALICVIRUSNS.
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
PS51218. SF3_HELICASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequencing and analyzing the complete nucleotide sequence of Rabbit haemorrhagic disease virus JX/CHA/97 strain isolated from China."
    Liu G., Ni Z., Zhang Y., Yun T.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: JX/CHA/97Imported.
  2. "Atomic model of rabbit hemorrhagic disease virus by cryo-electron microscopy and crystallography."
    Wang X., Xu F., Liu J., Gao B., Liu Y., Zhai Y., Ma J., Zhang K., Baker T.S., Schulten K., Zheng D., Pang H., Sun F.
    PLoS Pathog. 9:e1003132-e1003132(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1766-1995.

Entry informationi

Entry nameiQ3HNQ2_RHDV
AccessioniPrimary (citable) accession number: Q3HNQ2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 8, 2005
Last sequence update: November 8, 2005
Last modified: July 9, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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