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Q3HNQ2

- Q3HNQ2_RHDV

UniProt

Q3HNQ2 - Q3HNQ2_RHDV

Protein
Submitted name:

Polyprotein

Gene

RHDV

Organism
Rabbit hemorrhagic disease virus (RHDV)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    NTP + H2O = NDP + phosphate.SAAS annotation
    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cysteine-type endopeptidase activity Source: InterPro
    3. RNA binding Source: InterPro
    4. RNA-directed RNA polymerase activity Source: UniProtKB-KW
    5. RNA helicase activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro
    2. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseSAAS annotation, Thiol proteaseSAAS annotation, Transferase

    Keywords - Biological processi

    Viral RNA replicationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    PolyproteinImported
    Gene namesi
    Name:RHDVImported
    OrganismiRabbit hemorrhagic disease virus (RHDV)Imported
    Taxonomic identifieri11976 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeLagovirus
    Virus hostiOryctolagus cuniculus (Rabbit) [TaxID: 9986]

    Subcellular locationi

    GO - Cellular componenti

    1. viral capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid proteinSAAS annotation, Virion

    PTM / Processingi

    Keywords - PTMi

    PhosphoproteinSAAS annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4EGTX-ray2.00A/B1993-2344[»]
    4EJRX-ray2.00A/B1766-1995[»]
    ProteinModelPortaliQ3HNQ2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains RdRp catalytic domain.SAAS annotation
    Contains SF3 helicase domain.SAAS annotation
    Contains SFhelicase domain.SAAS annotation

    Family and domain databases

    Gene3Di2.60.120.20. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR004005. Calicivirus_coat.
    IPR004004. Helic/Pol/Pept_Calicivir-typ.
    IPR000605. Helicase_SF3_ssDNA/RNA_vir.
    IPR014759. Helicase_SF3_ssRNA_vir.
    IPR027417. P-loop_NTPase.
    IPR000317. Peptidase_C24.
    IPR001205. RNA-dir_pol_C.
    IPR007094. RNA-dir_pol_PSvirus.
    IPR009003. Trypsin-like_Pept_dom.
    IPR029053. Viral_coat.
    [Graphical view]
    PfamiPF00915. Calici_coat. 1 hit.
    PF03510. Peptidase_C24. 1 hit.
    PF00680. RdRP_1. 1 hit.
    PF00910. RNA_helicase. 1 hit.
    [Graphical view]
    PRINTSiPR00916. 2CENDOPTASE.
    PR00918. CALICVIRUSNS.
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
    PS51218. SF3_HELICASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3HNQ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPMSRLIGM TTAILPEKKP LSFFLDLRDK TPPCCIRATG ELAWPVFLGQ     50
    NENEGLLETC DKCGKWLNGF GNFGLEDLGN VCLCSIAQQK HKFGPVCLCN 100
    RAYIHDCGRW RRRSRFLKHY KALNKVIPCA YQFDEGSSPS VFEGEVDDLF 150
    VELGAPTSMG FMDKKLLKKG KKLMDKFVDV DEPCLTSRDA GLLDSIASDN 200
    TIRAKLEEEY GIEMVQAARD RKDFMKNLRL ALDNRPANPV TWYTKLGNIT 250
    DKGKQWAKKV VYGACKATEP LKTLASILLV GLHNVIAVDT TVMLSTFKPV 300
    NLLAILMDWT NDLTGFVTTL VRLLELYGVV QVTVNLIIEG VKSFWDKVIC 350
    ATDRCFDLLK RLFDTFEDSV PTGPTAGCLI FMAFVFSTVV GYLPNNNVIT 400
    TFMKGAGKLT TFAGVIGAIR TLWITINQHM VAKDLTSIQQ KVMTVVKMAN 450
    EAATLDQLEI VSCLCSDLEN TLTNRCTLPS YNQHLGILNA SQKVVSDLHT 500
    MVLGKINMTK QRPQPVAVIF KGAPGIGKTH LVHRIARDLG CQHPSTINFG 550
    LDHFDSYTGE EVAIADEFNT CGDGESWVEL FIQMVNTNPC PLNCDKVENK 600
    NKVFNSKYLL CTTNSNTILN ATHPRAGAFY RRVLIVEARN KAVESWQATR 650
    HGSRPGKSCY SKDMSHLTFQ VYPHNMPAPG FVFVGDKLVR SQVAPREYKY 700
    SELLDLIKSE HPDVASFEGA NKFNFIYPDA QYEQALLMWK QYFVMYGCVA 750
    RLAKNFVDDI PYNQVHISKA SDPKIDGCVE YQCKFQHLWR MVPQFVLGCV 800
    NMTNQLGTPL TQQQLDRITN GVEGVTVTTV NNILPFHSQT TLINPSFIKL 850
    IWAVRKHLKG LSGVTKVAQF IWRVMTNPVD AYGSLVRTLT GAATFSDNPV 900
    STTIICSNCT IQIHSCGGLL VRYSRDPVPV ASDNADRGDQ GVDVFTDPNL 950
    ISGFSWRRIA HLFVEVISHL CANHLVNLAT MAALGAVATK AFQGVKGKTK 1000
    RGRGARVNLG NDEYDEWQAA RREFVNAHDM TAEEYLAMKN KAAMGSDDQD 1050
    SVMFRSWWTR RQLRPDEDQV TIVGRGGVRN EVIRTRARQA PKGPKTLDDG 1100
    GFYDNDYEGL PGFMRHNGSG WMIHIGNGLY ISNTHTARSS CSEIVTCSPT 1150
    TDLCLVKGEI IRSVAQIAEG TPVCDWKKSP ISTYGIKKTL SDSTKIDVLA 1200
    YDGCTQTTHG DCGLPLYDSS GKIVAIHTGK LLGFSKMCTL VDLTITKGVY 1250
    ETSNFFCGEP IDYRGITAHR LVGAEPRPPV SGTRYARVPG VPDEYRTGYR 1300
    PANLGRGDPD SDKSLMNIAV KSLQVYQQEP KLDKVDEFIE RAAADVLGYL 1350
    RFLTKGERQV NLNFKAAFNT LDLSTSCGPF VPGKKIDHIK DGVMDQVLAK 1400
    HLYKCWSVAN SGKALHHIYA CGLKDELRPL DKVKEGKKRL LWGCDVGVAV 1450
    CAAAVFHNIC YKLKMVARFG PIAVGVDMTS RDFDVIINNL TVKASDFLCL 1500
    DYSKWDSTMS PCVVRLAIDI LADCCEQTEL TKSVVLTLKS HPMTILDAMI 1550
    VQTKRGLPSG MPFTSVINSI CHWLLWSAAV YKSCAEIGLH CSNLYEDAPF 1600
    YTYGDDGVYA MTPMMVSLLP AIIENLRDYG LSPTAADKTE FIDVCPLNKI 1650
    SFLKRTFELT DIGWVSKLDK SSILRQLEWS KTTSRHMVIE ETYDLAKEER 1700
    GVQLEELQVA AAAHGQEFFN FVRKELERQQ AYTQFSVYSY DAARKVLADR 1750
    KRVVSVVPDD EFVNVMEGKT RTAPQGEAAG TATTASVPGT TTDGMDPGVV 1800
    AATSVVTAEN SSASVATAGI GGPPQQVDQQ ETWRTNFYYN DVFTWSVADA 1850
    PGSILYTVQH SPQNNPFTAV LSQMYAGWAG GMQFRFIVAG SGVFGGRLVA 1900
    AVIPPGIEIG PGLEVRQFPH VVIDARSLEP VTITMPDLRP NMYHPTGDPG 1950
    LVPTLVLSVY NNLINPFGGS TNAIQVTVET RPSDDFEFVM IRAPSSKTVD 2000
    SISPAGLLTT PVLTGVGNDN RWNGQIVGLQ PVPGGFSTCN RHWNLNGSTY 2050
    GWSSPRFADI DHRRGSASYS GNSSTNVLQF WYANAGSAID NPISQVAPDG 2100
    FPDMSFVPFN SPNIPTAGWV GFGGIWNSNN GAPAATTVQA YELGFATGAP 2150
    NNLQPTTNTS GAQTVAKSIY AVVTGTNQNP TGLFVMASGV ISTPNASAVT 2200
    YTPQPDRIVT TPGTPAAAPV GKNTPIMFAS VVRRTGDVNA AAGSTNGTQY 2250
    GTGSQPLPVT IGLSLNNYSS ALMPGQFFVW QLTFASGFME IGLSVDGYFY 2300
    AGTGASTTLI DLTELIDVRP VGPRPSKSTL VFNLGGTTNG FSYV 2344
    Length:2,344
    Mass (Da):257,035
    Last modified:November 8, 2005 - v1
    Checksum:iB5E2D9F0570D50EE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ205345 mRNA. Translation: ABA46865.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ205345 mRNA. Translation: ABA46865.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4EGT X-ray 2.00 A/B 1993-2344 [» ]
    4EJR X-ray 2.00 A/B 1766-1995 [» ]
    ProteinModelPortali Q3HNQ2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.120.20. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR004005. Calicivirus_coat.
    IPR004004. Helic/Pol/Pept_Calicivir-typ.
    IPR000605. Helicase_SF3_ssDNA/RNA_vir.
    IPR014759. Helicase_SF3_ssRNA_vir.
    IPR027417. P-loop_NTPase.
    IPR000317. Peptidase_C24.
    IPR001205. RNA-dir_pol_C.
    IPR007094. RNA-dir_pol_PSvirus.
    IPR009003. Trypsin-like_Pept_dom.
    IPR029053. Viral_coat.
    [Graphical view ]
    Pfami PF00915. Calici_coat. 1 hit.
    PF03510. Peptidase_C24. 1 hit.
    PF00680. RdRP_1. 1 hit.
    PF00910. RNA_helicase. 1 hit.
    [Graphical view ]
    PRINTSi PR00916. 2CENDOPTASE.
    PR00918. CALICVIRUSNS.
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
    PS51218. SF3_HELICASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequencing and analyzing the complete nucleotide sequence of Rabbit haemorrhagic disease virus JX/CHA/97 strain isolated from China."
      Liu G., Ni Z., Zhang Y., Yun T.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: JX/CHA/97Imported.
    2. "Atomic model of rabbit hemorrhagic disease virus by cryo-electron microscopy and crystallography."
      Wang X., Xu F., Liu J., Gao B., Liu Y., Zhai Y., Ma J., Zhang K., Baker T.S., Schulten K., Zheng D., Pang H., Sun F.
      PLoS Pathog. 9:e1003132-e1003132(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1766-1995.

    Entry informationi

    Entry nameiQ3HNQ2_RHDV
    AccessioniPrimary (citable) accession number: Q3HNQ2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 8, 2005
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3