Q3HNQ2 (Q3HNQ2_RHDV) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Polyprotein EMBL ABA46865.1

Gene names

Name:

RHDV EMBL ABA46865.1

Organism

Rabbit hemorrhagic disease virus (RHDV) EMBL ABA46865.1

Taxonomic identifier

11976 [NCBI]

Taxonomic lineage

Viruses › ssRNA viruses › ssRNA positive-strand viruses, no DNA stage › Caliciviridae › Lagovirus

Virus host

Oryctolagus cuniculus (Rabbit) [TaxID: 9986]

Protein attributes

Sequence length	2344 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
Sequence similarities	Contains 1 RdRp catalytic domain. SAAS SAAS001205 Contains 1 SF3 helicase domain. SAAS SAAS001205

Ontologies

Keywords
Biological process	Viral RNA replication SAAS SAAS001205
Ligand	ATP-binding RuleBase RU003299 SAAS SAAS014759 Nucleotide-binding
Molecular function	Hydrolase Nucleotidyltransferase Protease RNA-directed RNA polymerase SAAS SAAS001205 Thiol protease SAAS SAAS001205 Transferase
Technical term	3D-structure PDB 4EGT PDB 4EJR
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro viral genome replication Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA binding Inferred from electronic annotation. Source: InterPro RNA helicase activity Inferred from electronic annotation. Source: InterPro RNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q3HNQ2 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: B5E2D9F0570D50EE	FASTA	2,344	257,035
	10 20 30 40 50 60 MPPMSRLIGM TTAILPEKKP LSFFLDLRDK TPPCCIRATG ELAWPVFLGQ NENEGLLETC 70 80 90 100 110 120 DKCGKWLNGF GNFGLEDLGN VCLCSIAQQK HKFGPVCLCN RAYIHDCGRW RRRSRFLKHY 130 140 150 160 170 180 KALNKVIPCA YQFDEGSSPS VFEGEVDDLF VELGAPTSMG FMDKKLLKKG KKLMDKFVDV 190 200 210 220 230 240 DEPCLTSRDA GLLDSIASDN TIRAKLEEEY GIEMVQAARD RKDFMKNLRL ALDNRPANPV 250 260 270 280 290 300 TWYTKLGNIT DKGKQWAKKV VYGACKATEP LKTLASILLV GLHNVIAVDT TVMLSTFKPV 310 320 330 340 350 360 NLLAILMDWT NDLTGFVTTL VRLLELYGVV QVTVNLIIEG VKSFWDKVIC ATDRCFDLLK 370 380 390 400 410 420 RLFDTFEDSV PTGPTAGCLI FMAFVFSTVV GYLPNNNVIT TFMKGAGKLT TFAGVIGAIR 430 440 450 460 470 480 TLWITINQHM VAKDLTSIQQ KVMTVVKMAN EAATLDQLEI VSCLCSDLEN TLTNRCTLPS 490 500 510 520 530 540 YNQHLGILNA SQKVVSDLHT MVLGKINMTK QRPQPVAVIF KGAPGIGKTH LVHRIARDLG 550 560 570 580 590 600 CQHPSTINFG LDHFDSYTGE EVAIADEFNT CGDGESWVEL FIQMVNTNPC PLNCDKVENK 610 620 630 640 650 660 NKVFNSKYLL CTTNSNTILN ATHPRAGAFY RRVLIVEARN KAVESWQATR HGSRPGKSCY 670 680 690 700 710 720 SKDMSHLTFQ VYPHNMPAPG FVFVGDKLVR SQVAPREYKY SELLDLIKSE HPDVASFEGA 730 740 750 760 770 780 NKFNFIYPDA QYEQALLMWK QYFVMYGCVA RLAKNFVDDI PYNQVHISKA SDPKIDGCVE 790 800 810 820 830 840 YQCKFQHLWR MVPQFVLGCV NMTNQLGTPL TQQQLDRITN GVEGVTVTTV NNILPFHSQT 850 860 870 880 890 900 TLINPSFIKL IWAVRKHLKG LSGVTKVAQF IWRVMTNPVD AYGSLVRTLT GAATFSDNPV 910 920 930 940 950 960 STTIICSNCT IQIHSCGGLL VRYSRDPVPV ASDNADRGDQ GVDVFTDPNL ISGFSWRRIA 970 980 990 1000 1010 1020 HLFVEVISHL CANHLVNLAT MAALGAVATK AFQGVKGKTK RGRGARVNLG NDEYDEWQAA 1030 1040 1050 1060 1070 1080 RREFVNAHDM TAEEYLAMKN KAAMGSDDQD SVMFRSWWTR RQLRPDEDQV TIVGRGGVRN 1090 1100 1110 1120 1130 1140 EVIRTRARQA PKGPKTLDDG GFYDNDYEGL PGFMRHNGSG WMIHIGNGLY ISNTHTARSS 1150 1160 1170 1180 1190 1200 CSEIVTCSPT TDLCLVKGEI IRSVAQIAEG TPVCDWKKSP ISTYGIKKTL SDSTKIDVLA 1210 1220 1230 1240 1250 1260 YDGCTQTTHG DCGLPLYDSS GKIVAIHTGK LLGFSKMCTL VDLTITKGVY ETSNFFCGEP 1270 1280 1290 1300 1310 1320 IDYRGITAHR LVGAEPRPPV SGTRYARVPG VPDEYRTGYR PANLGRGDPD SDKSLMNIAV 1330 1340 1350 1360 1370 1380 KSLQVYQQEP KLDKVDEFIE RAAADVLGYL RFLTKGERQV NLNFKAAFNT LDLSTSCGPF 1390 1400 1410 1420 1430 1440 VPGKKIDHIK DGVMDQVLAK HLYKCWSVAN SGKALHHIYA CGLKDELRPL DKVKEGKKRL 1450 1460 1470 1480 1490 1500 LWGCDVGVAV CAAAVFHNIC YKLKMVARFG PIAVGVDMTS RDFDVIINNL TVKASDFLCL 1510 1520 1530 1540 1550 1560 DYSKWDSTMS PCVVRLAIDI LADCCEQTEL TKSVVLTLKS HPMTILDAMI VQTKRGLPSG 1570 1580 1590 1600 1610 1620 MPFTSVINSI CHWLLWSAAV YKSCAEIGLH CSNLYEDAPF YTYGDDGVYA MTPMMVSLLP 1630 1640 1650 1660 1670 1680 AIIENLRDYG LSPTAADKTE FIDVCPLNKI SFLKRTFELT DIGWVSKLDK SSILRQLEWS 1690 1700 1710 1720 1730 1740 KTTSRHMVIE ETYDLAKEER GVQLEELQVA AAAHGQEFFN FVRKELERQQ AYTQFSVYSY 1750 1760 1770 1780 1790 1800 DAARKVLADR KRVVSVVPDD EFVNVMEGKT RTAPQGEAAG TATTASVPGT TTDGMDPGVV 1810 1820 1830 1840 1850 1860 AATSVVTAEN SSASVATAGI GGPPQQVDQQ ETWRTNFYYN DVFTWSVADA PGSILYTVQH 1870 1880 1890 1900 1910 1920 SPQNNPFTAV LSQMYAGWAG GMQFRFIVAG SGVFGGRLVA AVIPPGIEIG PGLEVRQFPH 1930 1940 1950 1960 1970 1980 VVIDARSLEP VTITMPDLRP NMYHPTGDPG LVPTLVLSVY NNLINPFGGS TNAIQVTVET 1990 2000 2010 2020 2030 2040 RPSDDFEFVM IRAPSSKTVD SISPAGLLTT PVLTGVGNDN RWNGQIVGLQ PVPGGFSTCN 2050 2060 2070 2080 2090 2100 RHWNLNGSTY GWSSPRFADI DHRRGSASYS GNSSTNVLQF WYANAGSAID NPISQVAPDG 2110 2120 2130 2140 2150 2160 FPDMSFVPFN SPNIPTAGWV GFGGIWNSNN GAPAATTVQA YELGFATGAP NNLQPTTNTS 2170 2180 2190 2200 2210 2220 GAQTVAKSIY AVVTGTNQNP TGLFVMASGV ISTPNASAVT YTPQPDRIVT TPGTPAAAPV 2230 2240 2250 2260 2270 2280 GKNTPIMFAS VVRRTGDVNA AAGSTNGTQY GTGSQPLPVT IGLSLNNYSS ALMPGQFFVW 2290 2300 2310 2320 2330 2340 QLTFASGFME IGLSVDGYFY AGTGASTTLI DLTELIDVRP VGPRPSKSTL VFNLGGTTNG FSYV

References

[1]	"Sequencing and analyzing the complete nucleotide sequence of Rabbit haemorrhagic disease virus JX/CHA/97 strain isolated from China." Liu G., Ni Z., Zhang Y., Yun T. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: JX/CHA/97 EMBL ABA46865.1.
[2]	"Atomic model of rabbit hemorrhagic disease virus by cryo-electron microscopy and crystallography." Wang X., Xu F., Liu J., Gao B., Liu Y., Zhai Y., Ma J., Zhang K., Baker T.S., Schulten K., Zheng D., Pang H., Sun F. PLoS Pathog. 9:e1003132-e1003132(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1766-1995.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

DQ205345 mRNA. Translation: ABA46865.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4EGT	X-ray	2.00	A/B	1993-2344	[»]
4EJR	X-ray	2.00	A/B	1766-1995	[»]

ProteinModelPortal

Q3HNQ2.

ModBase

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Protocols and materials databases

StructuralBiologyKnowledgebase

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Family and domain databases

InterPro

IPR003593. AAA+_ATPase.
IPR004005. Calicivirus_coat.
IPR004004. Helic/Pol/Pept_Calicivir-typ.
IPR000605. Helicase_SF3_ssDNA/RNA_vir.
IPR014759. Helicase_SF3_ssRNA_vir.
IPR000317. Peptidase_C24.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]

Pfam

PF00915. Calici_coat. 1 hit.
PF03510. Peptidase_C24. 1 hit.
PF00680. RdRP_1. 1 hit.
PF00910. RNA_helicase. 1 hit.
[Graphical view]

PRINTS

PR00916. 2CENDOPTASE.
PR00918. CALICVIRUSNS.

SMART

SM00382. AAA. 1 hit.
[Graphical view]

SUPFAM

SSF50494. Pept_Ser_Cys. 1 hit.

PROSITE

PS50507. RDRP_SSRNA_POS. 1 hit.
PS51218. SF3_HELICASE_2. 1 hit.
[Graphical view]

ProtoNet

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Entry information

Entry name

Q3HNQ2_RHDV

Accession

Primary (citable) accession number: Q3HNQ2

Entry history

Integrated into UniProtKB/TrEMBL:	November 8, 2005
Last sequence update:	November 8, 2005
Last modified:	May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)