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Q3HNQ2

- Q3HNQ2_RHDV

UniProt

Q3HNQ2 - Q3HNQ2_RHDV

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Protein

Genome polyprotein

Gene

RHDV

Organism
Rabbit hemorrhagic disease virus (RHDV)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cysteine-type endopeptidase activity Source: InterPro
  3. RNA binding Source: InterPro
  4. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  5. RNA helicase activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
  2. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseSAAS annotation, Thiol proteaseSAAS annotation, Transferase

Keywords - Biological processi

Viral RNA replicationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Genome polyproteinSAAS annotation
Gene namesi
Name:RHDVImported
OrganismiRabbit hemorrhagic disease virus (RHDV)Imported
Taxonomic identifieri11976 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeLagovirus
Virus hostiOryctolagus cuniculus (Rabbit) [TaxID: 9986]

Subcellular locationi

GO - Cellular componenti

  1. viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinSAAS annotation, Virion

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4EGTX-ray2.00A/B1993-2344[»]
4EJRX-ray2.00A/B1766-1995[»]
ProteinModelPortaliQ3HNQ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains RdRp catalytic domain.SAAS annotation
Contains SF3 helicase domain.SAAS annotation
Contains SFhelicase domain.SAAS annotation

Family and domain databases

Gene3Di2.60.120.20. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR004005. Calicivirus_coat.
IPR004004. Helic/Pol/Pept_Calicivir-typ.
IPR000605. Helicase_SF3_ssDNA/RNA_vir.
IPR014759. Helicase_SF3_ssRNA_vir.
IPR027417. P-loop_NTPase.
IPR000317. Peptidase_C24.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
IPR009003. Trypsin-like_Pept_dom.
IPR029053. Viral_coat.
[Graphical view]
PfamiPF00915. Calici_coat. 1 hit.
PF03510. Peptidase_C24. 1 hit.
PF00680. RdRP_1. 1 hit.
PF00910. RNA_helicase. 1 hit.
[Graphical view]
PRINTSiPR00916. 2CENDOPTASE.
PR00918. CALICVIRUSNS.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
PS51218. SF3_HELICASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3HNQ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPPMSRLIGM TTAILPEKKP LSFFLDLRDK TPPCCIRATG ELAWPVFLGQ
60 70 80 90 100
NENEGLLETC DKCGKWLNGF GNFGLEDLGN VCLCSIAQQK HKFGPVCLCN
110 120 130 140 150
RAYIHDCGRW RRRSRFLKHY KALNKVIPCA YQFDEGSSPS VFEGEVDDLF
160 170 180 190 200
VELGAPTSMG FMDKKLLKKG KKLMDKFVDV DEPCLTSRDA GLLDSIASDN
210 220 230 240 250
TIRAKLEEEY GIEMVQAARD RKDFMKNLRL ALDNRPANPV TWYTKLGNIT
260 270 280 290 300
DKGKQWAKKV VYGACKATEP LKTLASILLV GLHNVIAVDT TVMLSTFKPV
310 320 330 340 350
NLLAILMDWT NDLTGFVTTL VRLLELYGVV QVTVNLIIEG VKSFWDKVIC
360 370 380 390 400
ATDRCFDLLK RLFDTFEDSV PTGPTAGCLI FMAFVFSTVV GYLPNNNVIT
410 420 430 440 450
TFMKGAGKLT TFAGVIGAIR TLWITINQHM VAKDLTSIQQ KVMTVVKMAN
460 470 480 490 500
EAATLDQLEI VSCLCSDLEN TLTNRCTLPS YNQHLGILNA SQKVVSDLHT
510 520 530 540 550
MVLGKINMTK QRPQPVAVIF KGAPGIGKTH LVHRIARDLG CQHPSTINFG
560 570 580 590 600
LDHFDSYTGE EVAIADEFNT CGDGESWVEL FIQMVNTNPC PLNCDKVENK
610 620 630 640 650
NKVFNSKYLL CTTNSNTILN ATHPRAGAFY RRVLIVEARN KAVESWQATR
660 670 680 690 700
HGSRPGKSCY SKDMSHLTFQ VYPHNMPAPG FVFVGDKLVR SQVAPREYKY
710 720 730 740 750
SELLDLIKSE HPDVASFEGA NKFNFIYPDA QYEQALLMWK QYFVMYGCVA
760 770 780 790 800
RLAKNFVDDI PYNQVHISKA SDPKIDGCVE YQCKFQHLWR MVPQFVLGCV
810 820 830 840 850
NMTNQLGTPL TQQQLDRITN GVEGVTVTTV NNILPFHSQT TLINPSFIKL
860 870 880 890 900
IWAVRKHLKG LSGVTKVAQF IWRVMTNPVD AYGSLVRTLT GAATFSDNPV
910 920 930 940 950
STTIICSNCT IQIHSCGGLL VRYSRDPVPV ASDNADRGDQ GVDVFTDPNL
960 970 980 990 1000
ISGFSWRRIA HLFVEVISHL CANHLVNLAT MAALGAVATK AFQGVKGKTK
1010 1020 1030 1040 1050
RGRGARVNLG NDEYDEWQAA RREFVNAHDM TAEEYLAMKN KAAMGSDDQD
1060 1070 1080 1090 1100
SVMFRSWWTR RQLRPDEDQV TIVGRGGVRN EVIRTRARQA PKGPKTLDDG
1110 1120 1130 1140 1150
GFYDNDYEGL PGFMRHNGSG WMIHIGNGLY ISNTHTARSS CSEIVTCSPT
1160 1170 1180 1190 1200
TDLCLVKGEI IRSVAQIAEG TPVCDWKKSP ISTYGIKKTL SDSTKIDVLA
1210 1220 1230 1240 1250
YDGCTQTTHG DCGLPLYDSS GKIVAIHTGK LLGFSKMCTL VDLTITKGVY
1260 1270 1280 1290 1300
ETSNFFCGEP IDYRGITAHR LVGAEPRPPV SGTRYARVPG VPDEYRTGYR
1310 1320 1330 1340 1350
PANLGRGDPD SDKSLMNIAV KSLQVYQQEP KLDKVDEFIE RAAADVLGYL
1360 1370 1380 1390 1400
RFLTKGERQV NLNFKAAFNT LDLSTSCGPF VPGKKIDHIK DGVMDQVLAK
1410 1420 1430 1440 1450
HLYKCWSVAN SGKALHHIYA CGLKDELRPL DKVKEGKKRL LWGCDVGVAV
1460 1470 1480 1490 1500
CAAAVFHNIC YKLKMVARFG PIAVGVDMTS RDFDVIINNL TVKASDFLCL
1510 1520 1530 1540 1550
DYSKWDSTMS PCVVRLAIDI LADCCEQTEL TKSVVLTLKS HPMTILDAMI
1560 1570 1580 1590 1600
VQTKRGLPSG MPFTSVINSI CHWLLWSAAV YKSCAEIGLH CSNLYEDAPF
1610 1620 1630 1640 1650
YTYGDDGVYA MTPMMVSLLP AIIENLRDYG LSPTAADKTE FIDVCPLNKI
1660 1670 1680 1690 1700
SFLKRTFELT DIGWVSKLDK SSILRQLEWS KTTSRHMVIE ETYDLAKEER
1710 1720 1730 1740 1750
GVQLEELQVA AAAHGQEFFN FVRKELERQQ AYTQFSVYSY DAARKVLADR
1760 1770 1780 1790 1800
KRVVSVVPDD EFVNVMEGKT RTAPQGEAAG TATTASVPGT TTDGMDPGVV
1810 1820 1830 1840 1850
AATSVVTAEN SSASVATAGI GGPPQQVDQQ ETWRTNFYYN DVFTWSVADA
1860 1870 1880 1890 1900
PGSILYTVQH SPQNNPFTAV LSQMYAGWAG GMQFRFIVAG SGVFGGRLVA
1910 1920 1930 1940 1950
AVIPPGIEIG PGLEVRQFPH VVIDARSLEP VTITMPDLRP NMYHPTGDPG
1960 1970 1980 1990 2000
LVPTLVLSVY NNLINPFGGS TNAIQVTVET RPSDDFEFVM IRAPSSKTVD
2010 2020 2030 2040 2050
SISPAGLLTT PVLTGVGNDN RWNGQIVGLQ PVPGGFSTCN RHWNLNGSTY
2060 2070 2080 2090 2100
GWSSPRFADI DHRRGSASYS GNSSTNVLQF WYANAGSAID NPISQVAPDG
2110 2120 2130 2140 2150
FPDMSFVPFN SPNIPTAGWV GFGGIWNSNN GAPAATTVQA YELGFATGAP
2160 2170 2180 2190 2200
NNLQPTTNTS GAQTVAKSIY AVVTGTNQNP TGLFVMASGV ISTPNASAVT
2210 2220 2230 2240 2250
YTPQPDRIVT TPGTPAAAPV GKNTPIMFAS VVRRTGDVNA AAGSTNGTQY
2260 2270 2280 2290 2300
GTGSQPLPVT IGLSLNNYSS ALMPGQFFVW QLTFASGFME IGLSVDGYFY
2310 2320 2330 2340
AGTGASTTLI DLTELIDVRP VGPRPSKSTL VFNLGGTTNG FSYV
Length:2,344
Mass (Da):257,035
Last modified:November 8, 2005 - v1
Checksum:iB5E2D9F0570D50EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ205345 mRNA. Translation: ABA46865.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ205345 mRNA. Translation: ABA46865.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4EGT X-ray 2.00 A/B 1993-2344 [» ]
4EJR X-ray 2.00 A/B 1766-1995 [» ]
ProteinModelPortali Q3HNQ2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.120.20. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR004005. Calicivirus_coat.
IPR004004. Helic/Pol/Pept_Calicivir-typ.
IPR000605. Helicase_SF3_ssDNA/RNA_vir.
IPR014759. Helicase_SF3_ssRNA_vir.
IPR027417. P-loop_NTPase.
IPR000317. Peptidase_C24.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
IPR009003. Trypsin-like_Pept_dom.
IPR029053. Viral_coat.
[Graphical view ]
Pfami PF00915. Calici_coat. 1 hit.
PF03510. Peptidase_C24. 1 hit.
PF00680. RdRP_1. 1 hit.
PF00910. RNA_helicase. 1 hit.
[Graphical view ]
PRINTSi PR00916. 2CENDOPTASE.
PR00918. CALICVIRUSNS.
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
PS51218. SF3_HELICASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequencing and analyzing the complete nucleotide sequence of Rabbit haemorrhagic disease virus JX/CHA/97 strain isolated from China."
    Liu G., Ni Z., Zhang Y., Yun T.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: JX/CHA/97Imported.
  2. "Atomic model of rabbit hemorrhagic disease virus by cryo-electron microscopy and crystallography."
    Wang X., Xu F., Liu J., Gao B., Liu Y., Zhai Y., Ma J., Zhang K., Baker T.S., Schulten K., Zheng D., Pang H., Sun F.
    PLoS Pathog. 9:e1003132-e1003132(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1766-1995.

Entry informationi

Entry nameiQ3HNQ2_RHDV
AccessioniPrimary (citable) accession number: Q3HNQ2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 26, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3