Q3HM41 (PB2_I18A0) Reviewed, UniProtKB/Swiss-Prot
Last modified October 16, 2013. Version 36. History...
Names and origin
|Protein names||Recommended name:|
Polymerase basic protein 2
RNA-directed RNA polymerase subunit P3
|Organism||Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1)) [Complete proteome]|
|Taxonomic identifier||88776 [NCBI]|
|Taxonomic lineage||Viruses › ssRNA negative-strand viruses › Orthomyxoviridae › Influenzavirus A ›|
|Virus host||Aves [TaxID: 8782]|
Homo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]
|Sequence length||759 AA.|
|Protein existence||Evidence at transcript level|
General annotation (Comments)
Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication By similarity.
Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA By similarity.
South Carolina isolate has been sequenced from formalid fixed-lung tissues of a 21-year-old male which died in 1918 at Ft. Jackson, SC. Brevig Mission isolate has been sequenced from lung tissues of an Inuit woman buried in the permafrost in a gravesite near Brevig Mission, Alaska. This sample was recovered by John Hultin, retired pathologist.
Belongs to the influenza viruses PB2 family.
Sequence annotation (Features)
|DQ208309 mRNA. Translation: ABA55038.1.|
3D structure databases
|SMR||Q3HM41. Positions 319-483, 685-759. |
Protocols and materials databases
Family and domain databases
|InterPro||IPR001591. RNA_pol_PB2_orthomyxovir. |
|Pfam||PF00604. Flu_PB2. 1 hit. |
|ProDom||PD001667. RNA_pol_PB2_orthomyxovir. 1 hit. |
[Graphical view] [Entries sharing at least one domain]
|Accession||Primary (citable) accession number: Q3HM41|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families