Q3HM40 (RDRP_I18A0) Reviewed, UniProtKB/Swiss-Prot
Last modified February 19, 2014. Version 32. History...
Names and origin
|Protein names||Recommended name:|
RNA-directed RNA polymerase catalytic subunit
Polymerase basic protein 1
RNA-directed RNA polymerase subunit P1
|Organism||Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1)) [Complete proteome]|
|Taxonomic identifier||88776 [NCBI]|
|Taxonomic lineage||Viruses › ssRNA negative-strand viruses › Orthomyxoviridae › Influenzavirus A ›|
|Virus host||Aves [TaxID: 8782]|
Homo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]
|Sequence length||757 AA.|
|Protein existence||Evidence at transcript level|
General annotation (Comments)
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus segments. Binds the promoter sequence of the encapsidated viral RNA. Displays an endonuclease activity involved in cap-stealing. Cleaves cellular pre-mRNA to generate primers for viral transcription By similarity.
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA By similarity.
South Carolina isolate has been sequenced from formalid fixed-lung tissues of a 21-year-old male which died in 1918 at Ft. Jackson, SC. Brevig Mission isolate has been sequenced from lung tissues of an Inuit woman buried in the permafrost in a gravesite near Brevig Mission, Alaska. This sample was recovered by John Hultin, retired pathologist.
Belongs to the influenza viruses polymerase PB1 family.
Contains 1 RdRp catalytic domain.
|Biological process||Host gene expression shutoff by virus|
Host transcription shutoff by virus
Inhibition of host RNA polymerase II by virus
Viral RNA replication
RNA-directed RNA polymerase
|Technical term||Complete proteome|
|Gene Ontology (GO)|
|Biological_process||suppression by virus of host RNA polymerase II activity|
Inferred from electronic annotation. Source: UniProtKB-KWtranscription, DNA-templated
Inferred from electronic annotation. Source: InterProtranscription, RNA-templated
Inferred from electronic annotation. Source: GOCviral genome replication
Inferred from electronic annotation. Source: InterPro
|Molecular_function||RNA-directed RNA polymerase activity|
Inferred from electronic annotation. Source: UniProtKB-KWnucleotide binding
Inferred from electronic annotation. Source: UniProtKB-KW
|Complete GO annotation...|
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Chain||1 – 757||757||RNA-directed RNA polymerase catalytic subunit||PRO_0000310574|
|Domain||286 – 483||198||RdRp catalytic|
|Region||249 – 256||8||Promoter-binding site By similarity|
|Motif||187 – 195||9||Nuclear localization signal By similarity|
|Motif||203 – 216||14||Nuclear localization signal By similarity|
|DQ208310 mRNA. Translation: ABA55039.1.|
3D structure databases
Protocols and materials databases
Family and domain databases
|InterPro||IPR007099. RNA-dir_pol_NSvirus. |
|Pfam||PF00602. Flu_PB1. 1 hit. |
|PIRSF||PIRSF000827. RdRPol_OMV. 1 hit. |
|PROSITE||PS50525. RDRP_SSRNA_NEG_SEG. 1 hit. |
|Accession||Primary (citable) accession number: Q3HM40|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families