Q3HM39 (PA_I18A0) Reviewed, UniProtKB/Swiss-Prot
Last modified February 19, 2014. Version 27. History...
Names and origin
|Protein names||Recommended name:|
Polymerase acidic protein
RNA-directed RNA polymerase subunit P2
|Organism||Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1)) [Complete proteome]|
|Taxonomic identifier||88776 [NCBI]|
|Taxonomic lineage||Viruses › ssRNA negative-strand viruses › Orthomyxoviridae › Influenzavirus A ›|
|Virus host||Aves [TaxID: 8782]|
Homo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]
|Sequence length||716 AA.|
|Protein existence||Evidence at transcript level|
General annotation (Comments)
Implicated in endonuclease cleavage of capped RNA primers. Displays an elongation factor activity in viral RNA synthesis. Dispensable for viral transcription, but not replication By similarity.
Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA By similarity.
Phosphorylated on serines and threonines by host kinases, including human casein kinase II By similarity.
South Carolina isolate has been sequenced from formalid fixed-lung tissues of a 21-year-old male which died in 1918 at Ft. Jackson, SC. Brevig Mission isolate has been sequenced from lung tissues of an Inuit woman buried in the permafrost in a gravesite near Brevig Mission, Alaska. This sample was recovered by John Hultin, retired pathologist.
Belongs to the influenza viruses PA family.
|Biological process||Host gene expression shutoff by virus|
Host transcription shutoff by virus
Inhibition of host RNA polymerase II by virus
|Coding sequence diversity||Ribosomal frameshifting|
|Technical term||Complete proteome|
|Gene Ontology (GO)|
|Biological_process||suppression by virus of host RNA polymerase II activity|
Inferred from electronic annotation. Source: UniProtKB-KWtranscription, DNA-templated
Inferred from electronic annotation. Source: InterProtranscription, RNA-templated
Inferred from electronic annotation. Source: GOC
Inferred from electronic annotation. Source: InterProRNA-directed RNA polymerase activity
Inferred from electronic annotation. Source: InterPro
|Complete GO annotation...|
|This entry describes 2 isoforms produced by ribosomal frameshifting. [Align] [Select]|
|Isoform PA (identifier: Q3HM39-1) |
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
|Isoform PA-X (identifier: P0CK68-1) |
The sequence of this isoform can be found in the external entry P0CK68.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Chain||1 – 716||716||Polymerase acidic protein||PRO_0000310571|
|||"Characterization of the 1918 influenza virus polymerase genes."|
Taubenberger J.K., Reid A.H., Lourens R.M., Wang R., Jin G., Fanning T.G.
Nature 437:889-893(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
|||"An overlapping protein-coding region in influenza A virus segment 3 modulates the host response."|
Jagger B.W., Wise H.M., Kash J.C., Walters K.A., Wills N.M., Xiao Y.L., Dunfee R.L., Schwartzman L.M., Ozinsky A., Bell G.L., Dalton R.M., Lo A., Efstathiou S., Atkins J.F., Firth A.E., Taubenberger J.K., Digard P.
Science 337:199-204(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING (ISOFORM PA-X).
|DQ208311 mRNA. Translation: ABA55040.1.|
3D structure databases
|SMR||Q3HM39. Positions 257-716. |
Protocols and materials databases
Family and domain databases
|InterPro||IPR001009. RNA-dir_pol_influenzavirus. |
|Pfam||PF00603. Flu_PA. 1 hit. |
|Accession||Primary (citable) accession number: Q3HM39|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families