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Protein

Probable RNA polymerase II transcription factor B subunit 1-1

Gene

TFB1-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-ATH-113418. Formation of the Early Elongation Complex.
R-ATH-5696395. Formation of Incision Complex in GG-NER.
R-ATH-5696400. Dual Incision in GG-NER.
R-ATH-674695. RNA Polymerase II Pre-transcription Events.
R-ATH-6781823. Formation of TC-NER Pre-Incision Complex.
R-ATH-6782135. Dual incision in TC-NER.
R-ATH-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-ATH-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-ATH-72086. mRNA Capping.
R-ATH-73776. RNA Polymerase II Promoter Escape.
R-ATH-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-ATH-75953. RNA Polymerase II Transcription Initiation.
R-ATH-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-ATH-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable RNA polymerase II transcription factor B subunit 1-1
Alternative name(s):
General transcription and DNA repair factor IIH subunit TFB1-1
Short name:
AtTFB1-11 Publication
Short name:
TFIIH subunit TFB1-1
Gene namesi
Name:TFB1-1Curated
Synonyms:GTF2H1-1Curated
Ordered Locus Names:At1g55750
ORF Names:F20N2.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G55750.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004060921 – 591Probable RNA polymerase II transcription factor B subunit 1-1Add BLAST591

Proteomic databases

PaxDbiQ3ECP0.

Expressioni

Gene expression databases

GenevisibleiQ3ECP0. AT.

Interactioni

Subunit structurei

Component of the TFIIH core complex, which is composed of 7 subunits, XPD, XPB, TFB1/GTF2H1, GTF2H2/P44, TFB4/GTF2H3, TFB2/GTF2H4 and TFB5/GTF2H5.1 Publication

Protein-protein interaction databases

BioGridi27249. 3 interactors.
IntActiQ3ECP0. 3 interactors.
STRINGi3702.AT1G55750.1.

Structurei

3D structure databases

ProteinModelPortaliQ3ECP0.
SMRiQ3ECP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 166BSD 1PROSITE-ProRule annotationAdd BLAST55
Domaini191 – 243BSD 2PROSITE-ProRule annotationAdd BLAST53

Sequence similaritiesi

Contains 2 BSD domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2074. Eukaryota.
ENOG410XRI6. LUCA.
HOGENOMiHOG000006252.
InParanoidiQ3ECP0.
KOiK03141.
OMAiLHHWTSI.
OrthoDBiEOG093608QO.
PhylomeDBiQ3ECP0.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR005607. BSD_dom.
IPR011993. PH_dom-like.
IPR027079. Tfb1/p62.
IPR013876. TFIIH_BTF_p62_N.
[Graphical view]
PANTHERiPTHR12856. PTHR12856. 1 hit.
PfamiPF03909. BSD. 1 hit.
PF08567. PH_TFIIH. 1 hit.
[Graphical view]
SMARTiSM00751. BSD. 2 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50858. BSD. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3ECP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGQIEKLV KYKSTVKDPG TPGFLRIREG MLLFVPNDPK SDSKLKVLTQ
60 70 80 90 100
NIKSQKYTKE GSNKPPWLNL TNKQAKSHIF EFENYPDMHA CRDFITKALA
110 120 130 140 150
KCELEPNKSV VSTSSEQLSI KELELRFKLL RENSELQRLH KQFVESKVLT
160 170 180 190 200
EDEFWATRKK LLGKDSIRKS KQQLGLKSMM VSGIKPSTDG RTNRVTFNLT
210 220 230 240 250
PEIIFQIFAE KPAVRQAFIN YVPSKMTEKD FWTKYFRAEY LYSTKNTAVA
260 270 280 290 300
AAEAAEDEEL AVFLKPDEIL ARETRHKIRR VDPTLDMEAD QGDDYTHLMD
310 320 330 340 350
HGIQRDGTMD VVEPQNDQFK RSLLQDLNRH AAVVLEGRSI DVESEDTRIV
360 370 380 390 400
AEALTRVKQV SKADGETTKD ANQERLERMS RVAGMEDLQA PQNFPLAPLS
410 420 430 440 450
IKDPRDYFES QQGNVLNVPR GAKGLKRNVH EAYGLLKESI LEIRATGLSD
460 470 480 490 500
PLIKPEVSFE VFSSLTRTIA TAKNINGKNP RESFLDRLPK STKDEVLHHW
510 520 530 540 550
TSIQELLKHF WSSYPITTTY LHTKVGKLKD AMSNTYSKLE AMKESVQSDL
560 570 580 590
RHQVSLLVRP MQQALDAAFH HYEVDLQRRT AKSGERPNGY V
Length:591
Mass (Da):67,514
Last modified:November 8, 2005 - v1
Checksum:i26CEAA2CE8178C2A
GO

Sequence cautioni

The sequence AAF79503 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene has been split into 2 genes: At1g55750 and At1g55760.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002328 Genomic DNA. Translation: AAF79503.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE33293.1.
AK226523 mRNA. Translation: BAE98663.1.
RefSeqiNP_175971.3. NM_104451.4.
UniGeneiAt.42907.

Genome annotation databases

EnsemblPlantsiAT1G55750.1; AT1G55750.1; AT1G55750.
GeneIDi842024.
GrameneiAT1G55750.1; AT1G55750.1; AT1G55750.
KEGGiath:AT1G55750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002328 Genomic DNA. Translation: AAF79503.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE33293.1.
AK226523 mRNA. Translation: BAE98663.1.
RefSeqiNP_175971.3. NM_104451.4.
UniGeneiAt.42907.

3D structure databases

ProteinModelPortaliQ3ECP0.
SMRiQ3ECP0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi27249. 3 interactors.
IntActiQ3ECP0. 3 interactors.
STRINGi3702.AT1G55750.1.

Proteomic databases

PaxDbiQ3ECP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G55750.1; AT1G55750.1; AT1G55750.
GeneIDi842024.
GrameneiAT1G55750.1; AT1G55750.1; AT1G55750.
KEGGiath:AT1G55750.

Organism-specific databases

TAIRiAT1G55750.

Phylogenomic databases

eggNOGiKOG2074. Eukaryota.
ENOG410XRI6. LUCA.
HOGENOMiHOG000006252.
InParanoidiQ3ECP0.
KOiK03141.
OMAiLHHWTSI.
OrthoDBiEOG093608QO.
PhylomeDBiQ3ECP0.

Enzyme and pathway databases

ReactomeiR-ATH-113418. Formation of the Early Elongation Complex.
R-ATH-5696395. Formation of Incision Complex in GG-NER.
R-ATH-5696400. Dual Incision in GG-NER.
R-ATH-674695. RNA Polymerase II Pre-transcription Events.
R-ATH-6781823. Formation of TC-NER Pre-Incision Complex.
R-ATH-6782135. Dual incision in TC-NER.
R-ATH-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-ATH-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-ATH-72086. mRNA Capping.
R-ATH-73776. RNA Polymerase II Promoter Escape.
R-ATH-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-ATH-75953. RNA Polymerase II Transcription Initiation.
R-ATH-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-ATH-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Miscellaneous databases

PROiQ3ECP0.

Gene expression databases

GenevisibleiQ3ECP0. AT.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR005607. BSD_dom.
IPR011993. PH_dom-like.
IPR027079. Tfb1/p62.
IPR013876. TFIIH_BTF_p62_N.
[Graphical view]
PANTHERiPTHR12856. PTHR12856. 1 hit.
PfamiPF03909. BSD. 1 hit.
PF08567. PH_TFIIH. 1 hit.
[Graphical view]
SMARTiSM00751. BSD. 2 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50858. BSD. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTFB1A_ARATH
AccessioniPrimary (citable) accession number: Q3ECP0
Secondary accession number(s): Q9LFZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: November 8, 2005
Last modified: November 30, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.