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Protein

Vacuolar protein-sorting-associated protein 37 homolog 2

Gene

VPS37-2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein-sorting-associated protein 37 homolog 2
Short name:
AtVPS37-2
Alternative name(s):
ESCRT-I complex subunit VPS37 homolog 2
Gene namesi
Name:VPS37-2
Ordered Locus Names:At2g36680
ORF Names:F13K3.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G36680
TAIRilocus:2040560 AT2G36680

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003681901 – 218Vacuolar protein-sorting-associated protein 37 homolog 2Add BLAST218

Proteomic databases

PaxDbiQ3EBL9

PTM databases

iPTMnetiQ3EBL9

Expressioni

Gene expression databases

ExpressionAtlasiQ3EBL9 differential
GenevisibleiQ3EBL9 AT

Interactioni

Subunit structurei

Component of the endosomal sorting required for transport complex I (ESCRT-I), composed of ELC, VPS28 and VPS37. Interacts with ELC.1 Publication

Protein-protein interaction databases

BioGridi3584, 3 interactors
IntActiQ3EBL9, 5 interactors
STRINGi3702.AT2G36680.1

Structurei

3D structure databases

ProteinModelPortaliQ3EBL9
SMRiQ3EBL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini137 – 218VPS37 C-terminalPROSITE-ProRule annotationAdd BLAST82

Sequence similaritiesi

Belongs to the VPS37 family.Curated

Phylogenomic databases

eggNOGiKOG3270 Eukaryota
ENOG4111UJN LUCA
HOGENOMiHOG000239803
InParanoidiQ3EBL9
KOiK12185
OMAiRSKYHRR
OrthoDBiEOG09360OF6
PhylomeDBiQ3EBL9

Family and domain databases

Gene3Di1.10.287.660, 1 hit
InterProiView protein in InterPro
IPR037202 ESCRT_assembly_dom
IPR029012 Helix_hairpin_bin_sf
IPR009851 Mod_r
IPR037859 Vps37
PANTHERiPTHR13678 PTHR13678, 1 hit
PfamiView protein in Pfam
PF07200 Mod_r, 1 hit
SUPFAMiSSF140111 SSF140111, 1 hit
PROSITEiView protein in PROSITE
PS51314 VPS37_C, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3EBL9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFNFWGSKEQ QQGQSRPSPE ASATPWYSPS LVTSPSSSRP QTSGQIPSHV
60 70 80 90 100
SPGEAAGIIA ILKDKSVDEL RKLLSDKDAY QQFLHSLDQV TIQNNIREEL
110 120 130 140 150
RKETLHLARE NLEKEPQIVE LRNQCRIIRT SELATAQEKL NELENQREEI
160 170 180 190 200
LKFYSPGSLL HRLQDAMNQV DEESEELQQK FMEKDIDTAA FVQKYKKLRS
210
KYHRRALIHL AAKTSSIG
Note: No experimental confirmation available.
Length:218
Mass (Da):24,987
Last modified:November 8, 2005 - v1
Checksum:i27EADEA09A48DB19
GO
Isoform 2 (identifier: Q3EBL9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-139: CRIIRTSELATAQEK → NNPYIRACDCSREAQ
     140-218: Missing.

Note: May be due to a competing acceptor splice site. No experimental confirmation available.
Show »
Length:139
Mass (Da):15,718
Checksum:iD32CCA4AFBFA8F4A
GO
Isoform 3 (identifier: Q3EBL9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-168: CRIIRTSELA...LLHRLQDAMN → VNNIIQSLSE...RACDCSREAQ
     169-218: Missing.

Note: Derived from EST data. No experimental confirmation available.
Show »
Length:168
Mass (Da):19,067
Checksum:iB186A719F0914D3A
GO

Sequence cautioni

The sequence AAD20144 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BX821771 differs from that shown. Reason: Frameshift at positions 1 and 153.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036799125 – 168CRIIR…QDAMN → VNNIIQSLSELIKYMKLLSI CIIFLKTVQNNPYIRACDCS REAQ in isoform 3. CuratedAdd BLAST44
Alternative sequenceiVSP_036800125 – 139CRIIR…TAQEK → NNPYIRACDCSREAQ in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_036801140 – 218Missing in isoform 2. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_036802169 – 218Missing in isoform 3. CuratedAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006282 Genomic DNA Translation: AAD20144.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC09282.1
CP002685 Genomic DNA Translation: AEC09283.1
CP002685 Genomic DNA Translation: AEC09284.1
CP002685 Genomic DNA Translation: AEC09285.1
AY070474 mRNA Translation: AAL49940.1
AY091674 mRNA Translation: AAM10273.1
BX821771 mRNA No translation available.
PIRiD84783
RefSeqiNP_001031495.1, NM_001036418.2 [Q3EBL9-3]
NP_001078013.1, NM_001084544.2 [Q3EBL9-3]
NP_850268.2, NM_179937.4 [Q3EBL9-1]
NP_850269.2, NM_179938.2 [Q3EBL9-2]
UniGeneiAt.28638

Genome annotation databases

EnsemblPlantsiAT2G36680.1; AT2G36680.1; AT2G36680 [Q3EBL9-1]
AT2G36680.2; AT2G36680.2; AT2G36680 [Q3EBL9-2]
AT2G36680.3; AT2G36680.3; AT2G36680 [Q3EBL9-3]
AT2G36680.4; AT2G36680.4; AT2G36680 [Q3EBL9-3]
GeneIDi818240
GrameneiAT2G36680.1; AT2G36680.1; AT2G36680 [Q3EBL9-1]
AT2G36680.2; AT2G36680.2; AT2G36680 [Q3EBL9-2]
AT2G36680.3; AT2G36680.3; AT2G36680 [Q3EBL9-3]
AT2G36680.4; AT2G36680.4; AT2G36680 [Q3EBL9-3]
KEGGiath:AT2G36680

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiVP372_ARATH
AccessioniPrimary (citable) accession number: Q3EBL9
Secondary accession number(s): Q8VYK5, Q9ZQA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 8, 2005
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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