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Protein

Cell division cycle 20.5, cofactor of APC complex

Gene

CDC20-5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-ATH-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
R-ATH-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-ATH-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle 20.5, cofactor of APC complex
Short name:
AtCDC20.5
Gene namesi
Name:CDC20-5
Synonyms:CDC20_5
Ordered Locus Names:At5g27570
ORF Names:F15A18.30
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G27570
TAIRilocus:2143636 AT5G27570

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004233101 – 450Cell division cycle 20.5, cofactor of APC complexAdd BLAST450

Proteomic databases

PaxDbiQ3E906
PRIDEiQ3E906

Expressioni

Gene expression databases

GenevisibleiQ3E906 AT

Interactioni

Subunit structurei

The APC/C is composed of at least 11 subunits that stay tightly associated throughout the cell cycle (By similarity). Binds to GIG1 and PYM. Part of the mitotic checkpoint complex (MCC); interacts with MAD2 and BUB1.By similarity2 Publications

GO - Molecular functioni

  • kinase binding Source: UniProtKB

Protein-protein interaction databases

ELMiQ3E906
IntActiQ3E906, 1 interactor
STRINGi3702.AT5G27570.1

Structurei

3D structure databases

ProteinModelPortaliQ3E906
SMRiQ3E906
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati129 – 166WD 1Add BLAST38
Repeati171 – 210WD 2Add BLAST40
Repeati214 – 251WD 3Add BLAST38
Repeati255 – 294WD 4Add BLAST40
Repeati304 – 346WD 5Add BLAST43
Repeati348 – 389WD 6Add BLAST42
Repeati392 – 431WD 7Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat CDC20/Fizzy family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0305 Eukaryota
ENOG410XQ8I LUCA
HOGENOMiHOG000195514
InParanoidiQ3E906
KOiK03363
OrthoDBiEOG093608P9

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR033010 Cdc20/Fizzy
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19918 PTHR19918, 2 hits
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q3E906-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNTSSHLKA QASCPLVEHF LRRKLSKENF DRFIPNRSAM DFDFANYALT
60 70 80 90 100
QGRKRNVDEV TSASRKAYMT QLAEAMNQNR TRILAFRNKP KALLSSNHSD
110 120 130 140 150
PPHQQPISVK PRRYIPQNSE RVLDAPGIAD DFYLNLLDWG SSNVLAIALG
160 170 180 190 200
DTVYLWDASS GSTYKLVTID EEEGPVTSIN WTQDGLDLAI GLDNSEVQLW
210 220 230 240 250
DCVSNRQVRT LRGGHESRVG SLAWNNHILT TGGMDGKIVN NDVRIRSSIV
260 270 280 290 300
ETYLGHTEEV CGLKWSESGK KLASGGNDNV VHIWDHRSVA SSNPTRQWLH
310 320 330 340 350
RFEEHTAAVR ALAWCPFQAS LLATGGGVGD GKIKFWNTHT GACLNSVETG
360 370 380 390 400
SQVCSLLWSK SERELLSSHG FTQNQLTLWK YPSMVKMAEL NGHTSRVLFM
410 420 430 440 450
AQSPDGCTVA SAAGDETLRL WNVFGEPPKT TKKAASKKYT DPFAHVNHIR
Length:450
Mass (Da):50,099
Last modified:January 31, 2018 - v3
Checksum:i76B8B9B59CD17F7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007478 Genomic DNA No translation available.
CP002688 Genomic DNA Translation: AED93702.2
RefSeqiNP_198109.2, NM_122639.2

Genome annotation databases

EnsemblPlantsiAT5G27570.1; AT5G27570.1; AT5G27570
GeneIDi832817
GrameneiAT5G27570.1; AT5G27570.1; AT5G27570
KEGGiath:AT5G27570

Similar proteinsi

Entry informationi

Entry nameiCD205_ARATH
AccessioniPrimary (citable) accession number: Q3E906
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 18, 2013
Last sequence update: January 31, 2018
Last modified: May 23, 2018
This is version 113 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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