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Protein

Cell division cycle 20.5, cofactor of APC complex

Gene

CDC20-5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle 20.5, cofactor of APC complex
Short name:
AtCDC20.5
Gene namesi
Name:CDC20-5
Synonyms:CDC20_5
Ordered Locus Names:At5g27570
ORF Names:F15A18.30
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G27570.
TAIRilocus:2143636. AT5G27570.

Subcellular locationi

GO - Cellular componenti

  • Cul4-RING E3 ubiquitin ligase complex Source: TAIR
  • nucleus Source: TAIR

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_000042331039 – 449Cell division cycle 20.5, cofactor of APC complexAdd BLAST411

Proteomic databases

PaxDbiQ3E906.

Expressioni

Gene expression databases

GenevisibleiQ3E906. AT.

Interactioni

Subunit structurei

The APC/C is composed of at least 11 subunits that stay tightly associated throughout the cell cycle (By similarity). Binds to GIG1 and PYM. Part of the mitotic checkpoint complex (MCC); interacts with MAD2 and BUB1.By similarity2 Publications

GO - Molecular functioni

  • anaphase-promoting complex binding Source: InterPro
  • kinase binding Source: UniProtKB

Protein-protein interaction databases

IntActiQ3E906. 1 interactor.
STRINGi3702.AT5G27570.1.

Structurei

3D structure databases

ProteinModelPortaliQ3E906.
SMRiQ3E906.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati128 – 165WD 1Add BLAST38
Repeati170 – 209WD 2Add BLAST40
Repeati213 – 250WD 3Add BLAST38
Repeati254 – 293WD 4Add BLAST40
Repeati303 – 345WD 5Add BLAST43
Repeati347 – 388WD 6Add BLAST42
Repeati391 – 430WD 7Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat CDC20/Fizzy family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0305. Eukaryota.
ENOG410XQ8I. LUCA.
HOGENOMiHOG000195514.
InParanoidiQ3E906.
KOiK03363.
OrthoDBiEOG093608P9.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR024977. Apc4_WD40_dom.
IPR033010. Cdc20/Fizzy.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
PANTHERiPTHR19918. PTHR19918. 1 hit.
PfamiView protein in Pfam
PF12894. ANAPC4_WD40. 1 hit.
PF00400. WD40. 3 hits.
SMARTiView protein in SMART
SM00320. WD40. 7 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3E906-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTSSHLKAQ ASCPLVEHFL RRKLSKENFD RFIPNRSAMD FDFANYALTQ
60 70 80 90 100
GRKRNVDEVT SASRKAYMTQ LAEAMNQNRT RILAFRNKPK ALLSSNHSDP
110 120 130 140 150
PHQQPISVKP RRYIPQNSER VLDAPGIADD FYLNLLDWGS SNVLAIALGD
160 170 180 190 200
TVYLWDASSG STYKLVTIDE EEGPVTSINW TQDGLDLAIG LDNSEVQLWD
210 220 230 240 250
CVSNRQVRTL RGGHESRVGS LAWNNHILTT GGMDGKIVNN DVRIRSSIVE
260 270 280 290 300
TYLGHTEEVC GLKWSESGKK LASGGNDNVV HIWDHRSVAS SNPTRQWLHR
310 320 330 340 350
FEEHTAAVRA LAWCPFQASL LATGGGVGDG KIKFWNTHTG ACLNSVETGS
360 370 380 390 400
QVCSLLWSKS ERELLSSHGF TQNQLTLWKY PSMVKMAELN GHTSRVLFMA
410 420 430 440
QSPDGCTVAS AAGDETLRLW NVFGEPPKTT KKAASKKYTD PFAHVNHIR
Length:449
Mass (Da):49,968
Last modified:September 18, 2013 - v2
Checksum:i17B5F142070F1E72
GO

Sequence cautioni

The sequence AED93702 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007478 Genomic DNA. No translation available.
CP002688 Genomic DNA. Translation: AED93702.1. Different initiation.
RefSeqiNP_198109.2. NM_122639.2.

Genome annotation databases

GeneIDi832817.
KEGGiath:AT5G27570.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCD205_ARATH
AccessioniPrimary (citable) accession number: Q3E906
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 18, 2013
Last sequence update: September 18, 2013
Last modified: June 7, 2017
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families