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Protein

Receptor-like protein kinase ANXUR2

Gene

ANX2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor-like protein kinase that controls pollen tube behavior by directing rupture at proper timing to release the sperm cell.1 Publication

Miscellaneous

Male paralog of FERONIA, a female factor expressed in synergid cells that controls pollen tube behavior.
Named Anxur after the husband of the Etruscan goddess of fertility Feronia.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei549ATPPROSITE-ProRule annotation1
Active sitei645Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi527 – 535ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processFertilization
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-like protein kinase ANXUR2 (EC:2.7.11.1)
Gene namesi
Name:ANX2
Ordered Locus Names:At5g28680
ORF Names:F4I4.60
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G28680.
TAIRilocus:2148830. AT5G28680.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 431ExtracellularSequence analysisAdd BLAST404
Transmembranei432 – 452HelicalSequence analysisAdd BLAST21
Topological domaini453 – 858CytoplasmicSequence analysisAdd BLAST406

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No effect on male fertility and pollen germination, but siliques slightly shorter. Anx1 and anx2 double mutants show defects in male gametophytes due to premature pollen tube rupture.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000038533228 – 858Receptor-like protein kinase ANXUR2Add BLAST831

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi293N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi331N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3E8W4.

PTM databases

iPTMnetiQ3E8W4.

Expressioni

Tissue specificityi

Expressed in pollen, but not in pistils or seedlings.1 Publication

Gene expression databases

GenevisibleiQ3E8W4. AT.

Interactioni

Protein-protein interaction databases

BioGridi18248. 1 interactor.
STRINGi3702.AT5G28680.1.

Structurei

3D structure databases

ProteinModelPortaliQ3E8W4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini521 – 794Protein kinasePROSITE-ProRule annotationAdd BLAST274

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi367 – 370Poly-Gly4
Compositional biasi819 – 824Poly-Gly6

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1187. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000238317.
InParanoidiQ3E8W4.
OMAiTPNTVHA.
OrthoDBiEOG0936005R.
PhylomeDBiQ3E8W4.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR024788. Malectin-like_Carb-bd_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF12819. Malectin_like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3E8W4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEKLRILFS FLCFFYVLLV SPSQSNGQDI SLSCGASEPA VDQDKKKWEP
60 70 80 90 100
DTKFLKTPNT VHAPATYQDP SLLSTVPYMT SRIFTAPATY EIPVKGDKRH
110 120 130 140 150
MLRLHFYPST YTGLNILDSY FSVAANDLTL LSNFSAAITC QALTQAYLVR
160 170 180 190 200
EYSLAPSEKD VLSIIFTPSD KHPKAFAFIN GIEVIPMPEL FDTASLVGFS
210 220 230 240 250
DQTSDTKTAN LQTMFRLNVG GQDIPGSQDS GGLTRTWYND APYIFSAGLG
260 270 280 290 300
VTLQASNNFR IDYQKMPVST APADVYKTAR SQGPNGDINM KSNLTWMFQV
310 320 330 340 350
DTNFTYIMRL HFCEFQLAKI NQKVFNIFIN NRTAQGDTNP ADILGWTGGK
360 370 380 390 400
GIPTYKDYAI YVDANTGGGG EEISLQMTPS TFGQPEYYDS QLNGLEIFKI
410 420 430 440 450
DTMKNLAGPN PKPSPMQANE DVKKDFQGDK RITAFVIGSA GGVAAVLFCA
460 470 480 490 500
LCFTMYQRKR KFSGSDSHTS SWLPIYGNSH TSATKSTISG KSNNGSHLSN
510 520 530 540 550
LAAGLCRRFS LSEIKHGTHN FDESNVIGVG GFGKVYKGVI DGGTKVAIKK
560 570 580 590 600
SNPNSEQGLN EFETEIELLS RLRHKHLVSL IGYCDEGGEM CLIYDYMSLG
610 620 630 640 650
TLREHLYNTK RPQLTWKRRL EIAIGAARGL HYLHTGAKYT IIHRDVKTTN
660 670 680 690 700
ILLDENWVAK VSDFGLSKTG PNMNGGHVTT VVKGSFGYLD PEYFRRQQLT
710 720 730 740 750
EKSDVYSFGV VLFEVLCARP ALNPSLSKEQ VSLGDWAMNC KRKGTLEDII
760 770 780 790 800
DPNLKGKINP ECLKKFADTA EKCLSDSGLD RPTMGDVLWN LEFALQLQET
810 820 830 840 850
ADGSRHRTPS NGGGSVDLGG GGGGVTVNIS AGESDLGDDL SSEENSGIFS

QIVNPKGR
Length:858
Mass (Da):94,297
Last modified:November 8, 2005 - v1
Checksum:iD83B1371D545EA1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272705 Genomic DNA. No translation available.
CP002688 Genomic DNA. Translation: AED93826.1.
CP002688 Genomic DNA. Translation: ANM68270.1.
RefSeqiNP_001318669.1. NM_001344080.1.
NP_198220.1. NM_122751.2.
UniGeneiAt.65563.

Genome annotation databases

EnsemblPlantsiAT5G28680.1; AT5G28680.1; AT5G28680.
AT5G28680.2; AT5G28680.2; AT5G28680.
GeneIDi832975.
GrameneiAT5G28680.1; AT5G28680.1; AT5G28680.
AT5G28680.2; AT5G28680.2; AT5G28680.
KEGGiath:AT5G28680.

Similar proteinsi

Entry informationi

Entry nameiANX2_ARATH
AccessioniPrimary (citable) accession number: Q3E8W4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: November 8, 2005
Last modified: November 22, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families