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Q3E834 (YOS1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein transport protein YOS1
Alternative name(s):
YIP one suppressor protein 1
Gene names
Name:YOS1
Ordered Locus Names:YER074W-A
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length85 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for protein transport between endoplasmic reticulum and Golgi apparatus. Ref.3

Subunit structure

Component of the YIP1-YIF1 complex, composed of at least YIF1, YIP1 and YOS1.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein Ref.3.

Sequence similarities

Belongs to the YOS1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 8585Protein transport protein YOS1
PRO_0000232636

Regions

Transmembrane2 – 2221Helical; Potential
Transmembrane65 – 8521Helical; Potential

Experimental info

Mutagenesis181N → A in YOS1-1; impairs interaction with YIP1, blocks ER-Golgi protein transport, and causes a severe growth defect at 37 degrees Celsius. Ref.3
Mutagenesis691P → A: Lethal. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q3E834 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 7AE4E85AD2B43787

FASTA859,436
        10         20         30         40         50         60 
MVLFGLGRLF YVILLLINAV AVLSEERFLR RIGLGRSNDE TPVFGQDQNT TKSKVVQLIG 

        70         80 
AVQTLLRIPL IGINILVIVY ELLLG 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Yos1p is a novel subunit of the Yip1p-Yif1p complex and is required for transport between the endoplasmic reticulum and the Golgi complex."
Heidtman M., Chen C.Z., Collins R.N., Barlowe C.
Mol. Biol. Cell 16:1673-1683(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH YIF1 AND YIP1, SUBCELLULAR LOCATION, MUTAGENESIS OF ASN-18 AND PRO-69.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18814 Genomic DNA. No translation available.
BK006939 Genomic DNA. Translation: DAA07734.1.
RefSeqNP_219496.2. NM_001184512.1.

3D structure databases

ProteinModelPortalQ3E834.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36818. 4 interactions.
STRING4932.YER074W-A.

Proteomic databases

PaxDbQ3E834.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYER074W-A; YER074W-A; YER074W-A.
GeneID856806.
KEGGsce:YER074W-A.

Organism-specific databases

CYGDYER074w-a.
SGDS000007651. YOS1.

Phylogenomic databases

eggNOGNOG329574.
GeneTreeENSGT00510000047648.
HOGENOMHOG000192480.
OMAFLNRIGW.
OrthoDBEOG78WM5G.

Enzyme and pathway databases

BioCycYEAST:G3O-30392-MONOMER.

Gene expression databases

GenevestigatorQ3E834.

Family and domain databases

InterProIPR013880. Yos1.
[Graphical view]
PANTHERPTHR15858. PTHR15858. 1 hit.
PfamPF08571. Yos1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio983062.
PROQ3E834.

Entry information

Entry nameYOS1_YEAST
AccessionPrimary (citable) accession number: Q3E834
Secondary accession number(s): D3DLY0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: November 8, 2005
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families