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Q3E834

- YOS1_YEAST

UniProt

Q3E834 - YOS1_YEAST

Protein

Protein transport protein YOS1

Gene

YOS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Required for protein transport between endoplasmic reticulum and Golgi apparatus.1 Publication

    GO - Biological processi

    1. ER to Golgi vesicle-mediated transport Source: SGD
    2. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30392-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein transport protein YOS1
    Alternative name(s):
    YIP one suppressor protein 1
    Gene namesi
    Name:YOS1
    Ordered Locus Names:YER074W-A
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYER074w-a.
    SGDiS000007651. YOS1.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication. Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: SGD
    2. ER to Golgi transport vesicle Source: SGD
    3. integral component of Golgi membrane Source: SGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi18 – 181N → A in YOS1-1; impairs interaction with YIP1, blocks ER-Golgi protein transport, and causes a severe growth defect at 37 degrees Celsius. 1 Publication
    Mutagenesisi69 – 691P → A: Lethal. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8585Protein transport protein YOS1PRO_0000232636Add
    BLAST

    Proteomic databases

    PaxDbiQ3E834.

    Expressioni

    Gene expression databases

    GenevestigatoriQ3E834.

    Interactioni

    Subunit structurei

    Component of the YIP1-YIF1 complex, composed of at least YIF1, YIP1 and YOS1.

    Protein-protein interaction databases

    BioGridi36818. 4 interactions.
    STRINGi4932.YER074W-A.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3E834.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei65 – 8521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the YOS1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG329574.
    GeneTreeiENSGT00510000047648.
    HOGENOMiHOG000192480.
    OMAiFLNRIGW.
    OrthoDBiEOG78WM5G.

    Family and domain databases

    InterProiIPR013880. Yos1.
    [Graphical view]
    PANTHERiPTHR15858. PTHR15858. 1 hit.
    PfamiPF08571. Yos1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3E834-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLFGLGRLF YVILLLINAV AVLSEERFLR RIGLGRSNDE TPVFGQDQNT   50
    TKSKVVQLIG AVQTLLRIPL IGINILVIVY ELLLG 85
    Length:85
    Mass (Da):9,436
    Last modified:November 8, 2005 - v1
    Checksum:i7AE4E85AD2B43787
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18814 Genomic DNA. No translation available.
    BK006939 Genomic DNA. Translation: DAA07734.1.
    RefSeqiNP_219496.2. NM_001184512.1.

    Genome annotation databases

    EnsemblFungiiYER074W-A; YER074W-A; YER074W-A.
    GeneIDi856806.
    KEGGisce:YER074W-A.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18814 Genomic DNA. No translation available.
    BK006939 Genomic DNA. Translation: DAA07734.1 .
    RefSeqi NP_219496.2. NM_001184512.1.

    3D structure databases

    ProteinModelPortali Q3E834.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36818. 4 interactions.
    STRINGi 4932.YER074W-A.

    Proteomic databases

    PaxDbi Q3E834.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YER074W-A ; YER074W-A ; YER074W-A .
    GeneIDi 856806.
    KEGGi sce:YER074W-A.

    Organism-specific databases

    CYGDi YER074w-a.
    SGDi S000007651. YOS1.

    Phylogenomic databases

    eggNOGi NOG329574.
    GeneTreei ENSGT00510000047648.
    HOGENOMi HOG000192480.
    OMAi FLNRIGW.
    OrthoDBi EOG78WM5G.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30392-MONOMER.

    Miscellaneous databases

    NextBioi 983062.
    PROi Q3E834.

    Gene expression databases

    Genevestigatori Q3E834.

    Family and domain databases

    InterProi IPR013880. Yos1.
    [Graphical view ]
    PANTHERi PTHR15858. PTHR15858. 1 hit.
    Pfami PF08571. Yos1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Yos1p is a novel subunit of the Yip1p-Yif1p complex and is required for transport between the endoplasmic reticulum and the Golgi complex."
      Heidtman M., Chen C.Z., Collins R.N., Barlowe C.
      Mol. Biol. Cell 16:1673-1683(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH YIF1 AND YIP1, SUBCELLULAR LOCATION, MUTAGENESIS OF ASN-18 AND PRO-69.

    Entry informationi

    Entry nameiYOS1_YEAST
    AccessioniPrimary (citable) accession number: Q3E834
    Secondary accession number(s): D3DLY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3