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Protein

Protein transport protein YOS1

Gene

YOS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for protein transport between endoplasmic reticulum and Golgi apparatus.1 Publication

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: SGD
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30392-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein YOS1
Alternative name(s):
YIP one suppressor protein 1
Gene namesi
Name:YOS1
Ordered Locus Names:YER074W-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER074W-A.
SGDiS000007651. YOS1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: SGD
  • ER to Golgi transport vesicle Source: SGD
  • integral component of Golgi membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi18N → A in YOS1-1; impairs interaction with YIP1, blocks ER-Golgi protein transport, and causes a severe growth defect at 37 degrees Celsius. 1 Publication1
Mutagenesisi69P → A: Lethal. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002326361 – 85Protein transport protein YOS1Add BLAST85

Proteomic databases

PRIDEiQ3E834.
TopDownProteomicsiQ3E834.

PTM databases

iPTMnetiQ3E834.

Interactioni

Subunit structurei

Component of the YIP1-YIF1 complex, composed of at least YIF1, YIP1 and YOS1.

Protein-protein interaction databases

BioGridi36818. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ3E834.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the YOS1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000047648.
HOGENOMiHOG000192480.
InParanoidiQ3E834.
OMAiPAFGATY.
OrthoDBiEOG092C5YK6.

Family and domain databases

InterProiIPR013880. Yos1.
[Graphical view]
PANTHERiPTHR15858. PTHR15858. 1 hit.
PfamiPF08571. Yos1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3E834-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLFGLGRLF YVILLLINAV AVLSEERFLR RIGLGRSNDE TPVFGQDQNT
60 70 80
TKSKVVQLIG AVQTLLRIPL IGINILVIVY ELLLG
Length:85
Mass (Da):9,436
Last modified:November 8, 2005 - v1
Checksum:i7AE4E85AD2B43787
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18814 Genomic DNA. No translation available.
BK006939 Genomic DNA. Translation: DAA07734.1.
RefSeqiNP_219496.2. NM_001184512.1.

Genome annotation databases

EnsemblFungiiYER074W-A; YER074W-A; YER074W-A.
GeneIDi856806.
KEGGisce:YER074W-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18814 Genomic DNA. No translation available.
BK006939 Genomic DNA. Translation: DAA07734.1.
RefSeqiNP_219496.2. NM_001184512.1.

3D structure databases

ProteinModelPortaliQ3E834.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36818. 3 interactors.

PTM databases

iPTMnetiQ3E834.

Proteomic databases

PRIDEiQ3E834.
TopDownProteomicsiQ3E834.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER074W-A; YER074W-A; YER074W-A.
GeneIDi856806.
KEGGisce:YER074W-A.

Organism-specific databases

EuPathDBiFungiDB:YER074W-A.
SGDiS000007651. YOS1.

Phylogenomic databases

GeneTreeiENSGT00510000047648.
HOGENOMiHOG000192480.
InParanoidiQ3E834.
OMAiPAFGATY.
OrthoDBiEOG092C5YK6.

Enzyme and pathway databases

BioCyciYEAST:G3O-30392-MONOMER.

Miscellaneous databases

PROiQ3E834.

Family and domain databases

InterProiIPR013880. Yos1.
[Graphical view]
PANTHERiPTHR15858. PTHR15858. 1 hit.
PfamiPF08571. Yos1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYOS1_YEAST
AccessioniPrimary (citable) accession number: Q3E834
Secondary accession number(s): D3DLY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.