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Protein

Protein transport protein YOS1

Gene

YOS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for protein transport between endoplasmic reticulum and Golgi apparatus.1 Publication

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: SGD
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30392-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein YOS1
Alternative name(s):
YIP one suppressor protein 1
Gene namesi
Name:YOS1
Ordered Locus Names:YER074W-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER074W-A
SGDiS000007651 YOS1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi18N → A in YOS1-1; impairs interaction with YIP1, blocks ER-Golgi protein transport, and causes a severe growth defect at 37 degrees Celsius. 1 Publication1
Mutagenesisi69P → A: Lethal. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002326361 – 85Protein transport protein YOS1Add BLAST85

Proteomic databases

PaxDbiQ3E834
PRIDEiQ3E834
TopDownProteomicsiQ3E834

PTM databases

iPTMnetiQ3E834

Interactioni

Subunit structurei

Component of the YIP1-YIF1 complex, composed of at least YIF1, YIP1 and YOS1.

Protein-protein interaction databases

BioGridi36818, 3 interactors
STRINGi4932.YER074W-A

Structurei

3D structure databases

ProteinModelPortaliQ3E834
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the YOS1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000047648
HOGENOMiHOG000192480
InParanoidiQ3E834
OMAiLCLNAIC
OrthoDBiEOG092C5YK6

Family and domain databases

InterProiView protein in InterPro
IPR013880 Yos1
PANTHERiPTHR15858 PTHR15858, 1 hit
PfamiView protein in Pfam
PF08571 Yos1, 1 hit

Sequencei

Sequence statusi: Complete.

Q3E834-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLFGLGRLF YVILLLINAV AVLSEERFLR RIGLGRSNDE TPVFGQDQNT
60 70 80
TKSKVVQLIG AVQTLLRIPL IGINILVIVY ELLLG
Length:85
Mass (Da):9,436
Last modified:November 8, 2005 - v1
Checksum:i7AE4E85AD2B43787
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18814 Genomic DNA No translation available.
BK006939 Genomic DNA Translation: DAA07734.1
RefSeqiNP_219496.2, NM_001184512.1

Genome annotation databases

EnsemblFungiiYER074W-A; YER074W-A; YER074W-A
GeneIDi856806
KEGGisce:YER074W-A

Similar proteinsi

Entry informationi

Entry nameiYOS1_YEAST
AccessioniPrimary (citable) accession number: Q3E834
Secondary accession number(s): D3DLY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: November 8, 2005
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health