ID   LSO1_YEAST              Reviewed;          93 AA.
AC   Q3E827; D6VWI0;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   08-NOV-2023, entry version 90.
DE   RecName: Full=Protein LSO1 {ECO:0000305};
DE   AltName: Full=Late-annotated small open reading frame 1 {ECO:0000303|PubMed:26450372};
GN   Name=LSO1 {ECO:0000303|PubMed:26450372, ECO:0000312|SGD:S000028523};
GN   OrderedLocusNames=YJR005C-A {ECO:0000312|SGD:S000028523};
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA   Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA   Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA   Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA   Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA   Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA   Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA   Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA   Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA   Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA   To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA   von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT   "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL   EMBO J. 15:2031-2049(1996).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   GENOME REANNOTATION.
RX   PubMed=12844361; DOI=10.1186/gb-2003-4-7-r45;
RA   Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A.,
RA   Gates K., Gaffney T.D., Philippsen P.;
RT   "Reinvestigation of the Saccharomyces cerevisiae genome annotation by
RT   comparison to the genome of a related fungus: Ashbya gossypii.";
RL   Genome Biol. 4:R45.1-R45.13(2003).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=26450372; DOI=10.1002/mbo3.303;
RA   An X., Zhang C., Sclafani R.A., Seligman P., Huang M.;
RT   "The late-annotated small ORF LSO1 is a target gene of the iron regulon of
RT   Saccharomyces cerevisiae.";
RL   MicrobiologyOpen 4:941-951(2015).
CC   -!- FUNCTION: Likely to play a role in iron homeostasis.
CC       {ECO:0000269|PubMed:26450372}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26450372}. Cytoplasm
CC       {ECO:0000269|PubMed:26450372}. Note=Under iron-replete conditions,
CC       enriched in the nucleus. Under iron-depleted conditions, expressed in
CC       both nucleus and cytoplasm. {ECO:0000269|PubMed:26450372}.
CC   -!- INDUCTION: By iron starvation. {ECO:0000269|PubMed:26450372}.
CC   -!- DISRUPTION PHENOTYPE: Mild slow-growth phenotype in response to reduced
CC       iron levels. {ECO:0000269|PubMed:26450372}.
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DR   EMBL; Z49506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK006943; DAA08796.1; -; Genomic_DNA.
DR   RefSeq; NP_878106.1; NM_001184533.1.
DR   AlphaFoldDB; Q3E827; -.
DR   SMR; Q3E827; -.
DR   BioGRID; 37011; 10.
DR   STRING; 4932.YJR005C-A; -.
DR   PaxDb; 4932-YJR005C-A; -.
DR   PeptideAtlas; Q3E827; -.
DR   EnsemblFungi; YJR005C-A_mRNA; YJR005C-A; YJR005C-A.
DR   GeneID; 1466469; -.
DR   KEGG; sce:YJR005C-A; -.
DR   AGR; SGD:S000028523; -.
DR   SGD; S000028523; LSO1.
DR   VEuPathDB; FungiDB:YJR005C-A; -.
DR   eggNOG; KOG3223; Eukaryota.
DR   GeneTree; ENSGT00940000176679; -.
DR   HOGENOM; CLU_186256_0_0_1; -.
DR   InParanoid; Q3E827; -.
DR   OMA; QEAQRWE; -.
DR   OrthoDB; 2036609at2759; -.
DR   BioCyc; YEAST:G3O-31805-MONOMER; -.
DR   BioGRID-ORCS; 1466469; 0 hits in 10 CRISPR screens.
DR   PRO; PR:Q3E827; -.
DR   Proteomes; UP000002311; Chromosome X.
DR   RNAct; Q3E827; Protein.
DR   GO; GO:0005737; C:cytoplasm; IDA:SGD.
DR   GO; GO:0005634; C:nucleus; IDA:SGD.
DR   GO; GO:0006879; P:intracellular iron ion homeostasis; IMP:SGD.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..93
FT                   /note="Protein LSO1"
FT                   /id="PRO_0000245415"
FT   REGION          1..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          20..83
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        6..73
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   93 AA;  10869 MW;  8E9268AEDD105BF0 CRC64;
     MHNTGKRYSE TAKKVAAGRA RKRRQAYEKD QLEKQQLEAQ EAQRWEEGAR TPNQKKLIME
     QKKTEKLRAK KERDQLLAAE EEALGKGGRG KRY
//