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Protein

N-terminal-borealin-like protein

Gene

NBL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the aurora kinase complex, also called chromosomal passenger complex (CPC), essential for chromosome segregation and metaphase chromosome alignment. Mediates the SLI15-BIR1 interaction within the CPC.1 Publication

GO - Molecular functioni

  • protein binding, bridging Source: SGD

GO - Biological processi

  • chromosome segregation Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31280-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
N-terminal-borealin-like protein
Gene namesi
Name:NBL1
Ordered Locus Names:YHR199C-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR199C-A.
SGDiS000029704. NBL1.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasmcytoskeletonspindle 1 Publication

  • Note: In G1, localizes along nuclear microtubules and at spindle poles. In late S phase to metaphase, is seen as a few small nuclear foci and also localizes diffusely within the nucleus. Also found along the spindle in early anaphase, at the spindle midzone in late anaphase, and finally concentrated at the plus ends of depolymerizing microtubules before mitotic exit.

GO - Cellular componenti

  • chromosome passenger complex Source: SGD
  • cytoplasm Source: UniProtKB-KW
  • nucleus Source: UniProtKB-SubCell
  • spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7373N-terminal-borealin-like proteinPRO_0000245397Add
BLAST

Proteomic databases

MaxQBiQ3E7Y6.

Interactioni

Subunit structurei

Component of the aurora kinase complex composed of at least BIR1, BNL1, IPL1 and SLI15.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BIR1P471345EBI-9513736,EBI-3648
SLI15P382835EBI-9513736,EBI-20842

GO - Molecular functioni

  • protein binding, bridging Source: SGD

Protein-protein interaction databases

BioGridi37086. 3 interactions.
IntActiQ3E7Y6. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ3E7Y6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the borealin family.Curated

Phylogenomic databases

OrthoDBiEOG092C5VLZ.

Sequencei

Sequence statusi: Complete.

Q3E7Y6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPALTPEER QKLRSAILHR MQLELETTEK LIENIKEETL KKLNLLQQPD
60 70
ATSAPQSKEL IREVLEQEGR RIE
Length:73
Mass (Da):8,547
Last modified:November 8, 2005 - v1
Checksum:i470C704C05F62FBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00030 Genomic DNA. No translation available.
BK006934 Genomic DNA. Translation: DAA06892.1.
RefSeqiNP_976247.1. NM_001184671.1.

Genome annotation databases

EnsemblFungiiYHR199C-A; YHR199C-A; YHR199C-A.
GeneIDi2746858.
KEGGisce:YHR199C-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00030 Genomic DNA. No translation available.
BK006934 Genomic DNA. Translation: DAA06892.1.
RefSeqiNP_976247.1. NM_001184671.1.

3D structure databases

ProteinModelPortaliQ3E7Y6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi37086. 3 interactions.
IntActiQ3E7Y6. 3 interactions.

Proteomic databases

MaxQBiQ3E7Y6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR199C-A; YHR199C-A; YHR199C-A.
GeneIDi2746858.
KEGGisce:YHR199C-A.

Organism-specific databases

EuPathDBiFungiDB:YHR199C-A.
SGDiS000029704. NBL1.

Phylogenomic databases

OrthoDBiEOG092C5VLZ.

Enzyme and pathway databases

BioCyciYEAST:G3O-31280-MONOMER.

Miscellaneous databases

PROiQ3E7Y6.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiNBL1_YEAST
AccessioniPrimary (citable) accession number: Q3E7Y6
Secondary accession number(s): D3DLE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 8, 2005
Last modified: September 7, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.