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Protein

40S ribosomal protein S22-B

Gene

RPS22B

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

Present with 19700 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for uS8 in yeast.Curated

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-32436-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-SCE-72702. Ribosomal scanning and start codon recognition.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S22-B1 Publication
Alternative name(s):
RP50
S24
Small ribosomal subunit protein uS8-B1 Publication
YP58
YS22
Gene namesi
Name:RPS22B1 Publication
Synonyms:RPS24B
Ordered Locus Names:YLR367W
ORF Names:L8039.6
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR367W.
SGDiS000004359. RPS22B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001266241 – 13040S ribosomal protein S22-BAdd BLAST130

Proteomic databases

MaxQBiQ3E7Y3.
PRIDEiQ3E7Y3.
TopDownProteomicsiQ3E7Y3.

Interactioni

Subunit structurei

Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridi31627. 128 interactors.
IntActiQ3E7Y3. 35 interactors.
MINTiMINT-8285374.
STRINGi4932.YLR367W.

Structurei

3D structure databases

ProteinModelPortaliQ3E7Y3.
SMRiQ3E7Y3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000003021.
HOGENOMiHOG000204097.
InParanoidiQ3E7Y3.
KOiK02957.
OMAiYIVMTTS.
OrthoDBiEOG092C5DJJ.

Family and domain databases

HAMAPiMF_01302_A. Ribosomal_S8_A. 1 hit.
InterProiView protein in InterPro
IPR000630. Ribosomal_S8.
PANTHERiPTHR11758. PTHR11758. 1 hit.
PfamiView protein in Pfam
PF00410. Ribosomal_S8. 1 hit.
SUPFAMiSSF56047. SSF56047. 1 hit.
PROSITEiView protein in PROSITE
PS00053. RIBOSOMAL_S8. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3E7Y3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRSSVLADA LNAINNAEKT GKRQVLLRPS SKVIIKFLQV MQKHGYIGEF
60 70 80 90 100
EYIDDHRSGK IVVQLNGRLN KCGVISPRFN VKIGDIEKWT ANLLPARQFG
110 120 130
YVILTTSAGI MDHEEARRKH VSGKILGFVY
Length:130
Mass (Da):14,626
Last modified:January 23, 2007 - v3
Checksum:iED71AAA7E0546DCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19103 Genomic DNA. Translation: AAB67567.1.
BK006945 Genomic DNA. Translation: DAA09670.1.
PIRiS51385.
RefSeqiNP_013471.1. NM_001182256.1.

Genome annotation databases

EnsemblFungiiYLR367W; YLR367W; YLR367W.
GeneIDi851082.
KEGGisce:YLR367W.

Similar proteinsi

Entry informationi

Entry nameiRS22B_YEAST
AccessioniPrimary (citable) accession number: Q3E7Y3
Secondary accession number(s): D6VZ04, P04648
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 99 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names