Reviewed, UniProtKB/Swiss-Prot Q3E7X8 (YE077_YEAST)

Names and origin

Protein names

Recommended name:
    Y' element ATP-dependent helicase YEL077C
    EC=3.6.1.-

Gene names

Ordered Locus Names:

YEL077C

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	1277 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance. Ref.2
Induction	Induced in absence of telomerase TLC1. Ref.2
Sequence similarities	Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Helicase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent helicase activity Inferred from electronic annotation. Source: InterPro nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1277	1277	Y' element ATP-dependent helicase YEL077C		PRO_0000268166
Regions
	Domain	222 – 399	178	Helicase ATP-binding
	Domain	454 – 605	152	Helicase C-terminal
	Nucleotide binding	235 – 242	8	ATP By similarity
	Motif	345 – 348	4	DEAH box
	Compositional bias	683 – 875	193	Thr-rich

Sequences

	Sequence		Length	Mass (Da)
	Q3E7X8-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 430F1585F29AFD27	FASTA	1,277	143,092
	10 20 30 40 50 60 MTLGNSYDAF NHDPWMDVVG FEDPNQVTNR DISRIVLYSY MFLNTAKGCL VEYATFRQYM 70 80 90 100 110 120 RELPKNAPQK LNFREMRQGL IALGRHCVGS RFETDLYESA TSELMANHSV QTGRNIYGVD 130 140 150 160 170 180 SFSLTSVSGT TATLLQERAS ERWIQWLGLE SDYHCSFSST RNAEDVVAGE AASSDHHQKI 190 200 210 220 230 240 SRVTRKRPRE PKSTNDILVA GQKLFGSSFE FRDLHQLRLC YEIYMADTPS VAVQAPPGYG 250 260 270 280 290 300 KTELFHLPLI ALASKGDVKY VSFLFVPYTV LLANCMIRLG RCGCLNVAPV RNFIEEGYDG 310 320 330 340 350 360 VTDLYVGIYD DLASTNFTDR IAAWENIVEC TFRTNNVKLG YLIVDEFHNF ETEVYRQSQF 370 380 390 400 410 420 GGITNLDFDA FEKAIFLSGT APEAVADAAL QRIGLTGLAK KSMDINELKR SEDLSRGLSS 430 440 450 460 470 480 YPTRMFNLIK EKSEVPLGHV HKIRKKVESQ PEEALKLLLA LFESEPESKA IVVASTTNEV 490 500 510 520 530 540 EELACSWRKY FRVVWIHGKL DAAEKVSRTK EFVTDGNMRV LIGTKLVTEG IDIKQLMMVI 550 560 570 580 590 600 MLDNRLNIIE LIQGVGRLRD GGLCYLLSRK NSWAARNRKG ELPPIKEGCI TEQVREFYGL 610 620 630 640 650 660 ESKKGKKGQH VGCCGSRTDL SADTVELIER MDRLAEKQAT ASMSIVALPS NFQESNSSDR 670 680 690 700 710 720 YRKYCSSDED SNTCIHGSAN ASTNASTNAI TTASTNVRTN ATTNASTNAT TNASTNATTN 730 740 750 760 770 780 SSTNATTTAS TNVRTSATTT ASINVRTSAT TTESTNSSTN ATTTASINVR TSATTTKSIN 790 800 810 820 830 840 SSTNATITES TNSNTNATTT ESTNSKTSAT TTASTNSNTS ATTTESTNSK TSATTTASTN 850 860 870 880 890 900 SNTSATTTES TNSNTSATTT ASTNSSTNAT TTESTNASAK EDANKDGNAE DNRFHPVTDI 910 920 930 940 950 960 NKESYKRKGS QMVLLERKKL KAQFPNTSEN MNVLQFLGFR SDEIKHLFLY GIDIYFCPEG 970 980 990 1000 1010 1020 VFTQYGLCKG CQKMFELCVC WAGQKVSYRR MAWEALAVER MLRNDEEYKE YLEDIEPYHG 1030 1040 1050 1060 1070 1080 DPVGYLKYFS VKRREIYSQI QRNYAWYLAI TRRRETISVL DSTRGKQGSQ VFRMSGRQIK 1090 1100 1110 1120 1130 1140 ELYYKVWSNL RESKTEVLQY FLNWDEKKCQ EEWEAKDDTV FVEALEKVGV FQRLRSMTSA 1150 1160 1170 1180 1190 1200 GLQGPQYVKL QFSRHHRQLR SRYELSLGMH LRDQIALGVT PSKVPHWTAF LSMLIGLFYN 1210 1220 1230 1240 1250 1260 KTFRQKLEYL LEQISEVWLL PHWLDLANVE VLAADNTKVP LYMLMVAVHK ELDSDDVPDG 1270 RFDIILLCRD SSREVGE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W. Nature 387:78-81(1997) [PubMed: 9169868] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase." Yamada M., Hayatsu N., Matsuura A., Ishikawa F. J. Biol. Chem. 273:33360-33366(1998) [PubMed: 9837911] [Abstract] Cited for: FUNCTION, INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U73806 Genomic DNA. No translation available.
RefSeq	NP_010835.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3E7X8.
Genome annotation databases
Ensembl	YEL077C; YEL077C; YEL077C; Saccharomyces cerevisiae. [Genome view]
GeneID	856630.
KEGG	sce:YEL077C.
NMPDR	fig|4932.3.peg.1882.
Organism-specific databases
CYGD	YEL077c.
SGD	S000006409. YEL077C.
Phylogenomic databases
HOGENOM	Q3E7X8.
OrthoDB	EOG97WQ52
Gene expression databases
Genevestigator	Q3E7X8.
Family and domain databases
InterPro	IPR014001. DEAD-like_N. IPR001650. DNA/RNA_helicase_C. IPR011545. DNA/RNA_helicase_DEAD/DEAH_N. [Graphical view]
Pfam	PF00270. DEAD. 1 hit. PF00271. Helicase_C. 1 hit. [Graphical view]
SMART	SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. [Graphical view]
PROSITE	PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	982577.

Entry information

Entry name

YE077_YEAST

Accession

Primary (citable) accession number: Q3E7X8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	November 8, 2005
Last modified:	November 24, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)