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Q3E7B6

- VA0E_YEAST

UniProt

Q3E7B6 - VA0E_YEAST

Protein

V-type proton ATPase subunit e

Gene

VMA9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Subunit of the integral membrane V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.1 Publication

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of ions Source: SGD
    2. hydrogen ion transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. ATP hydrolysis coupled proton transport Source: InterPro
    2. cell growth Source: UniProtKB
    3. cell wall mannoprotein biosynthetic process Source: SGD
    4. protein complex assembly Source: SGD
    5. transmembrane transport Source: SGD
    6. vacuolar acidification Source: SGD

    Keywords - Biological processi

    Hydrogen ion transport, Ion transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29423-MONOMER.

    Protein family/group databases

    TCDBi3.A.2.2.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-type proton ATPase subunit e
    Short name:
    V-ATPase subunit e
    Alternative name(s):
    Low dye-binding protein 10
    Vacuolar proton pump subunit e
    Gene namesi
    Name:VMA9
    Synonyms:CWH36, LDB10
    Ordered Locus Names:YCL005W-A
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome III

    Organism-specific databases

    CYGDiYCL005w-a.
    SGDiS000028508. VMA9.

    Subcellular locationi

    Vacuole membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. fungal-type vacuole membrane Source: SGD
    2. integral component of membrane Source: UniProtKB-KW
    3. vacuolar proton-transporting V-type ATPase, V0 domain Source: SGD

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7373V-type proton ATPase subunit ePRO_0000071737Add
    BLAST

    Proteomic databases

    PaxDbiQ3E7B6.

    Expressioni

    Gene expression databases

    GenevestigatoriQ3E7B6.

    Interactioni

    Subunit structurei

    V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d and e).1 Publication

    Protein-protein interaction databases

    BioGridi37085. 223 interactions.
    STRINGi4932.YCL005W-A.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3E7B6.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei36 – 5621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the V-ATPase e1/e2 subunit family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG86391.
    HOGENOMiHOG000000895.
    OMAiLMWAITF.
    OrthoDBiEOG7GXPRB.

    Family and domain databases

    InterProiIPR008389. ATPase_V0-cplx_e1/e2_su.
    [Graphical view]
    PANTHERiPTHR12263. PTHR12263. 1 hit.
    PfamiPF05493. ATP_synt_H. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3E7B6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSFYTVVGV FIVVSAMSVL FWIMAPKNNQ AVWRSTVILT LAMMFLMWAI   50
    TFLCQLHPLV APRRSDLRPE FAE 73
    Length:73
    Mass (Da):8,381
    Last modified:November 8, 2005 - v1
    Checksum:iB1440E10D0D34818
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. No translation available.
    BK006937 Genomic DNA. Translation: DAA07474.1.
    RefSeqiNP_958835.1. NM_001184518.1.

    Genome annotation databases

    EnsemblFungiiYCL005W-A; YCL005W-A; YCL005W-A.
    GeneIDi2732686.
    KEGGisce:YCL005W-A.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. No translation available.
    BK006937 Genomic DNA. Translation: DAA07474.1 .
    RefSeqi NP_958835.1. NM_001184518.1.

    3D structure databases

    ProteinModelPortali Q3E7B6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 37085. 223 interactions.
    STRINGi 4932.YCL005W-A.

    Protein family/group databases

    TCDBi 3.A.2.2.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    Proteomic databases

    PaxDbi Q3E7B6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YCL005W-A ; YCL005W-A ; YCL005W-A .
    GeneIDi 2732686.
    KEGGi sce:YCL005W-A.

    Organism-specific databases

    CYGDi YCL005w-a.
    SGDi S000028508. VMA9.

    Phylogenomic databases

    eggNOGi NOG86391.
    HOGENOMi HOG000000895.
    OMAi LMWAITF.
    OrthoDBi EOG7GXPRB.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29423-MONOMER.

    Miscellaneous databases

    NextBioi 983847.

    Gene expression databases

    Genevestigatori Q3E7B6.

    Family and domain databases

    InterProi IPR008389. ATPase_V0-cplx_e1/e2_su.
    [Graphical view ]
    PANTHERi PTHR12263. PTHR12263. 1 hit.
    Pfami PF05493. ATP_synt_H. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of yeast chromosome III."
      Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
      , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
      Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii."
      Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A., Gates K., Gaffney T.D., Philippsen P.
      Genome Biol. 4:R45.1-R45.13(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: ATCC 204511 / S288c / AB972.
    4. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
      Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
      Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
    5. "Genome-wide analysis of iron-dependent growth reveals a novel yeast gene required for vacuolar acidification."
      Davis-Kaplan S.R., McVey Ward D., Shiflett S.L., Kaplan J.
      J. Biol. Chem. 279:4322-4329(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "The yeast vacuolar proton-translocating ATPase contains a subunit homologous to the Manduca sexta and bovine e subunits that is essential for function."
      Sambade M., Kane P.M.
      J. Biol. Chem. 279:17361-17365(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiVA0E_YEAST
    AccessioniPrimary (citable) accession number: Q3E7B6
    Secondary accession number(s): D6VR05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome III
      Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

    External Data

    Dasty 3