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Q3E7B6

- VA0E_YEAST

UniProt

Q3E7B6 - VA0E_YEAST

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Protein
V-type proton ATPase subunit e
Gene
VMA9, CWH36, LDB10, YCL005W-A
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Subunit of the integral membrane V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.1 Publication

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of ions Source: SGD
  2. hydrogen ion transmembrane transporter activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: InterPro
  2. cell growth Source: UniProtKB
  3. cell wall mannoprotein biosynthetic process Source: SGD
  4. protein complex assembly Source: SGD
  5. transmembrane transport Source: SGD
  6. vacuolar acidification Source: SGD
Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29423-MONOMER.

Protein family/group databases

TCDBi3.A.2.2.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit e
Short name:
V-ATPase subunit e
Alternative name(s):
Low dye-binding protein 10
Vacuolar proton pump subunit e
Gene namesi
Name:VMA9
Synonyms:CWH36, LDB10
Ordered Locus Names:YCL005W-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome III

Organism-specific databases

CYGDiYCL005w-a.
SGDiS000028508. VMA9.

Subcellular locationi

Vacuole membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421Helical; Reviewed prediction
Add
BLAST
Transmembranei36 – 5621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. fungal-type vacuole membrane Source: SGD
  2. integral component of membrane Source: UniProtKB-KW
  3. vacuolar proton-transporting V-type ATPase, V0 domain Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7373V-type proton ATPase subunit e
PRO_0000071737Add
BLAST

Proteomic databases

PaxDbiQ3E7B6.

Expressioni

Gene expression databases

GenevestigatoriQ3E7B6.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d and e).1 Publication

Protein-protein interaction databases

BioGridi37085. 223 interactions.
STRINGi4932.YCL005W-A.

Structurei

3D structure databases

ProteinModelPortaliQ3E7B6.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG86391.
HOGENOMiHOG000000895.
OMAiLMWAITF.
OrthoDBiEOG7GXPRB.

Family and domain databases

InterProiIPR008389. ATPase_V0-cplx_e1/e2_su.
[Graphical view]
PANTHERiPTHR12263. PTHR12263. 1 hit.
PfamiPF05493. ATP_synt_H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3E7B6-1 [UniParc]FASTAAdd to Basket

« Hide

MSSFYTVVGV FIVVSAMSVL FWIMAPKNNQ AVWRSTVILT LAMMFLMWAI   50
TFLCQLHPLV APRRSDLRPE FAE 73
Length:73
Mass (Da):8,381
Last modified:November 8, 2005 - v1
Checksum:iB1440E10D0D34818
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59720 Genomic DNA. No translation available.
BK006937 Genomic DNA. Translation: DAA07474.1.
RefSeqiNP_958835.1. NM_001184518.1.

Genome annotation databases

EnsemblFungiiYCL005W-A; YCL005W-A; YCL005W-A.
GeneIDi2732686.
KEGGisce:YCL005W-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59720 Genomic DNA. No translation available.
BK006937 Genomic DNA. Translation: DAA07474.1 .
RefSeqi NP_958835.1. NM_001184518.1.

3D structure databases

ProteinModelPortali Q3E7B6.
ModBasei Search...

Protein-protein interaction databases

BioGridi 37085. 223 interactions.
STRINGi 4932.YCL005W-A.

Protein family/group databases

TCDBi 3.A.2.2.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Proteomic databases

PaxDbi Q3E7B6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YCL005W-A ; YCL005W-A ; YCL005W-A .
GeneIDi 2732686.
KEGGi sce:YCL005W-A.

Organism-specific databases

CYGDi YCL005w-a.
SGDi S000028508. VMA9.

Phylogenomic databases

eggNOGi NOG86391.
HOGENOMi HOG000000895.
OMAi LMWAITF.
OrthoDBi EOG7GXPRB.

Enzyme and pathway databases

BioCyci YEAST:G3O-29423-MONOMER.

Miscellaneous databases

NextBioi 983847.

Gene expression databases

Genevestigatori Q3E7B6.

Family and domain databases

InterProi IPR008389. ATPase_V0-cplx_e1/e2_su.
[Graphical view ]
PANTHERi PTHR12263. PTHR12263. 1 hit.
Pfami PF05493. ATP_synt_H. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii."
    Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A., Gates K., Gaffney T.D., Philippsen P.
    Genome Biol. 4:R45.1-R45.13(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 204511 / S288c / AB972.
  4. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
    Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
    Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
  5. "Genome-wide analysis of iron-dependent growth reveals a novel yeast gene required for vacuolar acidification."
    Davis-Kaplan S.R., McVey Ward D., Shiflett S.L., Kaplan J.
    J. Biol. Chem. 279:4322-4329(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "The yeast vacuolar proton-translocating ATPase contains a subunit homologous to the Manduca sexta and bovine e subunits that is essential for function."
    Sambade M., Kane P.M.
    J. Biol. Chem. 279:17361-17365(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiVA0E_YEAST
AccessioniPrimary (citable) accession number: Q3E7B6
Secondary accession number(s): D6VR05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 8, 2005
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3

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