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Protein

V-type proton ATPase subunit e

Gene

VMA9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Subunit of the integral membrane V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.1 Publication

GO - Molecular functioni

  • ATPase coupled ion transmembrane transporter activity Source: SGD
  • proton-transporting ATPase activity, rotational mechanism Source: GO_Central

GO - Biological processi

  • ATP hydrolysis coupled proton transport Source: InterPro
  • cell growth Source: UniProtKB
  • cell wall mannoprotein biosynthetic process Source: SGD
  • protein complex assembly Source: SGD
  • transmembrane transport Source: SGD
  • vacuolar acidification Source: SGD
Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29423-MONOMER.

Protein family/group databases

TCDBi3.A.2.2.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit e
Short name:
V-ATPase subunit e
Alternative name(s):
Low dye-binding protein 10
Vacuolar proton pump subunit e
Gene namesi
Name:VMA9
Synonyms:CWH36, LDB10
Ordered Locus Names:YCL005W-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCL005W-A.
SGDiS000028508. VMA9.

Subcellular locationi

  • Vacuole membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • fungal-type vacuole membrane Source: SGD
  • integral component of membrane Source: UniProtKB-KW
  • vacuolar proton-transporting V-type ATPase, V0 domain Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000717371 – 73V-type proton ATPase subunit eAdd BLAST73

Proteomic databases

PRIDEiQ3E7B6.
TopDownProteomicsiQ3E7B6.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d and e).1 Publication

Protein-protein interaction databases

BioGridi37085. 223 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ3E7B6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase e1/e2 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000000895.
InParanoidiQ3E7B6.
OMAiLMWAITF.
OrthoDBiEOG092C5YH6.

Family and domain databases

InterProiIPR008389. ATPase_V0-cplx_e1/e2_su.
[Graphical view]
PANTHERiPTHR12263. PTHR12263. 1 hit.
PfamiPF05493. ATP_synt_H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3E7B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSFYTVVGV FIVVSAMSVL FWIMAPKNNQ AVWRSTVILT LAMMFLMWAI
60 70
TFLCQLHPLV APRRSDLRPE FAE
Length:73
Mass (Da):8,381
Last modified:November 8, 2005 - v1
Checksum:iB1440E10D0D34818
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. No translation available.
BK006937 Genomic DNA. Translation: DAA07474.1.
RefSeqiNP_958835.1. NM_001184518.1.

Genome annotation databases

EnsemblFungiiYCL005W-A; YCL005W-A; YCL005W-A.
GeneIDi2732686.
KEGGisce:YCL005W-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. No translation available.
BK006937 Genomic DNA. Translation: DAA07474.1.
RefSeqiNP_958835.1. NM_001184518.1.

3D structure databases

ProteinModelPortaliQ3E7B6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi37085. 223 interactors.

Protein family/group databases

TCDBi3.A.2.2.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Proteomic databases

PRIDEiQ3E7B6.
TopDownProteomicsiQ3E7B6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYCL005W-A; YCL005W-A; YCL005W-A.
GeneIDi2732686.
KEGGisce:YCL005W-A.

Organism-specific databases

EuPathDBiFungiDB:YCL005W-A.
SGDiS000028508. VMA9.

Phylogenomic databases

HOGENOMiHOG000000895.
InParanoidiQ3E7B6.
OMAiLMWAITF.
OrthoDBiEOG092C5YH6.

Enzyme and pathway databases

BioCyciYEAST:G3O-29423-MONOMER.

Miscellaneous databases

PROiQ3E7B6.

Family and domain databases

InterProiIPR008389. ATPase_V0-cplx_e1/e2_su.
[Graphical view]
PANTHERiPTHR12263. PTHR12263. 1 hit.
PfamiPF05493. ATP_synt_H. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVA0E_YEAST
AccessioniPrimary (citable) accession number: Q3E7B6
Secondary accession number(s): D6VR05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 8, 2005
Last modified: October 5, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.