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Protein

Cytochrome c oxidase assembly factor 3, mitochondrial

Gene

COA3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for assembly of cytochrome c oxidase (complex IV). With COX14, regulates negatively COX1 translation and is involved in MSS51 association with newly synthesized COX1.4 Publications

Miscellaneous

Present with 2530 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • mitochondrial respiratory chain complex IV assembly Source: SGD
  • negative regulation of mitochondrial translation Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-31802-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly factor 3, mitochondrial
Alternative name(s):
Cytochrome c oxidase protein 25
Required for respiratory growth protein 10
Gene namesi
Name:COA3
Synonyms:COX25, RRG10
Ordered Locus Names:YJL062W-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL062W-A.
SGDiS000007611. COA3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26Mitochondrial matrixAdd BLAST26
Transmembranei27 – 49HelicalSequence analysisAdd BLAST23
Topological domaini50 – 85Mitochondrial intermembraneAdd BLAST36

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002454121 – 85Cytochrome c oxidase assembly factor 3, mitochondrialAdd BLAST85

Proteomic databases

MaxQBiQ3E7B2.
PRIDEiQ3E7B2.

Interactioni

Subunit structurei

Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes composed at least COA3, COX14, COX5A, SHY1 and SSC1. Interacts with COX1 and MSS51.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33691. 200 interactors.
IntActiQ3E7B2. 12 interactors.
MINTiMINT-2492439.
STRINGi4932.YJL062W-A.

Structurei

3D structure databases

ProteinModelPortaliQ3E7B2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COA3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ3E7B2.
KOiK18176.
OMAiFFWRNTI.
OrthoDBiEOG092C5QUH.

Sequencei

Sequence statusi: Complete.

Q3E7B2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLNPSKYQD TRTWKMTPAM IRARKPFFKG NMLGLTLLLG VTGSVYYYTY
60 70 80
HFLHKDNDFA DVPIPPIDPQ ELEALKKEYE AKKKA
Length:85
Mass (Da):9,882
Last modified:November 8, 2005 - v1
Checksum:i41403CD21F898C18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49338 Genomic DNA. No translation available.
BK006943 Genomic DNA. Translation: DAA08735.1.
RefSeqiNP_076894.3. NM_001184477.3.

Genome annotation databases

EnsemblFungiiYJL062W-A; YJL062W-A; YJL062W-A.
GeneIDi853383.
KEGGisce:YJL062W-A.

Similar proteinsi

Entry informationi

Entry nameiCOA3_YEAST
AccessioniPrimary (citable) accession number: Q3E7B2
Secondary accession number(s): D6VWB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 8, 2005
Last modified: September 27, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names