Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q3E7B2

- COA3_YEAST

UniProt

Q3E7B2 - COA3_YEAST

Protein

Cytochrome c oxidase assembly factor 3, mitochondrial

Gene

COA3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Required for assembly of cytochrome c oxidase (complex IV). With COX14, regulates negatively COX1 translation and is involved in MSS51 association with newly synthesized COX1.4 Publications

    GO - Biological processi

    1. mitochondrial respiratory chain complex IV assembly Source: SGD
    2. negative regulation of mitochondrial translation Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31802-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase assembly factor 3, mitochondrial
    Alternative name(s):
    Cytochrome c oxidase protein 25
    Required for respiratory growth protein 10
    Gene namesi
    Name:COA3
    Synonyms:COX25, RRG10
    Ordered Locus Names:YJL062W-A
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJL062w-a.
    SGDiS000007611. COA3.

    Subcellular locationi

    Mitochondrion inner membrane 4 Publications; Single-pass membrane protein 4 Publications

    GO - Cellular componenti

    1. integral component of mitochondrial inner membrane Source: SGD
    2. mitochondrial inner membrane Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8585Cytochrome c oxidase assembly factor 3, mitochondrialPRO_0000245412Add
    BLAST

    Proteomic databases

    MaxQBiQ3E7B2.
    PaxDbiQ3E7B2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ3E7B2.

    Interactioni

    Subunit structurei

    Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes composed at least COA3, COX14, COX5A, SHY1 and SSC1. Interacts with COX1 and MSS51.2 Publications

    Protein-protein interaction databases

    BioGridi33691. 17 interactions.
    MINTiMINT-2492439.
    STRINGi4932.YJL062W-A.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3E7B2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626Mitochondrial matrixAdd
    BLAST
    Topological domaini50 – 8536Mitochondrial intermembraneAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4923HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the COA3 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG81147.
    KOiK18176.
    OMAiFFWRNTI.
    OrthoDBiEOG7Z3FJ7.

    Sequencei

    Sequence statusi: Complete.

    Q3E7B2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLNPSKYQD TRTWKMTPAM IRARKPFFKG NMLGLTLLLG VTGSVYYYTY   50
    HFLHKDNDFA DVPIPPIDPQ ELEALKKEYE AKKKA 85
    Length:85
    Mass (Da):9,882
    Last modified:November 8, 2005 - v1
    Checksum:i41403CD21F898C18
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49338 Genomic DNA. No translation available.
    BK006943 Genomic DNA. Translation: DAA08735.1.
    RefSeqiNP_076894.3. NM_001184477.3.

    Genome annotation databases

    EnsemblFungiiYJL062W-A; YJL062W-A; YJL062W-A.
    GeneIDi853383.
    KEGGisce:YJL062W-A.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49338 Genomic DNA. No translation available.
    BK006943 Genomic DNA. Translation: DAA08735.1 .
    RefSeqi NP_076894.3. NM_001184477.3.

    3D structure databases

    ProteinModelPortali Q3E7B2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33691. 17 interactions.
    MINTi MINT-2492439.
    STRINGi 4932.YJL062W-A.

    Proteomic databases

    MaxQBi Q3E7B2.
    PaxDbi Q3E7B2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJL062W-A ; YJL062W-A ; YJL062W-A .
    GeneIDi 853383.
    KEGGi sce:YJL062W-A.

    Organism-specific databases

    CYGDi YJL062w-a.
    SGDi S000007611. COA3.

    Phylogenomic databases

    eggNOGi NOG81147.
    KOi K18176.
    OMAi FFWRNTI.
    OrthoDBi EOG7Z3FJ7.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31802-MONOMER.

    Miscellaneous databases

    NextBioi 973840.

    Gene expression databases

    Genevestigatori Q3E7B2.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Functional genomics of genes with small open reading frames (sORFs) in S. cerevisiae."
      Kastenmayer J.P., Ni L., Chu A., Kitchen L.E., Au W.-C., Yang H., Carter C.D., Wheeler D., Davis R.W., Boeke J.D., Snyder M.A., Basrai M.A.
      Genome Res. 16:365-373(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics."
      Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.
      J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    8. "Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae."
      Merz S., Westermann B.
      Genome Biol. 10:R95.1-R95.18(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "Coa3 and Cox14 are essential for negative feedback regulation of COX1 translation in mitochondria."
      Mick D.U., Vukotic M., Piechura H., Meyer H.E., Warscheid B., Deckers M., Rehling P.
      J. Cell Biol. 191:141-154(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN COA COMPLEXES, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH SHY1; COX1 AND MSS51, SUBCELLULAR LOCATION, TOPOLOGY, FUNCTION.
    10. "Cox25 teams up with Mss51, Ssc1, and Cox14 to regulate mitochondrial cytochrome c oxidase subunit 1 expression and assembly in Saccharomyces cerevisiae."
      Fontanesi F., Clemente P., Barrientos A.
      J. Biol. Chem. 286:555-566(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN COA COMPLEXES, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH COX1, SUBCELLULAR LOCATION, TOPOLOGY, FUNCTION.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCOA3_YEAST
    AccessioniPrimary (citable) accession number: Q3E7B2
    Secondary accession number(s): D6VWB9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2530 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3