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Q3E7B2

- COA3_YEAST

UniProt

Q3E7B2 - COA3_YEAST

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Protein

Cytochrome c oxidase assembly factor 3, mitochondrial

Gene

COA3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Required for assembly of cytochrome c oxidase (complex IV). With COX14, regulates negatively COX1 translation and is involved in MSS51 association with newly synthesized COX1.4 Publications

GO - Biological processi

  1. mitochondrial respiratory chain complex IV assembly Source: SGD
  2. negative regulation of mitochondrial translation Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31802-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly factor 3, mitochondrial
Alternative name(s):
Cytochrome c oxidase protein 25
Required for respiratory growth protein 10
Gene namesi
Name:COA3
Synonyms:COX25, RRG10
Ordered Locus Names:YJL062W-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJL062w-a.
SGDiS000007611. COA3.

Subcellular locationi

Mitochondrion inner membrane 4 Publications; Single-pass membrane protein 4 Publications

GO - Cellular componenti

  1. integral component of mitochondrial inner membrane Source: SGD
  2. mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8585Cytochrome c oxidase assembly factor 3, mitochondrialPRO_0000245412Add
BLAST

Proteomic databases

MaxQBiQ3E7B2.
PaxDbiQ3E7B2.

Expressioni

Gene expression databases

GenevestigatoriQ3E7B2.

Interactioni

Subunit structurei

Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes composed at least COA3, COX14, COX5A, SHY1 and SSC1. Interacts with COX1 and MSS51.2 Publications

Protein-protein interaction databases

BioGridi33691. 17 interactions.
MINTiMINT-2492439.
STRINGi4932.YJL062W-A.

Structurei

3D structure databases

ProteinModelPortaliQ3E7B2.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Mitochondrial matrixAdd
BLAST
Topological domaini50 – 8536Mitochondrial intermembraneAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4923HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the COA3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG81147.
InParanoidiQ3E7B2.
KOiK18176.
OMAiFFWRNTI.
OrthoDBiEOG7Z3FJ7.

Sequencei

Sequence statusi: Complete.

Q3E7B2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLNPSKYQD TRTWKMTPAM IRARKPFFKG NMLGLTLLLG VTGSVYYYTY
60 70 80
HFLHKDNDFA DVPIPPIDPQ ELEALKKEYE AKKKA
Length:85
Mass (Da):9,882
Last modified:November 8, 2005 - v1
Checksum:i41403CD21F898C18
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49338 Genomic DNA. No translation available.
BK006943 Genomic DNA. Translation: DAA08735.1.
RefSeqiNP_076894.3. NM_001184477.3.

Genome annotation databases

EnsemblFungiiYJL062W-A; YJL062W-A; YJL062W-A.
GeneIDi853383.
KEGGisce:YJL062W-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49338 Genomic DNA. No translation available.
BK006943 Genomic DNA. Translation: DAA08735.1 .
RefSeqi NP_076894.3. NM_001184477.3.

3D structure databases

ProteinModelPortali Q3E7B2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33691. 17 interactions.
MINTi MINT-2492439.
STRINGi 4932.YJL062W-A.

Proteomic databases

MaxQBi Q3E7B2.
PaxDbi Q3E7B2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJL062W-A ; YJL062W-A ; YJL062W-A .
GeneIDi 853383.
KEGGi sce:YJL062W-A.

Organism-specific databases

CYGDi YJL062w-a.
SGDi S000007611. COA3.

Phylogenomic databases

eggNOGi NOG81147.
InParanoidi Q3E7B2.
KOi K18176.
OMAi FFWRNTI.
OrthoDBi EOG7Z3FJ7.

Enzyme and pathway databases

BioCyci YEAST:G3O-31802-MONOMER.

Miscellaneous databases

NextBioi 973840.

Gene expression databases

Genevestigatori Q3E7B2.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Functional genomics of genes with small open reading frames (sORFs) in S. cerevisiae."
    Kastenmayer J.P., Ni L., Chu A., Kitchen L.E., Au W.-C., Yang H., Carter C.D., Wheeler D., Davis R.W., Boeke J.D., Snyder M.A., Basrai M.A.
    Genome Res. 16:365-373(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics."
    Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.
    J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  8. "Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae."
    Merz S., Westermann B.
    Genome Biol. 10:R95.1-R95.18(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Coa3 and Cox14 are essential for negative feedback regulation of COX1 translation in mitochondria."
    Mick D.U., Vukotic M., Piechura H., Meyer H.E., Warscheid B., Deckers M., Rehling P.
    J. Cell Biol. 191:141-154(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN COA COMPLEXES, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH SHY1; COX1 AND MSS51, SUBCELLULAR LOCATION, TOPOLOGY, FUNCTION.
  10. "Cox25 teams up with Mss51, Ssc1, and Cox14 to regulate mitochondrial cytochrome c oxidase subunit 1 expression and assembly in Saccharomyces cerevisiae."
    Fontanesi F., Clemente P., Barrientos A.
    J. Biol. Chem. 286:555-566(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN COA COMPLEXES, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH COX1, SUBCELLULAR LOCATION, TOPOLOGY, FUNCTION.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOA3_YEAST
AccessioniPrimary (citable) accession number: Q3E7B2
Secondary accession number(s): D6VWB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 8, 2005
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2530 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3