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Q3E7B2 (COA3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase assembly factor 3, mitochondrial
Alternative name(s):
Cytochrome c oxidase protein 25
Required for respiratory growth protein 10
Gene names
Name:COA3
Synonyms:COX25, RRG10
Ordered Locus Names:YJL062W-A
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length85 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for assembly of cytochrome c oxidase (complex IV). With COX14, regulates negatively COX1 translation and is involved in MSS51 association with newly synthesized COX1. Ref.6 Ref.8 Ref.9 Ref.10

Subunit structure

Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes composed at least COA3, COX14, COX5A, SHY1 and SSC1. Interacts with COX1 and MSS51. Ref.9 Ref.10

Subcellular location

Mitochondrion inner membrane; Single-pass membrane protein Ref.4 Ref.7 Ref.9 Ref.10.

Miscellaneous

Present with 2530 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the COA3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 8585Cytochrome c oxidase assembly factor 3, mitochondrial
PRO_0000245412

Regions

Topological domain1 – 2626Mitochondrial matrix Ref.9 Ref.10
Transmembrane27 – 4923Helical; Potential
Topological domain50 – 8536Mitochondrial intermembrane Ref.9 Ref.10

Sequences

Sequence LengthMass (Da)Tools
Q3E7B2 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 41403CD21F898C18

FASTA859,882
        10         20         30         40         50         60 
MVLNPSKYQD TRTWKMTPAM IRARKPFFKG NMLGLTLLLG VTGSVYYYTY HFLHKDNDFA 

        70         80 
DVPIPPIDPQ ELEALKKEYE AKKKA 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Genomic exploration of the hemiascomycetous yeasts: 4. The genome of Saccharomyces cerevisiae revisited."
Blandin G., Durrens P., Tekaia F., Aigle M., Bolotin-Fukuhara M., Bon E., Casaregola S., de Montigny J., Gaillardin C., Lepingle A., Llorente B., Malpertuy A., Neuveglise C., Ozier-Kalogeropoulos O., Perrin A., Potier S., Souciet J.-L., Talla E. expand/collapse author list , Toffano-Nioche C., Wesolowski-Louvel M., Marck C., Dujon B.
FEBS Lett. 487:31-36(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Functional genomics of genes with small open reading frames (sORFs) in S. cerevisiae."
Kastenmayer J.P., Ni L., Chu A., Kitchen L.E., Au W.-C., Yang H., Carter C.D., Wheeler D., Davis R.W., Boeke J.D., Snyder M.A., Basrai M.A.
Genome Res. 16:365-373(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics."
Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.
J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[8]"Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae."
Merz S., Westermann B.
Genome Biol. 10:R95.1-R95.18(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[9]"Coa3 and Cox14 are essential for negative feedback regulation of COX1 translation in mitochondria."
Mick D.U., Vukotic M., Piechura H., Meyer H.E., Warscheid B., Deckers M., Rehling P.
J. Cell Biol. 191:141-154(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN COA COMPLEXES, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH SHY1; COX1 AND MSS51, SUBCELLULAR LOCATION, TOPOLOGY, FUNCTION.
[10]"Cox25 teams up with Mss51, Ssc1, and Cox14 to regulate mitochondrial cytochrome c oxidase subunit 1 expression and assembly in Saccharomyces cerevisiae."
Fontanesi F., Clemente P., Barrientos A.
J. Biol. Chem. 286:555-566(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN COA COMPLEXES, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH COX1, SUBCELLULAR LOCATION, TOPOLOGY, FUNCTION.
[11]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z49338 Genomic DNA. No translation available.
BK006943 Genomic DNA. Translation: DAA08735.1.
RefSeqNP_076894.3. NM_001184477.3.

3D structure databases

ProteinModelPortalQ3E7B2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33691. 17 interactions.
MINTMINT-2492439.
STRING4932.YJL062W-A.

Proteomic databases

PaxDbQ3E7B2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYJL062W-A; YJL062W-A; YJL062W-A.
GeneID853383.
KEGGsce:YJL062W-A.

Organism-specific databases

CYGDYJL062w-a.
SGDS000007611. YJL062W-A.

Phylogenomic databases

eggNOGNOG81147.
OMAFFWRNTI.
OrthoDBEOG7Z3FJ7.

Enzyme and pathway databases

BioCycYEAST:G3O-31802-MONOMER.

Gene expression databases

GenevestigatorQ3E7B2.

Family and domain databases

ProtoNetSearch...

Other

NextBio973840.

Entry information

Entry nameCOA3_YEAST
AccessionPrimary (citable) accession number: Q3E7B2
Secondary accession number(s): D6VWB9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 8, 2005
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families