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Protein

Cytochrome c oxidase assembly factor 3, mitochondrial

Gene

COA3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for assembly of cytochrome c oxidase (complex IV). With COX14, regulates negatively COX1 translation and is involved in MSS51 association with newly synthesized COX1.4 Publications

GO - Biological processi

  • mitochondrial respiratory chain complex IV assembly Source: SGD
  • negative regulation of mitochondrial translation Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31802-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly factor 3, mitochondrial
Alternative name(s):
Cytochrome c oxidase protein 25
Required for respiratory growth protein 10
Gene namesi
Name:COA3
Synonyms:COX25, RRG10
Ordered Locus Names:YJL062W-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL062W-A.
SGDiS000007611. COA3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Mitochondrial matrixAdd
BLAST
Transmembranei27 – 4923HelicalSequence analysisAdd
BLAST
Topological domaini50 – 8536Mitochondrial intermembraneAdd
BLAST

GO - Cellular componenti

  • integral component of mitochondrial inner membrane Source: SGD
  • mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8585Cytochrome c oxidase assembly factor 3, mitochondrialPRO_0000245412Add
BLAST

Proteomic databases

MaxQBiQ3E7B2.

Interactioni

Subunit structurei

Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes composed at least COA3, COX14, COX5A, SHY1 and SSC1. Interacts with COX1 and MSS51.2 Publications

Protein-protein interaction databases

BioGridi33691. 19 interactions.
IntActiQ3E7B2. 1 interaction.
MINTiMINT-2492439.

Structurei

3D structure databases

ProteinModelPortaliQ3E7B2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COA3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ3E7B2.
KOiK18176.
OMAiFFWRNTI.
OrthoDBiEOG092C5QUH.

Sequencei

Sequence statusi: Complete.

Q3E7B2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLNPSKYQD TRTWKMTPAM IRARKPFFKG NMLGLTLLLG VTGSVYYYTY
60 70 80
HFLHKDNDFA DVPIPPIDPQ ELEALKKEYE AKKKA
Length:85
Mass (Da):9,882
Last modified:November 8, 2005 - v1
Checksum:i41403CD21F898C18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49338 Genomic DNA. No translation available.
BK006943 Genomic DNA. Translation: DAA08735.1.
RefSeqiNP_076894.3. NM_001184477.3.

Genome annotation databases

EnsemblFungiiYJL062W-A; YJL062W-A; YJL062W-A.
GeneIDi853383.
KEGGisce:YJL062W-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49338 Genomic DNA. No translation available.
BK006943 Genomic DNA. Translation: DAA08735.1.
RefSeqiNP_076894.3. NM_001184477.3.

3D structure databases

ProteinModelPortaliQ3E7B2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33691. 19 interactions.
IntActiQ3E7B2. 1 interaction.
MINTiMINT-2492439.

Proteomic databases

MaxQBiQ3E7B2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL062W-A; YJL062W-A; YJL062W-A.
GeneIDi853383.
KEGGisce:YJL062W-A.

Organism-specific databases

EuPathDBiFungiDB:YJL062W-A.
SGDiS000007611. COA3.

Phylogenomic databases

InParanoidiQ3E7B2.
KOiK18176.
OMAiFFWRNTI.
OrthoDBiEOG092C5QUH.

Enzyme and pathway databases

BioCyciYEAST:G3O-31802-MONOMER.

Miscellaneous databases

PROiQ3E7B2.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCOA3_YEAST
AccessioniPrimary (citable) accession number: Q3E7B2
Secondary accession number(s): D6VWB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 8, 2005
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2530 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.