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Q3E7A4 (CMC2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cx9C motif-Containing protein 2
Alternative name(s):
Mitochondrial metallochaperone-like protein CMC2
Gene names
Name:CMC2
Ordered Locus Names:YBL059C-A
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length109 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration. May be involved in copper trafficking and distribution to mitochondrial COX and SOD1. Ref.5 Ref.6

Subunit structure

Interacts with CMC1. Ref.6

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note: Imported in the mitochondrion inner membrane space by the MIA40-ERV1 machinery. Ref.5 Ref.6

Miscellaneous

Present with 279 molecules/cell in log phase SD medium. Ref.4

Sequence similarities

Belongs to the CMC1 family.

Contains 1 CHCH domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SLU7Q027751EBI-2088942,EBI-17379

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 109109Cx9C motif-Containing protein 2
PRO_0000248414

Regions

Domain6 – 4944CHCH

Sequences

Sequence LengthMass (Da)Tools
Q3E7A4 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 5D740EFEC60E5E5F

FASTA10912,947
        10         20         30         40         50         60 
MHPQLEAERF HSCLDFINAL DKCHQKEYYK RIFGLCNNEK DALNKCLKEA SLNNKKRAVI 

        70         80         90        100 
ESRIKRADVE KRWKKIEEEE YGEDAILKTI LDRQYAKKKQ ESDNDANSK 

« Hide

References

« Hide 'large scale' references
[1]"Sequencing and functional analysis of a 32,560 bp segment on the left arm of yeast chromosome II. Identification of 26 open reading frames, including the KIP1 and SEC17 genes."
Scherens B., el Bakkoury M., Vierendeels F., Dubois E., Messenguy F.
Yeast 9:1355-1371(1993) [PubMed: 8154187] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Complete DNA sequence of yeast chromosome II."
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. expand/collapse author list , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
EMBO J. 13:5795-5809(1994) [PubMed: 7813418] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: S288c / YPH1.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"Systematic analysis of the twin cx(9)c protein family."
Longen S., Bien M., Bihlmaier K., Kloeppel C., Kauff F., Hammermeister M., Westermann B., Herrmann J.M., Riemer J.
J. Mol. Biol. 393:356-368(2009) [PubMed: 19703468] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[6]"The conserved mitochondrial twin Cx9C protein Cmc2 Is a Cmc1 homologue essential for cytochrome c oxidase biogenesis."
Horn D., Zhou W., Trevisson E., Al-Ali H., Harris T.K., Salviati L., Barrientos A.
J. Biol. Chem. 285:15088-15099(2010) [PubMed: 20220131] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CMC1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z23261 Genomic DNA. No translation available.
Z35821 Genomic DNA. No translation available.
BK006936 Genomic DNA. Translation: DAA07060.1.
RefSeqNP_031358.1. NM_001184440.1.

3D structure databases

ProteinModelPortalQ3E7A4.
ModBaseSearch...

Protein-protein interaction databases

IntActQ3E7A4. 1 interaction.
MINTMINT-4476311.
STRINGQ3E7A4.

Proteomic databases

PeptideAtlasQ3E7A4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYBL059C-A; YBL059C-A; YBL059C-A.
GeneID852220.
KEGGsce:YBL059C-A.
NMPDRfig|4932.3.peg.183.

Organism-specific databases

CYGDYBL059c-a.
SGDS000007488. CMC2.

Phylogenomic databases

eggNOGfuNOG11703.
GeneTreeEFGT00050000006668.
HOGENOMHBG397763.
OMAALEECHR.
OrthoDBEOG4RFQ39.

Gene expression databases

ArrayExpressQ3E7A4.
GenevestigatorQ3E7A4.

Family and domain databases

InterProIPR013892. Cyt_c_biogenesis_Cmc1-like.
[Graphical view]
PfamPF08583. Cmc1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio970736.

Entry information

Entry nameCMC2_YEAST
AccessionPrimary (citable) accession number: Q3E7A4
Secondary accession number(s): D6VPU0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: November 8, 2005
Last modified: December 14, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome II

Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

SIMILARITY comments

Index of protein domains and families