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Protein

BolA-like protein 1

Gene

BOL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates [4Fe-4S] cluster insertion into a subset of mitochondrial proteins such as LIAS and succinate dehydrogenase (SDH) (PubMed:27532772). Required during the last step of iron-sulfur protein assembly when the iron-sulfur cluster is inserted into the target protein (PubMed:27532772). Probably acts together with the monothiol glutaredoxin GRX5, earlier than BOL3 and NFU1 in the [4Fe-4S] cluster insertion process (PubMed:27532773). Not required for [2Fe-2S] cluster insertion into mitochondrial proteins (PubMed:27532772).2 Publications

Miscellaneous

Present with 238 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • iron-sulfur cluster assembly Source: SGD
  • protein maturation by iron-sulfur cluster transfer Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-28901-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
BolA-like protein 1Curated
Gene namesi
Name:BOL12 Publications
Ordered Locus Names:YAL044W-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL044W-A
SGDiS000007586 BOL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Disruption phenotypei

No visible phenotype (PubMed:27532773, PubMed:27532772). Cells lacking BOL1 and BOL3 display defects in a subset of mitochondrial [4Fe-4S] enzymes (PubMed:27532772).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi56H → A: No effect. 1 Publication1
Mutagenesisi56H → C: Partial loss of function. 1 Publication1
Mutagenesisi93H → A or C: Loss of function. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002484091 – 110BolA-like protein 1Add BLAST110

Proteomic databases

MaxQBiQ3E793
PaxDbiQ3E793
PRIDEiQ3E793

Interactioni

Subunit structurei

Interacts with GRX5.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi31782, 25 interactors
IntActiQ3E793, 12 interactors
STRINGi4932.YAL044W-A

Structurei

3D structure databases

ProteinModelPortaliQ3E793
SMRiQ3E793
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BolA/IbaG family.Curated

Phylogenomic databases

GeneTreeiENSGT00510000048165
HOGENOMiHOG000255169
InParanoidiQ3E793
KOiK22066
OMAiFNDSYKH
OrthoDBiEOG092C5RHO

Family and domain databases

InterProiView protein in InterPro
IPR002634 BolA
IPR036065 BolA-like_sf
PANTHERiPTHR12735 PTHR12735, 1 hit
PfamiView protein in Pfam
PF01722 BolA, 1 hit
PIRSFiPIRSF003113 BolA, 1 hit
SUPFAMiSSF82657 SSF82657, 1 hit

Sequencei

Sequence statusi: Complete.

Q3E793-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKRAMSTDG PVARTILKRL ECGFPDYKNF AFGLYNDSHK HKGHAGVQGN
60 70 80 90 100
VSAETHFRIE MVSKKFEGLK LPQRHRMVYS LLQDEMAQAN GIHALQLSLK
110
TPQEYESKAK
Length:110
Mass (Da):12,537
Last modified:November 8, 2005 - v1
Checksum:iBF19118A3F4FDA35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA No translation available.
BK006935 Genomic DNA Translation: DAA06941.1
RefSeqiNP_075206.1, NM_001184453.1

Genome annotation databases

EnsemblFungiiYAL044W-A; YAL044W-A; YAL044W-A
GeneIDi851252
KEGGisce:YAL044W-A

Similar proteinsi

Entry informationi

Entry nameiBOL1_YEAST
AccessioniPrimary (citable) accession number: Q3E793
Secondary accession number(s): D6VPH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: November 8, 2005
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health