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Q3E757

- RL11B_YEAST

UniProt

Q3E757 - RL11B_YEAST

Protein

60S ribosomal protein L11-B

Gene

RPL11B

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Binds to 5S ribosomal RNA.

    GO - Molecular functioni

    1. rRNA binding Source: UniProtKB-KW
    2. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD
    2. ribosomal large subunit assembly Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30797-MONOMER.
    ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L11-B
    Alternative name(s):
    L16
    RP39
    YL22
    Gene namesi
    Name:RPL11B
    Synonyms:RP39B, RPL16B
    Ordered Locus Names:YGR085C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    SGDiS000003317. RPL11B.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: The SYO1/RPL11/RPL5 complex is transported into the nucleus by KAP104.

    GO - Cellular componenti

    1. cytosolic large ribosomal subunit Source: SGD
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 17417360S ribosomal protein L11-BPRO_0000125105Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine2 Publications

    Post-translational modificationi

    N-terminally acetylated by acetyltransferase NatA.2 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ3E757.
    PaxDbiQ3E757.
    PRIDEiQ3E757.

    Expressioni

    Gene expression databases

    GenevestigatoriQ3E757.

    Interactioni

    Subunit structurei

    Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S). Forms a heterotrimeric complex with RPL5 and SYO1. Interaction of this complex with KAP104 allows the nuclear import of the heterotrimer.1 Publication

    Protein-protein interaction databases

    BioGridi33327. 140 interactions.
    DIPiDIP-29386N.
    IntActiQ3E757. 18 interactions.
    MINTiMINT-564941.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2NOQelectron microscopy7.30H7-171[»]
    3J0Qelectron microscopy10.60k7-171[»]
    4B6Aelectron microscopy8.10J1-174[»]
    ProteinModelPortaliQ3E757.
    SMRiQ3E757. Positions 6-174.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ3E757.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L5P family.Curated

    Phylogenomic databases

    eggNOGiCOG0094.
    GeneTreeiENSGT00390000013411.
    HOGENOMiHOG000231312.
    KOiK02868.
    OMAiISERRRC.
    OrthoDBiEOG7GBG86.

    Family and domain databases

    Gene3Di3.30.1440.10. 1 hit.
    InterProiIPR002132. Ribosomal_L5.
    IPR020929. Ribosomal_L5_CS.
    IPR022803. Ribosomal_L5_domain.
    [Graphical view]
    PANTHERiPTHR11994. PTHR11994. 1 hit.
    PfamiPF00281. Ribosomal_L5. 1 hit.
    PF00673. Ribosomal_L5_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002161. Ribosomal_L5. 1 hit.
    SUPFAMiSSF55282. SSF55282. 1 hit.
    PROSITEiPS00358. RIBOSOMAL_L5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3E757-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTKAQNPMR DLKIEKLVLN ISVGESGDRL TRASKVLEQL SGQTPVQSKA    50
    RYTVRTFGIR RNEKIAVHVT VRGPKAEEIL ERGLKVKEYQ LRDRNFSATG 100
    NFGFGIDEHI DLGIKYDPSI GIFGMDFYVV MNRPGARVTR RKRCKGTVGN 150
    SHKTTKEDTV SWFKQKYDAD VLDK 174
    Length:174
    Mass (Da):19,750
    Last modified:January 23, 2007 - v3
    Checksum:i04F6CD88FEBD63E4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti138 – 1381V → A(PubMed:6390341)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72870 Genomic DNA. Translation: CAA97087.1.
    M12933 Genomic DNA. Translation: AAA34990.1.
    BK006941 Genomic DNA. Translation: DAA08178.1.
    PIRiA02764. R5BY16.
    RefSeqiNP_011599.1. NM_001181214.1.

    Genome annotation databases

    EnsemblFungiiYGR085C; YGR085C; YGR085C.
    GeneIDi852976.
    KEGGisce:YGR085C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72870 Genomic DNA. Translation: CAA97087.1 .
    M12933 Genomic DNA. Translation: AAA34990.1 .
    BK006941 Genomic DNA. Translation: DAA08178.1 .
    PIRi A02764. R5BY16.
    RefSeqi NP_011599.1. NM_001181214.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2NOQ electron microscopy 7.30 H 7-171 [» ]
    3J0Q electron microscopy 10.60 k 7-171 [» ]
    4B6A electron microscopy 8.10 J 1-174 [» ]
    ProteinModelPortali Q3E757.
    SMRi Q3E757. Positions 6-174.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33327. 140 interactions.
    DIPi DIP-29386N.
    IntActi Q3E757. 18 interactions.
    MINTi MINT-564941.

    Proteomic databases

    MaxQBi Q3E757.
    PaxDbi Q3E757.
    PRIDEi Q3E757.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGR085C ; YGR085C ; YGR085C .
    GeneIDi 852976.
    KEGGi sce:YGR085C.

    Organism-specific databases

    SGDi S000003317. RPL11B.

    Phylogenomic databases

    eggNOGi COG0094.
    GeneTreei ENSGT00390000013411.
    HOGENOMi HOG000231312.
    KOi K02868.
    OMAi ISERRRC.
    OrthoDBi EOG7GBG86.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30797-MONOMER.
    Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Miscellaneous databases

    EvolutionaryTracei Q3E757.
    NextBioi 972774.

    Gene expression databases

    Genevestigatori Q3E757.

    Family and domain databases

    Gene3Di 3.30.1440.10. 1 hit.
    InterProi IPR002132. Ribosomal_L5.
    IPR020929. Ribosomal_L5_CS.
    IPR022803. Ribosomal_L5_domain.
    [Graphical view ]
    PANTHERi PTHR11994. PTHR11994. 1 hit.
    Pfami PF00281. Ribosomal_L5. 1 hit.
    PF00673. Ribosomal_L5_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002161. Ribosomal_L5. 1 hit.
    SUPFAMi SSF55282. SSF55282. 1 hit.
    PROSITEi PS00358. RIBOSOMAL_L5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Tripartite upstream promoter element essential for expression of Saccharomyces cerevisiae ribosomal protein genes."
      Rotenberg M.O., Woolford J.L. Jr.
      Mol. Cell. Biol. 6:674-687(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11.
    5. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    6. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
      Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
      J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2 BY NATA.
    7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: INTERACTION WITH RPL5 AND SYO1, SUBCELLULAR LOCATION.
    11. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (7.3 ANGSTROMS) OF 7-171.

    Entry informationi

    Entry nameiRL11B_YEAST
    AccessioniPrimary (citable) accession number: Q3E757
    Secondary accession number(s): D6VUL7, P06380
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 85 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 21200 molecules/cell in log phase SD medium.1 Publication
    There are 2 genes for L11 in yeast.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3