Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S ribosomal protein L11-B

Gene

RPL11B

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

Present with 21200 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for uL5 in yeast.Curated

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • ribosomal large subunit assembly Source: SGD
  • translation Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30797-MONOMER
ReactomeiR-SCE-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SCE-1799339 SRP-dependent cotranslational protein targeting to membrane
R-SCE-72689 Formation of a pool of free 40S subunits
R-SCE-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-SCE-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SCE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L11-B1 Publication
Alternative name(s):
L16
Large ribosomal subunit protein uL5-B1 Publication
RP39
YL22
Gene namesi
Name:RPL11B1 Publication
Synonyms:RP39B, RPL16B
Ordered Locus Names:YGR085C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR085C
SGDiS000003317 RPL11B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001251052 – 17460S ribosomal protein L11-BAdd BLAST173

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei75N6,N6,N6-trimethyllysine1 Publication1

Post-translational modificationi

N-terminally acetylated by acetyltransferase NatA.1 Publication

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

MaxQBiQ3E757
PaxDbiQ3E757
PRIDEiQ3E757

PTM databases

iPTMnetiQ3E757

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102). uL5 forms a heterotrimeric complex with uL18/RPL5 and SYO1. Interaction of this complex with KAP104 allows the nuclear import of the heterotrimer (PubMed:23118189).1 Publication2 Publications

Protein-protein interaction databases

BioGridi33327, 279 interactors
DIPiDIP-29386N
IntActiQ3E757, 20 interactors
MINTiQ3E757
STRINGi4932.YGR085C

Structurei

Secondary structure

1174
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi14 – 21Combined sources8
Beta strandi25 – 27Combined sources3
Helixi28 – 41Combined sources14
Beta strandi46 – 48Combined sources3
Beta strandi55 – 57Combined sources3
Beta strandi66 – 71Combined sources6
Helixi74 – 86Combined sources13
Turni87 – 89Combined sources3
Beta strandi90 – 92Combined sources3
Beta strandi93 – 96Combined sources4
Beta strandi102 – 107Combined sources6
Helixi109 – 111Combined sources3
Turni118 – 120Combined sources3
Beta strandi125 – 131Combined sources7
Turni134 – 136Combined sources3
Helixi137 – 140Combined sources4
Beta strandi141 – 144Combined sources4
Helixi150 – 152Combined sources3
Helixi156 – 164Combined sources9
Turni165 – 167Combined sources3
Beta strandi170 – 172Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NOQelectron microscopy7.30H7-171[»]
3J0Qelectron microscopy10.60k7-171[»]
4U3MX-ray3.00M1/m12-174[»]
4U3NX-ray3.20M1/m12-174[»]
4U3UX-ray2.90M1/m12-174[»]
4U4NX-ray3.10M1/m12-174[»]
4U4OX-ray3.60M1/m12-174[»]
4U4QX-ray3.00M1/m12-174[»]
4U4RX-ray2.80M1/m12-174[»]
4U4UX-ray3.00M1/m12-174[»]
4U4YX-ray3.20M1/m12-174[»]
4U4ZX-ray3.10M1/m12-174[»]
4U50X-ray3.20M1/m12-174[»]
4U51X-ray3.20M1/m12-174[»]
4U52X-ray3.00M1/m12-174[»]
4U53X-ray3.30M1/m12-174[»]
4U55X-ray3.20M1/m12-174[»]
4U56X-ray3.45M1/m12-174[»]
4U6FX-ray3.10M1/m12-174[»]
4V8Telectron microscopy8.10J1-174[»]
5DATX-ray3.15M1/m12-174[»]
5DC3X-ray3.25M1/m12-174[»]
5DGFX-ray3.30M1/m12-174[»]
5DGVX-ray3.10M1/m12-174[»]
5I4LX-ray3.10M1/m16-174[»]
5LYBX-ray3.25M1/m16-174[»]
5MEIX-ray3.50CM/s6-174[»]
5NDVX-ray3.30M1/m16-174[»]
5NDWX-ray3.70M1/m16-174[»]
5OBMX-ray3.40M1/m16-174[»]
5ON6X-ray3.10CM/s6-174[»]
5TBWX-ray3.00CM/s6-174[»]
5TGAX-ray3.30M1/m16-174[»]
5TGMX-ray3.50M1/m16-174[»]
ProteinModelPortaliQ3E757
SMRiQ3E757
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ3E757

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00910000144211
HOGENOMiHOG000231312
InParanoidiQ3E757
KOiK02868
OMAiDDSMKWF
OrthoDBiEOG092C53PI

Family and domain databases

Gene3Di3.30.1440.10, 1 hit
InterProiView protein in InterPro
IPR002132 Ribosomal_L5
IPR031309 Ribosomal_L5_C
IPR020929 Ribosomal_L5_CS
IPR022803 Ribosomal_L5_dom_sf
IPR031310 Ribosomal_L5_N
PANTHERiPTHR11994 PTHR11994, 1 hit
PfamiView protein in Pfam
PF00281 Ribosomal_L5, 1 hit
PF00673 Ribosomal_L5_C, 1 hit
PIRSFiPIRSF002161 Ribosomal_L5, 1 hit
SUPFAMiSSF55282 SSF55282, 1 hit
PROSITEiView protein in PROSITE
PS00358 RIBOSOMAL_L5, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3E757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKAQNPMR DLKIEKLVLN ISVGESGDRL TRASKVLEQL SGQTPVQSKA
60 70 80 90 100
RYTVRTFGIR RNEKIAVHVT VRGPKAEEIL ERGLKVKEYQ LRDRNFSATG
110 120 130 140 150
NFGFGIDEHI DLGIKYDPSI GIFGMDFYVV MNRPGARVTR RKRCKGTVGN
160 170
SHKTTKEDTV SWFKQKYDAD VLDK
Length:174
Mass (Da):19,750
Last modified:January 23, 2007 - v3
Checksum:i04F6CD88FEBD63E4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti138V → A (PubMed:6390341).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72870 Genomic DNA Translation: CAA97087.1
M12933 Genomic DNA Translation: AAA34990.1
BK006941 Genomic DNA Translation: DAA08178.1
PIRiA02764 R5BY16
RefSeqiNP_011599.1, NM_001181214.1

Genome annotation databases

EnsemblFungiiYGR085C; YGR085C; YGR085C
GeneIDi852976
KEGGisce:YGR085C

Similar proteinsi

Entry informationi

Entry nameiRL11B_YEAST
AccessioniPrimary (citable) accession number: Q3E757
Secondary accession number(s): D6VUL7, P06380
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 121 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health