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Protein

40S ribosomal protein S21-B

Gene

RPS21B

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). eS21 is required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability (PubMed:14627813).1 Publication1 Publication

Miscellaneous

Present with 15300 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for eS21 in yeast.Curated

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
Biological processrRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-31583-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S21-B1 Publication
Alternative name(s):
S26
Small ribosomal subunit protein eS21-B1 Publication
YS25
Gene namesi
Name:RPS21B1 Publication
Synonyms:RPS25B, RPS26B
Ordered Locus Names:YJL136C
ORF Names:J0664
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL136C
SGDiS000003672 RPS21B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Reduction in growth rate, a decrease in free 40S subunits, an increase in the amount of free 60S subunits and a decrease in polysome size.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001947621 – 8740S ribosomal protein S21-BAdd BLAST87

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1

Post-translational modificationi

N-terminally acetylated by acetyltransferase NatB.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ3E754
PaxDbiQ3E754
PRIDEiQ3E754
TopDownProteomicsiQ3E754

PTM databases

iPTMnetiQ3E754

Interactioni

Subunit structurei

Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridi33621, 332 interactors
IntActiQ3E754, 3 interactors
MINTiQ3E754
STRINGi4932.YJL136C

Structurei

3D structure databases

ProteinModelPortaliQ3E754
SMRiQ3E754
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000183557
InParanoidiQ3E754
KOiK02971
OMAiCPRKCSA
OrthoDBiEOG092C5XGV

Family and domain databases

Gene3Di3.30.1230.20, 1 hit
InterProiView protein in InterPro
IPR001931 Ribosomal_S21e
IPR018279 Ribosomal_S21e_CS
IPR038579 Ribosomal_S21e_sf
PANTHERiPTHR10442 PTHR10442, 1 hit
PfamiView protein in Pfam
PF01249 Ribosomal_S21e, 1 hit
PIRSFiPIRSF002148 Ribosomal_S21e, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006584 Ribosomal_S21e, 1 hit
PROSITEiView protein in PROSITE
PS00996 RIBOSOMAL_S21E, 1 hit

Sequencei

Sequence statusi: Complete.

Q3E754-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENDKGQLVE LYVPRKCSAT NRIIKADDHA SVQINVAKVD EEGRAIPGEY
60 70 80
ITYALSGYVR SRGESDDSLN RLAQNDGLLK NVWSYSR
Length:87
Mass (Da):9,760
Last modified:November 8, 2005 - v1
Checksum:i52E1C247575A7410
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87371 Genomic DNA Translation: CAA60819.1
Z49411 Genomic DNA Translation: CAA89431.1
BK006943 Genomic DNA Translation: DAA08665.1
PIRiS56918
RefSeqiNP_012399.1, NM_001181569.1

Genome annotation databases

EnsemblFungiiYJL136C; YJL136C; YJL136C
GeneIDi853305
KEGGisce:YJL136C

Similar proteinsi

Entry informationi

Entry nameiRS21B_YEAST
AccessioniPrimary (citable) accession number: Q3E754
Secondary accession number(s): D6VW49, P05760
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 8, 2005
Last modified: April 25, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health