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Q3E754

- RS21B_YEAST

UniProt

Q3E754 - RS21B_YEAST

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Protein
40S ribosomal protein S21-B
Gene
RPS21B, RPS25B, RPS26B, YJL136C, J0664
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.1 Publication

GO - Molecular functioni

  1. structural constituent of ribosome Source: SGD
Complete GO annotation...

GO - Biological processi

  1. cytoplasmic translation Source: SGD
  2. endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  3. endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Biological processi

rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-31583-MONOMER.
ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S21-B
Alternative name(s):
S26
YS25
Gene namesi
Name:RPS21B
Synonyms:RPS25B, RPS26B
Ordered Locus Names:YJL136C
ORF Names:J0664
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJL136c.
SGDiS000003672. RPS21B.

Subcellular locationi

Cytoplasm 2 Publications

GO - Cellular componenti

  1. cytosolic small ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Reduction in growth rate, a decrease in free 40S subunits, an increase in the amount of free 60S subunits and a decrease in polysome size.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 878740S ribosomal protein S21-B
PRO_0000194762Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Post-translational modificationi

N-terminally acetylated by acetyltransferase NatB.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ3E754.
PaxDbiQ3E754.
PeptideAtlasiQ3E754.

Expressioni

Gene expression databases

GenevestigatoriQ3E754.

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi33621. 123 interactions.
IntActiQ3E754. 2 interactions.
MINTiMINT-4491071.

Structurei

3D structure databases

ProteinModelPortaliQ3E754.
SMRiQ3E754. Positions 1-87.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG301320.
GeneTreeiENSGT00390000017515.
HOGENOMiHOG000183557.
KOiK02971.
OMAiQNEEGAM.
OrthoDBiEOG7FNCM4.

Family and domain databases

InterProiIPR001931. Ribosomal_S21e.
IPR018279. Ribosomal_S21e_CS.
[Graphical view]
PANTHERiPTHR10442. PTHR10442. 1 hit.
PfamiPF01249. Ribosomal_S21e. 1 hit.
[Graphical view]
PIRSFiPIRSF002148. Ribosomal_S21e. 1 hit.
ProDomiPD006584. Ribosomal_S21e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00996. RIBOSOMAL_S21E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3E754-1 [UniParc]FASTAAdd to Basket

« Hide

MENDKGQLVE LYVPRKCSAT NRIIKADDHA SVQINVAKVD EEGRAIPGEY   50
ITYALSGYVR SRGESDDSLN RLAQNDGLLK NVWSYSR 87
Length:87
Mass (Da):9,760
Last modified:November 8, 2005 - v1
Checksum:i52E1C247575A7410
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87371 Genomic DNA. Translation: CAA60819.1.
Z49411 Genomic DNA. Translation: CAA89431.1.
BK006943 Genomic DNA. Translation: DAA08665.1.
PIRiS56918.
RefSeqiNP_012399.1. NM_001181569.1.

Genome annotation databases

EnsemblFungiiYJL136C; YJL136C; YJL136C.
GeneIDi853305.
KEGGisce:YJL136C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87371 Genomic DNA. Translation: CAA60819.1 .
Z49411 Genomic DNA. Translation: CAA89431.1 .
BK006943 Genomic DNA. Translation: DAA08665.1 .
PIRi S56918.
RefSeqi NP_012399.1. NM_001181569.1.

3D structure databases

ProteinModelPortali Q3E754.
SMRi Q3E754. Positions 1-87.
ModBasei Search...

Protein-protein interaction databases

BioGridi 33621. 123 interactions.
IntActi Q3E754. 2 interactions.
MINTi MINT-4491071.

Proteomic databases

MaxQBi Q3E754.
PaxDbi Q3E754.
PeptideAtlasi Q3E754.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJL136C ; YJL136C ; YJL136C .
GeneIDi 853305.
KEGGi sce:YJL136C.

Organism-specific databases

CYGDi YJL136c.
SGDi S000003672. RPS21B.

Phylogenomic databases

eggNOGi NOG301320.
GeneTreei ENSGT00390000017515.
HOGENOMi HOG000183557.
KOi K02971.
OMAi QNEEGAM.
OrthoDBi EOG7FNCM4.

Enzyme and pathway databases

BioCyci YEAST:G3O-31583-MONOMER.
Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.

Miscellaneous databases

NextBioi 973633.

Gene expression databases

Genevestigatori Q3E754.

Family and domain databases

InterProi IPR001931. Ribosomal_S21e.
IPR018279. Ribosomal_S21e_CS.
[Graphical view ]
PANTHERi PTHR10442. PTHR10442. 1 hit.
Pfami PF01249. Ribosomal_S21e. 1 hit.
[Graphical view ]
PIRSFi PIRSF002148. Ribosomal_S21e. 1 hit.
ProDomi PD006584. Ribosomal_S21e. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS00996. RIBOSOMAL_S21E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of a 40.7 kb segment from the left arm of yeast chromosome X reveals 14 known genes and 13 new open reading frames including homologues of genes clustered on the right arm of chromosome XI."
    Katsoulou C., Tzermia M., Tavernarakis N., Alexandraki D.
    Yeast 12:787-797(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
    Planta R.J., Mager W.H.
    Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, SUBUNIT.
  5. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
    Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
    J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION AT MET-1 BY NATB.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "Ribosomal proteins Rps0 and Rps21 of Saccharomyces cerevisiae have overlapping functions in the maturation of the 3' end of 18S rRNA."
    Tabb-Massey A., Caffrey J.M., Logsden P., Taylor S., Trent J.O., Ellis S.R.
    Nucleic Acids Res. 31:6798-6805(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiRS21B_YEAST
AccessioniPrimary (citable) accession number: Q3E754
Secondary accession number(s): D6VW49, P05760
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 8, 2005
Last modified: September 3, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 15300 molecules/cell in log phase SD medium.
There are 2 genes for S21 in yeast.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

Similar proteinsi