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Q3E754

- RS21B_YEAST

UniProt

Q3E754 - RS21B_YEAST

Protein

40S ribosomal protein S21-B

Gene

RPS21B

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.1 Publication

    GO - Molecular functioni

    1. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD
    2. endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    3. endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Biological processi

    rRNA processing

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31583-MONOMER.
    ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S21-B
    Alternative name(s):
    S26
    YS25
    Gene namesi
    Name:RPS21B
    Synonyms:RPS25B, RPS26B
    Ordered Locus Names:YJL136C
    ORF Names:J0664
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJL136c.
    SGDiS000003672. RPS21B.

    Subcellular locationi

    Cytoplasm 2 Publications

    GO - Cellular componenti

    1. cytosolic small ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Disruption phenotypei

    Reduction in growth rate, a decrease in free 40S subunits, an increase in the amount of free 60S subunits and a decrease in polysome size.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 878740S ribosomal protein S21-BPRO_0000194762Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Post-translational modificationi

    N-terminally acetylated by acetyltransferase NatB.1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ3E754.
    PaxDbiQ3E754.
    PeptideAtlasiQ3E754.

    Expressioni

    Gene expression databases

    GenevestigatoriQ3E754.

    Interactioni

    Subunit structurei

    Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

    Protein-protein interaction databases

    BioGridi33621. 123 interactions.
    IntActiQ3E754. 2 interactions.
    MINTiMINT-4491071.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3E754.
    SMRiQ3E754. Positions 1-87.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S21e family.Curated

    Phylogenomic databases

    eggNOGiNOG301320.
    GeneTreeiENSGT00390000017515.
    HOGENOMiHOG000183557.
    KOiK02971.
    OMAiQNEEGAM.
    OrthoDBiEOG7FNCM4.

    Family and domain databases

    InterProiIPR001931. Ribosomal_S21e.
    IPR018279. Ribosomal_S21e_CS.
    [Graphical view]
    PANTHERiPTHR10442. PTHR10442. 1 hit.
    PfamiPF01249. Ribosomal_S21e. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002148. Ribosomal_S21e. 1 hit.
    ProDomiPD006584. Ribosomal_S21e. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    PROSITEiPS00996. RIBOSOMAL_S21E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3E754-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENDKGQLVE LYVPRKCSAT NRIIKADDHA SVQINVAKVD EEGRAIPGEY   50
    ITYALSGYVR SRGESDDSLN RLAQNDGLLK NVWSYSR 87
    Length:87
    Mass (Da):9,760
    Last modified:November 8, 2005 - v1
    Checksum:i52E1C247575A7410
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X87371 Genomic DNA. Translation: CAA60819.1.
    Z49411 Genomic DNA. Translation: CAA89431.1.
    BK006943 Genomic DNA. Translation: DAA08665.1.
    PIRiS56918.
    RefSeqiNP_012399.1. NM_001181569.1.

    Genome annotation databases

    EnsemblFungiiYJL136C; YJL136C; YJL136C.
    GeneIDi853305.
    KEGGisce:YJL136C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X87371 Genomic DNA. Translation: CAA60819.1 .
    Z49411 Genomic DNA. Translation: CAA89431.1 .
    BK006943 Genomic DNA. Translation: DAA08665.1 .
    PIRi S56918.
    RefSeqi NP_012399.1. NM_001181569.1.

    3D structure databases

    ProteinModelPortali Q3E754.
    SMRi Q3E754. Positions 1-87.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33621. 123 interactions.
    IntActi Q3E754. 2 interactions.
    MINTi MINT-4491071.

    Proteomic databases

    MaxQBi Q3E754.
    PaxDbi Q3E754.
    PeptideAtlasi Q3E754.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJL136C ; YJL136C ; YJL136C .
    GeneIDi 853305.
    KEGGi sce:YJL136C.

    Organism-specific databases

    CYGDi YJL136c.
    SGDi S000003672. RPS21B.

    Phylogenomic databases

    eggNOGi NOG301320.
    GeneTreei ENSGT00390000017515.
    HOGENOMi HOG000183557.
    KOi K02971.
    OMAi QNEEGAM.
    OrthoDBi EOG7FNCM4.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31583-MONOMER.
    Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Miscellaneous databases

    NextBioi 973633.

    Gene expression databases

    Genevestigatori Q3E754.

    Family and domain databases

    InterProi IPR001931. Ribosomal_S21e.
    IPR018279. Ribosomal_S21e_CS.
    [Graphical view ]
    PANTHERi PTHR10442. PTHR10442. 1 hit.
    Pfami PF01249. Ribosomal_S21e. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002148. Ribosomal_S21e. 1 hit.
    ProDomi PD006584. Ribosomal_S21e. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    PROSITEi PS00996. RIBOSOMAL_S21E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of a 40.7 kb segment from the left arm of yeast chromosome X reveals 14 known genes and 13 new open reading frames including homologues of genes clustered on the right arm of chromosome XI."
      Katsoulou C., Tzermia M., Tavernarakis N., Alexandraki D.
      Yeast 12:787-797(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    5. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
      Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
      J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION AT MET-1 BY NATB.
    6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "Ribosomal proteins Rps0 and Rps21 of Saccharomyces cerevisiae have overlapping functions in the maturation of the 3' end of 18S rRNA."
      Tabb-Massey A., Caffrey J.M., Logsden P., Taylor S., Trent J.O., Ellis S.R.
      Nucleic Acids Res. 31:6798-6805(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiRS21B_YEAST
    AccessioniPrimary (citable) accession number: Q3E754
    Secondary accession number(s): D6VW49, P05760
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 15300 molecules/cell in log phase SD medium.1 Publication
    There are 2 genes for S21 in yeast.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Ribosomal proteins
      Ribosomal proteins families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3