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Q3C2P8

- SPRE2_RAT

UniProt

Q3C2P8 - SPRE2_RAT

Protein

Sprouty-related, EVH1 domain-containing protein 2

Gene

Spred2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.By similarity

    GO - Molecular functioni

    1. protein serine/threonine kinase inhibitor activity Source: Ensembl

    GO - Biological processi

    1. inactivation of MAPK activity Source: Ensembl
    2. multicellular organismal development Source: InterPro
    3. negative regulation of peptidyl-threonine phosphorylation Source: Ensembl
    4. positive regulation of DNA damage response, signal transduction by p53 class mediator Source: Ensembl
    5. regulation of protein deacetylation Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sprouty-related, EVH1 domain-containing protein 2
    Short name:
    Spred-2
    Gene namesi
    Name:Spred2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 14

    Organism-specific databases

    RGDi1309304. Spred2.

    Subcellular locationi

    Membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmic vesiclesecretory vesicle membrane Curated; Peripheral membrane protein Curated; Cytoplasmic side Curated. Cytoplasm
    Note: Especially found in the cytoplasm of the stratum spinosum cells called membrane-coated granules.By similarity

    GO - Cellular componenti

    1. plasma membrane Source: Ensembl
    2. transport vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 410410Sprouty-related, EVH1 domain-containing protein 2PRO_0000354679Add
    BLAST

    Post-translational modificationi

    Phosphorylated on tyrosine. Phosphorylation of Tyr-224 and Tyr-227 are required for ubiquitination By similarity.By similarity
    Ubiquitinated; leading to degradation by the proteasome.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ3C2P8.
    PRIDEiQ3C2P8.

    PTM databases

    PhosphoSiteiQ3C2P8.

    Expressioni

    Gene expression databases

    GenevestigatoriQ3C2P8.

    Interactioni

    Subunit structurei

    Interacts with Ras By similarity. Homodimer and heterodimer. Able to interact with SPRED1 to form heterodimers By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000053806.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3C2P8.
    SMRiQ3C2P8. Positions 1-124.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 122118WH1PROSITE-ProRule annotationAdd
    BLAST
    Domaini197 – 25256KBDPROSITE-ProRule annotationAdd
    BLAST
    Domaini300 – 408109SPRPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 KBD domain.PROSITE-ProRule annotation
    Contains 1 SPR (sprouty) domain.PROSITE-ProRule annotation
    Contains 1 WH1 domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG277322.
    GeneTreeiENSGT00730000110272.
    HOGENOMiHOG000220886.
    HOVERGENiHBG057556.
    KOiK04703.
    OMAiCEYCRDM.
    OrthoDBiEOG7T7GV7.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR023337. KBD.
    IPR011993. PH_like_dom.
    IPR007875. Sprouty.
    IPR000697. WH1/EVH1.
    [Graphical view]
    PfamiPF05210. Sprouty. 1 hit.
    PF00568. WH1. 1 hit.
    [Graphical view]
    PROSITEiPS51488. KBD. 1 hit.
    PS51227. SPR. 1 hit.
    PS50229. WH1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3C2P8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEETHPDDD SYIVRVKAVV MTRDDSSGGW FPQEGGGISR VGVCKVMHPE    50
    GNGRSGFLIH GERQKDKLVV LECYVRKDLV YTKANPTFHH WKVDNRKFGL 100
    TFQSPADARA FDRGVRKAIE DLIEGSTTSS STIHNEAELG DDDVFTTATD 150
    SSSNSSQKRE PNTRTISSPT SCEHRRIYTL DPYPMDLYHP DQRLPRSYPQ 200
    VTFPEDDEEI VRINPREKIW MTGYEDYRHA PVRGKYLDST EDADSYVRFA 250
    KGEVPKHEYT YPYVDSSDFG FGEDPKGNVI KTQPPRAKSR RRKENGERSR 300
    CVYCRDMFNH EENRRGHCQD APDAVRTCIR RVSCMWCADS MLYHCMSDPE 350
    GDYTDPCSCD TSDEKFCLRW MALIALSFLA PCMCCYLPLR ACHHCGVMCR 400
    CCGGKHKAAA 410
    Length:410
    Mass (Da):46,805
    Last modified:November 22, 2005 - v1
    Checksum:i18F2F3FBB616BCBB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB125136 mRNA. Translation: BAE46587.1.
    RefSeqiNP_001040559.1. NM_001047094.1.
    UniGeneiRn.225245.

    Genome annotation databases

    EnsembliENSRNOT00000006573; ENSRNOP00000006573; ENSRNOG00000004888.
    GeneIDi305539.
    KEGGirno:305539.
    UCSCiRGD:1309304. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB125136 mRNA. Translation: BAE46587.1 .
    RefSeqi NP_001040559.1. NM_001047094.1.
    UniGenei Rn.225245.

    3D structure databases

    ProteinModelPortali Q3C2P8.
    SMRi Q3C2P8. Positions 1-124.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000053806.

    PTM databases

    PhosphoSitei Q3C2P8.

    Proteomic databases

    PaxDbi Q3C2P8.
    PRIDEi Q3C2P8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000006573 ; ENSRNOP00000006573 ; ENSRNOG00000004888 .
    GeneIDi 305539.
    KEGGi rno:305539.
    UCSCi RGD:1309304. rat.

    Organism-specific databases

    CTDi 200734.
    RGDi 1309304. Spred2.

    Phylogenomic databases

    eggNOGi NOG277322.
    GeneTreei ENSGT00730000110272.
    HOGENOMi HOG000220886.
    HOVERGENi HBG057556.
    KOi K04703.
    OMAi CEYCRDM.
    OrthoDBi EOG7T7GV7.

    Miscellaneous databases

    NextBioi 654751.

    Gene expression databases

    Genevestigatori Q3C2P8.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR023337. KBD.
    IPR011993. PH_like_dom.
    IPR007875. Sprouty.
    IPR000697. WH1/EVH1.
    [Graphical view ]
    Pfami PF05210. Sprouty. 1 hit.
    PF00568. WH1. 1 hit.
    [Graphical view ]
    PROSITEi PS51488. KBD. 1 hit.
    PS51227. SPR. 1 hit.
    PS50229. WH1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of cDNA encoding rat Spred-2."
      Saitoh A., Hirasawa N., Ohuchi K.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiSPRE2_RAT
    AccessioniPrimary (citable) accession number: Q3C2P8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2008
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3