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Q3C2P8 (SPRE2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sprouty-related, EVH1 domain-containing protein 2

Short name=Spred-2
Gene names
Name:Spred2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase By similarity.

Subunit structure

Interacts with Ras By similarity. Homodimer and heterodimer. Able to interact with SPRED1 to form heterodimers By similarity.

Subcellular location

Membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasmic vesiclesecretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side Potential. Cytoplasm. Note: Especially found in the cytoplasm of the stratum spinosum cells called membrane-coated granules By similarity.

Post-translational modification

Phosphorylated on tyrosine. Phosphorylation of Tyr-224 and Tyr-227 are required for ubiquitination By similarity.

Ubiquitinated; leading to degradation by the proteasome By similarity.

Sequence similarities

Contains 1 KBD domain.

Contains 1 SPR (sprouty) domain.

Contains 1 WH1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 410410Sprouty-related, EVH1 domain-containing protein 2
PRO_0000354679

Regions

Domain5 – 122118WH1
Domain197 – 25256KBD
Domain300 – 408109SPR

Sequences

Sequence LengthMass (Da)Tools
Q3C2P8 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 18F2F3FBB616BCBB

FASTA41046,805
        10         20         30         40         50         60 
MTEETHPDDD SYIVRVKAVV MTRDDSSGGW FPQEGGGISR VGVCKVMHPE GNGRSGFLIH 

        70         80         90        100        110        120 
GERQKDKLVV LECYVRKDLV YTKANPTFHH WKVDNRKFGL TFQSPADARA FDRGVRKAIE 

       130        140        150        160        170        180 
DLIEGSTTSS STIHNEAELG DDDVFTTATD SSSNSSQKRE PNTRTISSPT SCEHRRIYTL 

       190        200        210        220        230        240 
DPYPMDLYHP DQRLPRSYPQ VTFPEDDEEI VRINPREKIW MTGYEDYRHA PVRGKYLDST 

       250        260        270        280        290        300 
EDADSYVRFA KGEVPKHEYT YPYVDSSDFG FGEDPKGNVI KTQPPRAKSR RRKENGERSR 

       310        320        330        340        350        360 
CVYCRDMFNH EENRRGHCQD APDAVRTCIR RVSCMWCADS MLYHCMSDPE GDYTDPCSCD 

       370        380        390        400        410 
TSDEKFCLRW MALIALSFLA PCMCCYLPLR ACHHCGVMCR CCGGKHKAAA 

« Hide

References

[1]"Identification of cDNA encoding rat Spred-2."
Saitoh A., Hirasawa N., Ohuchi K.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB125136 mRNA. Translation: BAE46587.1.
RefSeqNP_001040559.1. NM_001047094.1.
UniGeneRn.225245.

3D structure databases

ProteinModelPortalQ3C2P8.
SMRQ3C2P8. Positions 1-124.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000053806.

PTM databases

PhosphoSiteQ3C2P8.

Proteomic databases

PaxDbQ3C2P8.
PRIDEQ3C2P8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000006573; ENSRNOP00000006573; ENSRNOG00000004888.
GeneID305539.
KEGGrno:305539.
UCSCRGD:1309304. rat.

Organism-specific databases

CTD200734.
RGD1309304. Spred2.

Phylogenomic databases

eggNOGNOG277322.
GeneTreeENSGT00730000110272.
HOGENOMHOG000220886.
HOVERGENHBG057556.
KOK04703.
OMACEYCRDM.
OrthoDBEOG7T7GV7.

Gene expression databases

GenevestigatorQ3C2P8.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR023337. KBD.
IPR011993. PH_like_dom.
IPR007875. Sprouty.
IPR000697. WH1/EVH1.
[Graphical view]
PfamPF05210. Sprouty. 1 hit.
PF00568. WH1. 1 hit.
[Graphical view]
PROSITEPS51488. KBD. 1 hit.
PS51227. SPR. 1 hit.
PS50229. WH1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio654751.

Entry information

Entry nameSPRE2_RAT
AccessionPrimary (citable) accession number: Q3C2P8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 22, 2005
Last modified: March 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families