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Q3C2P8

- SPRE2_RAT

UniProt

Q3C2P8 - SPRE2_RAT

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Protein

Sprouty-related, EVH1 domain-containing protein 2

Gene
Spred2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase By similarity.

GO - Molecular functioni

  1. protein serine/threonine kinase inhibitor activity Source: Ensembl

GO - Biological processi

  1. inactivation of MAPK activity Source: Ensembl
  2. multicellular organismal development Source: InterPro
  3. negative regulation of peptidyl-threonine phosphorylation Source: Ensembl
  4. positive regulation of DNA damage response, signal transduction by p53 class mediator Source: Ensembl
  5. regulation of protein deacetylation Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sprouty-related, EVH1 domain-containing protein 2
Short name:
Spred-2
Gene namesi
Name:Spred2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 14

Organism-specific databases

RGDi1309304. Spred2.

Subcellular locationi

Membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasmic vesiclesecretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side Reviewed prediction. Cytoplasm
Note: Especially found in the cytoplasm of the stratum spinosum cells called membrane-coated granules By similarity.

GO - Cellular componenti

  1. plasma membrane Source: Ensembl
  2. transport vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Sprouty-related, EVH1 domain-containing protein 2PRO_0000354679Add
BLAST

Post-translational modificationi

Phosphorylated on tyrosine. Phosphorylation of Tyr-224 and Tyr-227 are required for ubiquitination By similarity.
Ubiquitinated; leading to degradation by the proteasome By similarity.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ3C2P8.
PRIDEiQ3C2P8.

PTM databases

PhosphoSiteiQ3C2P8.

Expressioni

Gene expression databases

GenevestigatoriQ3C2P8.

Interactioni

Subunit structurei

Interacts with Ras By similarity. Homodimer and heterodimer. Able to interact with SPRED1 to form heterodimers By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053806.

Structurei

3D structure databases

ProteinModelPortaliQ3C2P8.
SMRiQ3C2P8. Positions 1-124.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 122118WH1Add
BLAST
Domaini197 – 25256KBDAdd
BLAST
Domaini300 – 408109SPRAdd
BLAST

Sequence similaritiesi

Contains 1 KBD domain.
Contains 1 WH1 domain.

Phylogenomic databases

eggNOGiNOG277322.
GeneTreeiENSGT00730000110272.
HOGENOMiHOG000220886.
HOVERGENiHBG057556.
KOiK04703.
OMAiCEYCRDM.
OrthoDBiEOG7T7GV7.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR023337. KBD.
IPR011993. PH_like_dom.
IPR007875. Sprouty.
IPR000697. WH1/EVH1.
[Graphical view]
PfamiPF05210. Sprouty. 1 hit.
PF00568. WH1. 1 hit.
[Graphical view]
PROSITEiPS51488. KBD. 1 hit.
PS51227. SPR. 1 hit.
PS50229. WH1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3C2P8-1 [UniParc]FASTAAdd to Basket

« Hide

MTEETHPDDD SYIVRVKAVV MTRDDSSGGW FPQEGGGISR VGVCKVMHPE    50
GNGRSGFLIH GERQKDKLVV LECYVRKDLV YTKANPTFHH WKVDNRKFGL 100
TFQSPADARA FDRGVRKAIE DLIEGSTTSS STIHNEAELG DDDVFTTATD 150
SSSNSSQKRE PNTRTISSPT SCEHRRIYTL DPYPMDLYHP DQRLPRSYPQ 200
VTFPEDDEEI VRINPREKIW MTGYEDYRHA PVRGKYLDST EDADSYVRFA 250
KGEVPKHEYT YPYVDSSDFG FGEDPKGNVI KTQPPRAKSR RRKENGERSR 300
CVYCRDMFNH EENRRGHCQD APDAVRTCIR RVSCMWCADS MLYHCMSDPE 350
GDYTDPCSCD TSDEKFCLRW MALIALSFLA PCMCCYLPLR ACHHCGVMCR 400
CCGGKHKAAA 410
Length:410
Mass (Da):46,805
Last modified:November 22, 2005 - v1
Checksum:i18F2F3FBB616BCBB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB125136 mRNA. Translation: BAE46587.1.
RefSeqiNP_001040559.1. NM_001047094.1.
UniGeneiRn.225245.

Genome annotation databases

EnsembliENSRNOT00000006573; ENSRNOP00000006573; ENSRNOG00000004888.
GeneIDi305539.
KEGGirno:305539.
UCSCiRGD:1309304. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB125136 mRNA. Translation: BAE46587.1 .
RefSeqi NP_001040559.1. NM_001047094.1.
UniGenei Rn.225245.

3D structure databases

ProteinModelPortali Q3C2P8.
SMRi Q3C2P8. Positions 1-124.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000053806.

PTM databases

PhosphoSitei Q3C2P8.

Proteomic databases

PaxDbi Q3C2P8.
PRIDEi Q3C2P8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000006573 ; ENSRNOP00000006573 ; ENSRNOG00000004888 .
GeneIDi 305539.
KEGGi rno:305539.
UCSCi RGD:1309304. rat.

Organism-specific databases

CTDi 200734.
RGDi 1309304. Spred2.

Phylogenomic databases

eggNOGi NOG277322.
GeneTreei ENSGT00730000110272.
HOGENOMi HOG000220886.
HOVERGENi HBG057556.
KOi K04703.
OMAi CEYCRDM.
OrthoDBi EOG7T7GV7.

Miscellaneous databases

NextBioi 654751.

Gene expression databases

Genevestigatori Q3C2P8.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR023337. KBD.
IPR011993. PH_like_dom.
IPR007875. Sprouty.
IPR000697. WH1/EVH1.
[Graphical view ]
Pfami PF05210. Sprouty. 1 hit.
PF00568. WH1. 1 hit.
[Graphical view ]
PROSITEi PS51488. KBD. 1 hit.
PS51227. SPR. 1 hit.
PS50229. WH1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of cDNA encoding rat Spred-2."
    Saitoh A., Hirasawa N., Ohuchi K.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSPRE2_RAT
AccessioniPrimary (citable) accession number: Q3C2P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 22, 2005
Last modified: March 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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