Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sprouty-related, EVH1 domain-containing protein 2

Gene

Spred2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Negatively regulates Ras signaling pathways and downstream activation of MAP kinases.By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-5658442 Regulation of RAS by GAPs
R-RNO-5658623 FGFRL1 modulation of FGFR1 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Sprouty-related, EVH1 domain-containing protein 2
Short name:
Spred-2
Gene namesi
Name:Spred2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1309304 Spred2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003546791 – 410Sprouty-related, EVH1 domain-containing protein 2Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei224PhosphotyrosineBy similarity1
Modified residuei227PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated on serine and threonine residues. Phosphorylated on tyrosine. Phosphorylation of Tyr-224 and Tyr-227 are required for ubiquitination.By similarity
Ubiquitinated; leading to degradation by the proteasome.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ3C2P8
PRIDEiQ3C2P8

PTM databases

iPTMnetiQ3C2P8
PhosphoSitePlusiQ3C2P8
SwissPalmiQ3C2P8

Expressioni

Gene expression databases

BgeeiENSRNOG00000004888
ExpressionAtlasiQ3C2P8 baseline and differential

Interactioni

Subunit structurei

Homodimer and heterodimer. Able to interact with SPRED1 to form heterodimers (By similarity). Interacts with Ras (By similarity). May interact with ZDHHC13 (via ANK repeats) and ZDHHC17 (via ANK repeats) (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006573

Structurei

3D structure databases

ProteinModelPortaliQ3C2P8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 122WH1PROSITE-ProRule annotationAdd BLAST118
Domaini197 – 252KBDPROSITE-ProRule annotationAdd BLAST56
Domaini300 – 408SPRPROSITE-ProRule annotationAdd BLAST109

Phylogenomic databases

eggNOGiENOG410IQ21 Eukaryota
ENOG410Y62R LUCA
GeneTreeiENSGT00730000110272
HOGENOMiHOG000220886
HOVERGENiHBG057556
InParanoidiQ3C2P8
KOiK04703

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR023337 KBD
IPR011993 PH-like_dom_sf
IPR007875 Sprouty
IPR000697 WH1/EVH1_dom
PfamiView protein in Pfam
PF05210 Sprouty, 1 hit
PF00568 WH1, 1 hit
SMARTiView protein in SMART
SM00461 WH1, 1 hit
PROSITEiView protein in PROSITE
PS51488 KBD, 1 hit
PS51227 SPR, 1 hit
PS50229 WH1, 1 hit

Sequencei

Sequence statusi: Complete.

Q3C2P8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEETHPDDD SYIVRVKAVV MTRDDSSGGW FPQEGGGISR VGVCKVMHPE
60 70 80 90 100
GNGRSGFLIH GERQKDKLVV LECYVRKDLV YTKANPTFHH WKVDNRKFGL
110 120 130 140 150
TFQSPADARA FDRGVRKAIE DLIEGSTTSS STIHNEAELG DDDVFTTATD
160 170 180 190 200
SSSNSSQKRE PNTRTISSPT SCEHRRIYTL DPYPMDLYHP DQRLPRSYPQ
210 220 230 240 250
VTFPEDDEEI VRINPREKIW MTGYEDYRHA PVRGKYLDST EDADSYVRFA
260 270 280 290 300
KGEVPKHEYT YPYVDSSDFG FGEDPKGNVI KTQPPRAKSR RRKENGERSR
310 320 330 340 350
CVYCRDMFNH EENRRGHCQD APDAVRTCIR RVSCMWCADS MLYHCMSDPE
360 370 380 390 400
GDYTDPCSCD TSDEKFCLRW MALIALSFLA PCMCCYLPLR ACHHCGVMCR
410
CCGGKHKAAA
Length:410
Mass (Da):46,805
Last modified:November 22, 2005 - v1
Checksum:i18F2F3FBB616BCBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB125136 mRNA Translation: BAE46587.1
RefSeqiNP_001040559.1, NM_001047094.1
UniGeneiRn.225245

Genome annotation databases

EnsembliENSRNOT00000006573; ENSRNOP00000006573; ENSRNOG00000004888
GeneIDi305539
KEGGirno:305539
UCSCiRGD:1309304 rat

Similar proteinsi

Entry informationi

Entry nameiSPRE2_RAT
AccessioniPrimary (citable) accession number: Q3C2P8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 22, 2005
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health