Q3C2I0 (B2LA1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bcl-2-related protein A1

Gene names

Name:

BCL2A1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection By similarity.
Subunit structure	Interacts directly with BCL2L11/BIM, BAK1, BID, BMF and BBC3 By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the Bcl-2 family.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cytoplasm
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of apoptotic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 175	175	Bcl-2-related protein A1		PRO_0000244412

Sequences

	Sequence		Length	Mass (Da)
	Q3C2I0 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 0CF1AE37FC92FD9B	FASTA	175	20,045
	10 20 30 40 50 60 MTDTEFGYVH GLAEDYLKYV LQIQQPGSKP SKTSRVLQDV ASSVQDEVER TLKQCLDKFD 70 80 90 100 110 120 VVSVDTARTI FNQVMEKEFE DGIVNWGRIV TIFAFEGILT KKLLGKCIAS DMDMCKDISF 130 140 150 160 170 FVAEFITENT GEWIKQNGGW ENGFVKKFET KSGWLTFLEV TGKICETLCR LKQYY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of the bovine antiapoptotic regulator, BCL2-related protein A1, and its expression in trophoblastic binucleate cells of bovine placenta." Ushizawa K., Takahashi T., Kaneyama K., Hosoe M., Hashizume K. Biol. Reprod. 74:344-351(2006) [PubMed: 16221993] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal spinal cord.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB195549 mRNA. Translation: BAE46584.1. BC123574 mRNA. Translation: AAI23575.1.
IPI	IPI00696172.
RefSeq	NP_001032177.1. NM_001037100.2.
UniGene	Bt.11884.
3D structure databases
ProteinModelPortal	Q3C2I0.
SMR	Q3C2I0. Positions 1-149.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3C2I0.
Proteomic databases
PRIDE	Q3C2I0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000000977; ENSBTAP00000000977; ENSBTAG00000000735.
GeneID	282151.
KEGG	bta:282151.
Organism-specific databases
CTD	597.
Phylogenomic databases
eggNOG	maNOG19634.
GeneTree	ENSGT00510000048456.
HOVERGEN	HBG004840.
InParanoid	Q3C2I0.
OMA	NGGWENG.
OrthoDB	EOG43R3NS.
PhylomeDB	Q3C2I0.
Family and domain databases
InterPro	IPR013282. Apop_reg_Bcl2Rel. IPR002475. Bcl2-like_apoptosis. IPR000712. Bcl2_BH. IPR020717. Bcl2_BH1_motif_CS. IPR020726. Bcl2_BH2_motif_CS. [Graphical view]
KO	K02162.
Pfam	PF00452. Bcl-2. 1 hit. [Graphical view]
PRINTS	PR01862. BCL2FAMILY. PR01867. BCL2RLATEDA1.
SMART	SM00337. BCL. 1 hit. [Graphical view]
PROSITE	PS50062. BCL2_FAMILY. 1 hit. PS01080. BH1. 1 hit. PS01258. BH2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B2LA1_BOVIN

Accession

Primary (citable) accession number: Q3C2I0
Secondary accession number(s): Q08DT4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	November 22, 2005
Last modified:	November 16, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program