ID   BSH_HUMAN               Reviewed;         233 AA.
AC   Q3C1V8;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 2.
DT   27-MAR-2024, entry version 136.
DE   RecName: Full=Brain-specific homeobox protein homolog;
GN   Name=BSX; Synonyms=BSX1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-93.
RA   Totoki Y., Yada T., Sakaki Y., Takeda T.;
RT   "Identification of novel human genes predicted by combining multiple gene
RT   finders.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA binding protein that function as transcriptional
CC       activator. Is essential for normal postnatal growth and nursing. Is an
CC       essential factor for neuronal neuropeptide Y and agouti-related peptide
CC       function and locomotory behavior in the control of energy balance (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q810B3}.
CC   -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Protein Spotlight; Note=Of fidgets and food - Issue
CC       85 of August 2007;
CC       URL="https://web.expasy.org/spotlight/back_issues/085";
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DR   EMBL; AP003040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB231738; BAE46889.1; -; mRNA.
DR   CCDS; CCDS41728.1; -.
DR   RefSeq; NP_001091639.1; NM_001098169.1.
DR   AlphaFoldDB; Q3C1V8; -.
DR   SMR; Q3C1V8; -.
DR   BioGRID; 133475; 1.
DR   IntAct; Q3C1V8; 1.
DR   STRING; 9606.ENSP00000344285; -.
DR   iPTMnet; Q3C1V8; -.
DR   PhosphoSitePlus; Q3C1V8; -.
DR   BioMuta; BSX; -.
DR   DMDM; 156630463; -.
DR   jPOST; Q3C1V8; -.
DR   MassIVE; Q3C1V8; -.
DR   PaxDb; 9606-ENSP00000344285; -.
DR   PeptideAtlas; Q3C1V8; -.
DR   Antibodypedia; 9208; 140 antibodies from 19 providers.
DR   DNASU; 390259; -.
DR   Ensembl; ENST00000343035.3; ENSP00000344285.2; ENSG00000188909.5.
DR   GeneID; 390259; -.
DR   KEGG; hsa:390259; -.
DR   MANE-Select; ENST00000343035.3; ENSP00000344285.2; NM_001098169.2; NP_001091639.1.
DR   UCSC; uc010rzs.3; human.
DR   AGR; HGNC:20450; -.
DR   CTD; 390259; -.
DR   DisGeNET; 390259; -.
DR   GeneCards; BSX; -.
DR   HGNC; HGNC:20450; BSX.
DR   HPA; ENSG00000188909; Not detected.
DR   MIM; 611074; gene.
DR   neXtProt; NX_Q3C1V8; -.
DR   OpenTargets; ENSG00000188909; -.
DR   PharmGKB; PA162377618; -.
DR   VEuPathDB; HostDB:ENSG00000188909; -.
DR   eggNOG; KOG0491; Eukaryota.
DR   GeneTree; ENSGT00940000161473; -.
DR   HOGENOM; CLU_104234_0_0_1; -.
DR   InParanoid; Q3C1V8; -.
DR   OMA; EPDSYML; -.
DR   OrthoDB; 4204245at2759; -.
DR   PhylomeDB; Q3C1V8; -.
DR   TreeFam; TF350735; -.
DR   PathwayCommons; Q3C1V8; -.
DR   SignaLink; Q3C1V8; -.
DR   BioGRID-ORCS; 390259; 11 hits in 1168 CRISPR screens.
DR   ChiTaRS; BSX; human.
DR   GenomeRNAi; 390259; -.
DR   Pharos; Q3C1V8; Tbio.
DR   PRO; PR:Q3C1V8; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q3C1V8; Protein.
DR   Bgee; ENSG00000188909; Expressed in primordial germ cell in gonad and 1 other cell type or tissue.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0042755; P:eating behavior; IEA:Ensembl.
DR   GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR   GO; GO:0060056; P:mammary gland involution; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR24333; HOMEO BOX HB9 LIKE A-RELATED; 1.
DR   PANTHER; PTHR24333:SF12; HOMEOBOX PROTEIN CEH-62; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..233
FT                   /note="Brain-specific homeobox protein homolog"
FT                   /id="PRO_0000299170"
FT   DNA_BIND        110..169
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          160..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        55
FT                   /note="G -> S (in Ref. 2; BAE46889)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   233 AA;  25933 MW;  D11ECA435986FA1C CRC64;
     MNLNFTSPLH PASSQRPTSF FIEDILLHKP KPLREVAPDH FASSLASRVP LLDYGYPLMP
     TPTLLAPHAH HPLHKGDHHH PYFLTTSGMP VPALFPHPQH AELPGKHCRR RKARTVFSDS
     QLSGLEKRFE IQRYLSTPER VELATALSLS ETQVKTWFQN RRMKHKKQLR KSQDEPKAPD
     GPESPEGSPR GSEAATAAEA RLSLPAGPFV LTEPEDEVDI GDEGELGSGP HVL
//