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Protein

Brain-specific homeobox protein homolog

Gene

BSX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

DNA binding protein that function as transcriptional activator. Is essentiel for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi110 – 169HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific homeobox protein homolog
Gene namesi
Name:BSX
Synonyms:BSX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:20450. BSX.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi390259.
OpenTargetsiENSG00000188909.
PharmGKBiPA162377618.

Polymorphism and mutation databases

BioMutaiBSX.
DMDMi156630463.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002991701 – 233Brain-specific homeobox protein homologAdd BLAST233

Proteomic databases

EPDiQ3C1V8.
PaxDbiQ3C1V8.
PRIDEiQ3C1V8.

PTM databases

iPTMnetiQ3C1V8.
PhosphoSitePlusiQ3C1V8.

Expressioni

Gene expression databases

BgeeiENSG00000188909.
CleanExiHS_BSX.

Organism-specific databases

HPAiHPA015654.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000344285.

Structurei

3D structure databases

ProteinModelPortaliQ3C1V8.
SMRiQ3C1V8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi68 – 80His-richAdd BLAST13

Sequence similaritiesi

Belongs to the distal-less homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0491. Eukaryota.
ENOG4111UAT. LUCA.
GeneTreeiENSGT00890000139333.
HOGENOMiHOG000231924.
HOVERGENiHBG050738.
InParanoidiQ3C1V8.
OMAiLHKPEHH.
OrthoDBiEOG091G0QT3.
PhylomeDBiQ3C1V8.
TreeFamiTF350735.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3C1V8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLNFTSPLH PASSQRPTSF FIEDILLHKP KPLREVAPDH FASSLASRVP
60 70 80 90 100
LLDYGYPLMP TPTLLAPHAH HPLHKGDHHH PYFLTTSGMP VPALFPHPQH
110 120 130 140 150
AELPGKHCRR RKARTVFSDS QLSGLEKRFE IQRYLSTPER VELATALSLS
160 170 180 190 200
ETQVKTWFQN RRMKHKKQLR KSQDEPKAPD GPESPEGSPR GSEAATAAEA
210 220 230
RLSLPAGPFV LTEPEDEVDI GDEGELGSGP HVL
Length:233
Mass (Da):25,933
Last modified:August 21, 2007 - v2
Checksum:iD11ECA435986FA1C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55G → S in BAE46889 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003040 Genomic DNA. No translation available.
AB231738 mRNA. Translation: BAE46889.1.
CCDSiCCDS41728.1.
RefSeqiNP_001091639.1. NM_001098169.1.
UniGeneiHs.449687.

Genome annotation databases

EnsembliENST00000343035; ENSP00000344285; ENSG00000188909.
GeneIDi390259.
KEGGihsa:390259.
UCSCiuc010rzs.3. human.

Similar proteinsi

Entry informationi

Entry nameiBSH_HUMAN
AccessioniPrimary (citable) accession number: Q3C1V8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: August 30, 2017
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families