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Q3C1V8 (BSH_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Brain-specific homeobox protein homolog
Gene names
Name:BSX
Synonyms:BSX1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length233 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

DNA binding protein that function as transcriptional activator. Is essentiel for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the distal-less homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 233233Brain-specific homeobox protein homolog
PRO_0000299170

Regions

DNA binding110 – 16960Homeobox
Compositional bias68 – 8013His-rich

Experimental info

Sequence conflict551G → S in BAE46889. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q3C1V8 [UniParc].

Last modified August 21, 2007. Version 2.
Checksum: D11ECA435986FA1C

FASTA23325,933
        10         20         30         40         50         60 
MNLNFTSPLH PASSQRPTSF FIEDILLHKP KPLREVAPDH FASSLASRVP LLDYGYPLMP 

        70         80         90        100        110        120 
TPTLLAPHAH HPLHKGDHHH PYFLTTSGMP VPALFPHPQH AELPGKHCRR RKARTVFSDS 

       130        140        150        160        170        180 
QLSGLEKRFE IQRYLSTPER VELATALSLS ETQVKTWFQN RRMKHKKQLR KSQDEPKAPD 

       190        200        210        220        230 
GPESPEGSPR GSEAATAAEA RLSLPAGPFV LTEPEDEVDI GDEGELGSGP HVL 

« Hide

References

[1]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Identification of novel human genes predicted by combining multiple gene finders."
Totoki Y., Yada T., Sakaki Y., Takeda T.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-93.
+Additional computationally mapped references.

Web resources

Protein Spotlight

Of fidgets and food - Issue 85 of August 2007

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP003040 Genomic DNA. No translation available.
AB231738 mRNA. Translation: BAE46889.1.
RefSeqNP_001091639.1. NM_001098169.1.
UniGeneHs.449687.

3D structure databases

ProteinModelPortalQ3C1V8.
SMRQ3C1V8. Positions 104-167.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000344285.

PTM databases

PhosphoSiteQ3C1V8.

Polymorphism databases

DMDM156630463.

Proteomic databases

PaxDbQ3C1V8.
PRIDEQ3C1V8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000343035; ENSP00000344285; ENSG00000188909.
GeneID390259.
KEGGhsa:390259.
UCSCuc010rzs.2. human.

Organism-specific databases

CTD390259.
GeneCardsGC11M122848.
HGNCHGNC:20450. BSX.
HPAHPA015654.
MIM611074. gene.
neXtProtNX_Q3C1V8.
PharmGKBPA162377618.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG242366.
HOGENOMHOG000231924.
HOVERGENHBG050738.
InParanoidQ3C1V8.
OMALHKPEHH.
OrthoDBEOG7QVM51.
PhylomeDBQ3C1V8.
TreeFamTF350735.

Gene expression databases

BgeeQ3C1V8.
CleanExHS_BSX.
GenevestigatorQ3C1V8.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi390259.
NextBio103586.
PROQ3C1V8.
SOURCESearch...

Entry information

Entry nameBSH_HUMAN
AccessionPrimary (citable) accession number: Q3C1V8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: February 19, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM