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Protein

Brain-specific homeobox protein homolog

Gene

BSX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

DNA binding protein that function as transcriptional activator. Is essentiel for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi110 – 16960HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: Ensembl
  2. sequence-specific DNA binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. eating behavior Source: Ensembl
  2. locomotory behavior Source: Ensembl
  3. mammary gland involution Source: Ensembl
  4. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific homeobox protein homolog
Gene namesi
Name:BSX
Synonyms:BSX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:20450. BSX.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB-SubCell
  3. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162377618.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233Brain-specific homeobox protein homologPRO_0000299170Add
BLAST

Proteomic databases

PaxDbiQ3C1V8.
PRIDEiQ3C1V8.

PTM databases

PhosphoSiteiQ3C1V8.

Expressioni

Gene expression databases

BgeeiQ3C1V8.
CleanExiHS_BSX.
GenevestigatoriQ3C1V8.

Organism-specific databases

HPAiHPA015654.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000344285.

Structurei

3D structure databases

ProteinModelPortaliQ3C1V8.
SMRiQ3C1V8. Positions 104-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi68 – 8013His-richAdd
BLAST

Sequence similaritiesi

Belongs to the distal-less homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG242366.
GeneTreeiENSGT00780000121835.
HOGENOMiHOG000231924.
HOVERGENiHBG050738.
InParanoidiQ3C1V8.
OMAiLHKPEHH.
OrthoDBiEOG7QVM51.
PhylomeDBiQ3C1V8.
TreeFamiTF350735.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3C1V8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLNFTSPLH PASSQRPTSF FIEDILLHKP KPLREVAPDH FASSLASRVP
60 70 80 90 100
LLDYGYPLMP TPTLLAPHAH HPLHKGDHHH PYFLTTSGMP VPALFPHPQH
110 120 130 140 150
AELPGKHCRR RKARTVFSDS QLSGLEKRFE IQRYLSTPER VELATALSLS
160 170 180 190 200
ETQVKTWFQN RRMKHKKQLR KSQDEPKAPD GPESPEGSPR GSEAATAAEA
210 220 230
RLSLPAGPFV LTEPEDEVDI GDEGELGSGP HVL
Length:233
Mass (Da):25,933
Last modified:August 21, 2007 - v2
Checksum:iD11ECA435986FA1C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551G → S in BAE46889. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003040 Genomic DNA. No translation available.
AB231738 mRNA. Translation: BAE46889.1.
CCDSiCCDS41728.1.
RefSeqiNP_001091639.1. NM_001098169.1.
UniGeneiHs.449687.

Genome annotation databases

EnsembliENST00000343035; ENSP00000344285; ENSG00000188909.
GeneIDi390259.
KEGGihsa:390259.
UCSCiuc010rzs.2. human.

Polymorphism databases

DMDMi156630463.

Cross-referencesi

Web resourcesi

Protein Spotlight

Of fidgets and food - Issue 85 of August 2007

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003040 Genomic DNA. No translation available.
AB231738 mRNA. Translation: BAE46889.1.
CCDSiCCDS41728.1.
RefSeqiNP_001091639.1. NM_001098169.1.
UniGeneiHs.449687.

3D structure databases

ProteinModelPortaliQ3C1V8.
SMRiQ3C1V8. Positions 104-167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000344285.

PTM databases

PhosphoSiteiQ3C1V8.

Polymorphism databases

DMDMi156630463.

Proteomic databases

PaxDbiQ3C1V8.
PRIDEiQ3C1V8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343035; ENSP00000344285; ENSG00000188909.
GeneIDi390259.
KEGGihsa:390259.
UCSCiuc010rzs.2. human.

Organism-specific databases

CTDi390259.
GeneCardsiGC11M122848.
HGNCiHGNC:20450. BSX.
HPAiHPA015654.
MIMi611074. gene.
neXtProtiNX_Q3C1V8.
PharmGKBiPA162377618.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG242366.
GeneTreeiENSGT00780000121835.
HOGENOMiHOG000231924.
HOVERGENiHBG050738.
InParanoidiQ3C1V8.
OMAiLHKPEHH.
OrthoDBiEOG7QVM51.
PhylomeDBiQ3C1V8.
TreeFamiTF350735.

Miscellaneous databases

GenomeRNAii390259.
NextBioi103586.
PROiQ3C1V8.
SOURCEiSearch...

Gene expression databases

BgeeiQ3C1V8.
CleanExiHS_BSX.
GenevestigatoriQ3C1V8.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Identification of novel human genes predicted by combining multiple gene finders."
    Totoki Y., Yada T., Sakaki Y., Takeda T.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-93.

Entry informationi

Entry nameiBSH_HUMAN
AccessioniPrimary (citable) accession number: Q3C1V8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: February 4, 2015
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.