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Q3C1V8

- BSH_HUMAN

UniProt

Q3C1V8 - BSH_HUMAN

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Protein

Brain-specific homeobox protein homolog

Gene
BSX, BSX1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

DNA binding protein that function as transcriptional activator. Is essentiel for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi110 – 16960HomeoboxAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: Ensembl
  2. sequence-specific DNA binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. eating behavior Source: Ensembl
  2. locomotory behavior Source: Ensembl
  3. mammary gland involution Source: Ensembl
  4. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific homeobox protein homolog
Gene namesi
Name:BSX
Synonyms:BSX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:20450. BSX.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB-SubCell
  3. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162377618.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233Brain-specific homeobox protein homologPRO_0000299170Add
BLAST

Proteomic databases

PaxDbiQ3C1V8.
PRIDEiQ3C1V8.

PTM databases

PhosphoSiteiQ3C1V8.

Expressioni

Gene expression databases

BgeeiQ3C1V8.
CleanExiHS_BSX.
GenevestigatoriQ3C1V8.

Organism-specific databases

HPAiHPA015654.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000344285.

Structurei

3D structure databases

ProteinModelPortaliQ3C1V8.
SMRiQ3C1V8. Positions 104-167.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi68 – 8013His-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG242366.
HOGENOMiHOG000231924.
HOVERGENiHBG050738.
InParanoidiQ3C1V8.
OMAiLHKPEHH.
OrthoDBiEOG7QVM51.
PhylomeDBiQ3C1V8.
TreeFamiTF350735.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3C1V8-1 [UniParc]FASTAAdd to Basket

« Hide

MNLNFTSPLH PASSQRPTSF FIEDILLHKP KPLREVAPDH FASSLASRVP    50
LLDYGYPLMP TPTLLAPHAH HPLHKGDHHH PYFLTTSGMP VPALFPHPQH 100
AELPGKHCRR RKARTVFSDS QLSGLEKRFE IQRYLSTPER VELATALSLS 150
ETQVKTWFQN RRMKHKKQLR KSQDEPKAPD GPESPEGSPR GSEAATAAEA 200
RLSLPAGPFV LTEPEDEVDI GDEGELGSGP HVL 233
Length:233
Mass (Da):25,933
Last modified:August 21, 2007 - v2
Checksum:iD11ECA435986FA1C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551G → S in BAE46889. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP003040 Genomic DNA. No translation available.
AB231738 mRNA. Translation: BAE46889.1.
CCDSiCCDS41728.1.
RefSeqiNP_001091639.1. NM_001098169.1.
UniGeneiHs.449687.

Genome annotation databases

EnsembliENST00000343035; ENSP00000344285; ENSG00000188909.
GeneIDi390259.
KEGGihsa:390259.
UCSCiuc010rzs.2. human.

Polymorphism databases

DMDMi156630463.

Cross-referencesi

Web resourcesi

Protein Spotlight

Of fidgets and food - Issue 85 of August 2007

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP003040 Genomic DNA. No translation available.
AB231738 mRNA. Translation: BAE46889.1 .
CCDSi CCDS41728.1.
RefSeqi NP_001091639.1. NM_001098169.1.
UniGenei Hs.449687.

3D structure databases

ProteinModelPortali Q3C1V8.
SMRi Q3C1V8. Positions 104-167.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000344285.

PTM databases

PhosphoSitei Q3C1V8.

Polymorphism databases

DMDMi 156630463.

Proteomic databases

PaxDbi Q3C1V8.
PRIDEi Q3C1V8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000343035 ; ENSP00000344285 ; ENSG00000188909 .
GeneIDi 390259.
KEGGi hsa:390259.
UCSCi uc010rzs.2. human.

Organism-specific databases

CTDi 390259.
GeneCardsi GC11M122848.
HGNCi HGNC:20450. BSX.
HPAi HPA015654.
MIMi 611074. gene.
neXtProti NX_Q3C1V8.
PharmGKBi PA162377618.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG242366.
HOGENOMi HOG000231924.
HOVERGENi HBG050738.
InParanoidi Q3C1V8.
OMAi LHKPEHH.
OrthoDBi EOG7QVM51.
PhylomeDBi Q3C1V8.
TreeFami TF350735.

Miscellaneous databases

GenomeRNAii 390259.
NextBioi 103586.
PROi Q3C1V8.
SOURCEi Search...

Gene expression databases

Bgeei Q3C1V8.
CleanExi HS_BSX.
Genevestigatori Q3C1V8.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Identification of novel human genes predicted by combining multiple gene finders."
    Totoki Y., Yada T., Sakaki Y., Takeda T.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-93.

Entry informationi

Entry nameiBSH_HUMAN
AccessioniPrimary (citable) accession number: Q3C1V8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: July 9, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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