Q3C1V8 (BSH_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Brain-specific homeobox protein homolog

Gene names

Name:	BSX
Synonyms:	BSX1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	233 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	DNA binding protein that function as transcriptional activator. Is essentiel for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the distal-less homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	eating behavior Inferred from electronic annotation. Source: Compara locomotory behavior Inferred from electronic annotation. Source: Compara mammary gland involution Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara nucleus Inferred from direct assay. Source: HPA transcription factor complex Inferred from electronic annotation. Source: Compara
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 233	233	Brain-specific homeobox protein homolog		PRO_0000299170
Regions
	DNA binding	110 – 169	60	Homeobox
	Compositional bias	68 – 80	13	His-rich
Experimental info
	Sequence conflict	55	1	G → S in BAE46889. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q3C1V8 [UniParc]. Last modified August 21, 2007. Version 2. Checksum: D11ECA435986FA1C	FASTA	233	25,933
	10 20 30 40 50 60 MNLNFTSPLH PASSQRPTSF FIEDILLHKP KPLREVAPDH FASSLASRVP LLDYGYPLMP 70 80 90 100 110 120 TPTLLAPHAH HPLHKGDHHH PYFLTTSGMP VPALFPHPQH AELPGKHCRR RKARTVFSDS 130 140 150 160 170 180 QLSGLEKRFE IQRYLSTPER VELATALSLS ETQVKTWFQN RRMKHKKQLR KSQDEPKAPD 190 200 210 220 230 GPESPEGSPR GSEAATAAEA RLSLPAGPFV LTEPEDEVDI GDEGELGSGP HVL

References

[1]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Identification of novel human genes predicted by combining multiple gene finders." Totoki Y., Yada T., Sakaki Y., Takeda T. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-93.
+	Additional computationally mapped references.

Web resources

Protein Spotlight

Of fidgets and food - Issue 85 of August 2007

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP003040 Genomic DNA. No translation available. AB231738 mRNA. Translation: BAE46889.1.
IPI	IPI00847613.
RefSeq	NP_001091639.1. NM_001098169.1.
UniGene	Hs.449687.
3D structure databases
ProteinModelPortal	Q3C1V8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000344285.
PTM databases
PhosphoSite	Q3C1V8.
Polymorphism databases
DMDM	156630463.
Proteomic databases
PaxDb	Q3C1V8.
PRIDE	Q3C1V8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000343035; ENSP00000344285; ENSG00000188909.
GeneID	390259.
KEGG	hsa:390259.
UCSC	uc010rzs.2. human.
Organism-specific databases
CTD	390259.
GeneCards	GC11M122848.
HGNC	HGNC:20450. BSX.
HPA	HPA015654.
MIM	611074. gene.
neXtProt	NX_Q3C1V8.
PharmGKB	PA162377618.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG242366.
HOGENOM	HOG000231924.
HOVERGEN	HBG050738.
InParanoid	Q3C1V8.
OMA	LHKPEHH.
OrthoDB	EOG4KKZ41.
PhylomeDB	Q3C1V8.
Gene expression databases
Bgee	Q3C1V8.
CleanEx	HS_BSX.
Genevestigator	Q3C1V8.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	390259.
NextBio	103586.
SOURCE	Search...

Entry information

Entry name

BSH_HUMAN

Accession

Primary (citable) accession number: Q3C1V8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	May 1, 2013
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.