Reviewed, UniProtKB/Swiss-Prot Q3C1V8 (BSH_HUMAN)

Names and origin

Protein names

Recommended name:
    Brain-specific homeobox protein homolog

Gene names

Name:	BSX
Synonyms:	BSX1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	233 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	DNA binding protein that function as transcriptional activator. Is essentiel for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the distal-less homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Activator
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transcription Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 233	233	Brain-specific homeobox protein homolog		PRO_0000299170
Regions
	DNA binding	110 – 169	60	Homeobox
	Compositional bias	68 – 80	13	His-rich
Experimental info
	Sequence conflict	55	1	G → S in BAE46889. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q3C1V8-1 [UniParc]. Last modified August 21, 2007. Version 2. Checksum: D11ECA435986FA1C	FASTA	233	25,933
	10 20 30 40 50 60 MNLNFTSPLH PASSQRPTSF FIEDILLHKP KPLREVAPDH FASSLASRVP LLDYGYPLMP 70 80 90 100 110 120 TPTLLAPHAH HPLHKGDHHH PYFLTTSGMP VPALFPHPQH AELPGKHCRR RKARTVFSDS 130 140 150 160 170 180 QLSGLEKRFE IQRYLSTPER VELATALSLS ETQVKTWFQN RRMKHKKQLR KSQDEPKAPD 190 200 210 220 230 GPESPEGSPR GSEAATAAEA RLSLPAGPFV LTEPEDEVDI GDEGELGSGP HVL

References

[1]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Identification of novel human genes predicted by combining multiple gene finders." Totoki Y., Yada T., Sakaki Y., Takeda T. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-93.
+	Additional computationally mapped references.

Web resources

Protein Spotlight

Of fidgets and food - Issue 85 of August 2007

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP003040 Genomic DNA. No translation available. AB231738 mRNA. Translation: BAE46889.1.
IPI	IPI00847613.
RefSeq	NP_001091639.1.
UniGene	Hs.449687
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3C1V8.
Proteomic databases
PRIDE	Q3C1V8.
Genome annotation databases
Ensembl	ENST00000343035; ENSP00000344285; ENSG00000188909; Homo sapiens. [Genome view]
GeneID	390259.
KEGG	hsa:390259.
NMPDR	fig|9606.3.peg.6773.
UCSC	uc001pyn.2. human.
Organism-specific databases
CTD	390259.
GeneCards	GC11M122354.
HGNC	HGNC:20450. BSX.
HPA	HPA015654.
MIM	611074. gene.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q3C1V8.
OMA	ILAPHPH
OrthoDB	EOG9QC3QS
Gene expression databases
Bgee	Q3C1V8.
CleanEx	HS_BSX.
Genevestigator	Q3C1V8.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	103586.
SOURCE	Search...

Entry information

Entry name

BSH_HUMAN

Accession

Primary (citable) accession number: Q3C1V8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	November 24, 2009
This is version 33 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.