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Q3C1V8

- BSH_HUMAN

UniProt

Q3C1V8 - BSH_HUMAN

Protein

Brain-specific homeobox protein homolog

Gene

BSX

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 2 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    DNA binding protein that function as transcriptional activator. Is essentiel for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi110 – 16960HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: Ensembl
    2. sequence-specific DNA binding transcription factor activity Source: Ensembl

    GO - Biological processi

    1. eating behavior Source: Ensembl
    2. locomotory behavior Source: Ensembl
    3. mammary gland involution Source: Ensembl
    4. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Brain-specific homeobox protein homolog
    Gene namesi
    Name:BSX
    Synonyms:BSX1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:20450. BSX.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: UniProtKB-SubCell
    3. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162377618.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 233233Brain-specific homeobox protein homologPRO_0000299170Add
    BLAST

    Proteomic databases

    PaxDbiQ3C1V8.
    PRIDEiQ3C1V8.

    PTM databases

    PhosphoSiteiQ3C1V8.

    Expressioni

    Gene expression databases

    BgeeiQ3C1V8.
    CleanExiHS_BSX.
    GenevestigatoriQ3C1V8.

    Organism-specific databases

    HPAiHPA015654.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000344285.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3C1V8.
    SMRiQ3C1V8. Positions 104-167.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi68 – 8013His-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the distal-less homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG242366.
    HOGENOMiHOG000231924.
    HOVERGENiHBG050738.
    InParanoidiQ3C1V8.
    OMAiLHKPEHH.
    OrthoDBiEOG7QVM51.
    PhylomeDBiQ3C1V8.
    TreeFamiTF350735.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3C1V8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLNFTSPLH PASSQRPTSF FIEDILLHKP KPLREVAPDH FASSLASRVP    50
    LLDYGYPLMP TPTLLAPHAH HPLHKGDHHH PYFLTTSGMP VPALFPHPQH 100
    AELPGKHCRR RKARTVFSDS QLSGLEKRFE IQRYLSTPER VELATALSLS 150
    ETQVKTWFQN RRMKHKKQLR KSQDEPKAPD GPESPEGSPR GSEAATAAEA 200
    RLSLPAGPFV LTEPEDEVDI GDEGELGSGP HVL 233
    Length:233
    Mass (Da):25,933
    Last modified:August 21, 2007 - v2
    Checksum:iD11ECA435986FA1C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti55 – 551G → S in BAE46889. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP003040 Genomic DNA. No translation available.
    AB231738 mRNA. Translation: BAE46889.1.
    CCDSiCCDS41728.1.
    RefSeqiNP_001091639.1. NM_001098169.1.
    UniGeneiHs.449687.

    Genome annotation databases

    EnsembliENST00000343035; ENSP00000344285; ENSG00000188909.
    GeneIDi390259.
    KEGGihsa:390259.
    UCSCiuc010rzs.2. human.

    Polymorphism databases

    DMDMi156630463.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Of fidgets and food - Issue 85 of August 2007

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP003040 Genomic DNA. No translation available.
    AB231738 mRNA. Translation: BAE46889.1 .
    CCDSi CCDS41728.1.
    RefSeqi NP_001091639.1. NM_001098169.1.
    UniGenei Hs.449687.

    3D structure databases

    ProteinModelPortali Q3C1V8.
    SMRi Q3C1V8. Positions 104-167.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000344285.

    PTM databases

    PhosphoSitei Q3C1V8.

    Polymorphism databases

    DMDMi 156630463.

    Proteomic databases

    PaxDbi Q3C1V8.
    PRIDEi Q3C1V8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000343035 ; ENSP00000344285 ; ENSG00000188909 .
    GeneIDi 390259.
    KEGGi hsa:390259.
    UCSCi uc010rzs.2. human.

    Organism-specific databases

    CTDi 390259.
    GeneCardsi GC11M122848.
    HGNCi HGNC:20450. BSX.
    HPAi HPA015654.
    MIMi 611074. gene.
    neXtProti NX_Q3C1V8.
    PharmGKBi PA162377618.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG242366.
    HOGENOMi HOG000231924.
    HOVERGENi HBG050738.
    InParanoidi Q3C1V8.
    OMAi LHKPEHH.
    OrthoDBi EOG7QVM51.
    PhylomeDBi Q3C1V8.
    TreeFami TF350735.

    Miscellaneous databases

    GenomeRNAii 390259.
    NextBioi 103586.
    PROi Q3C1V8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3C1V8.
    CleanExi HS_BSX.
    Genevestigatori Q3C1V8.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Identification of novel human genes predicted by combining multiple gene finders."
      Totoki Y., Yada T., Sakaki Y., Takeda T.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-93.

    Entry informationi

    Entry nameiBSH_HUMAN
    AccessioniPrimary (citable) accession number: Q3C1V8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 71 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3