Q3C165 (Q3C165_LEIIN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase RuleBase RU000612
EC=5.3.1.9 RuleBase RU000612

Gene names

Name:

pgi EMBL CAF05816.1

Organism

Leishmania infantum EMBL CAF05816.1

Taxonomic identifier

5671 [NCBI]

Taxonomic lineage

Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmania

Protein attributes

Sequence length	605 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. RuleBase RU000612
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. RuleBase RU000612
Subcellular location	Cytoplasm By similarity RuleBase RU003642.
Sequence similarities	Belongs to the GPI family. RuleBase RU000612

Ontologies

Keywords
Biological process	Gluconeogenesis RuleBase RU000612 Glycolysis RuleBase RU000612
Molecular function	Isomerase RuleBase RU000612 EMBL CAF05816.1
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q3C165 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: CD58D1518493D690	FASTA	605	67,067
	10 20 30 40 50 60 MSDYLSKLKE HVLESTEVNG CTPSMATSTF NAPYEVARRT KVLGATDSSL LSLPAWKRLQ 70 80 90 100 110 120 SLYEKHGNES ILSHFENDHQ RFGRYSIEVG LHSEENFLFL DYSKSHINDE IKDALVALAE 130 140 150 160 170 180 ERGVRAFAKA MFDGQRVNST ENRAVLHVAL RNRSNRPIIV DGKDVMTDVN NVLAQMKDFT 190 200 210 220 230 240 EKVRSGEWKG QTGKSISNIV NIGIGGSDLG PVMVTEALKP FSKRDMHCFF VSNVDGTHMA 250 260 270 280 290 300 EVLKQVNLEE TIFIIASKTF TTQETLTNAM SARNALMDYL KANNISTDGA VAKHFVALST 310 320 330 340 350 360 NTEKVREFGI DTVNMFVFWD WVGGRYSVWS AIGLSVMLSI GYDNFVEFLT GAHVMDNHFA 370 380 390 400 410 420 SAPTEQNLPM MLALVGIWYN NFFGAETEAV LPYDQYLWRL PAYLQQLDME SNGKGVTKKS 430 440 450 460 470 480 GAVAVQTGPI IFGEAGTNGQ HAFYQLIHQG TKIIPCDFIG CVQTQNRVGD HHRILMSNFF 490 500 510 520 530 540 AQTEALMVGK SAEEVRQELA KSGMSDEAIQ SMIPHKTFTG NRPSNSILVN ALTPRALGAI 550 560 570 580 590 600 IAMYEHKVLV QGAIWGINSY DQWGVELGKV LAKSILPQLK SGNIVSDHDG STNGLINMFN TRAHL

References

[1]	"Localized cutaneous leishmaniasis due to Leishmania donovani and Leishmania tropica: preliminary findings of the study of 161 new cases from a new endemic focus in himachal pradesh, India." Sharma N.L., Mahajan V.K., Kanga A., Sood A., Katoch V.M., Mauricio I., Singh C.D., Parwan U.C., Sharma V.K., Sharma R.C. Am. J. Trop. Med. Hyg. 72:819-824(2005) [PubMed: 15964970] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: MHOM/FR/1978/LEM75 EMBL CAF05816.1.
[2]	"Towards multilocus sequence typing of the Leishmania donovani complex: resolving genotypes and haplotypes for five polymorphic metabolic enzymes (ASAT, GPI, NH1, NH2, PGD)." Mauricio I.L., Yeo M., Baghaei M., Doto D., Pratlong F., Zemanova E., Dedet J.P., Lukes J., Miles M.A. Int. J. Parasitol. 36:757-769(2006) [PubMed: 16725143] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: MHOM/CN/1980/Strain A EMBL CAF05836.1, MHOM/ES/1986/BCN16 EMBL CAJ43258.1, MHOM/ES/1993/PM1 EMBL CAJ43256.1, MHOM/FR/1978/LEM75 EMBL CAF05816.1, MHOM/FR/1980/LEM189 EMBL CAF05825.1, MHOM/FR/1995/LPN114 EMBL CAJ43255.1, MHOM/FR/1996/LEM3249 EMBL CAF05817.1, MHOM/FR/1997/LSL29 EMBL CAJ43257.1, MHOM/IT/1979/Francesca EMBL CAJ40957.1, MHOM/IT/93/ISS800 EMBL CAF05832.1, MHOM/MT/1985/BUCK EMBL CAF05818.1 and MHOM/PT/2000/IMT260 EMBL CAJ43259.1.
[3]	"Glucose-6-phosphate isomerase gene of the Leishmania donovani complex." Mauricio I.L., Baghaei M., Miles M.M. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: MHOM/TU/1980/IPT-1 EMBL CAF05846.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ620617 Genomic DNA. Translation: CAF05816.1. AJ620618 Genomic DNA. Translation: CAF05817.1. AJ620619 Genomic DNA. Translation: CAF05818.1. AJ620626 Genomic DNA. Translation: CAF05825.1. AJ620633 Genomic DNA. Translation: CAF05832.1. AJ620637 Genomic DNA. Translation: CAF05836.1. AJ620647 Genomic DNA. Translation: CAF05846.1. AM117192 Genomic DNA. Translation: CAJ40957.1. AM157721 Genomic DNA. Translation: CAJ43255.1. AM157722 Genomic DNA. Translation: CAJ43256.1. AM157723 Genomic DNA. Translation: CAJ43257.1. AM157724 Genomic DNA. Translation: CAJ43258.1. AM157725 Genomic DNA. Translation: CAJ43259.1.
3D structure databases
ProteinModelPortal	Q3C165.
SMR	Q3C165. Positions 49-604.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3C165.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOGENOM	HBG352954.
OMA	GPKIVSQ.
PhylomeDB	Q3C165.
ProtClustDB	CLSZ2430346.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q3C165_LEIIN

Accession

Primary (citable) accession number: Q3C165

Entry history

Integrated into UniProtKB/TrEMBL:	November 22, 2005
Last sequence update:	November 22, 2005
Last modified:	December 14, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)