Q3BYE8 (HGD_XANC5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homogentisate 1,2-dioxygenase
EC=1.13.11.5

Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase

Gene names

Name:	hmgA
Ordered Locus Names:	XCV0484

Organism

Xanthomonas campestris pv. vesicatoria (strain 85-10) [Complete proteome] [HAMAP]

Taxonomic identifier

316273 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas › Xanthomonas euvesicatoria

Protein attributes

Sequence length	439 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Homogentisate + O2 = 4-maleylacetoacetate. HAMAP-Rule MF_00334
Cofactor	Iron By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP-Rule MF_00334
Sequence similarities	Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP tyrosine catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 439	439	Homogentisate 1,2-dioxygenase HAMAP-Rule MF_00334		PRO_0000225797
Sites
	Metal binding	332	1	Iron By similarity
	Metal binding	338	1	Iron By similarity
	Metal binding	368	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3BYE8 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: FDD983F3E7BE9E8A	FASTA	439	48,511
	10 20 30 40 50 60 MPMHDQTSYM TGFGNEFATE AVAGSLPVGQ NSPQRVAHGL YAEQLSGTAF TAPRGENRRS 70 80 90 100 110 120 WLYRIRPAAV HGRFSLIEQS RLHNDFGGGP VPPDQMRWSP LPLPATRTDF VDGLYTMAGN 130 140 150 160 170 180 GSPEAMTGVA VHLYAANASM RDRFFYNADG ELLLVPQLGR LRVCTELGVL ELEPQQIGVI 190 200 210 220 230 240 PRGLRFRVEL LDSEARGYVC ENFGGLLRLP ELGPIGANGL ANPRDFQTPR AAFEQREGRF 250 260 270 280 290 300 ELVAKFQGHL WRADIGHSPL DVVAWHGNYA PYRYDLRRFN TIGSISFDHP DPSIFTVLTS 310 320 330 340 350 360 PSDTHGTANM DFAIFPPRWL VAQHTFRPPW FHRNVASEFM GLVHGVYDAK AEGFAPGGAS 370 380 390 400 410 420 LHNCMSGHGP DAATFDKASQ ADLTRPDVIA DTMAFMFETR AVLRPTQQAL NAAHRQADYQ 430 QCWSGLRAAF QPPTTEDAT

References

[1]

"Insights into genome plasticity and pathogenicity of the plant pathogenic Bacterium Xanthomonas campestris pv. vesicatoria revealed by the complete genome sequence." Thieme F., Koebnik R., Bekel T., Berger C., Boch J., Buettner D., Caldana C., Gaigalat L., Goesmann A., Kay S., Kirchner O., Lanz C., Linke B., McHardy A.C., Meyer F., Mittenhuber G., Nies D.H., Niesbach-Kloesgen U. , Patschkowski T., Rueckert C., Rupp O., Schneiker S., Schuster S.C., Vorhoelter F.J., Weber E., Puehler A., Bonas U., Bartels D., Kaiser O. J. Bacteriol. 187:7254-7266(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 85-10.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM039952 Genomic DNA. Translation: CAJ22115.1.
RefSeq	YP_362215.1. NC_007508.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	316273.XCV0484.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAJ22115; CAJ22115; XCV0484.
GeneID	3729843.
KEGG	xcv:XCV0484.
PATRIC	24090310. VBIXanCam71633_0669.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3508.
HOGENOM	HOG000139824.
KO	K00451.
OMA	AVTKWGL.
ProtClustDB	PRK05341.
Enzyme and pathway databases
UniPathway	UPA00139; UER00339.
Family and domain databases
Gene3D	2.60.120.10. 2 hits.
HAMAP	MF_00334. Homogentis_dioxygen.
InterPro	IPR005708. Homogentis_dOase. IPR022950. Homogentis_dOase_bac. IPR014710. RmlC-like_jellyroll. IPR011051. RmlC_Cupin. [Graphical view]
PANTHER	PTHR11056. PTHR11056. 1 hit.
Pfam	PF04209. HgmA. 1 hit. [Graphical view]
SUPFAM	SSF51182. RmlC_like_cupin. 1 hit.
TIGRFAMs	TIGR01015. hmgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HGD_XANC5

Accession

Primary (citable) accession number: Q3BYE8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	November 22, 2005
Last modified:	May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program