Reviewed, UniProtKB/Swiss-Prot Q3BYE8 (HGD_XANC5)

Names and origin

Protein names

Recommended name:
    Homogentisate 1,2-dioxygenase
    EC=1.13.11.5
Alternative name(s):
    Homogentisicase
    Homogentisate oxygenase
    Homogentisic acid oxidase

Gene names

Name:	hmgA
Ordered Locus Names:	XCV0484

Organism

Xanthomonas campestris pv. vesicatoria (strain 85-10) [Complete proteome] [HAMAP]

Taxonomic identifier

316273 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length	439 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Homogentisate + O(2) = 4-maleylacetoacetate.
Cofactor	Iron By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 4/6.
Sequence similarities	Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 439	439	Homogentisate 1,2-dioxygenase		PRO_0000225797
Sites
	Metal binding	332	1	Iron By similarity
	Metal binding	338	1	Iron By similarity
	Metal binding	368	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3BYE8-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: FDD983F3E7BE9E8A	FASTA	439	48,511
	10 20 30 40 50 60 MPMHDQTSYM TGFGNEFATE AVAGSLPVGQ NSPQRVAHGL YAEQLSGTAF TAPRGENRRS 70 80 90 100 110 120 WLYRIRPAAV HGRFSLIEQS RLHNDFGGGP VPPDQMRWSP LPLPATRTDF VDGLYTMAGN 130 140 150 160 170 180 GSPEAMTGVA VHLYAANASM RDRFFYNADG ELLLVPQLGR LRVCTELGVL ELEPQQIGVI 190 200 210 220 230 240 PRGLRFRVEL LDSEARGYVC ENFGGLLRLP ELGPIGANGL ANPRDFQTPR AAFEQREGRF 250 260 270 280 290 300 ELVAKFQGHL WRADIGHSPL DVVAWHGNYA PYRYDLRRFN TIGSISFDHP DPSIFTVLTS 310 320 330 340 350 360 PSDTHGTANM DFAIFPPRWL VAQHTFRPPW FHRNVASEFM GLVHGVYDAK AEGFAPGGAS 370 380 390 400 410 420 LHNCMSGHGP DAATFDKASQ ADLTRPDVIA DTMAFMFETR AVLRPTQQAL NAAHRQADYQ 430 QCWSGLRAAF QPPTTEDAT

References

[1]

"Insights into genome plasticity and pathogenicity of the plant pathogenic Bacterium Xanthomonas campestris pv. vesicatoria revealed by the complete genome sequence." Thieme F., Koebnik R., Bekel T., Berger C., Boch J., Buettner D., Caldana C., Gaigalat L., Goesmann A., Kay S., Kirchner O., Lanz C., Linke B., McHardy A.C., Meyer F., Mittenhuber G., Nies D.H., Niesbach-Kloesgen U. , Patschkowski T., Rueckert C., Rupp O., Schneiker S., Schuster S.C., Vorhoelter F.J., Weber E., Puehler A., Bonas U., Bartels D., Kaiser O. J. Bacteriol. 187:7254-7266(2005) [PubMed: 16237009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM039952 Genomic DNA. Translation: CAJ22115.1.
RefSeq	YP_362215.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3729843.
GenomeReviews	Gene locus XCV0484 in contig AM039952_GR.
KEGG	xcv:XCV0484.
NMPDR	fig|316273.3.peg.723.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3BYE8.
Enzyme and pathway databases
BioCyc	XCAM316273:XCV0484-MON.
Family and domain databases
HAMAP	MF_00334. [Tree]
InterPro	IPR005708. Homogentis_dOase. [Graphical view]
PANTHER	PTHR11056. Homogentis_dOase. 1 hit.
Pfam	PF04209. HgmA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01015. hmgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HGD_XANC5

Accession

Primary (citable) accession number: Q3BYE8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	November 22, 2005
Last modified:	November 4, 2008
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)