SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q3BYE8

- HGD_XANC5

UniProt

Q3BYE8 - HGD_XANC5

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Homogentisate 1,2-dioxygenase
Gene
hmgA, XCV0484
Organism
Xanthomonas campestris pv. vesicatoria (strain 85-10)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate By similarity.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Iron By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei289 – 2891Proton acceptor By similarity
Metal bindingi332 – 3321Iron By similarity
Metal bindingi338 – 3381Iron By similarity
Binding sitei347 – 3471homogentisate By similarity
Metal bindingi368 – 3681Iron By similarity
Binding sitei368 – 3681homogentisate By similarity

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
  2. tyrosine catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciXCAM316273:GJF8-492-MONOMER.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
Short name:
HGDO
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene namesi
Name:hmgA
Ordered Locus Names:XCV0484
OrganismiXanthomonas campestris pv. vesicatoria (strain 85-10)
Taxonomic identifieri316273 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000007069: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 439439Homogentisate 1,2-dioxygenaseUniRule annotation
PRO_0000225797Add
BLAST

Interactioni

Subunit structurei

Hexamer; dimer of trimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi316273.XCV0484.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
KOiK00451.
OMAiRCFYNSD.
OrthoDBiEOG6D5FZK.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00334. Homogentis_dioxygen.
InterProiIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3BYE8-1 [UniParc]FASTAAdd to Basket

« Hide

MPMHDQTSYM TGFGNEFATE AVAGSLPVGQ NSPQRVAHGL YAEQLSGTAF    50
TAPRGENRRS WLYRIRPAAV HGRFSLIEQS RLHNDFGGGP VPPDQMRWSP 100
LPLPATRTDF VDGLYTMAGN GSPEAMTGVA VHLYAANASM RDRFFYNADG 150
ELLLVPQLGR LRVCTELGVL ELEPQQIGVI PRGLRFRVEL LDSEARGYVC 200
ENFGGLLRLP ELGPIGANGL ANPRDFQTPR AAFEQREGRF ELVAKFQGHL 250
WRADIGHSPL DVVAWHGNYA PYRYDLRRFN TIGSISFDHP DPSIFTVLTS 300
PSDTHGTANM DFAIFPPRWL VAQHTFRPPW FHRNVASEFM GLVHGVYDAK 350
AEGFAPGGAS LHNCMSGHGP DAATFDKASQ ADLTRPDVIA DTMAFMFETR 400
AVLRPTQQAL NAAHRQADYQ QCWSGLRAAF QPPTTEDAT 439
Length:439
Mass (Da):48,511
Last modified:November 22, 2005 - v1
Checksum:iFDD983F3E7BE9E8A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM039952 Genomic DNA. Translation: CAJ22115.1.
RefSeqiWP_011346147.1. NC_007508.1.
YP_362215.1. NC_007508.1.

Genome annotation databases

EnsemblBacteriaiCAJ22115; CAJ22115; XCV0484.
GeneIDi3729843.
KEGGixcv:XCV0484.
PATRICi24090310. VBIXanCam71633_0669.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM039952 Genomic DNA. Translation: CAJ22115.1 .
RefSeqi WP_011346147.1. NC_007508.1.
YP_362215.1. NC_007508.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316273.XCV0484.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ22115 ; CAJ22115 ; XCV0484 .
GeneIDi 3729843.
KEGGi xcv:XCV0484.
PATRICi 24090310. VBIXanCam71633_0669.

Phylogenomic databases

eggNOGi COG3508.
HOGENOMi HOG000139824.
KOi K00451.
OMAi RCFYNSD.
OrthoDBi EOG6D5FZK.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00339 .
BioCyci XCAM316273:GJF8-492-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
HAMAPi MF_00334. Homogentis_dioxygen.
InterProi IPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR11056. PTHR11056. 1 hit.
Pfami PF04209. HgmA. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR01015. hmgA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 85-10.

Entry informationi

Entry nameiHGD_XANC5
AccessioniPrimary (citable) accession number: Q3BYE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 22, 2005
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi