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Q3BYE8

- HGD_XANC5

UniProt

Q3BYE8 - HGD_XANC5

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Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Xanthomonas campestris pv. vesicatoria (strain 85-10)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Iron.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei289 – 2891Proton acceptorUniRule annotation
Metal bindingi332 – 3321IronUniRule annotation
Metal bindingi338 – 3381IronUniRule annotation
Binding sitei347 – 3471homogentisateUniRule annotation
Metal bindingi368 – 3681IronUniRule annotation
Binding sitei368 – 3681homogentisateUniRule annotation

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
  2. tyrosine catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciXCAM316273:GJF8-492-MONOMER.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
Short name:
HGDOUniRule annotation
Alternative name(s):
Homogentisate oxygenaseUniRule annotation
Homogentisic acid oxidaseUniRule annotation
HomogentisicaseUniRule annotation
Gene namesi
Name:hmgAUniRule annotation
Ordered Locus Names:XCV0484
OrganismiXanthomonas campestris pv. vesicatoria (strain 85-10)
Taxonomic identifieri316273 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000007069: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 439439Homogentisate 1,2-dioxygenasePRO_0000225797Add
BLAST

Interactioni

Subunit structurei

Hexamer; dimer of trimers.UniRule annotation

Protein-protein interaction databases

STRINGi316273.XCV0484.

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
KOiK00451.
OMAiRCFYNSD.
OrthoDBiEOG6D5FZK.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00334. Homogentis_dioxygen.
InterProiIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3BYE8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPMHDQTSYM TGFGNEFATE AVAGSLPVGQ NSPQRVAHGL YAEQLSGTAF
60 70 80 90 100
TAPRGENRRS WLYRIRPAAV HGRFSLIEQS RLHNDFGGGP VPPDQMRWSP
110 120 130 140 150
LPLPATRTDF VDGLYTMAGN GSPEAMTGVA VHLYAANASM RDRFFYNADG
160 170 180 190 200
ELLLVPQLGR LRVCTELGVL ELEPQQIGVI PRGLRFRVEL LDSEARGYVC
210 220 230 240 250
ENFGGLLRLP ELGPIGANGL ANPRDFQTPR AAFEQREGRF ELVAKFQGHL
260 270 280 290 300
WRADIGHSPL DVVAWHGNYA PYRYDLRRFN TIGSISFDHP DPSIFTVLTS
310 320 330 340 350
PSDTHGTANM DFAIFPPRWL VAQHTFRPPW FHRNVASEFM GLVHGVYDAK
360 370 380 390 400
AEGFAPGGAS LHNCMSGHGP DAATFDKASQ ADLTRPDVIA DTMAFMFETR
410 420 430
AVLRPTQQAL NAAHRQADYQ QCWSGLRAAF QPPTTEDAT
Length:439
Mass (Da):48,511
Last modified:November 22, 2005 - v1
Checksum:iFDD983F3E7BE9E8A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM039952 Genomic DNA. Translation: CAJ22115.1.
RefSeqiWP_011346147.1. NC_007508.1.
YP_362215.1. NC_007508.1.

Genome annotation databases

EnsemblBacteriaiCAJ22115; CAJ22115; XCV0484.
GeneIDi3729843.
KEGGixcv:XCV0484.
PATRICi24090310. VBIXanCam71633_0669.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM039952 Genomic DNA. Translation: CAJ22115.1 .
RefSeqi WP_011346147.1. NC_007508.1.
YP_362215.1. NC_007508.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316273.XCV0484.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ22115 ; CAJ22115 ; XCV0484 .
GeneIDi 3729843.
KEGGi xcv:XCV0484.
PATRICi 24090310. VBIXanCam71633_0669.

Phylogenomic databases

eggNOGi COG3508.
HOGENOMi HOG000139824.
KOi K00451.
OMAi RCFYNSD.
OrthoDBi EOG6D5FZK.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00339 .
BioCyci XCAM316273:GJF8-492-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
HAMAPi MF_00334. Homogentis_dioxygen.
InterProi IPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR11056. PTHR11056. 1 hit.
Pfami PF04209. HgmA. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR01015. hmgA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 85-10.

Entry informationi

Entry nameiHGD_XANC5
AccessioniPrimary (citable) accession number: Q3BYE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 22, 2005
Last modified: October 1, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3