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Q3BXK7

- BETB_XANC5

UniProt

Q3BXK7 - BETB_XANC5

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Protein
NAD/NADP-dependent betaine aldehyde dehydrogenase
Gene
betB, XCV0775
Organism
Xanthomonas campestris pv. vesicatoria (strain 85-10)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

Binds 2 potassium ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi93 – 931Potassium 1 By similarity
Active sitei162 – 1621Charge relay system By similarity
Metal bindingi180 – 1801Potassium 1; via carbonyl oxygen By similarity
Binding sitei209 – 2091NAD/NADP; via amide nitrogen By similarity
Metal bindingi246 – 2461Potassium 2; via carbonyl oxygen By similarity
Sitei248 – 2481Seems to be a necessary countercharge to the potassium cations By similarity
Active sitei252 – 2521Proton acceptor By similarity
Binding sitei286 – 2861NAD/NADP By similarity
Binding sitei387 – 3871NAD/NADP By similarity
Metal bindingi457 – 4571Potassium 2; via carbonyl oxygen By similarity
Metal bindingi460 – 4601Potassium 2; via carbonyl oxygen By similarity
Active sitei464 – 4641Charge relay system By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi150 – 1534NAD/NADP By similarity
Nucleotide bindingi176 – 1794NAD/NADP By similarity
Nucleotide bindingi229 – 2346NAD/NADP By similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

BioCyciXCAM316273:GJF8-790-MONOMER.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betB
Ordered Locus Names:XCV0775
OrganismiXanthomonas campestris pv. vesicatoria (strain 85-10)
Taxonomic identifieri316273 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000007069: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation
PRO_1000047060Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei286 – 2861Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi316273.XCV0775.

Structurei

3D structure databases

ProteinModelPortaliQ3BXK7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OMAiCTDEMTI.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3BXK7-1 [UniParc]FASTAAdd to Basket

« Hide

MPRFSDQLLY IGGRYVPARG GHTFEVVNPA TGEVLANVHN AGADDLDAAV    50
DSAQAGQRQW AALTTVERSR ILLRAVALLR ERNDALAELE TLNTGKPLSE 100
TRSVDVVTGA DVLEYYAGVA QALQGAQVPL REGSFFYTRH EPLGVVGAIG 150
AWNYPIQIAL WKAAPALAAG NAMIFKPSEV TPLTALKLAE IFTEAGLPDG 200
VFNVLPGDGA SVGTALTEHP QIEKISFTGG TATGRKVMAS ASSSSLKEVT 250
MELGGKSPLI VCADADLDLA ADIAMMANFY SSGQVCTNGT RVFVPRALRH 300
AFEARLLARV QRIHIGDPLD ERTTFGPLVS AAHMQRVLEH IEQGKAEGAR 350
LLCGGERLQD GALAQGYYVA PTIFSDCTDV MTIVREEIFG PVLSLLTYDD 400
EDEAVTRANA TTYGLAAGVV TPDLARAHRL IHRLEAGICW VNTWGESPAP 450
MPVGGYKQSG VGRENGLATL QAYTRTKSVQ IELERYASVF 490
Length:490
Mass (Da):52,392
Last modified:November 22, 2005 - v1
Checksum:iB86DD85BC53A38ED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM039952 Genomic DNA. Translation: CAJ22406.1.
RefSeqiWP_011346383.1. NC_007508.1.
YP_362506.1. NC_007508.1.

Genome annotation databases

EnsemblBacteriaiCAJ22406; CAJ22406; XCV0775.
GeneIDi3729800.
KEGGixcv:XCV0775.
PATRICi24090928. VBIXanCam71633_0976.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM039952 Genomic DNA. Translation: CAJ22406.1 .
RefSeqi WP_011346383.1. NC_007508.1.
YP_362506.1. NC_007508.1.

3D structure databases

ProteinModelPortali Q3BXK7.
ModBasei Search...

Protein-protein interaction databases

STRINGi 316273.XCV0775.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ22406 ; CAJ22406 ; XCV0775 .
GeneIDi 3729800.
KEGGi xcv:XCV0775.
PATRICi 24090928. VBIXanCam71633_0976.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00130.
OMAi CTDEMTI.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .
BioCyci XCAM316273:GJF8-790-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00804. BADH.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01804. BADH. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 85-10.

Entry informationi

Entry nameiBETB_XANC5
AccessioniPrimary (citable) accession number: Q3BXK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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