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Q3BW89 (GCSP_XANC5) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:XCV1243
OrganismXanthomonas campestris pv. vesicatoria (strain 85-10) [Complete proteome] [HAMAP]
Taxonomic identifier316273 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Protein attributes

Sequence length954 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 954954Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045626

Amino acid modifications

Modified residue7021N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3BW89 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 17303C000C2FAECC

FASTA954102,578
        10         20         30         40         50         60 
MSQTPSSLRD LEHHSAFVER HIGPNDAEIA QMLDVVGHAC LDALTDAIVP GNIKSPAPLA 

        70         80         90        100        110        120 
LPEAITEEEA LAKIRAIADK NTVFRNFIGQ GYYGTHTPKV ILRNILENPA WYTAYTPYQA 

       130        140        150        160        170        180 
EISQGRMEAL INFQTLCADL TGMQIANASL LDEATAAAEA MTLAKRSAKS RSNTFFVHDA 

       190        200        210        220        230        240 
VHPQTLELLR TRAEPLDIVL RVGTPEEALQ AECFGVLLQY PDSFGHIGDH AALADAVHAQ 

       250        260        270        280        290        300 
GGLVAVATDL LALTLIAAPG EWGADIVVGN SQRFGVPFGF GGPHAAFMAC RDAYKRSMPG 

       310        320        330        340        350        360 
RLIGVSIDAA GNPAYRLTLQ TREQHIRREK ATSNICTAQV LLAVMASMYA VYHGPDGLTR 

       370        380        390        400        410        420 
IARRTHRLAA ILAAALRSAG VTVGERFFDT LHVKAIDANA IHARARAAGI NLRAIDSEAV 

       430        440        450        460        470        480 
GISLDETSTR ADVVALAALF GAQADVDALD AATADALPQG LLRTTPFLTH PVFNTHHSEH 

       490        500        510        520        530        540 
ELLRYMRSLA DKDLAMDRTM IPLGSCTMKL NATAEMIPVT WPEFGAIHPL APAEQSAGYA 

       550        560        570        580        590        600 
QLIDELEAML VECTGYDAVS LQPNSGAQGE YAGLLAIRAY HRSRGEAHRD ICLIPESAHG 

       610        620        630        640        650        660 
TNPASAQMCG MTVVVTKCDA NGNVDVDDIR AKAEKYSDRL AALMITYPST HGVFEEDVVA 

       670        680        690        700        710        720 
ICEAVHAHGG QVYTDGANMN ALVGVAKPGK WGSDVSHLNL HKTFCIPHGG GGPGVGPCAV 

       730        740        750        760        770        780 
KSHLAPYLPK TLGGEGDVGM VSAASYGSAS ILPISWMYVT MMGSAGLRKA TQVALLNANY 

       790        800        810        820        830        840 
IAKRLAPHYK TLYTGRNGLV AHECILDVRP LEKTSGIGAE DIAKRLIDFG FHAPTLSFPV 

       850        860        870        880        890        900 
AGTLMVEPTE SESQHELDRF IDAMIQIREE IRAIEDGRLD REDNPLKHAP HTATQVSASE 

       910        920        930        940        950 
WTHAYPRELA AFPLPSLKQQ KYWPPVARVD NVYGDKNVMC ACIPVDAYKE DVEA 

« Hide

References

[1]"Insights into genome plasticity and pathogenicity of the plant pathogenic Bacterium Xanthomonas campestris pv. vesicatoria revealed by the complete genome sequence."
Thieme F., Koebnik R., Bekel T., Berger C., Boch J., Buettner D., Caldana C., Gaigalat L., Goesmann A., Kay S., Kirchner O., Lanz C., Linke B., McHardy A.C., Meyer F., Mittenhuber G., Nies D.H., Niesbach-Kloesgen U. expand/collapse author list , Patschkowski T., Rueckert C., Rupp O., Schneiker S., Schuster S.C., Vorhoelter F.J., Weber E., Puehler A., Bonas U., Bartels D., Kaiser O.
J. Bacteriol. 187:7254-7266(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 85-10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM039952 Genomic DNA. Translation: CAJ22874.1.
RefSeqYP_362974.1. NC_007508.1.

3D structure databases

ProteinModelPortalQ3BW89.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING316273.XCV1243.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ22874; CAJ22874; XCV1243.
GeneID3730132.
KEGGxcv:XCV1243.
PATRIC24091936. VBIXanCam71633_1464.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAIRVQVII.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycXCAM316273:GJF8-1278-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_XANC5
AccessionPrimary (citable) accession number: Q3BW89
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: February 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families