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Q3BUF7

- HISX_XANC5

UniProt

Q3BUF7 - HISX_XANC5

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Xanthomonas campestris pv. vesicatoria (strain 85-10)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271NADUniRule annotation
Binding sitei189 – 1891NADUniRule annotation
Binding sitei212 – 2121NADUniRule annotation
Binding sitei237 – 2371SubstrateUniRule annotation
Metal bindingi259 – 2591ZincUniRule annotation
Binding sitei259 – 2591SubstrateUniRule annotation
Metal bindingi262 – 2621ZincUniRule annotation
Binding sitei262 – 2621SubstrateUniRule annotation
Active sitei326 – 3261Proton acceptorUniRule annotation
Active sitei327 – 3271Proton acceptorUniRule annotation
Binding sitei327 – 3271SubstrateUniRule annotation
Metal bindingi360 – 3601ZincUniRule annotation
Binding sitei360 – 3601SubstrateUniRule annotation
Binding sitei414 – 4141SubstrateUniRule annotation
Metal bindingi419 – 4191ZincUniRule annotation
Binding sitei419 – 4191SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciXCAM316273:GJF8-1931-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:XCV1875
OrganismiXanthomonas campestris pv. vesicatoria (strain 85-10)
Taxonomic identifieri316273 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000007069: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Histidinol dehydrogenasePRO_0000135883Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316273.XCV1875.

Structurei

3D structure databases

ProteinModelPortaliQ3BUF7.
SMRiQ3BUF7. Positions 2-428.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3BUF7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKILDWSQLD GAARTDALTR PVQTVATQTR DAVAALIADV RARGDAALRE
60 70 80 90 100
ITARFDGVSL ESFAVSEADF AAAEAAVAPE LRQAMQDAVA RIDAFHRAGM
110 120 130 140 150
SEGYAVETAP GVVCEKIVRP IGRVGLYVPA GSAPLPSTAL MLGVPARLAG
160 170 180 190 200
CREVVLCTPP RKDGSVDPAV LVAAQLTGVR RVFKLGGAQA IAAMAYGTES
210 220 230 240 250
VPSCDKLFGP GNSYVTEAKQ QVAQSGAAAI DMPAGPSEVL VIADAGAQPA
260 270 280 290 300
FVAADLLSQA EHGPDSQVLL LSDSDGLIDA VQVQLEVQLA QLSRADIARQ
310 320 330 340 350
ALAQSRMIKV QALDEAFAIS NRYAPEHLIL ALREPRAWLA QVEAAGSVFL
360 370 380 390 400
GDYTPEALGD YCSGTNHVLP TSGAARAYSG VSVASFQNMV SVQAASKAGI
410 420 430
DGIGQCALIL ARAEGLDAHA NAVALRMGVA A
Length:431
Mass (Da):44,549
Last modified:November 22, 2005 - v1
Checksum:i0E6646E63769E2D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM039952 Genomic DNA. Translation: CAJ23552.1.
RefSeqiYP_363606.1. NC_007508.1.

Genome annotation databases

EnsemblBacteriaiCAJ23552; CAJ23552; XCV1875.
GeneIDi3729837.
KEGGixcv:XCV1875.
PATRICi24093292. VBIXanCam71633_2133.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM039952 Genomic DNA. Translation: CAJ23552.1 .
RefSeqi YP_363606.1. NC_007508.1.

3D structure databases

ProteinModelPortali Q3BUF7.
SMRi Q3BUF7. Positions 2-428.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316273.XCV1875.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ23552 ; CAJ23552 ; XCV1875 .
GeneIDi 3729837.
KEGGi xcv:XCV1875.
PATRICi 24093292. VBIXanCam71633_2133.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci XCAM316273:GJF8-1931-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 85-10.

Entry informationi

Entry nameiHISX_XANC5
AccessioniPrimary (citable) accession number: Q3BUF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 22, 2005
Last modified: November 26, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3