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Q3BUF7

- HISX_XANC5

UniProt

Q3BUF7 - HISX_XANC5

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Protein
Histidinol dehydrogenase
Gene
hisD, XCV1875
Organism
Xanthomonas campestris pv. vesicatoria (strain 85-10)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271NAD By similarity
Binding sitei189 – 1891NAD By similarity
Binding sitei212 – 2121NAD By similarity
Binding sitei237 – 2371Substrate By similarity
Metal bindingi259 – 2591Zinc By similarity
Binding sitei259 – 2591Substrate By similarity
Metal bindingi262 – 2621Zinc By similarity
Binding sitei262 – 2621Substrate By similarity
Active sitei326 – 3261Proton acceptor By similarity
Active sitei327 – 3271Proton acceptor By similarity
Binding sitei327 – 3271Substrate By similarity
Metal bindingi360 – 3601Zinc By similarity
Binding sitei360 – 3601Substrate By similarity
Binding sitei414 – 4141Substrate By similarity
Metal bindingi419 – 4191Zinc By similarity
Binding sitei419 – 4191Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciXCAM316273:GJF8-1931-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:XCV1875
OrganismiXanthomonas campestris pv. vesicatoria (strain 85-10)
Taxonomic identifieri316273 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000007069: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Histidinol dehydrogenaseUniRule annotation
PRO_0000135883Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316273.XCV1875.

Structurei

3D structure databases

ProteinModelPortaliQ3BUF7.
SMRiQ3BUF7. Positions 2-428.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3BUF7-1 [UniParc]FASTAAdd to Basket

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MKILDWSQLD GAARTDALTR PVQTVATQTR DAVAALIADV RARGDAALRE    50
ITARFDGVSL ESFAVSEADF AAAEAAVAPE LRQAMQDAVA RIDAFHRAGM 100
SEGYAVETAP GVVCEKIVRP IGRVGLYVPA GSAPLPSTAL MLGVPARLAG 150
CREVVLCTPP RKDGSVDPAV LVAAQLTGVR RVFKLGGAQA IAAMAYGTES 200
VPSCDKLFGP GNSYVTEAKQ QVAQSGAAAI DMPAGPSEVL VIADAGAQPA 250
FVAADLLSQA EHGPDSQVLL LSDSDGLIDA VQVQLEVQLA QLSRADIARQ 300
ALAQSRMIKV QALDEAFAIS NRYAPEHLIL ALREPRAWLA QVEAAGSVFL 350
GDYTPEALGD YCSGTNHVLP TSGAARAYSG VSVASFQNMV SVQAASKAGI 400
DGIGQCALIL ARAEGLDAHA NAVALRMGVA A 431
Length:431
Mass (Da):44,549
Last modified:November 22, 2005 - v1
Checksum:i0E6646E63769E2D2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM039952 Genomic DNA. Translation: CAJ23552.1.
RefSeqiWP_011347185.1. NC_007508.1.
YP_363606.1. NC_007508.1.

Genome annotation databases

EnsemblBacteriaiCAJ23552; CAJ23552; XCV1875.
GeneIDi3729837.
KEGGixcv:XCV1875.
PATRICi24093292. VBIXanCam71633_2133.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM039952 Genomic DNA. Translation: CAJ23552.1 .
RefSeqi WP_011347185.1. NC_007508.1.
YP_363606.1. NC_007508.1.

3D structure databases

ProteinModelPortali Q3BUF7.
SMRi Q3BUF7. Positions 2-428.
ModBasei Search...

Protein-protein interaction databases

STRINGi 316273.XCV1875.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ23552 ; CAJ23552 ; XCV1875 .
GeneIDi 3729837.
KEGGi xcv:XCV1875.
PATRICi 24093292. VBIXanCam71633_2133.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci XCAM316273:GJF8-1931-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 85-10.

Entry informationi

Entry nameiHISX_XANC5
AccessioniPrimary (citable) accession number: Q3BUF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 22, 2005
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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