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Q3BRE4

- SYL_XANC5

UniProt

Q3BRE4 - SYL_XANC5

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Xanthomonas campestris pv. vesicatoria (strain 85-10)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei641 – 6411ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciXCAM316273:GJF8-3031-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:XCV2938
OrganismiXanthomonas campestris pv. vesicatoria (strain 85-10)
Taxonomic identifieri316273 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000007069: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 880880Leucine--tRNA ligasePRO_0000334839Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316273.XCV2938.

Structurei

3D structure databases

ProteinModelPortaliQ3BRE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 5611"HIGH" regionAdd
BLAST
Motifi638 – 6425"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3BRE4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTVEPNVYD PQQVETSAQQ FWDATRAFQV DENSEKPKFY CLSMLPYPSG
60 70 80 90 100
ALHMGHVRNY TISDVVSRYK RMTGHNVLQP MGWDAFGLPA ENAAIKNKTA
110 120 130 140 150
PAKWTYANIE HMRAQLKSLG YAIDWSREFA TCTPDYYVHE QRMFTRLMRK
160 170 180 190 200
GLAYRRNAVV NWDPIDQTVL ANEQVIDGRG WRSGALVEKR EIPQWFLRIT
210 220 230 240 250
DYAQELLDGL DQLDGWPDSV KTMQRNWIGR SEGLEIQFDV RDIDGAPLDP
260 270 280 290 300
LRVFTTRPDT LMGVTFVSIA AEHPLALHAA KSNPELAALL ETLKHGGVSE
310 320 330 340 350
AELETQEKRG MATGLTAVHP ISGEQVPVWV ANFVLMGYGT GAVMAVPGHD
360 370 380 390 400
QRDFEFANKY GLPIVQVVKL REPRNEEEQT WDATHWRDWY TDKSRELELI
410 420 430 440 450
NSAEFDGLDF GGAFEALAER FERKGQGQRR VNYRLRDWGV SRQRYWGCPI
460 470 480 490 500
PVIYCAKCGA VPVPEDQLPV VLPENVEFSG TGSPIKTDPT WRQTTCPDCG
510 520 530 540 550
GPAERETDTF DTFMESSWYV ARYTSPNARD MVDRRANYWM PADLYVGGIE
560 570 580 590 600
HAILHLMYFR FYHKLMRDAR LVDSDEPVTN LLTQGMVIAE TFYRDADNGG
610 620 630 640 650
KDWINPADVE IQRDERGRVT GAVLIADGQP VHIGGTEKMS KSKNNGVDPQ
660 670 680 690 700
SMVAKYGADT VRLFSMFAAP PEQSLEWNEA GVDGMARFMR RLWVQVHKHV
710 720 730 740 750
GEGAAVALDV AVLSAEQKAI RRKTHETIGK VSDDYGRRHS FNTAIAAVME
760 770 780 790 800
LSNALAKFDD ASEQGRAVRQ EALEAMVLLL NPITPHASHA LWQVLGRGET
810 820 830 840 850
LLENVAFPQA DASALVRDAL TLAVQINGKL RGTIDVAADA TREQIEALAQ
860 870 880
AEPNAAKFLE GLSVRKIIIV PGKIVNIVAG
Length:880
Mass (Da):98,598
Last modified:May 20, 2008 - v2
Checksum:iA7CB171CE5E416A9
GO

Sequence cautioni

The sequence CAJ24617.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM039952 Genomic DNA. Translation: CAJ24617.1. Different initiation.
RefSeqiWP_011348004.1. NC_007508.1.
YP_364669.1. NC_007508.1.

Genome annotation databases

EnsemblBacteriaiCAJ24617; CAJ24617; XCV2938.
GeneIDi3729986.
KEGGixcv:XCV2938.
PATRICi24095450. VBIXanCam71633_3196.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM039952 Genomic DNA. Translation: CAJ24617.1 . Different initiation.
RefSeqi WP_011348004.1. NC_007508.1.
YP_364669.1. NC_007508.1.

3D structure databases

ProteinModelPortali Q3BRE4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316273.XCV2938.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ24617 ; CAJ24617 ; XCV2938 .
GeneIDi 3729986.
KEGGi xcv:XCV2938.
PATRICi 24095450. VBIXanCam71633_3196.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci XCAM316273:GJF8-3031-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 85-10.

Entry informationi

Entry nameiSYL_XANC5
AccessioniPrimary (citable) accession number: Q3BRE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3