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Protein

Xylose isomerase

Gene

xylA1

Organism
Xanthomonas campestris pv. vesicatoria (strain 85-10)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei109 – 1091UniRule annotation
Active sitei112 – 1121UniRule annotation
Metal bindingi240 – 2401Magnesium 1UniRule annotation
Metal bindingi276 – 2761Magnesium 1UniRule annotation
Metal bindingi276 – 2761Magnesium 2UniRule annotation
Metal bindingi279 – 2791Magnesium 2UniRule annotation
Metal bindingi304 – 3041Magnesium 1UniRule annotation
Metal bindingi315 – 3151Magnesium 2UniRule annotation
Metal bindingi317 – 3171Magnesium 2UniRule annotation
Metal bindingi347 – 3471Magnesium 1UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciXCAM316273:GJF8-1856-MONOMER.
XCAM316273:GJF8-4444-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylA1UniRule annotation
Ordered Locus Names:XCV1808, XCV4330
OrganismiXanthomonas campestris pv. vesicatoria (strain 85-10)
Taxonomic identifieri316273 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000007069 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Xylose isomerasePRO_0000236977Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi316273.XCV4330.

Structurei

3D structure databases

ProteinModelPortaliQ3BMF2.
SMRiQ3BMF2. Positions 10-444.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2115.
HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.
OrthoDBiEOG62NX4R.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3BMF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTVYIGAK EYFPGIGKIG FEGRDSDNPL AFKVYDANKT IGDKTMAEHL
60 70 80 90 100
RFAVAYWHSF CGNGADPFGP GTRAYPWDAG TTALNRAEAK ADAAFEFFTK
110 120 130 140 150
LGVPYYCFHD IDLAPDADDI GEYEKNLKHM VGIAKQRQAD TGIKLLWGTA
160 170 180 190 200
NLFSHPRYMN GASTNPDFNV VARAAVQVKA AIDATVELGG ENYVFWGGRE
210 220 230 240 250
GYACLHNTQM KREQDNMARF LTLARDYGRA IGFKGNFLIE PKPMEPMKHQ
260 270 280 290 300
YDFDSATVIG FLRQHGLDQD FKLNIEANHA TLSGHSFEHD LQVASDAGLL
310 320 330 340 350
GSIDANRGNP QNGWDTDQFP TDLYDTVGAM LVVLRQGGLA PGGLNFDAKV
360 370 380 390 400
RRESSDPQDL FLAHIGGMDA FARGLEVANA LLTASPLEQW RAERYASFDS
410 420 430 440
GAGADFAAGK TTLADLAKHA ASNAPQQLSG RQEAYENLIN QYLTR
Length:445
Mass (Da):48,791
Last modified:November 22, 2005 - v1
Checksum:i4249F0C771C88ECD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM039952 Genomic DNA. Translation: CAJ26061.1.
AM039952 Genomic DNA. Translation: CAJ23485.1.
RefSeqiWP_011347136.1. NC_007508.1.
YP_363539.1. NC_007508.1.
YP_366061.1. NC_007508.1.

Genome annotation databases

EnsemblBacteriaiCAJ23485; CAJ23485; XCV1808.
CAJ26061; CAJ26061; XCV4330.
KEGGixcv:XCV1808.
xcv:XCV4330.
PATRICi24093160. VBIXanCam71633_2069.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM039952 Genomic DNA. Translation: CAJ26061.1.
AM039952 Genomic DNA. Translation: CAJ23485.1.
RefSeqiWP_011347136.1. NC_007508.1.
YP_363539.1. NC_007508.1.
YP_366061.1. NC_007508.1.

3D structure databases

ProteinModelPortaliQ3BMF2.
SMRiQ3BMF2. Positions 10-444.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi316273.XCV4330.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ23485; CAJ23485; XCV1808.
CAJ26061; CAJ26061; XCV4330.
KEGGixcv:XCV1808.
xcv:XCV4330.
PATRICi24093160. VBIXanCam71633_2069.

Phylogenomic databases

eggNOGiCOG2115.
HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.
OrthoDBiEOG62NX4R.

Enzyme and pathway databases

BioCyciXCAM316273:GJF8-1856-MONOMER.
XCAM316273:GJF8-4444-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 85-10.

Entry informationi

Entry nameiXYLA_XANC5
AccessioniPrimary (citable) accession number: Q3BMF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 22, 2005
Last modified: April 1, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.