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Protein

Blood vessel epicardial substance

Gene

Bves

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca2+-independent manner. Important for skeletal muscle and heart development. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density. Is a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

cAMP, cAMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Blood vessel epicardial substance
Alternative name(s):
Popeye domain-containing protein 1
Short name:
Popeye protein 1
Gene namesi
Name:Bves
Synonyms:Pop1, Popdc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1561100. Bves.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4848ExtracellularSequence analysisAdd
BLAST
Transmembranei49 – 6921HelicalSequence analysisAdd
BLAST
Topological domaini70 – 701CytoplasmicSequence analysis
Transmembranei71 – 9121HelicalSequence analysisAdd
BLAST
Topological domaini92 – 921ExtracellularSequence analysis
Transmembranei93 – 11321HelicalSequence analysisAdd
BLAST
Topological domaini114 – 356243CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Blood vessel epicardial substancePRO_0000394477Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence analysis
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence analysis
Modified residuei295 – 2951PhosphoserineCombined sources
Modified residuei318 – 3181PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ3BCU4.

PTM databases

iPTMnetiQ3BCU4.

Expressioni

Tissue specificityi

Strongly expressed in heart and skeletal muscle. Weakly expressed in brain, spleen, liver, kidney and lung.2 Publications

Interactioni

Subunit structurei

Homodimer. Homodimerization requires the C-terminus cytoplasmic region (By similarity). Interacts (via the C-terminus cytoplasmic tail) with TJP1. Interacts (via the C-terminus cytoplasmic tail) with ARHGEF25/GEFT (via the DH domain). Interacts (via the C-terminus cytoplasmic tail) with VAMP3. Interacts with KCNK2; the interaction enhances KCNK2 surface expression and is inhibited by cAMP (By similarity). Interacts with CAV3 (By similarity).By similarity

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni93 – 11523Required for interaction with CAV3By similarityAdd
BLAST
Regioni136 – 18651Required for interaction with KCNK2By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the popeye family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG053638.
InParanoidiQ3BCU4.
PhylomeDBiQ3BCU4.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR006916. Popeye_prot.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PANTHERiPTHR12101. PTHR12101. 1 hit.
PfamiPF04831. Popeye. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3BCU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFTEPSPLA QSTVVGFLPE LESLTPVPSN ETSCENWREV HHLVFHAANV
60 70 80 90 100
CFAVGLLIPT TLHLHMILLR VMLSIGCTLY VVWATLYRCA LDMMIWNSVF
110 120 130 140 150
LGINILHLSY LLYKKRPVKI EKDLGGVYHR LFEPLRVPPD LFRRLTGQFC
160 170 180 190 200
VIQTLKRGQV YATEDKTSVD DRLSILLKGR MKVSYRGHFL HNIYPCAFID
210 220 230 240 250
SPEFRSTQMH KGEKFQVTIV ADDNCRFLCW SRERLTYFLE SEPFLYEIFR
260 270 280 290 300
YLIGKDITNK LYSLNDPTLN DKKVKKLEPQ MSLSTQISML EMRNSITSSS
310 320 330 340 350
DIEDGLHHFL RGSSSTASLP MSSPQQRASP KMKPIEEGLE DDDEVFVPVS

PAHQLP
Length:356
Mass (Da):40,860
Last modified:September 19, 2006 - v2
Checksum:i3FC1347C9D510311
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY786529 mRNA. Translation: AAX14396.2.
RefSeqiNP_001071058.1. NM_001077590.1.
UniGeneiRn.41396.

Genome annotation databases

GeneIDi365603.
KEGGirno:365603.
UCSCiRGD:1561100. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY786529 mRNA. Translation: AAX14396.2.
RefSeqiNP_001071058.1. NM_001077590.1.
UniGeneiRn.41396.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ3BCU4.

Proteomic databases

PRIDEiQ3BCU4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi365603.
KEGGirno:365603.
UCSCiRGD:1561100. rat.

Organism-specific databases

CTDi11149.
RGDi1561100. Bves.

Phylogenomic databases

HOVERGENiHBG053638.
InParanoidiQ3BCU4.
PhylomeDBiQ3BCU4.

Miscellaneous databases

PROiQ3BCU4.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR006916. Popeye_prot.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PANTHERiPTHR12101. PTHR12101. 1 hit.
PfamiPF04831. Popeye. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Popdc gene family in the rat: molecular cloning, characterization and expression analysis in the heart and cultured cardiomyocytes."
    Parnes D., Jacoby V., Sharabi A., Schlesinger H., Brand T., Kessler-Icekson G.
    Biochim. Biophys. Acta 1769:586-592(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Wistar.
    Tissue: Heart.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295 AND SER-318, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Popeye domain containing 1 (Popdc1/Bves) is a caveolae-associated protein involved in ischemia tolerance."
    Alcalay Y., Hochhauser E., Kliminski V., Dick J., Zahalka M.A., Parnes D., Schlesinger H., Abassi Z., Shainberg A., Schindler R.F., Brand T., Kessler-Icekson G.
    PLoS ONE 8:E71100-E71100(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiPOPD1_RAT
AccessioniPrimary (citable) accession number: Q3BCU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: September 19, 2006
Last modified: July 6, 2016
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.