Q3BBW0 (NBPF9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuroblastoma breakpoint family member 9

Gene names

Name:

NBPF9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	867 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cytoplasm Probable.
Tissue specificity	Expressed in a neuroblastoma cell line. Ref.1
Miscellaneous	Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.
Sequence similarities	Belongs to the NBPF family. Contains 6 NBPF domains.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Coiled coil Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 867	867	Neuroblastoma breakpoint family member 9		PRO_0000288044
Regions
	Domain	165 – 259	95	NBPF 1
	Domain	436 – 528	93	NBPF 2
	Domain	529 – 617	89	NBPF 3
	Domain	620 – 675	56	NBPF 4
	Domain	676 – 768	93	NBPF 5
	Domain	769 – 867	99	NBPF 6
	Coiled coil	68 – 128	61	Potential
	Coiled coil	339 – 399	61	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3BBW0 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 8F1596E9893337E0	FASTA	867	99,594
	10 20 30 40 50 60 MVVSAGPLSS EKAEMNILEI NEKLHPQLAE KKQQFRNLKE KCFVTQLACF LANQQNKYKY 70 80 90 100 110 120 EECKDLIKSM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH SQERELTQLR EKLREGRDAS 130 140 150 160 170 180 RSLNQHLQAL LTPDKPDKSQ GQDLQEQLAE GCRLAQQLFQ KLSPENDEDE DEDVQVEEAE 190 200 210 220 230 240 KVLESSAPRE VQKAEESKVP EDSLEECAIT CSNSHGPCDS NQPHKNINIT FEEDKVNSAL 250 260 270 280 290 300 VVDRESSHDE CQDAVNILPV PGPTSSATNV SMVVSAGPLS SEKAEMNILE INEKLHPQLA 310 320 330 340 350 360 EKKQQFRNLK EKCFVTQLAC FLANQQNKYK YEECKDLIKS MLRNERQFKE EKLAEQLKQA 370 380 390 400 410 420 EELRQYKVLV HSQERELTQL REKLREGRDA SRSLNQHLQA LLTPDKPDKS QGQDLQEQLA 430 440 450 460 470 480 EGCRLTQHLV QKLSPENDND DDEDVQVEVA EKVQKSSAPR EMQKAEEKEV PEDSLEECAI 490 500 510 520 530 540 TCSNSHGPYD SNQPHRKTKI TFEEDKVDST LTGSSSHVEW EDAVHIIPEN ESDDEEEEEK 550 560 570 580 590 600 GPVSPRNLQE SEEEEVPQES WDEGYSTLSI PPEMLASYQS YSSTFHSLEE QQVCMAVDIG 610 620 630 640 650 660 RHRWDQVKKE DQEATGPRLS RELLDEKGPE VLQDSLDRCY STPSGYLELP DLGQPYSSAV 670 680 690 700 710 720 YSLEEQYLGL ALDVDRIKKD QEEEEDQGPP CPRLSRELLE VVEPEVLQDS LDRCYSTPSS 730 740 750 760 770 780 CLEQPDSCQP YGSSFYALEE KHVGFSLDVG EIEKKGKGKK RRGRRSKKER RRGRKEGEED 790 800 810 820 830 840 QNPPCPRLNG VLMEVEEPEV LQDSLDGCYS TPSMYFELPD SFQHYRSVFY SFEEQHISFA 850 860 LYVDNRFFTL TVTSLHLVFQ MEVIFPQ

References

[1]

"A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution." Vandepoele K., Van Roy N., Staes K., Speleman F., van Roy F. Mol. Biol. Evol. 22:2265-2274(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Mammary gland.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY894565 mRNA. Translation: AAX85104.1.
IPI	IPI00655925.
UniGene	Hs.714127. Hs.721588.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000319422.
Polymorphism databases
DMDM	121942449.
Proteomic databases
PaxDb	Q3BBW0.
PRIDE	Q3BBW0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC01P144614.
HGNC	HGNC:31991. NBPF9.
MIM	613999. gene.
neXtProt	NX_Q3BBW0.
GenAtlas	Search...
Phylogenomic databases
eggNOG	biNOG22098.
HOGENOM	HOG000049041.
HOVERGEN	HBG058300.
Gene expression databases
Genevestigator	Q3BBW0.
Family and domain databases
InterPro	IPR010630. NBPF_dom. [Graphical view]
Pfam	PF06758. DUF1220. 6 hits. [Graphical view]
PROSITE	PS51316. NBPF. 6 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NBPF9. human.
SOURCE	Search...

Entry information

Entry name

NBPF9_HUMAN

Accession

Primary (citable) accession number: Q3BBW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	November 22, 2005
Last modified:	April 3, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.