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Protein

Putative neuroblastoma breakpoint family member 8

Gene

NBPF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Names & Taxonomyi

Protein namesi
Recommended name:
Putative neuroblastoma breakpoint family member 8
Gene namesi
Name:NBPF8
Synonyms:NBPF8P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:31990. NBPF8.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671289.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 869869Putative neuroblastoma breakpoint family member 8PRO_0000288043Add
BLAST

Proteomic databases

PaxDbiQ3BBV2.
PRIDEiQ3BBV2.

PTM databases

PhosphoSiteiQ3BBV2.

Expressioni

Tissue specificityi

Expressed in the mammary gland.1 Publication

Gene expression databases

CleanExiHS_NBPF8.
GenevestigatoriQ3BBV2.

Interactioni

Protein-protein interaction databases

IntActiQ3BBV2. 3 interactions.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini130 – 22495NBPF 1PROSITE-ProRule annotationAdd
BLAST
Domaini401 – 49393NBPF 2PROSITE-ProRule annotationAdd
BLAST
Domaini494 – 58289NBPF 3PROSITE-ProRule annotationAdd
BLAST
Domaini585 – 64056NBPF 4PROSITE-ProRule annotationAdd
BLAST
Domaini641 – 73292NBPF 5PROSITE-ProRule annotationAdd
BLAST
Domaini735 – 80874NBPF 6PROSITE-ProRule annotationAdd
BLAST
Domaini809 – 86961NBPF 7PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili54 – 9542Sequence AnalysisAdd
BLAST
Coiled coili304 – 36663Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi500 – 5045Poly-Glu
Compositional biasi515 – 5206Poly-Glu
Compositional biasi722 – 7254Poly-Glu

Sequence similaritiesi

Belongs to the NBPF family.Curated
Contains 7 NBPF domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG116165.
HOGENOMiHOG000049041.
HOVERGENiHBG058300.
InParanoidiQ3BBV2.
PhylomeDBiQ3BBV2.

Family and domain databases

InterProiIPR010630. NBPF_dom.
[Graphical view]
PfamiPF06758. DUF1220. 7 hits.
[Graphical view]
PROSITEiPS51316. NBPF. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3BBV2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVVSAGPWSS EKAEMNILEI NEKLRPQLAE NKQQFVNLKE MFSNSTGRLP
60 70 80 90 100
GQPTEEIQQY KVLVHSQERE LTQLKEKLRE GRDASRSLNE HLQALLTLDE
110 120 130 140 150
PDKSQGQDLQ EQLAEGCRLA QHLVQKLSPE NDEDEDEDVQ VEEDEKVLES
160 170 180 190 200
SAPREVQKAE ESKVPEDSLE ECAITCSNSH GPCDSIQPHK NIKITFEEDK
210 220 230 240 250
VNSSLVVDRE SSHDGCQDAL NILPVPGPTS SATNVSMVVS AGPLSSEKAE
260 270 280 290 300
MNILEINEKL CPQLAEKKQQ FRSLKEKCFV TQVACFLAKQ QNKYKYEECK
310 320 330 340 350
DLIKSMLRNE RQFKEEKLAE QLKQAEELRQ YKVLVHSQER ELTQLREKLR
360 370 380 390 400
EGRDASRSLN EHLQALLTPD EPDKSQGQDL QEQLAEGCRL AQHLVQKLSP
410 420 430 440 450
ENDNDDDEDV QVEVAEKVQK SSSPREMQKA EEKEVPEDSL EECAITCSNS
460 470 480 490 500
HGPYDSNQPH RKTKITFEED KVDSTLIGSS SHVEWEDAVH IIPENESDDE
510 520 530 540 550
EEEEKGPVSP RNLQESEEEE VPQESWDEGY STLSIPPERL ASYQSYSSTF
560 570 580 590 600
HSLEEQQVCM AVDIGRHRWD QVKKEDQEAT GPRLSRELLD EKGPEVLQDS
610 620 630 640 650
LDRCYSTPSG CLELTDSCQP YRSAFYILEQ QRVGLAVDMD EIEKYQEVEE
660 670 680 690 700
DQDPSCPRLS RELLDEKEPE VLQDSLDRCY STPSGYLELP DLGQPYSSAV
710 720 730 740 750
YSLEEQYLGL ALDVDRIKKD QEEEEDQGPP CPRLSRELLE VVEPEVLQDS
760 770 780 790 800
LDRCYSTPSS CLEQPDSCQP YGSSFYALEE KHVGFSLDVG EIEKKGKGKI
810 820 830 840 850
GRGRRSKKKR RRGRKEGEED QNPPCPRLNS VLMEVEEPEV LQDSLDRCYS
860
TPSMYCELRD SFQHYRSVF
Length:869
Mass (Da):99,215
Last modified:November 22, 2005 - v1
Checksum:iEE327029B4C572ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX842679 Genomic DNA. No translation available.
AY894573 mRNA. Translation: AAX85112.1.
UniGeneiHs.445080.
Hs.571820.
Hs.721588.

Polymorphism databases

DMDMi121942441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX842679 Genomic DNA. No translation available.
AY894573 mRNA. Translation: AAX85112.1.
UniGeneiHs.445080.
Hs.571820.
Hs.721588.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3BBV2. 3 interactions.

PTM databases

PhosphoSiteiQ3BBV2.

Polymorphism databases

DMDMi121942441.

Proteomic databases

PaxDbiQ3BBV2.
PRIDEiQ3BBV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiGC01P144178.
H-InvDBHIX0000985.
HGNCiHGNC:31990. NBPF8.
MIMi613998. gene.
neXtProtiNX_Q3BBV2.
PharmGKBiPA142671289.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG116165.
HOGENOMiHOG000049041.
HOVERGENiHBG058300.
InParanoidiQ3BBV2.
PhylomeDBiQ3BBV2.

Miscellaneous databases

PROiQ3BBV2.
SOURCEiSearch...

Gene expression databases

CleanExiHS_NBPF8.
GenevestigatoriQ3BBV2.

Family and domain databases

InterProiIPR010630. NBPF_dom.
[Graphical view]
PfamiPF06758. DUF1220. 7 hits.
[Graphical view]
PROSITEiPS51316. NBPF. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution."
    Vandepoele K., Van Roy N., Staes K., Speleman F., van Roy F.
    Mol. Biol. Evol. 22:2265-2274(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Mammary gland.

Entry informationi

Entry nameiNBPF8_HUMAN
AccessioniPrimary (citable) accession number: Q3BBV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 22, 2005
Last modified: January 7, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.