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Q3BBV2

- NBPF8_HUMAN

UniProt

Q3BBV2 - NBPF8_HUMAN

Protein

Putative neuroblastoma breakpoint family member 8

Gene

NBPF8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative neuroblastoma breakpoint family member 8
    Gene namesi
    Name:NBPF8
    Synonyms:NBPF8P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:31990. NBPF8.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671289.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 869869Putative neuroblastoma breakpoint family member 8PRO_0000288043Add
    BLAST

    Proteomic databases

    PaxDbiQ3BBV2.
    PRIDEiQ3BBV2.

    PTM databases

    PhosphoSiteiQ3BBV2.

    Expressioni

    Tissue specificityi

    Expressed in the mammary gland.1 Publication

    Gene expression databases

    CleanExiHS_NBPF8.
    GenevestigatoriQ3BBV2.

    Interactioni

    Protein-protein interaction databases

    IntActiQ3BBV2. 3 interactions.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini130 – 22495NBPF 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini401 – 49393NBPF 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini494 – 58289NBPF 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini585 – 64056NBPF 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini641 – 73292NBPF 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini735 – 80874NBPF 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini809 – 86961NBPF 7PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili54 – 9542Sequence AnalysisAdd
    BLAST
    Coiled coili304 – 36663Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi500 – 5045Poly-Glu
    Compositional biasi515 – 5206Poly-Glu
    Compositional biasi722 – 7254Poly-Glu

    Sequence similaritiesi

    Belongs to the NBPF family.Curated
    Contains 7 NBPF domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG116165.
    HOGENOMiHOG000049041.
    HOVERGENiHBG058300.
    InParanoidiQ3BBV2.
    PhylomeDBiQ3BBV2.

    Family and domain databases

    InterProiIPR010630. NBPF_dom.
    [Graphical view]
    PfamiPF06758. DUF1220. 7 hits.
    [Graphical view]
    PROSITEiPS51316. NBPF. 7 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3BBV2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVSAGPWSS EKAEMNILEI NEKLRPQLAE NKQQFVNLKE MFSNSTGRLP    50
    GQPTEEIQQY KVLVHSQERE LTQLKEKLRE GRDASRSLNE HLQALLTLDE 100
    PDKSQGQDLQ EQLAEGCRLA QHLVQKLSPE NDEDEDEDVQ VEEDEKVLES 150
    SAPREVQKAE ESKVPEDSLE ECAITCSNSH GPCDSIQPHK NIKITFEEDK 200
    VNSSLVVDRE SSHDGCQDAL NILPVPGPTS SATNVSMVVS AGPLSSEKAE 250
    MNILEINEKL CPQLAEKKQQ FRSLKEKCFV TQVACFLAKQ QNKYKYEECK 300
    DLIKSMLRNE RQFKEEKLAE QLKQAEELRQ YKVLVHSQER ELTQLREKLR 350
    EGRDASRSLN EHLQALLTPD EPDKSQGQDL QEQLAEGCRL AQHLVQKLSP 400
    ENDNDDDEDV QVEVAEKVQK SSSPREMQKA EEKEVPEDSL EECAITCSNS 450
    HGPYDSNQPH RKTKITFEED KVDSTLIGSS SHVEWEDAVH IIPENESDDE 500
    EEEEKGPVSP RNLQESEEEE VPQESWDEGY STLSIPPERL ASYQSYSSTF 550
    HSLEEQQVCM AVDIGRHRWD QVKKEDQEAT GPRLSRELLD EKGPEVLQDS 600
    LDRCYSTPSG CLELTDSCQP YRSAFYILEQ QRVGLAVDMD EIEKYQEVEE 650
    DQDPSCPRLS RELLDEKEPE VLQDSLDRCY STPSGYLELP DLGQPYSSAV 700
    YSLEEQYLGL ALDVDRIKKD QEEEEDQGPP CPRLSRELLE VVEPEVLQDS 750
    LDRCYSTPSS CLEQPDSCQP YGSSFYALEE KHVGFSLDVG EIEKKGKGKI 800
    GRGRRSKKKR RRGRKEGEED QNPPCPRLNS VLMEVEEPEV LQDSLDRCYS 850
    TPSMYCELRD SFQHYRSVF 869
    Length:869
    Mass (Da):99,215
    Last modified:November 22, 2005 - v1
    Checksum:iEE327029B4C572ED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX842679 Genomic DNA. No translation available.
    AY894573 mRNA. Translation: AAX85112.1.
    UniGeneiHs.445080.
    Hs.571820.
    Hs.721588.

    Polymorphism databases

    DMDMi121942441.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX842679 Genomic DNA. No translation available.
    AY894573 mRNA. Translation: AAX85112.1 .
    UniGenei Hs.445080.
    Hs.571820.
    Hs.721588.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q3BBV2. 3 interactions.

    PTM databases

    PhosphoSitei Q3BBV2.

    Polymorphism databases

    DMDMi 121942441.

    Proteomic databases

    PaxDbi Q3BBV2.
    PRIDEi Q3BBV2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    H-InvDB HIX0000985.
    HGNCi HGNC:31990. NBPF8.
    MIMi 613998. gene.
    neXtProti NX_Q3BBV2.
    PharmGKBi PA142671289.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG116165.
    HOGENOMi HOG000049041.
    HOVERGENi HBG058300.
    InParanoidi Q3BBV2.
    PhylomeDBi Q3BBV2.

    Miscellaneous databases

    PROi Q3BBV2.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_NBPF8.
    Genevestigatori Q3BBV2.

    Family and domain databases

    InterProi IPR010630. NBPF_dom.
    [Graphical view ]
    Pfami PF06758. DUF1220. 7 hits.
    [Graphical view ]
    PROSITEi PS51316. NBPF. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution."
      Vandepoele K., Van Roy N., Staes K., Speleman F., van Roy F.
      Mol. Biol. Evol. 22:2265-2274(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiNBPF8_HUMAN
    AccessioniPrimary (citable) accession number: Q3BBV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

    Caution

    Could be the product of a pseudogene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3