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Q3BBV2

- NBPF8_HUMAN

UniProt

Q3BBV2 - NBPF8_HUMAN

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Protein
Putative neuroblastoma breakpoint family member 8
Gene
NBPF8, NBPF8P
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Protein uncertaini

Names & Taxonomyi

Protein namesi
Recommended name:
Putative neuroblastoma breakpoint family member 8
Gene namesi
Name:NBPF8
Synonyms:NBPF8P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:31990. NBPF8.

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671289.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 869869Putative neuroblastoma breakpoint family member 8
PRO_0000288043Add
BLAST

Proteomic databases

PaxDbiQ3BBV2.
PRIDEiQ3BBV2.

PTM databases

PhosphoSiteiQ3BBV2.

Expressioni

Tissue specificityi

Expressed in the mammary gland.1 Publication

Gene expression databases

CleanExiHS_NBPF8.
GenevestigatoriQ3BBV2.

Interactioni

Protein-protein interaction databases

IntActiQ3BBV2. 3 interactions.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini130 – 22495NBPF 1
Add
BLAST
Domaini401 – 49393NBPF 2
Add
BLAST
Domaini494 – 58289NBPF 3
Add
BLAST
Domaini585 – 64056NBPF 4
Add
BLAST
Domaini641 – 73292NBPF 5
Add
BLAST
Domaini735 – 80874NBPF 6
Add
BLAST
Domaini809 – 86961NBPF 7
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili54 – 9542 Reviewed prediction
Add
BLAST
Coiled coili304 – 36663 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi500 – 5045Poly-Glu
Compositional biasi515 – 5206Poly-Glu
Compositional biasi722 – 7254Poly-Glu

Sequence similaritiesi

Belongs to the NBPF family.
Contains 7 NBPF domains.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG116165.
HOGENOMiHOG000049041.
HOVERGENiHBG058300.
InParanoidiQ3BBV2.
PhylomeDBiQ3BBV2.

Family and domain databases

InterProiIPR010630. NBPF_dom.
[Graphical view]
PfamiPF06758. DUF1220. 7 hits.
[Graphical view]
PROSITEiPS51316. NBPF. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3BBV2-1 [UniParc]FASTAAdd to Basket

« Hide

MVVSAGPWSS EKAEMNILEI NEKLRPQLAE NKQQFVNLKE MFSNSTGRLP    50
GQPTEEIQQY KVLVHSQERE LTQLKEKLRE GRDASRSLNE HLQALLTLDE 100
PDKSQGQDLQ EQLAEGCRLA QHLVQKLSPE NDEDEDEDVQ VEEDEKVLES 150
SAPREVQKAE ESKVPEDSLE ECAITCSNSH GPCDSIQPHK NIKITFEEDK 200
VNSSLVVDRE SSHDGCQDAL NILPVPGPTS SATNVSMVVS AGPLSSEKAE 250
MNILEINEKL CPQLAEKKQQ FRSLKEKCFV TQVACFLAKQ QNKYKYEECK 300
DLIKSMLRNE RQFKEEKLAE QLKQAEELRQ YKVLVHSQER ELTQLREKLR 350
EGRDASRSLN EHLQALLTPD EPDKSQGQDL QEQLAEGCRL AQHLVQKLSP 400
ENDNDDDEDV QVEVAEKVQK SSSPREMQKA EEKEVPEDSL EECAITCSNS 450
HGPYDSNQPH RKTKITFEED KVDSTLIGSS SHVEWEDAVH IIPENESDDE 500
EEEEKGPVSP RNLQESEEEE VPQESWDEGY STLSIPPERL ASYQSYSSTF 550
HSLEEQQVCM AVDIGRHRWD QVKKEDQEAT GPRLSRELLD EKGPEVLQDS 600
LDRCYSTPSG CLELTDSCQP YRSAFYILEQ QRVGLAVDMD EIEKYQEVEE 650
DQDPSCPRLS RELLDEKEPE VLQDSLDRCY STPSGYLELP DLGQPYSSAV 700
YSLEEQYLGL ALDVDRIKKD QEEEEDQGPP CPRLSRELLE VVEPEVLQDS 750
LDRCYSTPSS CLEQPDSCQP YGSSFYALEE KHVGFSLDVG EIEKKGKGKI 800
GRGRRSKKKR RRGRKEGEED QNPPCPRLNS VLMEVEEPEV LQDSLDRCYS 850
TPSMYCELRD SFQHYRSVF 869
Length:869
Mass (Da):99,215
Last modified:November 22, 2005 - v1
Checksum:iEE327029B4C572ED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX842679 Genomic DNA. No translation available.
AY894573 mRNA. Translation: AAX85112.1.
UniGeneiHs.445080.
Hs.571820.
Hs.721588.

Polymorphism databases

DMDMi121942441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX842679 Genomic DNA. No translation available.
AY894573 mRNA. Translation: AAX85112.1 .
UniGenei Hs.445080.
Hs.571820.
Hs.721588.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

IntActi Q3BBV2. 3 interactions.

PTM databases

PhosphoSitei Q3BBV2.

Polymorphism databases

DMDMi 121942441.

Proteomic databases

PaxDbi Q3BBV2.
PRIDEi Q3BBV2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

H-InvDBi HIX0000985.
HGNCi HGNC:31990. NBPF8.
MIMi 613998. gene.
neXtProti NX_Q3BBV2.
PharmGKBi PA142671289.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG116165.
HOGENOMi HOG000049041.
HOVERGENi HBG058300.
InParanoidi Q3BBV2.
PhylomeDBi Q3BBV2.

Miscellaneous databases

PROi Q3BBV2.
SOURCEi Search...

Gene expression databases

CleanExi HS_NBPF8.
Genevestigatori Q3BBV2.

Family and domain databases

InterProi IPR010630. NBPF_dom.
[Graphical view ]
Pfami PF06758. DUF1220. 7 hits.
[Graphical view ]
PROSITEi PS51316. NBPF. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution."
    Vandepoele K., Van Roy N., Staes K., Speleman F., van Roy F.
    Mol. Biol. Evol. 22:2265-2274(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Mammary gland.

Entry informationi

Entry nameiNBPF8_HUMAN
AccessioniPrimary (citable) accession number: Q3BBV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 22, 2005
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

Caution

Could be the product of a pseudogene.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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