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Q3BBV2 (NBPF8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative neuroblastoma breakpoint family member 8
Gene names
Name:NBPF8
Synonyms:NBPF8P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length869 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Subcellular location

Cytoplasm Probable.

Tissue specificity

Expressed in the mammary gland. Ref.2

Miscellaneous

Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

Sequence similarities

Belongs to the NBPF family.

Contains 7 NBPF domains.

Caution

Could be the product of a pseudogene.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainCoiled coil
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 869869Putative neuroblastoma breakpoint family member 8
PRO_0000288043

Regions

Domain130 – 22495NBPF 1
Domain401 – 49393NBPF 2
Domain494 – 58289NBPF 3
Domain585 – 64056NBPF 4
Domain641 – 73292NBPF 5
Domain735 – 80874NBPF 6
Domain809 – 86961NBPF 7
Coiled coil54 – 9542 Potential
Coiled coil304 – 36663 Potential
Compositional bias500 – 5045Poly-Glu
Compositional bias515 – 5206Poly-Glu
Compositional bias722 – 7254Poly-Glu

Sequences

Sequence LengthMass (Da)Tools
Q3BBV2 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: EE327029B4C572ED

FASTA86999,215
        10         20         30         40         50         60 
MVVSAGPWSS EKAEMNILEI NEKLRPQLAE NKQQFVNLKE MFSNSTGRLP GQPTEEIQQY 

        70         80         90        100        110        120 
KVLVHSQERE LTQLKEKLRE GRDASRSLNE HLQALLTLDE PDKSQGQDLQ EQLAEGCRLA 

       130        140        150        160        170        180 
QHLVQKLSPE NDEDEDEDVQ VEEDEKVLES SAPREVQKAE ESKVPEDSLE ECAITCSNSH 

       190        200        210        220        230        240 
GPCDSIQPHK NIKITFEEDK VNSSLVVDRE SSHDGCQDAL NILPVPGPTS SATNVSMVVS 

       250        260        270        280        290        300 
AGPLSSEKAE MNILEINEKL CPQLAEKKQQ FRSLKEKCFV TQVACFLAKQ QNKYKYEECK 

       310        320        330        340        350        360 
DLIKSMLRNE RQFKEEKLAE QLKQAEELRQ YKVLVHSQER ELTQLREKLR EGRDASRSLN 

       370        380        390        400        410        420 
EHLQALLTPD EPDKSQGQDL QEQLAEGCRL AQHLVQKLSP ENDNDDDEDV QVEVAEKVQK 

       430        440        450        460        470        480 
SSSPREMQKA EEKEVPEDSL EECAITCSNS HGPYDSNQPH RKTKITFEED KVDSTLIGSS 

       490        500        510        520        530        540 
SHVEWEDAVH IIPENESDDE EEEEKGPVSP RNLQESEEEE VPQESWDEGY STLSIPPERL 

       550        560        570        580        590        600 
ASYQSYSSTF HSLEEQQVCM AVDIGRHRWD QVKKEDQEAT GPRLSRELLD EKGPEVLQDS 

       610        620        630        640        650        660 
LDRCYSTPSG CLELTDSCQP YRSAFYILEQ QRVGLAVDMD EIEKYQEVEE DQDPSCPRLS 

       670        680        690        700        710        720 
RELLDEKEPE VLQDSLDRCY STPSGYLELP DLGQPYSSAV YSLEEQYLGL ALDVDRIKKD 

       730        740        750        760        770        780 
QEEEEDQGPP CPRLSRELLE VVEPEVLQDS LDRCYSTPSS CLEQPDSCQP YGSSFYALEE 

       790        800        810        820        830        840 
KHVGFSLDVG EIEKKGKGKI GRGRRSKKKR RRGRKEGEED QNPPCPRLNS VLMEVEEPEV 

       850        860 
LQDSLDRCYS TPSMYCELRD SFQHYRSVF 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution."
Vandepoele K., Van Roy N., Staes K., Speleman F., van Roy F.
Mol. Biol. Evol. 22:2265-2274(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Mammary gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX842679 Genomic DNA. No translation available.
AY894573 mRNA. Translation: AAX85112.1.
UniGeneHs.445080.
Hs.571820.
Hs.721588.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ3BBV2. 3 interactions.

PTM databases

PhosphoSiteQ3BBV2.

Polymorphism databases

DMDM121942441.

Proteomic databases

PaxDbQ3BBV2.
PRIDEQ3BBV2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

H-InvDBHIX0000985.
HGNCHGNC:31990. NBPF8.
MIM613998. gene.
neXtProtNX_Q3BBV2.
PharmGKBPA142671289.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG116165.
HOGENOMHOG000049041.
HOVERGENHBG058300.
InParanoidQ3BBV2.
PhylomeDBQ3BBV2.

Gene expression databases

CleanExHS_NBPF8.
GenevestigatorQ3BBV2.

Family and domain databases

InterProIPR010630. NBPF_dom.
[Graphical view]
PfamPF06758. DUF1220. 7 hits.
[Graphical view]
PROSITEPS51316. NBPF. 7 hits.
[Graphical view]
ProtoNetSearch...

Other

PROQ3BBV2.
SOURCESearch...

Entry information

Entry nameNBPF8_HUMAN
AccessionPrimary (citable) accession number: Q3BBV2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 22, 2005
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM