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Q3BBV1

- NBPFK_HUMAN

UniProt

Q3BBV1 - NBPFK_HUMAN

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Protein

Neuroblastoma breakpoint family member 20

Gene

NBPF20

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroblastoma breakpoint family member 20
Gene namesi
Name:NBPF20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:32000. NBPF20.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671289.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 942942Neuroblastoma breakpoint family member 20PRO_0000288051Add
BLAST

Proteomic databases

PRIDEiQ3BBV1.

PTM databases

PhosphoSiteiQ3BBV1.

Expressioni

Gene expression databases

GenevestigatoriQ3BBV1.

Interactioni

Protein-protein interaction databases

BioGridi134774. 1 interaction.
STRINGi9606.ENSP00000358203.

Structurei

3D structure databases

ProteinModelPortaliQ3BBV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini165 – 25995NBPF 1PROSITE-ProRule annotationAdd
BLAST
Domaini436 – 52893NBPF 2PROSITE-ProRule annotationAdd
BLAST
Domaini529 – 60072NBPF 3PROSITE-ProRule annotationAdd
BLAST
Domaini601 – 69292NBPF 4PROSITE-ProRule annotationAdd
BLAST
Domaini695 – 75056NBPF 5PROSITE-ProRule annotationAdd
BLAST
Domaini751 – 84393NBPF 6PROSITE-ProRule annotationAdd
BLAST
Domaini844 – 94299NBPF 7PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili70 – 13061Sequence AnalysisAdd
BLAST
Coiled coili341 – 40161Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi535 – 5395Poly-Glu
Compositional biasi550 – 5556Poly-Glu
Compositional biasi757 – 7604Poly-Glu

Sequence similaritiesi

Belongs to the NBPF family.Curated
Contains 7 NBPF domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

HOGENOMiHOG000049041.
HOVERGENiHBG058300.
InParanoidiQ3BBV1.
PhylomeDBiQ3BBV1.

Family and domain databases

InterProiIPR010630. NBPF_dom.
[Graphical view]
PfamiPF06758. DUF1220. 7 hits.
[Graphical view]
PROSITEiPS51316. NBPF. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3BBV1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVVSAGPWSS EKAEMNILEI NEKLRPQLAE NKQQFGNLKE RCFLTQLAGF
60 70 80 90 100
LANRQKKYKY EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH
110 120 130 140 150
SQERELTQLK EKLREGRDAS RSLNEHLQAL LTPDEPDKSQ GQDLQEQLAE
160 170 180 190 200
GCRLAQHLVQ KLSPENDEDE DEDVQVEEDE KVLESPAPRE VQKAEESKVT
210 220 230 240 250
EDSLEECAIT CSNSHGPCDS NQPHKNIKIT FEEDEVNSTL VVDRESSHDE
260 270 280 290 300
CQDALNILPV PGPTSSATNV SMVVSAGPLS SEKAEMNILE INEKLRPQLA
310 320 330 340 350
EKKQQFRNLK EKCFLTQLAG FLANQQNKYK YEECKDLIKF MLRNERQFKE
360 370 380 390 400
EKLAEQLKQA EELRQYKVLV HAQERELTQL REKLREGRDA SRSLNEHLQA
410 420 430 440 450
LLTPDEPDKS QGQDLQEQLA EGCRLAQHLV QKLSPENDND DNEDVQVEVA
460 470 480 490 500
EKVQKSSAPR EMQKAEEKEV PEDSLEECAI TYSNSHGPYD SNQPHRKTKI
510 520 530 540 550
TFEEDKVDST LIGSSSHVER EDAVHIIPEN ESDDEEEEEK GPVSPRNLQE
560 570 580 590 600
SEEEEVPQES WDEGYSTPSI PPEMLASYKS YSSTFHSLEE QQVCMAVDIG
610 620 630 640 650
RHRWDQVKKE DQEATGPRLS RELLDEKGPE VLQDSLYRCY STPSGCLELT
660 670 680 690 700
DSCQPYRSAF YVLEQQRVGL AVDMDEIEKY QEVEEDQDPS CPRLSRELLD
710 720 730 740 750
EKEPEVLQDS LGRWYSTPSG YPELPDLGQP YSSAVYSLEE QYLGLALDLD
760 770 780 790 800
RIKKDQEEEE DQGPPCPRLS RELLEVVEPE VLQDSLDRCY STPSSCLEQP
810 820 830 840 850
DSWQPYGSSF YALEEKHVGF SLDVGEIEKK GKGKKRRGRR SKKERRRGRK
860 870 880 890 900
EGEEDQNPPC PRLNGVLMEV EEPEVLQDSL DGCYSTPSMY FELPDSFQHY
910 920 930 940
RSVFYSFEEQ HISFALYVDN RFFTLTVTSL HLVFQMEVIF PQ
Length:942
Mass (Da):108,576
Last modified:November 22, 2005 - v1
Checksum:i2E5A04DA513B3486
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY894574 mRNA. Translation: AAX85113.1.
RefSeqiNP_001032764.2. NM_001037675.3.
NP_001264373.1. NM_001277444.1.
UniGeneiHs.445080.
Hs.534675.
Hs.714127.

Genome annotation databases

GeneIDi400818.
KEGGihsa:400818.
UCSCiuc009wig.2. human.

Polymorphism databases

DMDMi121942440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY894574 mRNA. Translation: AAX85113.1 .
RefSeqi NP_001032764.2. NM_001037675.3.
NP_001264373.1. NM_001277444.1.
UniGenei Hs.445080.
Hs.534675.
Hs.714127.

3D structure databases

ProteinModelPortali Q3BBV1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 134774. 1 interaction.
STRINGi 9606.ENSP00000358203.

PTM databases

PhosphoSitei Q3BBV1.

Polymorphism databases

DMDMi 121942440.

Proteomic databases

PRIDEi Q3BBV1.

Protocols and materials databases

DNASUi 400818.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 400818.
KEGGi hsa:400818.
UCSCi uc009wig.2. human.

Organism-specific databases

CTDi 400818.
GeneCardsi GC01M148250.
HGNCi HGNC:32000. NBPF20.
MIMi 614007. gene.
neXtProti NX_Q3BBV1.
PharmGKBi PA142671289.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000049041.
HOVERGENi HBG058300.
InParanoidi Q3BBV1.
PhylomeDBi Q3BBV1.

Miscellaneous databases

GenomeRNAii 400818.
NextBioi 106229.
PROi Q3BBV1.
SOURCEi Search...

Gene expression databases

Genevestigatori Q3BBV1.

Family and domain databases

InterProi IPR010630. NBPF_dom.
[Graphical view ]
Pfami PF06758. DUF1220. 7 hits.
[Graphical view ]
PROSITEi PS51316. NBPF. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution."
    Vandepoele K., Van Roy N., Staes K., Speleman F., van Roy F.
    Mol. Biol. Evol. 22:2265-2274(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiNBPFK_HUMAN
AccessioniPrimary (citable) accession number: Q3BBV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 22, 2005
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3