Q3BBV1 (NBPFK_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuroblastoma breakpoint family member 20

Gene names

Name:

NBPF20

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	942 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cytoplasm Probable.
Miscellaneous	Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.
Sequence similarities	Belongs to the NBPF family. Contains 7 NBPF domains.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Coiled coil Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 942	942	Neuroblastoma breakpoint family member 20		PRO_0000288051
Regions
	Domain	165 – 259	95	NBPF 1
	Domain	436 – 528	93	NBPF 2
	Domain	529 – 600	72	NBPF 3
	Domain	601 – 692	92	NBPF 4
	Domain	695 – 750	56	NBPF 5
	Domain	751 – 843	93	NBPF 6
	Domain	844 – 942	99	NBPF 7
	Coiled coil	70 – 130	61	Potential
	Coiled coil	341 – 401	61	Potential
	Compositional bias	535 – 539	5	Poly-Glu
	Compositional bias	550 – 555	6	Poly-Glu
	Compositional bias	757 – 760	4	Poly-Glu

Sequences

	Sequence		Length	Mass (Da)
	Q3BBV1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 2E5A04DA513B3486	FASTA	942	108,576
	10 20 30 40 50 60 MVVSAGPWSS EKAEMNILEI NEKLRPQLAE NKQQFGNLKE RCFLTQLAGF LANRQKKYKY 70 80 90 100 110 120 EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH SQERELTQLK EKLREGRDAS 130 140 150 160 170 180 RSLNEHLQAL LTPDEPDKSQ GQDLQEQLAE GCRLAQHLVQ KLSPENDEDE DEDVQVEEDE 190 200 210 220 230 240 KVLESPAPRE VQKAEESKVT EDSLEECAIT CSNSHGPCDS NQPHKNIKIT FEEDEVNSTL 250 260 270 280 290 300 VVDRESSHDE CQDALNILPV PGPTSSATNV SMVVSAGPLS SEKAEMNILE INEKLRPQLA 310 320 330 340 350 360 EKKQQFRNLK EKCFLTQLAG FLANQQNKYK YEECKDLIKF MLRNERQFKE EKLAEQLKQA 370 380 390 400 410 420 EELRQYKVLV HAQERELTQL REKLREGRDA SRSLNEHLQA LLTPDEPDKS QGQDLQEQLA 430 440 450 460 470 480 EGCRLAQHLV QKLSPENDND DNEDVQVEVA EKVQKSSAPR EMQKAEEKEV PEDSLEECAI 490 500 510 520 530 540 TYSNSHGPYD SNQPHRKTKI TFEEDKVDST LIGSSSHVER EDAVHIIPEN ESDDEEEEEK 550 560 570 580 590 600 GPVSPRNLQE SEEEEVPQES WDEGYSTPSI PPEMLASYKS YSSTFHSLEE QQVCMAVDIG 610 620 630 640 650 660 RHRWDQVKKE DQEATGPRLS RELLDEKGPE VLQDSLYRCY STPSGCLELT DSCQPYRSAF 670 680 690 700 710 720 YVLEQQRVGL AVDMDEIEKY QEVEEDQDPS CPRLSRELLD EKEPEVLQDS LGRWYSTPSG 730 740 750 760 770 780 YPELPDLGQP YSSAVYSLEE QYLGLALDLD RIKKDQEEEE DQGPPCPRLS RELLEVVEPE 790 800 810 820 830 840 VLQDSLDRCY STPSSCLEQP DSWQPYGSSF YALEEKHVGF SLDVGEIEKK GKGKKRRGRR 850 860 870 880 890 900 SKKERRRGRK EGEEDQNPPC PRLNGVLMEV EEPEVLQDSL DGCYSTPSMY FELPDSFQHY 910 920 930 940 RSVFYSFEEQ HISFALYVDN RFFTLTVTSL HLVFQMEVIF PQ

References

[1]	"A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution." Vandepoele K., Van Roy N., Staes K., Speleman F., van Roy F. Mol. Biol. Evol. 22:2265-2274(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY894574 mRNA. Translation: AAX85113.1.
IPI	IPI00642376.
RefSeq	NP_001032764.2. NM_001037675.3.
UniGene	Hs.534675. Hs.714127.
3D structure databases
ProteinModelPortal	Q3BBV1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000358203.
PTM databases
PhosphoSite	Q3BBV1.
Proteomic databases
PRIDE	Q3BBV1.
Protocols and materials databases
DNASU	400818.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	400818.
KEGG	hsa:400818.
UCSC	uc009wig.1. human.
Organism-specific databases
CTD	400818.
GeneCards	GC01M148250.
HGNC	HGNC:32000. NBPF20.
MIM	614007. gene.
neXtProt	NX_Q3BBV1.
PharmGKB	PA142671289.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000049041.
HOVERGEN	HBG058300.
Gene expression databases
Genevestigator	Q3BBV1.
Family and domain databases
InterPro	IPR010630. NBPF_dom. [Graphical view]
Pfam	PF06758. DUF1220. 7 hits. [Graphical view]
PROSITE	PS51316. NBPF. 7 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	400818.
NextBio	106229.
SOURCE	Search...

Entry information

Entry name

NBPFK_HUMAN

Accession

Primary (citable) accession number: Q3BBV1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	November 22, 2005
Last modified:	May 29, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.