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Q3BBV1 (NBPFK_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuroblastoma breakpoint family member 20
Gene names
Name:NBPF20
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length942 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cytoplasm Probable.

Miscellaneous

Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

Sequence similarities

Belongs to the NBPF family.

Contains 7 NBPF domains.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainCoiled coil
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 942942Neuroblastoma breakpoint family member 20
PRO_0000288051

Regions

Domain165 – 25995NBPF 1
Domain436 – 52893NBPF 2
Domain529 – 60072NBPF 3
Domain601 – 69292NBPF 4
Domain695 – 75056NBPF 5
Domain751 – 84393NBPF 6
Domain844 – 94299NBPF 7
Coiled coil70 – 13061 Potential
Coiled coil341 – 40161 Potential
Compositional bias535 – 5395Poly-Glu
Compositional bias550 – 5556Poly-Glu
Compositional bias757 – 7604Poly-Glu

Sequences

Sequence LengthMass (Da)Tools
Q3BBV1 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 2E5A04DA513B3486

FASTA942108,576
        10         20         30         40         50         60 
MVVSAGPWSS EKAEMNILEI NEKLRPQLAE NKQQFGNLKE RCFLTQLAGF LANRQKKYKY 

        70         80         90        100        110        120 
EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH SQERELTQLK EKLREGRDAS 

       130        140        150        160        170        180 
RSLNEHLQAL LTPDEPDKSQ GQDLQEQLAE GCRLAQHLVQ KLSPENDEDE DEDVQVEEDE 

       190        200        210        220        230        240 
KVLESPAPRE VQKAEESKVT EDSLEECAIT CSNSHGPCDS NQPHKNIKIT FEEDEVNSTL 

       250        260        270        280        290        300 
VVDRESSHDE CQDALNILPV PGPTSSATNV SMVVSAGPLS SEKAEMNILE INEKLRPQLA 

       310        320        330        340        350        360 
EKKQQFRNLK EKCFLTQLAG FLANQQNKYK YEECKDLIKF MLRNERQFKE EKLAEQLKQA 

       370        380        390        400        410        420 
EELRQYKVLV HAQERELTQL REKLREGRDA SRSLNEHLQA LLTPDEPDKS QGQDLQEQLA 

       430        440        450        460        470        480 
EGCRLAQHLV QKLSPENDND DNEDVQVEVA EKVQKSSAPR EMQKAEEKEV PEDSLEECAI 

       490        500        510        520        530        540 
TYSNSHGPYD SNQPHRKTKI TFEEDKVDST LIGSSSHVER EDAVHIIPEN ESDDEEEEEK 

       550        560        570        580        590        600 
GPVSPRNLQE SEEEEVPQES WDEGYSTPSI PPEMLASYKS YSSTFHSLEE QQVCMAVDIG 

       610        620        630        640        650        660 
RHRWDQVKKE DQEATGPRLS RELLDEKGPE VLQDSLYRCY STPSGCLELT DSCQPYRSAF 

       670        680        690        700        710        720 
YVLEQQRVGL AVDMDEIEKY QEVEEDQDPS CPRLSRELLD EKEPEVLQDS LGRWYSTPSG 

       730        740        750        760        770        780 
YPELPDLGQP YSSAVYSLEE QYLGLALDLD RIKKDQEEEE DQGPPCPRLS RELLEVVEPE 

       790        800        810        820        830        840 
VLQDSLDRCY STPSSCLEQP DSWQPYGSSF YALEEKHVGF SLDVGEIEKK GKGKKRRGRR 

       850        860        870        880        890        900 
SKKERRRGRK EGEEDQNPPC PRLNGVLMEV EEPEVLQDSL DGCYSTPSMY FELPDSFQHY 

       910        920        930        940 
RSVFYSFEEQ HISFALYVDN RFFTLTVTSL HLVFQMEVIF PQ 

« Hide

References

[1]"A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution."
Vandepoele K., Van Roy N., Staes K., Speleman F., van Roy F.
Mol. Biol. Evol. 22:2265-2274(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY894574 mRNA. Translation: AAX85113.1.
RefSeqNP_001032764.2. NM_001037675.3.
NP_001264373.1. NM_001277444.1.
UniGeneHs.445080.
Hs.534675.
Hs.714127.

3D structure databases

ProteinModelPortalQ3BBV1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid134774. 1 interaction.
STRING9606.ENSP00000358203.

PTM databases

PhosphoSiteQ3BBV1.

Polymorphism databases

DMDM121942440.

Proteomic databases

PRIDEQ3BBV1.

Protocols and materials databases

DNASU400818.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID400818.
KEGGhsa:400818.
UCSCuc009wig.2. human.

Organism-specific databases

CTD400818.
GeneCardsGC01M148250.
HGNCHGNC:32000. NBPF20.
MIM614007. gene.
neXtProtNX_Q3BBV1.
PharmGKBPA142671289.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000049041.
HOVERGENHBG058300.
PhylomeDBQ3BBV1.

Gene expression databases

GenevestigatorQ3BBV1.

Family and domain databases

InterProIPR010630. NBPF_dom.
[Graphical view]
PfamPF06758. DUF1220. 7 hits.
[Graphical view]
PROSITEPS51316. NBPF. 7 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi400818.
NextBio106229.
PROQ3BBV1.
SOURCESearch...

Entry information

Entry nameNBPFK_HUMAN
AccessionPrimary (citable) accession number: Q3BBV1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 22, 2005
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM