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Q3BBV1

- NBPFK_HUMAN

UniProt

Q3BBV1 - NBPFK_HUMAN

Protein

Neuroblastoma breakpoint family member 20

Gene

NBPF20

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuroblastoma breakpoint family member 20
    Gene namesi
    Name:NBPF20
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:32000. NBPF20.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671289.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 942942Neuroblastoma breakpoint family member 20PRO_0000288051Add
    BLAST

    Proteomic databases

    PRIDEiQ3BBV1.

    PTM databases

    PhosphoSiteiQ3BBV1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ3BBV1.

    Interactioni

    Protein-protein interaction databases

    BioGridi134774. 1 interaction.
    STRINGi9606.ENSP00000358203.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3BBV1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini165 – 25995NBPF 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini436 – 52893NBPF 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini529 – 60072NBPF 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini601 – 69292NBPF 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini695 – 75056NBPF 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini751 – 84393NBPF 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini844 – 94299NBPF 7PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili70 – 13061Sequence AnalysisAdd
    BLAST
    Coiled coili341 – 40161Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi535 – 5395Poly-Glu
    Compositional biasi550 – 5556Poly-Glu
    Compositional biasi757 – 7604Poly-Glu

    Sequence similaritiesi

    Belongs to the NBPF family.Curated
    Contains 7 NBPF domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    HOGENOMiHOG000049041.
    HOVERGENiHBG058300.
    PhylomeDBiQ3BBV1.

    Family and domain databases

    InterProiIPR010630. NBPF_dom.
    [Graphical view]
    PfamiPF06758. DUF1220. 7 hits.
    [Graphical view]
    PROSITEiPS51316. NBPF. 7 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3BBV1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVSAGPWSS EKAEMNILEI NEKLRPQLAE NKQQFGNLKE RCFLTQLAGF    50
    LANRQKKYKY EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH 100
    SQERELTQLK EKLREGRDAS RSLNEHLQAL LTPDEPDKSQ GQDLQEQLAE 150
    GCRLAQHLVQ KLSPENDEDE DEDVQVEEDE KVLESPAPRE VQKAEESKVT 200
    EDSLEECAIT CSNSHGPCDS NQPHKNIKIT FEEDEVNSTL VVDRESSHDE 250
    CQDALNILPV PGPTSSATNV SMVVSAGPLS SEKAEMNILE INEKLRPQLA 300
    EKKQQFRNLK EKCFLTQLAG FLANQQNKYK YEECKDLIKF MLRNERQFKE 350
    EKLAEQLKQA EELRQYKVLV HAQERELTQL REKLREGRDA SRSLNEHLQA 400
    LLTPDEPDKS QGQDLQEQLA EGCRLAQHLV QKLSPENDND DNEDVQVEVA 450
    EKVQKSSAPR EMQKAEEKEV PEDSLEECAI TYSNSHGPYD SNQPHRKTKI 500
    TFEEDKVDST LIGSSSHVER EDAVHIIPEN ESDDEEEEEK GPVSPRNLQE 550
    SEEEEVPQES WDEGYSTPSI PPEMLASYKS YSSTFHSLEE QQVCMAVDIG 600
    RHRWDQVKKE DQEATGPRLS RELLDEKGPE VLQDSLYRCY STPSGCLELT 650
    DSCQPYRSAF YVLEQQRVGL AVDMDEIEKY QEVEEDQDPS CPRLSRELLD 700
    EKEPEVLQDS LGRWYSTPSG YPELPDLGQP YSSAVYSLEE QYLGLALDLD 750
    RIKKDQEEEE DQGPPCPRLS RELLEVVEPE VLQDSLDRCY STPSSCLEQP 800
    DSWQPYGSSF YALEEKHVGF SLDVGEIEKK GKGKKRRGRR SKKERRRGRK 850
    EGEEDQNPPC PRLNGVLMEV EEPEVLQDSL DGCYSTPSMY FELPDSFQHY 900
    RSVFYSFEEQ HISFALYVDN RFFTLTVTSL HLVFQMEVIF PQ 942
    Length:942
    Mass (Da):108,576
    Last modified:November 22, 2005 - v1
    Checksum:i2E5A04DA513B3486
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY894574 mRNA. Translation: AAX85113.1.
    RefSeqiNP_001032764.2. NM_001037675.3.
    NP_001264373.1. NM_001277444.1.
    UniGeneiHs.445080.
    Hs.534675.
    Hs.714127.

    Genome annotation databases

    GeneIDi400818.
    KEGGihsa:400818.
    UCSCiuc009wig.2. human.

    Polymorphism databases

    DMDMi121942440.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY894574 mRNA. Translation: AAX85113.1 .
    RefSeqi NP_001032764.2. NM_001037675.3.
    NP_001264373.1. NM_001277444.1.
    UniGenei Hs.445080.
    Hs.534675.
    Hs.714127.

    3D structure databases

    ProteinModelPortali Q3BBV1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 134774. 1 interaction.
    STRINGi 9606.ENSP00000358203.

    PTM databases

    PhosphoSitei Q3BBV1.

    Polymorphism databases

    DMDMi 121942440.

    Proteomic databases

    PRIDEi Q3BBV1.

    Protocols and materials databases

    DNASUi 400818.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 400818.
    KEGGi hsa:400818.
    UCSCi uc009wig.2. human.

    Organism-specific databases

    CTDi 400818.
    GeneCardsi GC01M148250.
    HGNCi HGNC:32000. NBPF20.
    MIMi 614007. gene.
    neXtProti NX_Q3BBV1.
    PharmGKBi PA142671289.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000049041.
    HOVERGENi HBG058300.
    PhylomeDBi Q3BBV1.

    Miscellaneous databases

    GenomeRNAii 400818.
    NextBioi 106229.
    PROi Q3BBV1.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q3BBV1.

    Family and domain databases

    InterProi IPR010630. NBPF_dom.
    [Graphical view ]
    Pfami PF06758. DUF1220. 7 hits.
    [Graphical view ]
    PROSITEi PS51316. NBPF. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution."
      Vandepoele K., Van Roy N., Staes K., Speleman F., van Roy F.
      Mol. Biol. Evol. 22:2265-2274(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiNBPFK_HUMAN
    AccessioniPrimary (citable) accession number: Q3BBV1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3